Mode
Text Size
Log in / Sign up

Generalized pustular psoriasis

Part of Psoriasis

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Generalized pustular psoriasis

7 trials tracked for Generalized pustular psoriasis: 4 in phase 3 or 4 and 2 with published results. The most-cited published study has 33 citations.

7Trials tracked
4Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 1 Phase 3 3 Phase 2 3
  1. Phase 4 A Study of Ixekizumab (LY2439821) in Participants in Japan With Generalized Pustular Psoriasis and Erythrodermic Psoriasis Completed · 33 cited
  2. Phase 3 Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Subjects With GPP Completed · 2 cited
  3. Phase 3 An Expanded Access Trial in Japan to Provide Spesolimab to People With a Flare-up in Generalized Pustular Psoriasis Who Have no Other Treatment Options Completed
  4. Phase 3 An Expanded Access Program in China to Provide Spesolimab to People With a Flare-up in Generalized Pustular Psoriasis Who Have no Other Treatment Options Completed
  5. Phase 2 Effisayil™ 1: A Study to Test Spesolimab (BI 655130) in Patients With a Flare-up of a Skin Disease Called Generalized Pustular Psoriasis Completed
  6. Phase 2 A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in Adults With Generalized Pustular Psoriasis Completed
Show 1 more trials
  1. Phase 2 A Study to Test Whether BI 655130 (Spesolimab) Prevents Flare-ups in Patients With Generalized Pustular Psoriasis Completed

Showing the 7 most-cited and recently-updated of 7 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Generalized pustular psoriasis: what the trials found

New clinical evidence indicates that Imsidolimab (750 mg) is associated with specific rates of skin clearance in patients with generalized pustular psoriasis, with 8% and 2% achieving GPPPGA scores of 0 or 1 across different study arms 1.

Spesolimab has demonstrated significant efficacy in managing GPP. Clinical data shows a statistically significant reduction in the occurrence of at least one GPP flare up to week 48 (p=0.0013) and an improved time to first worsening of the Psoriasis Symptom Scale (p=0.0134) 5. Furthermore, spesolimab was associated with a significantly higher proportion of patients achieving a GPPPGA pustulation subscore of 0 at week 1 (p=0.0004) and a GPPPGA score of 0 or 1 at week 1 (p=0.0118), as well as a higher proportion of patients achieving GPPASI 75 at week 4 (p=0.0081) 7.

Ixekizumab was evaluated in a maintenance dosing period where results showed limited data on specific improvements; however, some participants achieved a Global Improvement Score (GIS) of 2 or improved by at least one point between weeks 12 and 20 2.

Recent results — preliminary, needs further review

  • Imsidolimab showed clinical response rates of 75.0% on the CGI scale and significant reductions in body surface area of erythema with pustules (up to -97.78%) and mJDA-SI total skin lesions scores (up to -62.20%) at week 16, though these findings are not yet corroborated 6.

For the clinician treating this condition

  • Spesolimab significantly reduces the frequency of GPP flares and delays the worsening of psoriasis symptoms over a 48-week period 5.
  • Spesolimab demonstrates rapid early results, with significant improvements in pustule resolution (GPPPGA subscore) and overall severity scores (GPPPGA and GPPASI) by week 1 and week 4 respectively 7.
  • Imsidolimab is associated with measurable rates of near-complete or complete clearance as measured by GPPPGA and PRS scales 1.

AI synthesis of 5 cited trials, updated Jun 20, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Psoriasis

Related studies from across the Psoriasis family.

