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Home › Conditions › Monkeypox

Monkeypox

Part of Orthopoxvirus Infection

18 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Monkeypox

5 trials tracked for Monkeypox: 1 in phase 3 or 4 and 1 with published results.

5Trials tracked
1Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 1 Phase 2 3 Other / NA 1
  1. Phase 4 Assessment of Safety Profile of MVA-BN Vaccine in the PALM-007 Study in DRC Completed
  2. Phase 2 A Phase 2 Randomized Multisite Trial to Inform Public Health Strategies Involving the Use of MVA-BN Vaccine for Mpox Completed
  3. Phase 2 Tecovirimat for Treatment of Monkeypox Virus Completed
  4. Phase 2 Trial to Evaluate the Immunogenicity of Dose Reduction Strategies of the MVA-BN Monkeypox Vaccine Completed
  5. N/A Morbidity, Mortality And Risk Factors of Mpox in HIV Negative High Risk Sexual Health Clinic Attenders and People Living With HIV Completed

Showing the 5 most-cited and recently-updated of 5 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Monkeypox: what the trials found

The MVA-BN vaccine and JYNNEOS are established interventions for Monkeypox. Clinical data for JYNNEOS shows significant seroconversion rates in trials, with specific results for Vaccinia Virus Specific PRNT ranging from 54.6% to 99.0% 2.

JYNNEOS has demonstrated a statistically significant increase in Vaccinia Virus Specific Plaque Reduction Neutralization Test (PRNT) Geometric Mean Titer at Day 43 (p=0.045) 4. Safety profiles for JYNNEOS include reported systemic and local adverse events following vaccination 4.

Recent results — preliminary, needs further review

  • Tecovirimat Oral Capsule was evaluated for lesion resolution; results showed mean times of 7-8 days regardless of symptom onset timing, with a high percentage of participants achieving negative blood PCR results 3.
  • Observational data indicates significant differences in clinical outcomes without intervention, including higher rates of severe lesions (p=0.097), various clinical complications (p=0.005), and hospitalization events (p=0.011) 5.

For the clinician treating this condition

  • JYNNEOS is an established intervention showing significant PRNT GMT increases at Day 43 and high seroconversion rates.
  • MVA-BN is a recognized vaccine for Monkeypox management.
  • Clinical data suggests that untreated cases may result in varying degrees of severe lesions and hospitalization.

AI synthesis of 4 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Case series describes severe monkeypox in hospitalized US patients
Infectious Disease
Case series describes severe monkeypox in hospitalized US patients U.S. hospitals report cases of severe monkeypox requiring hospitalization
A case series describes hospitalized patients with severe monkeypox in the United States.
U.S. hospitals report severe monkeypox cases requiring hospitalization, signaling a need for doctors to monitor these serious infections clo…
CDC Apr 5, 2026
Phase 2 trial assesses JYNNEOS vaccine in adolescents for monkeypox prevention
Pediatrics Phase II
Phase 2 trial assesses JYNNEOS vaccine in adolescents for monkeypox prevention Is the monkeypox vaccine safe and effective for teenagers?
A Phase 2 open-label, non-placebo controlled trial evaluated the standard subcutaneous JYNNEOS regimen in 315 vaccinia-naïve adolescents (12…
A new study is looking at whether the standard monkeypox vaccine works for adolescents.
CT.gov Apr 4, 2026
Case report describes first confirmed monkeypox infection in a Florida infant
Pediatrics
Case report describes first confirmed monkeypox infection in a Florida infant What happens when a baby gets monkeypox? Florida reports its first case
A case report describes the first confirmed monkeypox infection in a young infant in Florida.
Florida reports its first monkeypox case in a baby, confirming that very young children can catch the virus and need household precautions.
CDC Apr 4, 2026
ACIP Recommends JYNNEOS Vaccine for Occupational Orthopoxvirus Exposure Risk
Allergy & Immunology
ACIP Recommends JYNNEOS Vaccine for Occupational Orthopoxvirus Exposure Risk U.S. health advisors recommend monkeypox vaccine for certain at-risk workers
The Advisory Committee on Immunization Practices (ACIP) issued a recommendation for preexposure vaccination with JYNNEOS (Smallpox and Monke…
U.S. health advisors now recommend the JYNNEOS vaccine for lab workers and healthcare staff at risk of exposure to monkeypox, smallpox, and …
CDC Apr 4, 2026
Monkeypox infections reported after two JYNNEOS vaccine doses in the United States
Infectious Disease
Monkeypox infections reported after two JYNNEOS vaccine doses in the United States Monkeypox infections reported in people who received two JYNNEOS vaccine doses
A report from the United States describes monkeypox virus infections occurring after receipt of two preexposure doses of the JYNNEOS vaccine…
Monkeypox infections have been reported in people who received two doses of the JYNNEOS vaccine, showing that vaccination is not a guarantee…
CDC Apr 4, 2026
Case report describes neurologic complications in two US patients with monkeypox
Neurology
Case report describes neurologic complications in two US patients with monkeypox Two U.S. patients developed neurological complications during monkeypox infections
A case report describes two patients in the United States who developed neurologic complications associated with monkeypox infection.
Two U.S. patients developed neurological complications during monkeypox infections, serving as an early alert for doctors to watch for these…
CDC Apr 3, 2026

Questions about Monkeypox

How sensitive and specific is the Pluslife RHAM test for detecting monkeypox?

The Pluslife RHAM test detects monkeypox with 94.2% sensitivity and 100% specificity when compared to standard PCR methods.

Full answer →