Extended Caffeine Therapy Reduces Intermittent Hypoxia Burden in Very Preterm Infants in Randomized Trial
Giving Caffeine a Longer Ride
This randomized clinical trial enrolled 160 infants <30 weeks + 6 days gestational age to evaluate extended caffeine therapy versus placebo.
Extending caffeine treatment for premature babies until 43 weeks reduced dangerous oxygen drops and lowered inflammation markers.
Full milk feeds from birth show no difference in hospital stay but lower costs for preterm infants
Does feeding preterm babies full milk from birth shorten their hospital stay?
This randomized controlled trial in 2088 preterm infants born at 30+0 to 32+6 weeks' gestation compared full milk feeds from birth to gradua…
Starting full milk feeds from birth for preterm babies costs slightly less but does not shorten hospital stays compared to gradual feeding w…
Factors associated with time to discharge among preterm neonates in a Ugandan NICU retrospective cohort study
Why Some Preterm Babies Stay in the NICU Longer
This retrospective cohort study analyzed 847 preterm neonates admitted to a Ugandan NICU to identify predictors of discharge.
Better prenatal care and local support help preterm babies go home sooner, with 70% leaving the hospital within four weeks in rural Uganda.
Intranasal breast milk improved cerebral oxygenation in 40 preterm infants compared to routine care
Small study suggests intranasal breast milk may improve oxygen levels in preterm infants
This randomized controlled trial enrolled 40 preterm infants with gestational ages between 28 and 36 weeks.
Giving fresh breast milk through the nose may help preterm babies maintain higher brain oxygen levels and lower breathing rates without caus…
Systematic review examines placental biology and social context in Black and African American women with pregnancy complications
The Organ That Records Stress, Racism, and Poverty — Before Birth
This systematic review investigates factors including placental biology, genetic variation, and socioeconomic exposures among Black and Afri…
The placenta records stress, racism, and poverty before birth, shaping higher complication rates for Black women through biology shaped by t…
Review of Treg-targeting strategies for pregnancy complications lacks reported outcomes or safety data
Review of Treg therapies for pregnancy complications shows mixed early results
This narrative review examines therapeutic strategies targeting regulatory T cells (Tregs) for conditions including recurrent implantation f…
New therapies targeting immune cells called Tregs show early promise for pregnancy complications like miscarriage and pre-eclampsia, but evi…
Gut microbiota signatures in preterm infants correlate with neurodevelopmental impairment risk at three months corrected age
Tiny Gut Clues May Predict Brain Risks in Preemies
This prospective, matched, longitudinal multi-omics study evaluated preterm infants to identify early biomarkers for neurodevelopmental impa…
A simple stool sample from a preterm baby may one day reveal who needs extra brain support long before any symptoms show up.
Self-reported racial discrimination associated with postpartum depression and low birth weight in pregnant women
Discrimination Linked to Baby's Low Weight and Mom's Mood
This systematic review and meta-analysis of 1,473,417 participants assessed associations between self-reported interpersonal racial discrimi…
Experiencing racism during pregnancy is a serious health risk that doctors must address to keep moms and babies safe.
Prospective cohort study assesses biomarkers for predicting spontaneous preterm birth in high-risk pregnancies
Can blood tests predict preterm birth months before symptoms appear?
This prospective cohort study enrolled 2272 pregnant women in the United Kingdom to investigate biomarkers for spontaneous preterm birth.
Blood tests detecting RNA fragments can predict early preterm birth months before symptoms appear, with added data on microbes and immune re…
Systematic review links neutrophil extracellular trap dysregulation to pregnancy complications
Web of White Blood Cells Linked to Pregnancy Risks
A systematic review of emerging evidence indicates that dysregulation of neutrophil extracellular trap (NET) formation and clearance is stro…
A sticky web of white blood cells meant to fight germs can instead trigger serious pregnancy risks like preeclampsia and preterm birth when …
Brain age gap shows neurodevelopmental delays in preterm neonates and worsens after CHD surgery
Brain Age Gap Reveals Hidden Delays in Preemies and Heart Defects
An observational study of 1056 MRI scans from preterm neonates (n=90) and neonates with congenital heart disease (CHD, n=160) found a progre…
Babies born too early or with heart defects show hidden brain delays that standard scans miss, revealing a silent lag in their development.
Mendelian randomization links genetic endometriosis liability to increased placenta praevia risk
Does endometriosis raise pregnancy risks? A genetic link points to one specific danger
A Mendelian randomization meta-analysis using summary-level GWAS data found genetic liability to endometriosis was robustly associated with …
A woman's genetic risk for endometriosis directly increases the chance of placenta praevia, a dangerous condition where the placenta grows t…