Systemic barriers like delayed diagnosis and limited surgery impact survival in high-grade gliomas
Systemic Barriers Impact Survival for Patients with High-Grade Gliomas
This meta-analysis of 30 independent studies evaluates survival outcomes for high-grade gliomas in low- and middle-income countries. Finding…
Limited access to surgery, chemotherapy, and early diagnosis creates significant hurdles for patients with high-grade gliomas in developing …
CAR T-cell therapies targeting specific antigens show potential for treating pediatric CNS tumors
New CAR T-cell therapies show promise for pediatric brain tumors
This narrative review synthesizes 18 studies, including preclinical and early-phase clinical trials, regarding CAR T-cell therapy for pediat…
CAR T-cell therapy is showing potential to shrink tumors and extend life in children with aggressive brain cancers like DIPG.
Targeted cytokine delivery platforms in canine oncology provide data for human immuno-oncology dose selection
Cytokine Therapies Show Potential for Treating Canine Cancers
This mini review synthesizes evidence on targeted cytokine delivery platforms, such as IL-12 and IFN-beta, in dogs with various spontaneous …
New research explores how targeted cytokine delivery systems can treat various cancers in dogs and provide data for future human cancer trea…
Intracranial immunotherapy delivery does not improve survival for pediatric high-grade glioma compared to systemic administration
Intracranial Delivery Shows Higher Neurotoxicity Risk in Pediatric Brain Tumors
This meta-analysis of 22 studies evaluated intracranial versus systemic immunotherapy delivery in pediatric patients with high-grade and dif…
New analysis shows that while delivery methods do not change survival for pediatric brain tumors, some routes carry a higher risk of severe …
Recurrence patterns in high-grade glioma after standard chemoradiotherapy: a retrospective review
Why tumors grow back inside the radiation beam, not just at the edges
This retrospective single-center review of 41 patients with high-grade glioma found that central recurrence was the most common pattern (36.…
New data shows brain tumors often return in the middle of the radiation zone, suggesting biology, not just targeting errors, drives failure.
GSC-associated gene signature predicts survival in adult and pediatric high-grade glioma patients
New Brain Tumor Test Predicts Survival More Accurately
This cohort study evaluated a GSC-associated gene signature involving the FAM86B1/FAM86B2 axis in adult and pediatric high-grade glioma pati…
A new model uses specific genes to predict how long patients might live with aggressive brain tumors.
Review of STING agonists for high-grade and diffuse midline glioma discusses systemic toxicity and delivery constraints
New Brain Drug Target Could Wake Up the Immune System
This narrative review examines the potential of STING agonists, cyclic dinucleotides, and related compounds for treating high-grade glioma a…
A new brain drug target aims to wake up the immune system's defenses against dangerous, hard-to-treat tumors that hide from the body's natur…
Locoregional CAR T-cell delivery reduces severe adverse events in high-grade glioma patients
Could a new way to deliver brain cancer therapy make it safer and more effective?
A meta-analysis of 14 clinical trials involving 194 high-grade glioma patients found locoregional CAR T-cell delivery was associated with re…
Delivering brain cancer therapy directly to the tumor instead of through the bloodstream cuts severe side effects by more than 60% and shows…
Research across Cancer
Related studies from across the Cancer family.
Lysine crotonylation drives tumor progression and may potentiate immunotherapy response in various solid tumors
New Biological Markers May Help Doctors Target Growth in Several Cancer Types
This narrative review explores the role of lysine crotonylation (Kcr) in cancer biology across multiple solid tumor types. The authors concl…
Scientists are looking at how a specific protein change called crotonylation helps cancer grow and may help improve immunotherapy results.
Dose-dense temozolomide shows no significant difference in progression-free survival compared to standard radiotherapy
Trial Shows Temozolomide and Radiation Offer Similar Results for Glioma
This Phase III randomized controlled trial of 478 patients with high-risk low-grade glioma found no significant difference in progression-fr…
A large trial found that dose-dense temozolomide and standard radiation provided similar survival outcomes for patients with high-risk low-g…
Low-grade glioma makes up 57% of mixed-grade glioma surgical cohorts, meta-analysis finds
New data clarifies the prevalence of low-grade glioma tumors
This meta-analysis of 191 cohort studies (25,847 patients) pooled the proportion of low-grade glioma across mixed-grade glioma surgical coho…
New data from over 25,000 patients helps doctors better understand the common types of low-grade glioma found in mixed tumor groups.