Icotrokinra increases likelihood of Investigator's Global Assessment 0 or 1 by risk ratio 7.27
Dermatology Meta-analysis
Icotrokinra increases likelihood of Investigator's Global Assessment 0 or 1 by risk ratio 7.27 Icotrokinra Shows Promise for Moderate to Severe Plaque Psoriasis
This meta-analysis of icotrokinra for moderate-to-severe plaque psoriasis in adolescents and adults found a risk ratio of 7.27 for Investiga…
A new treatment called icotrokinra shows significant skin clearance and improved scores for adults and teens with moderate to severe plaque …
Telitacicept Shows Satisfactory Response in Complex Overlap Syndrome Case
Neurology Guideline
Telitacicept Shows Satisfactory Response in Complex Overlap Syndrome Case Telitacicept Shows Potential in Rare Overlap Syndrome Case
This is a single case report describing a patient with systemic lupus erythematosus, immune-mediated necrotizing myopathy, Sjögren's syndrom…
A single case report describes a patient with four autoimmune conditions who responded well to a regimen containing telitacicept.
Vigorous activity and regular exercise are associated with lower psoriasis prevalence in patients with psoriasis
Allergy & Immunology Meta-analysis
Vigorous activity and regular exercise are associated with lower psoriasis prevalence in patients with psoriasis Regular Exercise May Help Manage Psoriasis and Joint Pain
This umbrella review synthesizes evidence on exercise, physical activity, and fitness for patients with psoriasis and psoriatic arthritis. T…
Regular physical activity and vigorous exercise may be linked to lower psoriasis prevalence and improved symptoms for those with psoriatic a…
Comparative Efficacy and Safety of Ustekinumab Biosimilars versus Reference Products in Plaque Psoriasis
Dermatology Meta-analysis
Comparative Efficacy and Safety of Ustekinumab Biosimilars versus Reference Products in Plaque Psoriasis Ustekinumab biosimilars show similar results to the original drug
Meta-analysis confirms that ustekinumab biosimilars demonstrate comparable efficacy and safety profiles to the reference product for moderat…
New data shows that biosimilar versions of the drug ustekinumab work just as well as the original for people with moderate to severe plaque …
Inflammatory memory mechanisms may drive chronic relapse and offer pathways for disease modification in rosacea
Dermatology Sys. Review
Inflammatory memory mechanisms may drive chronic relapse and offer pathways for disease modification in rosacea New framework explores why rosacea and psoriasis keep returning
This hypothesis-generating critical review explores inflammatory memory, including epigenetic memory and trained immunity, as a framework fo…
Scientists are looking into how the body remembers inflammation, which could help explain why skin conditions like rosacea often flare up re…
Keratinocytes drive psoriasis inflammation through bidirectional epithelial-immune crosstalk
Dermatology Sys. Review
Keratinocytes drive psoriasis inflammation through bidirectional epithelial-immune crosstalk Skin cells play a key role in driving psoriasis inflammation
This narrative review synthesizes evidence that keratinocytes are active participants in a bidirectional epithelial-immune network driving p…
New research shows that skin cells are not just passive victims of psoriasis but active participants in driving the cycle of inflammation.
IRF4 acts as a context-encoded mediator in immune compartments and skin repair processes
Dermatology Sys. Review
IRF4 acts as a context-encoded mediator in immune compartments and skin repair processes Understanding the Role of IRF4 in Treating Skin Inflammation Conditions
This narrative review examines the role of Interferon regulatory factor 4 (IRF4) in immune compartments and skin conditions. The review iden…
Scientists are looking at how the IRF4 protein affects skin diseases like psoriasis and eczema to find better ways to manage symptoms.
Neural interactions and cellular components in psoriasis may offer new therapeutic targets for treatment
Dermatology Sys. Review
Neural interactions and cellular components in psoriasis may offer new therapeutic targets for treatment New Research Identifies Nervous System Links in Psoriasis Treatment
This systematic review examines the interactions between multiple cellular components and the nervous system in psoriasis. The review aims t…
New research explores how the nervous system interacts with skin cells in psoriasis to help identify new ways to treat the condition.
Ustekinumab May Improve Inverse Psoriasis in Single Case Report
Dermatology Guideline
Ustekinumab May Improve Inverse Psoriasis in Single Case Report Ustekinumab Shows Promise for Treatment of Inverse Psoriasis
This is a single case report of a 32-year-old male with inverse psoriasis treated with four subcutaneous ustekinumab injections. Skin lesion…
A new case report shows how a specific medication, ustekinumab, significantly improved skin lesions and itching for a patient with inverse p…
Guselkumab achieves 88.8% IGA 0/1 at week 16 in Chinese patients with plaque psoriasis
Dermatology RCT
Guselkumab achieves 88.8% IGA 0/1 at week 16 in Chinese patients with plaque psoriasis Trial shows guselkumab helps Chinese patients with plaque psoriasis
This Phase 4 randomized controlled trial of 327 Chinese patients with moderate-to-severe plaque psoriasis found guselkumab significantly sup…
A new trial shows that guselkumab significantly improves skin clarity for Chinese patients living with moderate to severe plaque psoriasis.
Vunakizumab may induce severe ulcerative colitis and hepatic enzyme elevation in patients with psoriatic arthritis
Allergy & Immunology Sys. Review
Vunakizumab may induce severe ulcerative colitis and hepatic enzyme elevation in patients with psoriatic arthritis Vunakizumab Linked to Severe Ulcerative Colitis in Single Case
This case report and literature review describes a single case of severe ulcerative colitis and hepatic enzyme elevation following vunakizum…
A single case report shows a patient developed severe ulcerative colitis and high liver enzymes after receiving vunakizumab injections.
BAT2306 shows comparable efficacy and safety to secukinumab in moderate-to-severe plaque psoriasis
Dermatology RCT
BAT2306 shows comparable efficacy and safety to secukinumab in moderate-to-severe plaque psoriasis Trial shows BAT2306 performs similarly to secukinumab for plaque psoriasis
This Phase 3 randomized controlled trial evaluated 502 adults with moderate-to-severe plaque-type psoriasis. The study found that BAT2306 de…
A new clinical trial shows that the medication BAT2306 offers similar results and safety for plaque psoriasis compared to the established dr…