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Home › Conditions › Degenerative Disc Disease

Degenerative Disc Disease

Subtypes of Degenerative Disc Disease

Intervertebral disc degeneration 5

7 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Degenerative Disc Disease

24 trials tracked for Degenerative Disc Disease: 4 in phase 3 or 4.

24Trials tracked
4Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 4 2 Phase 3 2 Phase 2 4 Other / NA 16
  1. Phase 4 Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms Completed
  2. Phase 4 BIO4 Clinical Case Study: Cervical Spine Completed
  3. Phase 3 Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Participants With Chronic Low Back Pain Completed
  4. Phase 3 Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease Completed
  5. Phase 2 A Multicenter, Randomized, Double-blind, Placebo Controlled, Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of 2 Doses of Intradiscal rhGDF-5 (Single Administration) for the Treatment of Early Stage Lumbar Disc Degeneration Completed
  6. Phase 2 Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV) Completed
Show 18 more trials
  1. Phase 2 Intradiscal rhGDF-5 Phase I/II Clinical Trial Completed
  2. Phase 2 TXA in Spinal Fusion Completed
  3. N/A Clinical Outcomes Associated With the Use of ViviGen® for the Treatment of Lumbar Degenerative Disc Disease Completed
  4. N/A Retrospective/Prospective Data Collection on the LDR ROIA Interbody Fusion Device With VerteBRIDGE Plating Completed
  5. N/A Assessment of nanOss Bioactive 3D in the Posterolateral Spine Completed
  6. N/A Retrospective Review of Integrity Implants FlareHawk® for Lumbar Fusion Completed
  7. N/A Retrospective Multicenter Clinical Evaluation of Complications for Single or Multilevel VEO® Lateral Access and Interbody Fusion System and eXtreme Lateral Interbody Fusion (XLIF®) Subjects Completed
  8. N/A Maverick Total Disc Replacement in a 'Real World' Patient Population Completed
  9. N/A Trial Evaluating the Safety and Effectiveness of NUBAC™ Disc Arthroplasty Completed
  10. N/A Retrospective/Prospective Data Collection on the LDR ROIC Interbody Fusion Device With VerteBRIDGE Plating Completed
  11. N/A ViBone in Cervical and Lumbar Spine Fusion Completed
  12. N/A Activ-L™ Artificial Disc Treatment of Degenerative Disc Disease in the Treatment of Degenerative Disc Disease Completed
  13. N/A LDR Spine USA Mobi-C(R) Cervical Disc Prosthesis IDE Completed
  14. N/A Safety and Efficacy of the CarboClear Pedicle Screw System Completed
  15. N/A Outcome Study of Patients Treated With Translational Cervical Plate Used to Treat Degenerative Disc Disease Completed
  16. N/A INFUSE® Bone Graft/ PEEK Interbody Spacer/ Anterior Cervical Plate Pivotal Clinical Trial Completed
  17. N/A Benefit of Lumbar Bracing for Chronic Low Back Pain Due to Degenerative Disc Disease Completed
  18. N/A Study of an Expandable Interbody Device for the Lumbar Spine Completed

Showing the 24 most-cited and recently-updated of 24 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
DEBC classification provides a complementary lesion-level imaging framework for intervertebral disc degeneration
Orthopedics & Sports Medicine Sys. Review
DEBC classification provides a complementary lesion-level imaging framework for intervertebral disc degeneration New imaging framework helps map spinal disc health and damage
This narrative and critical review evaluates the DEBC classification framework as an imaging tool for intervertebral disc degeneration. The …
A new way to look at spine images helps doctors better understand the different types of tissue changes in aging discs.
Frontiers Jul 25, 2026
Targeting metabolic checkpoints and mechanotransduction may address structural deterioration in axial spondyloarthritis
Allergy & Immunology Sys. Review
Targeting metabolic checkpoints and mechanotransduction may address structural deterioration in axial spondyloarthritis New research identifies why current treatments fail to stop spinal damage
This narrative review explores the limitations of current anti-inflammatory therapies for axial spondyloarthritis and intervertebral disc de…
Current medications may only mask inflammation while structural damage continues. New research points toward targeting the underlying enviro…
Frontiers Jun 30, 2026
Ferroptosis-driven domino effect links disc degeneration to spinal cord injury
Neurology Sys. Review
Ferroptosis-driven domino effect links disc degeneration to spinal cord injury Ferroptosis Linked to Spinal Cord Injury and Disc Degeneration
This mini review proposes a ferroptosis-mediated domino effect connecting intervertebral disc degeneration, spinal deformity, and spinal cor…
A new theoretical framework suggests that a specific type of cell death may link disc degeneration to spinal cord injury.
Frontiers Jun 19, 2026
Senolytic clearance and epigenetic remodeling offer a proposed roadmap to treat intervertebral disc degeneration
Geriatrics & Aging Sys. Review
Senolytic clearance and epigenetic remodeling offer a proposed roadmap to treat intervertebral disc degeneration New strategies target aging cells to treat spinal disc decay
This systematic review examines the role of cellular senescence and epigenetic dysregulation in intervertebral disc degeneration (IDD). The …
Scientists have identified a way to stop the cycle of cell aging that causes spinal discs to break down and lose their function.
Frontiers Jun 17, 2026
Review of senescence-associated secretory phenotype in aging osteoarthritis and disc degeneration
Geriatrics & Aging Sys. Review
Review of senescence-associated secretory phenotype in aging osteoarthritis and disc degeneration Aging cells release signals that may worsen bone and joint disease in older adults
This narrative review examines the senescence-associated secretory phenotype (SASP) in aging populations with osteoarthritis, intervertebral…
A review suggests aging cell signals could drive bone and joint problems. This insight helps doctors understand why these conditions worsen …
Frontiers May 18, 2026
Systematic review and meta-analysis of rehabilitation interventions for lumbar degenerative disc disease surgery patients
Physical Medicine & Rehab Meta-analysis
Systematic review and meta-analysis of rehabilitation interventions for lumbar degenerative disc disease surgery patients After Back Surgery, One Simple Change Boosts Strength and Movement
This systematic review and meta-analysis evaluates rehabilitation and behavior change interventions for adults with lumbar degenerative disc…
This review shows that structured exercise and psychological support can improve recovery after back surgery, but not all rehab methods work…
Apr 22, 2026
PRP injection associated with lower healthcare use and costs versus lumbar surgery for DDD in retrospective study
Orthopedics & Sports Medicine Cohort
PRP injection associated with lower healthcare use and costs versus lumbar surgery for DDD in retrospective study For back pain, could an injection be a simpler, cheaper path than surgery?
A retrospective observational cohort study of adults with lumbar DDD compared PRP injection to lumbar fusion or decompression procedures.
Adults with back pain who received PRP injections instead of major spine surgery spent significantly less money and needed fewer follow-up v…
medRxiv Apr 4, 2026