RPN1 overexpression promotes immune evasion and treatment resistance in multiple malignancies including hepatocellular carcinoma
RPN1 Protein Linked to Worse Outcomes in Several Cancers
This systematic review examines the role of RPN1 in glioma, hepatocellular carcinoma, sarcoma, and triple-negative breast cancer. The author…
High levels of the RPN1 protein are linked to aggressive cancer features and help tumors hide from the body's immune system.
Egg consumption associated with reduced glioma risk in Eastern populations and increased head and neck cancer risk
Egg consumption shows mixed links to glioma and head and neck cancer
This meta-analysis of observational studies involving 1,274,437 participants found that egg consumption was associated with a reduced risk o…
New data shows a link between egg consumption and lower glioma risk in some groups, but a potential link to higher head and neck cancer risk…
Multiparametric MRI and image-guided neurointerventions provide critical roles in brain tumor management and surveillance
Advanced Imaging and Interventions Improve Brain Tumor Management
This narrative review examines the roles of advanced diagnostic imaging and image-generated neurointerventions in managing brain tumors, inc…
Newer imaging techniques and minimally invasive procedures are expanding how doctors detect, plan, and treat various types of brain tumors.
Metachronous pancreatic metastasis from ovarian cancer is rare, mostly high-grade serous
Ovarian cancer can spread to pancreas, rare review finds
This systematic review of 7 studies (8 cases) found that metachronous pancreatic metastasis from ovarian cancer is rare and most often origi…
A rare spread of ovarian cancer to the pancreas may be treatable with surgery or chemo, but evidence is thin.
Reactive oxygen species promote tumorigenic programs and platinum-based chemotherapy resistance in high-grade serous ovarian cancer
Reactive Oxygen Species May Drive Ovarian Cancer Progression
This narrative review of 19 in vitro studies synthesizes how reactive oxygen species (ROS) drive tumor progression, metastatic potential, an…
New research explores how reactive oxygen species (ROS) may help ovarian cancer cells grow, spread, and resist common chemotherapy treatment…
Peer support may impact fear of disease progression and psychological symptoms in patients with glioma
Peer support may ease fear in glioma patients
This is a protocol for a systematic review and meta-analysis regarding the impact of peer support on fear of disease progression, fatigue, d…
A new meta-analysis protocol will examine whether peer support reduces fear of disease progression in glioma patients.
Symptomatic radiation necrosis occurs in 5.7% of intracranial brachytherapy patients
Brachytherapy for brain tumors: 5.7% risk of radiation necrosis
This meta-analysis of 3666 patients undergoing intracranial brachytherapy for glioma, brain metastases, or meningioma found a pooled inciden…
About 1 in 18 patients who get internal radiation for brain tumors develop symptomatic radiation necrosis, a new analysis finds.
Immunohistochemical profiling helps differentiate synchronous primary breast invasive carcinoma from metastatic ovarian carcinoma
One woman diagnosed with two different types of cancer simultaneously
This case report and literature review describes a patient with concurrent primary breast cancer and metastatic high-grade serous ovarian ca…
A rare case reveals how one patient can have both breast and ovarian cancer at once, highlighting a complex diagnostic challenge.
MRI Radiomics Predicts TERTp Mutation in Glioma with Moderate Accuracy
MRI Radiomics Help Predict TERTp Mutation in Glioma Patients
Meta-analysis of 14 studies shows MRI radiomics predicts TERTp mutation in glioma with AUC 0.79; combined models improve accuracy to 0.82.
New analysis shows MRI-based radiomics can help predict specific genetic mutations in glioma, potentially aiding early diagnosis and treatme…
Questions about High-grade glioma
Does delivering CAR T-cells locally reduce severe side effects in high-grade glioma?
Delivering CAR T-cells directly into the tumor or brain ventricles significantly lowers severe side effects compared to giving them through the bloodstream for high-grade glioma patients.
Full answer →Can a specific gene signature predict survival for high-grade glioma patients?
Yes, specific gene signatures can predict survival for high-grade glioma patients by analyzing tumor biology, immune interactions, and cellular processes like autophagy.
Full answer →What is the most common way high-grade glioma comes back after standard treatment?
After standard surgery and radiation, high-grade glioma most often returns in the center of the original tumor area or just at the edge of the radiation field.
Full answer →