Preoperatively detected PTEN alterations in thyroid nodules correlate with a 32.4% risk of invasive malignancy
Molecular testing helps identify risk in thyroid nodules
This meta-analysis of 87 patients with Bethesda III/IV thyroid nodules identifies a 32.4% risk of invasive malignancy in those with preopera…
New molecular testing can help doctors identify the risk of cancer in thyroid nodules, providing a clearer picture for patients with uncerta…
Plectin knockdown and troglitazone treatment inhibit growth and migration in papillary thyroid carcinoma cell lines
Plectin and Troglitazone Show Promise in Thyroid Cancer
This guideline synthesizes preclinical data regarding plectin (PLEC) as a potential target in papillary thyroid carcinoma. The findings sugg…
Researchers found that plectin is elevated in papillary thyroid cancer and that troglitazone may fight it by targeting plectin.
No established correlation exists between paragangliomas and cervical lymph node metastasis in papillary thyroid carcinoma
Distinguishing Between Thyroid Cancer and Paraganglioma for Better Diagnosis
This case report and literature review examines the relationship between paragangliomas and cervical lymph node metastasis in patients with …
Doctors must accurately distinguish between thyroid cancer and paragangliomas to ensure correct treatment plans and accurate patient prognos…
FNA-Tg and BRAF V600E analysis can rectify histopathological misdiagnosis of cervical lymph node metastasis
Combined Testing Corrects Diagnosis of Thyroid Cancer Lymph Node Spread
This case report describes a 52-year-old female with papillary thyroid carcinoma where combined FNA-Tg and BRAF V600E analysis corrected a h…
A new testing method using FNA-Tg and BRAF V600E analysis helped correctly identify cancer spread in a patient with thyroid cancer.
Case report and review: IVIg and efgartigimod in Guillain-Barré with Graves disease and thyroid cancer
Doctors treat a rare relapse of Guillain-Barré syndrome with new immune therapies
This case report and literature review describes a 33-year-old man with Guillain-Barré syndrome, Graves disease, and papillary thyroid carci…
A 33-year-old man with Guillain-Barré syndrome found relief after doctors treated his underlying thyroid cancer and used new immune therapie…
Machine learning model predicts central lymph node metastasis in papillary thyroid carcinoma
New AI tool predicts hidden cancer spread in early thyroid cases
This retrospective cohort study of 710 patients with clinically node-negative T1–T2 papillary thyroid carcinoma developed an interpretable m…
A smart new computer model can spot hidden cancer spread in early thyroid cases, helping surgeons decide exactly what to remove during opera…
Case series describes four clear cell variant papillary thyroid carcinoma cases with NCOA4-RET fusions
Rare Thyroid Cancer Has Unique Genetic Signature
This case series with literature review describes four pathologically confirmed cases of clear cell variant of papillary thyroid carcinoma d…
A rare thyroid cancer type may have a specific genetic cause that doctors can now look for.
Nomogram model using NLR, age, and ultrasound features discriminates papillary thyroid carcinoma from benign nodules
New Tool Predicts Thyroid Cancer Without Surgery
This multicenter cohort study evaluated a nomogram model incorporating inflammatory biomarker NLR, patient age, and ultrasound features to d…
You wake up, brush your teeth, and notice a small lump in your neck.
Autopsy study finds 55% thyroid nodular disease prevalence in Mexico City hospital patients
Autopsy study finds high thyroid nodule rates in Mexico City, no link to salt iodination
A retrospective cohort study of 487 autopsies from a third-level hospital in Mexico City found a thyroid nodular disease prevalence of 55% a…
Autopsies in Mexico City reveal thyroid nodules are very common, yet changing salt iodination rules did not increase their rates.
BRAFV600E mutation testing shows diagnostic value in high-suspicion thyroid nodules with non-malignant cytology
When a thyroid nodule looks suspicious but tests say it's fine, what's the next step?
A prospective observational study of 562 ultrasound-high-suspicion thyroid nodules with non-malignant or indeterminate cytology found BRAFV6…
A positive genetic test for a specific mutation makes a suspicious thyroid nodule ten times more likely to be cancer, helping doctors decide…
Deep learning model using preoperative CT predicts lymph node metastasis in papillary thyroid carcinoma
Can a new AI model help thyroid cancer patients avoid unnecessary surgery?
A retrospective cohort study of 1560 PTC patients developed and validated ThyLNT, a Transformer-based 2.5D deep learning model using preoper…
A new AI model predicts lymph node spread in thyroid cancer better than standard scans, potentially sparing patients from unnecessary surger…
TyG-BMI index shows positive association with papillary thyroid carcinoma odds in Chinese cohort
Study finds link between metabolic index and thyroid cancer risk in Chinese patients
A retrospective cohort study of 538 Chinese individuals with thyroid nodules or papillary thyroid carcinoma found the triglyceride-glucose-B…
Higher TyG-BMI scores linked to greater odds of papillary thyroid cancer in a Chinese study, with risk rising as the index score increased.
Research across Head and Neck Cancer
Related studies from across the Head and Neck Cancer family.
Gut Microbiome and Metabolites May Modulate Thyroid Cancer Immunity and Treatment Response
Gut bacteria and metabolites may influence thyroid cancer treatment
This narrative review examines how gut dysbiosis, bacterial outer membrane components such as lipopolysaccharides, and metabolites including…
Your gut health might play a hidden role in how your body responds to thyroid cancer treatments and immune system interactions.
