Targeting metabolic checkpoints and mechanotransduction may address structural deterioration in axial spondyloarthritis
New research identifies why current treatments fail to stop spinal damage
This narrative review explores the limitations of current anti-inflammatory therapies for axial spondyloarthritis and intervertebral disc de…
Current medications may only mask inflammation while structural damage continues. New research points toward targeting the underlying enviro…
Ferroptosis-driven domino effect links disc degeneration to spinal cord injury
Ferroptosis Linked to Spinal Cord Injury and Disc Degeneration
This mini review proposes a ferroptosis-mediated domino effect connecting intervertebral disc degeneration, spinal deformity, and spinal cor…
A new theoretical framework suggests that a specific type of cell death may link disc degeneration to spinal cord injury.
Senolytic clearance and epigenetic remodeling offer a proposed roadmap to treat intervertebral disc degeneration
New strategies target aging cells to treat spinal disc decay
This systematic review examines the role of cellular senescence and epigenetic dysregulation in intervertebral disc degeneration (IDD). The …
Scientists have identified a way to stop the cycle of cell aging that causes spinal discs to break down and lose their function.
Review of senescence-associated secretory phenotype in aging osteoarthritis and disc degeneration
Aging cells release signals that may worsen bone and joint disease in older adults
This narrative review examines the senescence-associated secretory phenotype (SASP) in aging populations with osteoarthritis, intervertebral…
A review suggests aging cell signals could drive bone and joint problems. This insight helps doctors understand why these conditions worsen …
Research across Degenerative Disc Disease
Related studies from across the Degenerative Disc Disease family.
Systematic review and meta-analysis of rehabilitation interventions for lumbar degenerative disc disease surgery patients
After Back Surgery, One Simple Change Boosts Strength and Movement
This systematic review and meta-analysis evaluates rehabilitation and behavior change interventions for adults with lumbar degenerative disc…
This review shows that structured exercise and psychological support can improve recovery after back surgery, but not all rehab methods work…
PRP injection associated with lower healthcare use and costs versus lumbar surgery for DDD in retrospective study
For back pain, could an injection be a simpler, cheaper path than surgery?
A retrospective observational cohort study of adults with lumbar DDD compared PRP injection to lumbar fusion or decompression procedures.
Adults with back pain who received PRP injections instead of major spine surgery spent significantly less money and needed fewer follow-up v…