Review of chemopreventive strategies for familial adenomatous polyposis including NSAIDs and other agents
Review of chemoprevention options for familial adenomatous polyposis
This review evaluates chemopreventive strategies for familial adenomatous polyposis, including nonsteroidal anti-inflammatory drugs, prostag…
A review examined chemopreventive strategies for familial adenomatous polyposis, including NSAIDs and other agents, though specific results …
Closing rectal wall defects after full-thickness excision reduces bleeding and re-admission rates compared to leaving defects open in patients with rectal neoplasms
Closing the rectal wall defect lowers bleeding and re-admission rates after surgery
A systematic review and meta-analysis of six studies found that closing rectal wall defects after full-thickness excision significantly lowe…
A review of six studies found that closing the rectal wall defect after surgery significantly reduced bleeding and re-admission rates compar…
Systematic review links gut microbial metabolites to colitis-associated colorectal cancer risk
Your Gut Bacteria Make Cancer Fighters or Fuel Inside You
This systematic review synthesizes evidence on gut microbial metabolites in colitis-associated colorectal cancer. Elevated plasma TMAO level…
• Gut chemicals either protect against or drive colon cancer growth • Helps people with inflammatory bowel disease facing high cancer risk •…
Tislelizumab plus chemotherapy and radiotherapy yields 89.1% 3-year disease-free survival in pMMR/MSS locally advanced rectal cancer
Early trial shows high survival rates for rectal cancer patients treated with tislelizumab
This Phase 2 clinical trial evaluated neoadjuvant tislelizumab, chemotherapy, and long-course radiotherapy in 50 patients with pMMR/MSS loca…
A Phase 2 trial found that adding tislelizumab to standard care helped 89% of patients stay free of cancer for three years. This approach wo…
Colonoscopic Surveillance in Lynch Syndrome Linked to Lower Mortality but Not Reduced Cancer Incidence
Colonoscopies Save Lives in High-Risk Patients
This observational cohort study of 4732 MMR-carriers in the English NHS found that colonoscopic surveillance was associated with decreased C…
You’ve just turned 35. Your mom had colon cancer at 42.
Electroacupuncture Shortens Time to First Defecation in Colorectal Cancer Surgery Patients
Electroacupuncture Speeds Gut Recovery After Colon Surgery
This randomized controlled trial enrolled 72 patients with malignant tumors of the sigmoid colon or rectum scheduled for laparoscopic surger…
You wake up after colon surgery. The cancer is out.
MRI-derived nomogram improves high-risk LARC stratification over single-feature models in a multicenter retrospective cohort
New MRI Tool Pinpoints Which Rectal Cancer Patients Need Intensive Treatment
This multicenter retrospective cohort study evaluated a nomogram integrating habitat heterogeneity, peritumoral (3 mm) radiomic features, an…
This new approach could spare some patients from harsh treatments while ensuring others get the aggressive care they need.
Phase I trial of regorafenib plus ipilimumab and nivolumab shows 27.6% response in MSS colorectal cancer
Who Really Responds to a Stubborn Colon Cancer Combo?
A phase I trial in 29 patients with microsatellite-stable metastatic colorectal cancer tested the combination of regorafenib, ipilimumab, an…
A three-drug combo helped some patients with stubborn colon cancer, and immune markers now predict who will benefit most.
Neoadjuvant CAPOX chemotherapy alone showed comparable survival to chemoradiotherapy in locally advanced rectal cancer with uninvolved mesorectal fascia
Some Rectal Cancer Patients May Skip Radiation Without Losing Ground
This Phase III RCT compared 4 cycles of CAPOX chemotherapy alone versus chemoradiotherapy in patients with locally advanced rectal cancer an…
Some rectal cancer patients can skip pre-surgery radiation and still achieve similar cure rates while avoiding long-term side effects like b…
ESD achieves R0 resection for large rectal intramucosal carcinoma involving dentate line in case report
Imagine a large, pre-cancerous growth in the most sensitive part of your rectum. Removing it used to mean major, life-altering surgery. But a new report shows a different path is possible
A case report describes a 70-year-old male with altered bowel habits who underwent endoscopic submucosal dissection for a large rectal tumor…
Doctors successfully removed a large, tricky rectal tumor with a minimally invasive technique, preserving the patient's natural bowel functi…
Dynamic ctDNA monitoring during neoadjuvant chemotherapy identifies high-risk rectal cancer patients
Blood test during chemo may help predict rectal cancer treatment response
A biomarker substudy of a multicenter RCT in 153 patients with low-/intermediate-risk locally advanced rectal cancer found that dynamic ctDN…
A blood test tracking tumor DNA during chemo can predict which rectal cancer patients won't respond well to treatment before surgery.