CEUS combined with AI or elastography improves diagnostic performance for malignant thyroid nodules
Contrast-Enhanced Ultrasound Shows Promise for Identifying Thyroid Nodules
This network meta-analysis of 5022 thyroid nodules evaluated the diagnostic performance of contrast-enhanced ultrasound (CEUS) combined with…
New analysis shows that combining contrast-enhanced ultrasound with other imaging tools can help doctors better identify malignant thyroid n…
Hashimoto's thyroiditis is a risk factor for papillary thyroid cancer with associated improved outcomes
Hashimoto's thyroiditis linked to both cancer risk and better outcomes
This narrative review examines the relationship between Hashimoto's thyroiditis (HT) and papillary thyroid cancer (PTC). The authors suggest…
A growing body of evidence shows that while Hashimoto's thyroiditis can increase cancer risk, it may also be linked to better outcomes for p…
Sociodemographic, laboratory, and ultrasonographic factors are associated with malignancy risk in thyroid nodules
Specific Factors Linked to Higher Risk in Thyroid Nodules
This systematic review and meta-analysis of 194 studies evaluated sociodemographic, laboratory, and ultrasound features to assess malignancy…
Certain factors like male sex and specific ultrasound features are linked to a higher risk of cancer in patients with thyroid nodules.
Intraoperative frozen section shows 98.8% specificity but limited sensitivity for detecting malignancy in Bethesda III nodules
Frozen Section Analysis Shows High Specificity for Thyroid Nodules
This systematic review and meta-analysis of 1,069 patients with thyroid nodules evaluates the diagnostic accuracy of intraoperative frozen s…
Intraoperative frozen section tests show high accuracy in identifying cancer in certain thyroid nodules, but results can vary significantly.
Contrast-enhanced ultrasound shows 81.6% diagnostic accuracy for differentiating benign from malignant thyroid nodules
Contrast-enhanced ultrasound shows promise for thyroid nodule diagnosis
This meta-analysis of 54 CEUS studies evaluated the diagnostic performance of contrast-enhanced ultrasound for characterizing thyroid nodule…
A new analysis finds contrast-enhanced ultrasound is 78.6% sensitive and 82.6% specific for telling benign from malignant thyroid nodules.
Case report review highlights suspicion of breast cancer metastasis to thyroid in a 54-year-old woman
Breast cancer can spread to the thyroid gland in rare cases
This case report review describes a 54-year-old woman with a history of breast cancer who developed metastasis to the thyroid. The authors n…
A single case report shows a 54-year-old woman survived after breast cancer spread to her thyroid, highlighting the need for careful diagnos…
Review of 32 cases of thyroid hemiagenesis with carcinoma highlights surgical and diagnostic patterns
Doctors found rare thyroid cancer cases in patients with one missing half of their gland
This review and case series of 32 patients with thyroid hemiagenesis complicated by thyroid carcinoma synthesized diagnostic and treatment p…
A review of thirty-two patients shows that having half a thyroid gland does not stop cancer from forming. Most cases were treated with surge…
TIRADS and Bethesda systems predict thyroid malignancy in 70 patients at Baghdad Teaching Hospital
Family history and neck swelling signal higher risk of thyroid cancer
This prospective cross-sectional study evaluated 70 patients with thyroid complaints at Baghdad Teaching Hospital.
A new look at thyroid nodules shows that family history and neck swelling are key signs of cancer, helping doctors catch it sooner.
Frozen visual encoders compared for thyroid nodule classification in the ThyroidEffi 1.0 dataset
Will AI Make Your Thyroid Biopsy Report More Trustworthy?
This cohort study evaluated frozen visual encoders, including MedSigLIP and ImageNet-pretrained models, on thyroid cytology cases with Bethe…
A new medical AI may not beat general AI on raw accuracy — but it knows when to hesitate, which matters more for the tricky thyroid biopsies…
Sedentary time, insomnia, and weight linked to high-risk thyroid nodules in retrospective cohort
Does sitting too much or poor sleep raise your risk for dangerous thyroid nodules?
A retrospective cohort study of 164 patients with thyroid nodules found that sedentary time >2 hours/day, insomnia, and elevated weight were…
Sitting too much, poor sleep, and higher weight raise the risk for dangerous thyroid nodules, while eating a diverse diet and smaller nodule…
Machine learning algorithm predicts skip metastasis in papillary thyroid cancer in retrospective cohort
Can a computer help spot tricky thyroid cancer spread?
A retrospective, single-center cohort study of 361 patients undergoing thyroidectomy with lymph node dissections developed a machine learnin…
A computer program can spot tricky thyroid cancer spread that jumps over nearby nodes, helping surgeons plan more effective operations befor…
Questions about Papillary Thyroid Carcinoma
Does finding a BRAFV600E mutation mean I have papillary thyroid carcinoma when my cytology results were non-malignant?
No, a BRAFV600E mutation alone does not confirm papillary thyroid carcinoma if your cytology was non-malignant; it raises suspicion but requires surgical pathology for a definitive diagnosis.
Full answer →How can a nomogram model using my age and ultrasound features help distinguish my papillary thyroid carcinoma from benign nodules?
A nomogram model combines your age, ultrasound features (like tumor size and microcalcifications), and sometimes blood markers to estimate the chance that a thyroid nodule is papillary thyroid carcinoma rather than benign.
Full answer →Can a machine learning model predict if I have lymph node metastasis in my papillary thyroid carcinoma?
Yes, several machine learning models can predict lymph node metastasis in papillary thyroid carcinoma with good accuracy, using clinical, imaging, and genetic data.
Full answer →