Earlier salivary melatonin onset associated with respiratory symptoms in early amyotrophic lateral sclerosis.
Sleep Timing Could Predict Survival in Early ALS
This prospective longitudinal observational study assessed salivary dim-light melatonin onset in 50 people living with amyotrophic lateral s…
New research suggests sleep timing predicts how fast ALS gets worse and who survives longer without extra help.
Network meta-analysis compares pharmacological and biological therapies for amyotrophic lateral sclerosis
New ALS Therapy Combo Shows Promise For Slowing Functional Decline
This network meta-analysis synthesized data from 109 trials involving 16,353 participants to evaluate pharmacological and biological therapi…
A major analysis suggests combining cell therapy with neuroprotective drugs may help ALS patients maintain physical function longer, though …
Reeldesemtiv showed no impact on device use in ALS trial terminated early for futility.
Wheelchair access varies wildly, and drug trial ended early without benefit for ALS patients.
This Phase 3 randomized clinical trial enrolled 482 participants with amyotrophic lateral sclerosis (ALS) across 83 sites. The study evaluat…
Access to wheelchairs differs greatly by region, and a major drug trial for ALS stopped early because it did not help patients.
Secondary analysis of pooled ALS trial data reveals entropy-based functional domain trajectories
New Method Reveals Hidden Treatment Signals in ALS Trials
This secondary analysis of pooled clinical trial data from the PRO-ACT database examined Shannon entropy trajectories of ALSFRS functional d…
This study suggests that the way we measure success in ALS clinical trials might be hiding real treatment benefits, and a new mathematical a…
Masitinib 4.5 mg/kg/day associated with survival in ALS post-hoc analysis
This Drug Could Add Nearly Two Years to ALS Life
This post-hoc analysis of a randomized, double-blind, placebo-controlled trial in 130 ALS patients found that masitinib 4.5 mg/kg/day was as…
A new look at data suggests a specific drug might significantly extend life for some people with ALS.
Meta-analysis links speech features to severity in Parkinsons, cerebral palsy, and ALS
Speech patterns may help track disease severity in Parkinsons and other conditions
This meta-analysis synthesizes evidence from 890 speakers across 5 languages to evaluate a training-free method for assessing speech degrada…
A new computer method tracks Parkinson's and other disease severity by measuring how specific speech sounds change without needing special t…
Cross-sectional CSF proteomic analysis identifies ALS-specific biomarker signature
ALS Blood Test Breakthrough Could Speed Diagnosis
This observational cross-sectional study analyzed CSF proteomics in 237 participants to identify ALS-specific biomarkers. The authors identi…
A new five-protein blood test pattern could finally help doctors spot ALS early, before nerve damage becomes too advanced.
Systematic review finds gut microbiome dysbiosis associated with ALS progression
Could gut bacteria changes be linked to ALS, or just happen alongside it?
This systematic review with narrative synthesis examined 61 studies on gut microbiome alterations in ALS. It found reduced microbial diversi…
People with ALS often show reduced gut bacteria diversity, but it is still unclear if these changes cause the disease or simply happen along…
Observational study finds no association between ZFHX3 GGC repeat expansions and ALS risk
New DNA Scan Rules Out ALS Link
This observational research article examined ZFHX3 GGC repeat expansions in 5,785 people with ALS and 7,982 healthy controls. It found no as…
A major genetic test confirms that a specific repeat in your DNA does not cause ALS, even though it can cause a different movement disorder.
REDDI pipeline improves balanced accuracy for classifying MCI, MS, Parkinson's, and ALS using MEG data.
Can a new computer tool help doctors spot brain diseases faster and more accurately?
This study developed a machine learning framework called REDDI that utilizes MEG resting-state data and Riemannian geometry for classifying …
A new computer tool helps doctors distinguish between hard-to-tell-apart brain diseases like Parkinson's and ALS with 13% better accuracy.
Systematic review validates iPSC-derived organoids as models for ALS pathology compared to traditional 2D or animal models.
Scientists Grow Tiny ALS Brains in Labs — What It Could Mean
This systematic review evaluated in vitro organoid models derived from human-specific neural and neuromuscular subtypes for Amyotrophic Late…
For the first time, scientists can watch ALS unfold in human tissue grown outside the body — which could speed up the search for treatments …
Muscle ultrasonography shows high diagnostic accuracy for fasciculation detection in ALS
A Simple Scan Could Speed Up an ALS Diagnosis
A systematic review and meta-analysis of 13 studies involving 1,176 participants found muscle ultrasonography has high sensitivity (0.87) an…
A common ultrasound machine may help doctors spot a key sign of ALS more quickly, potentially shortening the difficult diagnostic journey.