Meta-analysis finds 3.2% prevalence of germline MMR mutations in patients with upper tract urothelial carcinoma
Study finds 3.2% of upper tract urothelial cancer patients have inherited DNA repair mutations
A systematic review and meta-analysis of 14 studies including 2378 patients with upper tract urothelial carcinoma (UTUC) found a pooled prev…
About 3% of upper tract urothelial cancer patients carry inherited DNA repair mutations that link their cancer to Lynch syndrome and affect …
Research across Cancer
Related studies from across the Cancer family.
Review of rectal abscess case after endoscopic mucosal resection highlights diagnostic considerations
Rectal Surgery Complication Doctors Rarely See But Must Spot Fast
This narrative review discusses a case of rectal submucosal abscess following endoscopic mucosal resection for a rectal polyp in a 74-year-o…
A 74-year-old woman developed a dangerous hidden infection after standard polyp removal, proving why doctors must recognize rare complicatio…
AI-Assisted Colonoscopy Improves Right-Sided Adenoma Detection in Gastroenterology Fellows
AI helps trainee doctors find more polyps in colonoscopies
This pragmatic randomized controlled trial assigned 16 gastroenterology fellows to AI-enhanced or conventional colonoscopy for 1045 procedur…
AI-assisted colonoscopy helped gastroenterology fellows detect more polyps on the right side of the colon, a hard-to-see area.
Neoadjuvant mFOLFOXIRI plus bevacizumab reduces peritoneal tumor burden in colorectal cancer patients
Chemo before surgery may reduce tumor burden in colorectal cancer patients
This phase II randomized controlled trial evaluated 53 patients with resectable peritoneal metastasis of colorectal cancer.
A trial suggests chemo before surgery might lower tumor markers for colorectal cancer patients with spread to the abdomen.
Early-Onset Colorectal Cancer Shows Superior Survival vs Late-Onset in Retrospective Cohort
Younger Colon Cancer Patients Live Longer After Surgery
A retrospective cohort study of 4,596 colorectal cancer patients found that early-onset disease (EOCRC) was associated with significantly be…
Even with tougher tumors, younger colon cancer patients are living longer after surgery than older patients, and doctors now have hard data …
Tumor debulking plus chemotherapy did not improve overall survival in multiorgan metastatic colorectal cancer patients
Surgery Doesn’t Extend Life for Advanced Colon Cancer
This randomized clinical trial enrolled 382 adult patients with multiorgan metastatic colorectal cancer across 27 hospitals in the Netherlan…
This large study shows that removing tumors in advanced colon cancer doesn’t help people live longer.
Global burden of early-onset colorectal cancer from alcohol, tobacco, and inactivity declined 1990-2021
More Young Adults Getting Colorectal Cancer — But One Risk Stands Out
This global cohort review analyzed early-onset colorectal cancer attributable to behavioral risk factors from 1990 to 2021.
While smoking and drinking risks drop, lack of physical activity is driving a sharp rise in colon cancer for adults under 50 worldwide.
Colonic stents versus diverting stoma for malignant left-sided colorectal obstruction show similar long-term oncologic results
Two Paths Through a Blocked Colon — Which One Is Safer?
