Research across Parkinson's Disease
Related studies from across the Parkinson's Disease family.
Twelve SNPs associated with Parkinson's disease-related gray matter volume reduction were identified in meta-analysis
Genetic variants linked to brain tissue loss in Parkinson's disease
This meta-analysis of 3212 patients with Parkinson's disease and 2056 controls identifies robust patterns of gray matter volume reduction an…
New research identifies specific genetic markers and brain tissue loss patterns in Parkinson's disease to help find future treatment targets…
Augmented fixation and soft-tissue reinforcement may address patellar fracture nonunion in patients with Parkinson's disease
Surgical Techniques for Patellar Fractures in Parkinson's Disease Patients
This case report and focused literature review describes a patient with Parkinson's disease who underwent revision surgery for a patellar fr…
A case report explores how surgeons manage complex knee fractures in patients with Parkinson's disease to improve mobility and manage pain.
Invasive spinal cord stimulation provides variable relief across diverse chronic neuropathic pain conditions
Different types of spinal cord stimulation help various chronic pains
This narrative review synthesizes evidence on invasive spinal cord stimulation (SCS) for various neurological and pain conditions. The autho…
Newer forms of spinal cord stimulation offer promising relief for complex nerve pain and failed back surgeries, but results vary by conditio…
tACS shows no significant motor benefit in Parkinson's disease, meta-analysis finds
Trial Shows No Significant Improvement in Parkinson's With tACS
This meta-analysis of small trials found no statistically significant difference between transcranial alternating current stimulation (tACS)…
A review of clinical data suggests that transcranial alternating current stimulation does not currently improve motor symptoms for people wi…
Exercise plus antioxidants may add neuroprotection in Alzheimer's and Parkinson's, but evidence is context-dependent
Exercise and Antioxidants May Offer Neuroprotection for Alzheimer's and Parkinson's
This narrative review examines exercise and antioxidant interventions (vitamins, selenium, zinc, flavonoids) for Alzheimer's and Parkinson's…
Combining exercise with antioxidants like vitamins and flavonoids may offer extra protection for the brain in some experimental settings.
PGE2 signaling via EP receptors drives tumor progression and context-dependent neuroinflammation in various diseases
Understanding the Role of PGE2 Signaling in Brain Health and Cancer
This systematic review examines the role of PGE2 signaling across neurological, oncological, and metabolic conditions. The findings indicate…
New research shows how different parts of a single protein pathway can either protect your brain or help tumors grow.
Rasagiline and selegiline show comparable efficacy and safety in early Parkinson's disease
Rasagiline and selegiline offer similar relief for early Parkinson's
This meta-analysis indirectly compared rasagiline with selegiline in early Parkinson's disease, finding no statistically significant differe…
Two common medications for early Parkinson's disease provide similar symptom relief, but one option may be more expensive than the other.
Ginseng components show potential neuroprotective effects in preclinical models of multiple neurodegenerative diseases
Ginsenosides Show Potential Neuroprotective Effects for Several Brain Diseases
This systematic review synthesizes evidence regarding the role of ginseng and its active components, such as ginsenosides, in models of Alzh…
Research into ginseng components suggests potential neuroprotective benefits for conditions like Alzheimer's and Parkinson's, though results…
Tavapadon improves motor function and ON-time in patients with Parkinson's disease
Tavapadon Shows Improved Motor Function in Parkinson's Disease Patients
This meta-analysis of 1540 patients found that tavapadon improved MDS-UPDRS Parts II and III scores by 10.55 points and increased good ON-ti…
A review of clinical data suggests that the medication tavapadon may improve motor skills and daily movement for people with Parkinson's dis…
Pain may precede Parkinson's diagnosis, affecting up to 59% before motor symptoms
Pain may signal Parkinson's before motor symptoms
This narrative review examines pain as an early feature of Parkinson's disease, reporting prevalence up to 59% before motor symptoms and up …
Pain can strike years before Parkinson's motor symptoms, affecting up to 72% of early-stage patients. Recognizing it could speed diagnosis.
Glucagon-like peptide-1 receptor agonists associated with reduced Parkinson's disease risk in type 2 diabetes
New Data Suggests Specific Diabetes Medications May Lower Risk of Parkinson Disease
Researchers analyzed real-world data to evaluate the association between GLP-1RAs and Parkinson's disease risk in patients with type 2 diabe…
A large study shows that people with type 2 diabetes taking GLP-1 receptor agonists may have a lower risk of developing Parkinson disease.
Parkinson's institutionalisation risk 37.2% by 10 years; older age, motor severity, cognition predict
Parkinson's Risk Factors Predict Nursing Home Placement
This meta-analysis of European incidence cohorts (n=1046) found a 37.2% cumulative incidence of institutionalisation by 10 years in people w…
Nearly 4 in 10 people with Parkinson's enter a nursing home within 10 years. Older age, worse motor symptoms, and lower cognitive scores rai…