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Home › Conditions › Lynch Syndrome

Lynch Syndrome

Part of Microsatellite-stable colorectal cancer

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Lynch Syndrome

2 trials tracked for Lynch Syndrome.

2Trials tracked
0Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 1 1 Other / NA 1
  1. Phase 1 Pediatric Reporting of Adult-Onset Genomic Results Completed
  2. N/A Overcoming Barriers to the Uptake of Cascade Screening for Lynch Syndrome: Workbook Feasibility Study Completed

Showing the 2 most-cited and recently-updated of 2 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Colonoscopic Surveillance in Lynch Syndrome Linked to Lower Mortality but Not Reduced Cancer Incidence
Oncology RCT
Colonoscopic Surveillance in Lynch Syndrome Linked to Lower Mortality but Not Reduced Cancer Incidence Colonoscopies Save Lives in High-Risk Patients
This observational cohort study of 4732 MMR-carriers in the English NHS found that colonoscopic surveillance was associated with decreased C…
You’ve just turned 35. Your mom had colon cancer at 42.
medRxiv Apr 24, 2026
Meta-analysis finds 3.2% prevalence of germline MMR mutations in patients with upper tract urothelial carcinoma
Gastroenterology Meta-analysis
Meta-analysis finds 3.2% prevalence of germline MMR mutations in patients with upper tract urothelial carcinoma Study finds 3.2% of upper tract urothelial cancer patients have inherited DNA repair mutations
A systematic review and meta-analysis of 14 studies including 2378 patients with upper tract urothelial carcinoma (UTUC) found a pooled prev…
About 3% of upper tract urothelial cancer patients carry inherited DNA repair mutations that link their cancer to Lynch syndrome and affect …
Apr 5, 2026
Case series identifies MSH2 variants in three families suspected of Lynch syndrome
Rheumatology
Case series identifies MSH2 variants in three families suspected of Lynch syndrome Genetic study identifies Lynch syndrome variants in three families with colon cancer history
A case series of three families with suspected Lynch syndrome used whole-exome sequencing and immunohistochemistry to characterize MSH2 vari…
Genetic testing found new disease-causing variants in three families with colon cancer history, offering clues for precision screening and g…
Frontiers Apr 1, 2026

Questions about Lynch Syndrome

Can Lynch Syndrome cause cancer in my bladder or kidney?

Yes, Lynch syndrome increases the risk of bladder and kidney cancers, especially in people with MSH2 mutations.

Full answer →
What specific gene mutations are found in families with suspected Lynch Syndrome?

Families with suspected Lynch Syndrome typically carry germline mutations in four specific DNA mismatch repair genes: MLH1, MSH2, MSH6, and PMS2.

Full answer →
Does having Lynch Syndrome mean I will definitely get colon cancer?

Having Lynch Syndrome greatly increases your risk of colon cancer, but it does not mean you will definitely get it. Regular colonoscopies can lower the chance of dying from the disease.

Full answer →