This single-center retrospective cohort study compared 24 patients treated with colonic stents to 32 patients who underwent a diverting stom…
For a blocked colon from cancer, a temporary stent works just as well as surgery to open the bowel, getting patients to treatment faster wit…
Observational study suggests colibactin mutations are enriched in rectum regardless of polyp status
Why do some colon cancers start in the rectum while others do not?
This observational study analyzed whole-genome sequencing of colon crypts from 11 donors without polyps and 10 with polyps.
A toxin from E. coli bacteria causes specific DNA damage in the rectum, which may explain why some colon cancers start there, especially in …
Robotic simultaneous resection for synchronous colorectal cancer and liver metastases shows feasibility and safety in a meta-analysis
Robots Are Removing Colon Cancer and Liver Tumors in One Operation
This single-arm meta-analysis included 165 patients aged 18 or older with synchronous colorectal cancer and liver metastases.
Robotic surgery safely removes colon cancer and liver tumors in one operation, sparing some patients a second major procedure.
Phase II RCT finds no OS benefit for hepatectomy in colorectal cancer with liver and lung metastases
Does removing liver tumors help when lung tumors remain? A small trial offers mixed answers
A phase II randomized trial in 27 patients with colorectal adenocarcinoma and resectable liver/unresectable lung metastases compared hepatec…
A small trial stopped early found no survival benefit for liver surgery when lung tumors remain, yet patients who actually got the operation…
Anti-EGFR rechallenge improves response and PFS but not OS in ctDNA wild-type chemorefractory mCRC
Anti-EGFR rechallenge shows benefit for some advanced colorectal cancer patients
A meta-analysis of three phase II randomized trials (n=320) in pretreated ctDNA RAS/BRAF wild-type mCRC found anti-EGFR rechallenge signific…
Giving anti-EGFR drugs again helps some advanced colorectal cancer patients shrink tumors and delay growth, though it does not extend overal…
FDA Approves Krazati (adagrasib) for KRAS G12C-Mutated NSCLC and in Combination for Colorectal Cancer
FDA approves a new targeted cancer drug called Krazati for lung and colorectal cancers
The FDA has approved Krazati as a single agent for adult patients with KRAS G12C-mutated locally advanced or metastatic NSCLC after at least…
FDA approves Krazati, a new targeted drug for lung and colorectal cancers with a specific genetic change after other treatments fail.
All Microsatellite-stable colorectal cancer Articles
- Review of chemopreventive strategies for familial adenomatous polyposis including NSAIDs and other agents
- Closing rectal wall defects after full-thickness excision reduces bleeding and re-admission rates compared to leaving defects open in patients with rectal neoplasms
- Systematic review links gut microbial metabolites to colitis-associated colorectal cancer risk
- Tislelizumab plus chemotherapy and radiotherapy yields 89.1% 3-year disease-free survival in pMMR/MSS locally advanced rectal cancer
- Colonoscopic Surveillance in Lynch Syndrome Linked to Lower Mortality but Not Reduced Cancer Incidence
- Electroacupuncture Shortens Time to First Defecation in Colorectal Cancer Surgery Patients
- MRI-derived nomogram improves high-risk LARC stratification over single-feature models in a multicenter retrospective cohort
- Phase I trial of regorafenib plus ipilimumab and nivolumab shows 27.6% response in MSS colorectal cancer
- Neoadjuvant CAPOX chemotherapy alone showed comparable survival to chemoradiotherapy in locally advanced rectal cancer with uninvolved mesorectal fascia
- ESD achieves R0 resection for large rectal intramucosal carcinoma involving dentate line in case report
- Dynamic ctDNA monitoring during neoadjuvant chemotherapy identifies high-risk rectal cancer patients
- Meta-analysis finds 3.2% prevalence of germline MMR mutations in patients with upper tract urothelial carcinoma
- Post hoc analysis links TMB ≥9 or BRAF-V600E to longer PFS with chemo-nivolumab in MSS/pMMR mCRC
- Case series identifies MSH2 variants in three families suspected of Lynch syndrome
- Phase 2 trial tests metformin with neoadjuvant radiochemotherapy for locally advanced rectal cancer