Masitinib 4.5 mg/kg/day associated with survival in ALS post-hoc analysis
This Drug Could Add Nearly Two Years to ALS Life
This post-hoc analysis of a randomized, double-blind, placebo-controlled trial in 130 ALS patients found that masitinib 4.5 mg/kg/day was as…
A new look at data suggests a specific drug might significantly extend life for some people with ALS.
Meta-analysis links speech features to severity in Parkinsons, cerebral palsy, and ALS
Speech patterns may help track disease severity in Parkinsons and other conditions
This meta-analysis synthesizes evidence from 890 speakers across 5 languages to evaluate a training-free method for assessing speech degrada…
A new computer method tracks Parkinson's and other disease severity by measuring how specific speech sounds change without needing special t…
Cross-sectional CSF proteomic analysis identifies ALS-specific biomarker signature
ALS Blood Test Breakthrough Could Speed Diagnosis
This observational cross-sectional study analyzed CSF proteomics in 237 participants to identify ALS-specific biomarkers.
A new five-protein blood test pattern could finally help doctors spot ALS early, before nerve damage becomes too advanced.
Systematic review finds gut microbiome dysbiosis associated with ALS progression
Could gut bacteria changes be linked to ALS, or just happen alongside it?
This systematic review with narrative synthesis examined 61 studies on gut microbiome alterations in ALS.
People with ALS often show reduced gut bacteria diversity, but it is still unclear if these changes cause the disease or simply happen along…
Observational study finds no association between ZFHX3 GGC repeat expansions and ALS risk
New DNA Scan Rules Out ALS Link
This observational research article examined ZFHX3 GGC repeat expansions in 5,785 people with ALS and 7,982 healthy controls.
A major genetic test confirms that a specific repeat in your DNA does not cause ALS, even though it can cause a different movement disorder.
REDDI pipeline improves balanced accuracy for classifying MCI, MS, Parkinson's, and ALS using MEG data
Can a new computer tool help doctors spot brain diseases faster and more accurately?
This study developed a machine learning framework called REDDI that utilizes MEG resting-state data and Riemannian geometry for classifying…
A new computer tool helps doctors distinguish between hard-to-tell-apart brain diseases like Parkinson's and ALS with 13% better accuracy.
Systematic review validates iPSC-derived organoids as models for ALS pathology compared to traditional 2D or animal models
Scientists Grow Tiny ALS Brains in Labs — What It Could Mean
This systematic review evaluated in vitro organoid models derived from human-specific neural and neuromuscular subtypes for Amyotrophic Late…
For the first time, scientists can watch ALS unfold in human tissue grown outside the body — which could speed up the search for treatments …
Muscle ultrasonography shows high diagnostic accuracy for fasciculation detection in ALS
A Simple Scan Could Speed Up an ALS Diagnosis
A systematic review and meta-analysis of 13 studies involving 1,176 participants found muscle ultrasonography has high sensitivity (0.87) an…
A common ultrasound machine may help doctors spot a key sign of ALS more quickly, potentially shortening the difficult diagnostic journey.
China's rehabilitation needs for neurological disorders increased significantly from 1990 to 2021
A Silent Wave of Disability is Rising. Here’s Who’s Most at Risk
This cross-sectional analysis of data from China between 1990 and 2021 examined rehabilitation needs for ten neurological conditions, includ…
China faces a rising wave of neurological disability driven by aging, with stroke, Alzheimer's, and Parkinson's creating urgent long-term ca…
FDG-PET reveals dysregulated glucose metabolism as a common feature across late-onset neurodegenerative diseases with unique patterns
FDG-PET scans show common brain glucose changes across several late-onset neurodegenerative diseases
This meta-analysis of 5,412 individuals with age-associated neurodegenerative diseases (A2ND) and 3,549 controls utilized FDG-PET to quantif…
FDG-PET scans reveal that dysregulated brain glucose metabolism is a shared feature across late-onset neurodegenerative diseases like Alzhei…
Meta-analysis finds no significant association between statin use and ALS survival outcomes
Do statins help people with ALS live longer? A new analysis finds no clear link
A meta-analysis of 3,739 ALS patients (889 statin users) from six studies found no statistically significant association between statin use …
A new analysis of 3,739 people with ALS found no link between taking statins and living longer.