Indoor residual spraying linked to over 70% reduction in malaria force of infection in Ghanaian children
A Clever Math Trick Just Measured Malaria Where Surveys Can't Reach
A cohort study in 1-5-year-old children in northern Ghana estimated malaria transmission using queuing theory approaches.
Borrowing math from call-center lines may help scientists prove whether malaria sprays actually work.
Ultra-sensitive PCR on residual DBS shows 7.7% P. falciparum prevalence in Rwandan adults
A Hidden Malaria Surge is Hiding in Plain Sight. Here’s the Truth
This observational cross-sectional analysis examined residual dried blood spots from the 2019-20 Demographic and Health Surveys in Rwanda.
A new way of testing shows malaria is both more common and declining faster in Rwanda than we thought, offering a clearer map to finally bea…
Research across Malaria
Related studies from across the Malaria family.
Natural products dominate antimalarial pipeline but few have in vivo or safety data
Malaria Drug Resistance Spurs Hunt for New Compounds
This systematic review of 252 eligible primary studies maps the antimalarial and antiplasmodial compound landscape, finding that 157 (62.3%)…
A review of 252 studies finds most new antimalarial candidates are natural products, but few have been tested in animals or people.
C-terminus IgG are more durable than NANP-repeats in RTS,S/AS01 malaria vaccine recipients
New data shows how malaria vaccine antibodies last longer
This observational ancillary study of a Phase 3 trial in 1292 children from six African countries found that C-terminus IgG levels declined …
A study of children in Africa shows that certain vaccine antibodies stay strong over time, helping to lower the risk of malaria.
Climate-informed surveillance-to-action models address policy gaps in Somali infectious disease management
Climate-Informed Models Could Improve Disease Tracking in Somalia
This narrative review evaluates existing surveillance assets and policy gaps for infectious diseases in Somalia. It identifies a need for be…
A new framework aims to better connect climate warning signals to local health actions to prevent outbreaks of diseases like cholera and mal…
Malaria presence at vaccination reduces HPV16 and HPV18 antibody levels in two-dose arms
Malaria Presence Linked to Lower HPV Vaccine Antibody Levels
This randomized controlled trial of 930 HIV-negative Tanzanian schoolgirls found that malaria presence at vaccination was associated with lo…
A study in Tanzania found that malaria may lower certain antibody responses in girls receiving two doses of the HPV vaccine.
Evaluating Mefloquine Dosage Effects and Tolerability in Artesunate-Mefloquine Regimens for Malaria
Meta-analysis shows mefloquine dose impacts malaria recurrence in children
A meta-analysis of individual patient data reveals that while higher mefloquine doses reduce recrudescence, early vomiting remains a signifi…
A large study of over 6,000 patients reveals how specific doses of mefloquine can help prevent malaria from returning in young children.
Explainable artificial intelligence offers a structured framework to improve neglected tropical disease diagnosis
Explainable artificial intelligence could improve diagnosis of neglected tropical diseases
This narrative review explores the role of explainable artificial intelligence (XAI) in diagnosing neglected tropical diseases like malaria …
New research explores how explainable AI can help doctors identify and treat overlooked infections like malaria in areas with limited resour…
SP+AQ cuts malaria incidence 54.6% versus SP alone in African children
Adding amodiaquine to sulfadoxine-pyrimethamine reduces malaria in children
This meta-analysis of 32 sites across 13 African countries found that sulfadoxine-pyrimethamine plus amodiaquine (SP+AQ) reduced malaria inc…
Combining two medicines significantly lowers malaria rates in children across Africa compared to using only one drug.
Schistosomiasis infection increases odds of malaria co-infection by 1.27 in children and adolescents
Schistosomiasis infection increases risk of malaria in African children
This systematic review and meta-analysis of 30 studies involving children and adolescents in Sub-Saharan Africa indicates that schistosomias…
Children with schistosomiasis have higher odds of also having malaria, especially those who have direct contact with water.
Pfkelch13 mutations occur in 6% of Plasmodium falciparum isolates across various African regions
New Data Shows Regional Differences in Malaria Drug Resistance
This meta-analysis of observational cohort studies evaluates the prevalence of pfkelch13 mutations in Plasmodium falciparum isolates from pa…
New research reveals varying levels of a specific genetic mutation that may link to reduced effectiveness of malaria treatments across Afric…
Malaria vaccines RTS,S/AS01 and R21/Matrix-M reduce malaria risk in children
Malaria vaccines cut risk by 23% in infants, 39% in toddlers
This systematic review and meta-analysis of 8 studies found that RTS,S/AS01 and R21/Matrix-M vaccines reduce malaria risk in children. In th…
Two malaria vaccines, RTS,S and R21, reduce malaria risk by 23% in young infants and 39% in older children, a review finds.
One in six blood donors in Cameroon carries Plasmodium infection, meta-analysis finds
1 in 6 blood donors in Cameroon carries malaria parasite
A systematic review and meta-analysis of 18 studies (~12,500 donations) found a 16.6% pooled prevalence of Plasmodium spp. in Cameroonian bl…
A review of 18 studies finds 16.6% of blood donations in Cameroon contain Plasmodium, the malaria parasite.
Clinical and laboratory abnormalities linked to higher mortality in malaria patients with acute kidney injury
Severe lab changes in malaria patients with kidney injury strongly predict death
This systematic review and meta-analysis evaluated the relationship between various clinical and laboratory abnormalities and mortality in m…
Severe lab changes like low blood pressure or breathing trouble in malaria patients with kidney injury greatly increase the risk of dying.