FDA Approves Nuplazid (pimavanserin) for Parkinson's Disease Psychosis
FDA approves first drug for hallucinations in Parkinson's disease
The FDA approved Nuplazid (pimavanserin) for hallucinations and delusions associated with Parkinson's disease psychosis. Approval was based …
The FDA approved Nuplazid (pimavanserin) to treat hallucinations and delusions in people with Parkinson's disease psychosis. It is the first…
FDA Approves Nuplazid (pimavanserin) for Parkinson's Disease Psychosis
FDA approves first drug for hallucinations in Parkinson's disease
FDA approved Nuplazid (pimavanserin) for hallucinations and delusions associated with Parkinson's disease psychosis. In a 6-week trial, Nupl…
The FDA approved Nuplazid (pimavanserin) to treat hallucinations and delusions in people with Parkinson's disease psychosis. It is the first…
Research across Parkinson's Disease
Related studies from across the Parkinson's Disease family.
Diabetes mellitus acts as a context-dependent modifier of risk and phenotype in neurological disorders
Diabetes May Influence Risk and Progress of Neurological Disorders
This narrative review synthesizes evidence regarding the role of diabetes mellitus (DM) as a disease modifier across various neurological co…
New research suggests that diabetes can change how certain neurological conditions progress, potentially opening doors for new treatment opt…
Transcranial Magnetic Stimulation reduces motor overflow in focal dystonia and improves stroke and cerebral palsy outcomes
TMS Treatment Shows Potential for Reducing Motor Overflow
This systematic review evaluates the effects of transcranial magnetic stimulation (TMS) on various neurological conditions including stroke,…
Transcranial Magnetic Stimulation may help reduce involuntary movements in patients with focal hand dystonia and other neurological conditio…
Sex-specific genetic risk loci and causal proteins in Parkinson's disease
Identifying Sex Specific Genetic Risks and Brain Proteins in Parkinson Disease
A meta-analysis identifies 10 candidate proteins with sex-biased causal links to Parkinson's disease, highlighting GALC and PSMG1 in females…
New research reveals how sex differences influence genetic risks and protein levels in Parkinson's disease to help tailor future treatments.
AhR signaling exhibits dual neurotoxic or neuroprotective effects depending on specific ligand types
Gut Health and AhR Signaling Linked to Alzheimer's and Parkinson's
This systematic review examines the role of Aryl hydrocarbon receptor (AhR) signaling in Alzheimer's and Parkinson's disease. The authors co…
New research highlights how different gut-related signals can either harm or protect the brain in conditions like Alzheimer's and Parkinson'…
Ligustilide shows neuroprotective effects across multiple CNS disorders in preclinical models
Ligustilide Shows Potential for Treating Various Brain Disorders
This systematic review of 55 original studies evaluates the neuroprotective potential of ligustilide (LIG) in various neurological condition…
Early research on the compound ligustilide shows potential to protect brain cells from damage caused by stroke, dementia, and other neurolog…
GCH1 p.Ser80Asn variant associated with increased Parkinson's Disease risk in East Asian populations
Rare GCH1 Variant Raises Parkinson's Risk in East Asians
Researchers investigated the association between the GCH1 p.Ser80Asn genetic variant and Parkinson's Disease risk specifically within East A…
A rare GCH1 gene variant increases Parkinson's disease risk fivefold in East Asian populations, affecting about 1 in 300 people.
Fecal microbiota transplantation improves motor function and constipation in patients with Parkinson disease
Fecal transplants improve Parkinson's motor symptoms in short term
This meta-analysis of 220 adults with mild to moderate Parkinson disease found that fecal microbiota transplantation (FMT) significantly imp…
A meta-analysis finds fecal transplants may temporarily improve motor and constipation symptoms in Parkinson's, but effects fade.
Safinamide 100 mg outperforms rasagiline 1 mg and zonisamide 25 mg for motor fluctuations
Safinamide beats rasagiline for Parkinson's motor symptoms
This network meta-analysis of randomized controlled trials evaluated various adjunct therapies for Asian Parkinson's disease patients with m…
For Asian Parkinson's patients, adding safinamide to levodopa reduces OFF-time more than rasagiline or zonisamide.
Evaluating the Impact of Digital Health Interventions on Chronic Disease Self-Care Outcomes
Digital health tools show mixed results for managing chronic diseases
Digital tools show promise for heart failure monitoring but lack consistent evidence for improving medication adherence or general diabetes …
New data shows that while digital tools like apps can help heart failure patients monitor their health, they may not improve medication habi…
Exercise, microbiota, and tRNA modifications may influence mitochondrial function and proteostasis in Parkinson's disease
Exercise and gut health may protect brain cells in Parkinson's
This narrative review explores the exercise-microbiota-queuine-tRNA axis as a potential mechanism for dopaminergic neuroprotection in Parkin…
New research explores how exercise, gut bacteria, and RNA modifications might work together to protect the brain from Parkinson's disease.
Current non-motor symptom classifications fail Parkinson's complexity, review finds
Parkinson's symptom classification fails patients, review finds
This narrative review critiques current symptom-based classification systems for non-motor symptoms (NMS) in Parkinson's disease, finding th…
Current systems for grouping Parkinson's non-motor symptoms miss their complexity, a new review reveals.
Bipolar disorder is associated with a 3.65-fold higher risk of Parkinson's disease in six cohort studies
People with bipolar disorder face higher risk of developing Parkinson's disease based on recent analysis
This meta-analysis of six cohort studies evaluated the incidence of Parkinson's disease in individuals with bipolar disorder. The pooled ana…
A review of six studies found people with bipolar disorder have a much higher chance of getting Parkinson's disease. However, experts say we…