GWAS meta-analysis identifies 89 loci for mitral valve prolapse and genetic links to hypertrophic cardiomyopathy
New DNA Clues Link Heart Valve to Dangerous Rhythms
This meta-analysis of genome-wide association studies (GWAS) evaluated genetic factors in over 2.2 million individuals, including 21,517 cas…
Imagine your heart has a tiny door that sometimes swings too wide.
Plasma proteins linked to HCM severity identified in MYBPC3 carriers and UK Biobank
Could blood proteins predict dangerous heart conditions like sudden cardiac arrest in people with specific gene mutations?
This observational study examined 144 MYBPC3 pathogenic variant carriers and 6,492 UK Biobank participants to identify plasma proteins assoc…
Blood proteins linked to heart failure and sudden cardiac arrest appear in people with specific gene mutations, offering new warning signs f…
Cardiac genetic testing mainstreaming increases uptake and reduces wait times but lowers informed decision making
Cardiac genetic testing in clinics increased access but reduced informed decision making
An observational study of patients with hypertrophic or dilated cardiomyopathy compared genetic testing offered in cardiology clinics (mains…
Offering genetic testing in cardiology clinics boosted access and cut wait times, yet only 62% of patients felt fully informed compared to 9…
Multimodality cardiac imaging aids differentiation between hypertrophic cardiomyopathy and cardiac amyloidosis
Imaging helps doctors tell apart two heart conditions causing thickened heart muscle
A narrative review synthesizes evidence on using echocardiography and cardiac MRI to distinguish hypertrophic cardiomyopathy (HCM) from card…
Heart imaging reveals distinct patterns that help doctors tell apart two thickened heart conditions requiring very different treatments.
Research across Cardiomyopathy
Related studies from across the Cardiomyopathy family.
Mast cell activation mediates heart failure and cardiomyopathy through diverse signaling and inflammatory pathways
Mast Cell Activity Linked to Heart Failure and Cardiomyopathy
This narrative review explores the role of cardiac mast cells in heart failure and cardiomyopathy. The authors synthesize evidence that mast…
New research explores how mast cells in the heart may drive heart failure and cardiomyopathy through various inflammatory and signaling path…
Acoramidis reduces risk of ACM and CVM regardless of baseline NT-proBNP and sTTR levels
New trial shows acoramidis works for heart muscle disease
This Phase 3 randomized controlled trial of 632 patients with transthyretin amyloid cardiomyopathy found that acoramidis reduced the risk of…
A new trial shows that the drug acoramidis helps patients with a specific heart condition regardless of their initial test results.
Heart Failure Evidence in Somalia Is Fragmented and Insufficient to Estimate National Burden
Review Identifies Common Causes of Heart Failure in Somalia
This scoping review synthesizes 12 studies on heart failure in Somalia, finding that evidence is geographically concentrated, methodological…
A review of 12 studies identifies key conditions like hypertension and heart disease that contribute to heart failure in the Somali region.
HDAC3 acts as a central epigenetic hub for Type 2 Diabetes and its complications
New research identifies a key protein linked to diabetes complications
This systematic review identifies HDAC3 as a critical regulator of immunometabolic homeostasis in Type 2 Diabetes. The review concludes that…
A specific protein called HDAC3 may play a central role in causing heart, kidney, and eye damage in people with Type 2 Diabetes.
Dystrophinopathy should be considered in adolescent males with nonischemic cardiomyopathy and heart failure
Heart failure treatment shows promise for a boy with muscular dystrophy
This case report describes a 17-year-old male with Duchenne muscular dystrophy and heart failure who showed LVEF improvement from 44% to 55%…
A 17-year-old boy with a rare muscle disease saw his heart function improve while receiving standard heart failure care.
Conduction system pacing reduces heart failure hospitalization and cardiomyopathy risk compared to right ventricular pacing
Conduction system pacing may lower heart failure hospital risks
This meta-analysis of randomized controlled trials involving 1466 patients with preserved or mildly reduced LVEF found that conduction syste…
A new type of heart pacing could significantly lower the risk of heart muscle damage and hospital stays for patients with heart failure.
Transthyretin stabilizers and RNA-silencing therapies attenuate cardiac remodeling in transthyretin amyloid cardiomyopathy
New Therapies May Slow Heart Damage in Amyloid Cardiomyopathy
This meta-analysis of 3646 adults with cardiac amyloidosis found that transthyretin stabilizers and RNA-silencing therapies are associated w…
Specific drug therapies may help stabilize heart structure and slow the progression of damage for adults with transthyretin amyloid cardiomy…
Gene, inflammation, and metabolic dysregulation drive pathophysiology in pediatric dilated cardiomyopathy
Gene, Inflammation, Metabolism Link in Child Heart Failure
This systematic review examines the role of the gene-inflammation-metabolism axis in pediatric dilated cardiomyopathy. The authors identify …
A new review links genes, inflammation, and metabolism in pediatric dilated cardiomyopathy, offering a roadmap for targeted treatments.
Supraventricular tachyarrhythmias occur more frequently in patients with Arrhythmogenic Cardiomyopathy and Brugada Syndrome
Heart conditions like Brugada syndrome increase risk of rapid heartbeats
This systematic review of 30 studies indicates that supraventricular tachyarrhythmias (SVT) are more frequent in patients with Arrhythmogeni…
Patients with certain heart conditions face a higher risk of fast heartbeats, which can lead to complications like heart failure or unnecess…
Vascular smooth muscle cell immune interactions drive remodeling across cardiovascular diseases
How blood vessel cells drive heart disease and high blood pressure
This narrative review synthesizes mechanisms of VSMC-immune interactions in atherosclerosis, hypertension, aortic aneurysms, and arteritis. …
A new review reveals how blood vessel cells change in heart disease, high blood pressure, and more.
Review of Diabetic Cardiomyopathy without reported trial data or specific outcomes
Review of Diabetic Cardiomyopathy offers new understanding of this heart condition
This narrative review addresses Diabetic cardiomyopathy but reports no specific population, sample size, or intervention details. The author…
This review looks at diabetic cardiomyopathy to help doctors understand this specific heart problem better for patients with diabetes.
Mini review examines sudden cardiac death risks in marathon runners across different age groups
Marathon running links to higher heart risk in older men and full-distance participants
This mini review synthesizes evidence on sudden cardiac death (SCD) and coronary artery disease in marathon runners. The authors note that r…
A review of marathon runners shows heart risks vary by age, sex, and race distance, with most events happening near the finish.
Questions about Hypertrophic Cardiomyopathy
Which echocardiographic and biochemical markers can predict mortality risk for children with hypertrophic cardiomyopathy?
In children with hypertrophic cardiomyopathy, echocardiographic markers like left atrial size and left ventricular wall thickness, and biochemical markers such as NT-proBNP, predict mortality risk.
Full answer →Can visual standardized quantification of LGE help doctors see heart scarring better in hypertrophic cardiomyopathy?
Yes, VISTAQ, a visual standardized method, helps doctors see and quantify heart scarring (LGE) in HCM with excellent reproducibility, without needing complex software.
Full answer →