Dexmedetomidine plus sufentanil cuts postoperative delirium risk to 4.9% vs 15.28% with sufentanil alone
Combining two drugs cuts confusion after lung surgery for older adults
This randomized controlled trial in 287 elderly patients undergoing thoracoscopic lung surgery found that IV patient-controlled dexmedetomid…
Older patients getting a specific mix of IV medicines had far less confusion after lung surgery compared to those getting only one drug.
Narrative review explores gut microbiota role in postoperative delirium in liver disease
Gut bacteria may help prevent delirium after surgery
This narrative review examines the potential link between gut microbiota alterations and postoperative delirium in older surgical patients w…
A review suggests that gut health could play a role in preventing postoperative delirium in older patients.
Systematic review and meta-analysis on frailty and delirium after TAVR
Frailty before TAVR surgery increases risk of postoperative delirium
This systematic review and meta-analysis of 7,702 patients undergoing TAVR found a significant association between preprocedural frailty and…
A meta-analysis of 7,702 patients found that preprocedural frailty significantly increases the risk of postoperative delirium after TAVR sur…
Systematic review and meta-analysis shows remimazolam versus non-remimazolam anesthesia and delirium risk
New Anesthesia Drug Does Not Raise Delirium Risk After Surgery
This systematic review and meta-analysis evaluates remimazolam compared with non-remimazolam agents in surgical patients. The analysis inclu…
A new anesthetic called remimazolam does not raise the risk of confusion after surgery, and it may protect children from waking up agitated.
Preoperative psychological factors are associated with postoperative cognitive outcomes in older adults
Psychological factors linked to cognitive issues after surgery in older adults
This systematic review and meta-analysis examined preoperative psychological factors in older adults aged 60 years or older.
A large review links preoperative anxiety and stress to worse cognitive outcomes after surgery for older patients.
Meta-analysis identifies risk factors for postoperative delirium in oral and maxillofacial surgery patients
Five Things Linked to Confusion After Oral and Jaw Surgery
This meta-analysis synthesizes data from 2,398 patients undergoing oral and maxillofacial surgery to identify risk factors for postoperative…
Five specific habits and traits significantly raise the risk of postoperative confusion after oral and jaw surgery procedures.
Meta-analysis links low Geriatric Nutritional Risk Index to postoperative delirium risk
Low Nutrition Risk Linked to Higher Delirium After Surgery
This meta-analysis of 12,332 surgical patients found that a low Geriatric Nutritional Risk Index (GNRI) is associated with a significantly i…
Surgical patients with lower nutritional scores faced a significantly higher risk of developing delirium after their operations.
Phase 2 RCT of IV CN-105 in older adults undergoing noncardiac surgery shows fewer grade 2+ adverse events versus placebo
Could a simple IV drug help older adults avoid confusion after surgery?
This Phase 2 randomized clinical trial enrolled 203 older adults (60 years or older) scheduled for noncardiac or nonintracranial surgery.
A new IV drug given before surgery reduced confusion and side effects in older adults, though more testing is needed to confirm it truly pre…
Electroacupuncture protocol aims to prevent postoperative delirium in elderly prostatectomy patients
Can acupuncture before prostate surgery help prevent confusion in older patients?
A double-center randomized controlled trial protocol outlines a study of electroacupuncture versus sham for preventing postoperative deliriu…
A new trial will test if electroacupuncture before prostate surgery can prevent postoperative delirium, a common and serious confusion in ol…
GBM model predicts postoperative delirium in elderly CHD patients with 0.856 AUC
Can a computer model predict post-surgery confusion in older heart patients? A new tool shows promise
A retrospective cohort study of 861 elderly patients with coronary heart disease (CHD) undergoing non-cardiac surgery developed a gradient b…
A new computer tool predicts post-surgery confusion in older heart patients by analyzing frailty, memory, and sleep patterns to help doctors…
Questions about Postoperative Delirium
Can electroacupuncture help prevent Postoperative Delirium in elderly patients having prostatectomy?
Electroacupuncture may help prevent postoperative delirium in elderly prostatectomy patients, but definitive evidence is not yet available; a large trial is underway.
Full answer →Will taking IV CN-105 reduce the chance of experiencing Postoperative Delirium during surgery?
A phase 2 trial found IV CN-105 safe and feasible, but did not show a significant reduction in postoperative delirium incidence compared to placebo.
Full answer →Does having a low Geriatric Nutritional Risk Index increase my risk of Postoperative Delirium?
Yes, a low Geriatric Nutritional Risk Index (GNRI) is linked to a higher risk of postoperative delirium, with meta-analyses showing about a 60% increase in risk.
Full answer →What specific risk factors for Postoperative Delirium exist for oral and maxillofacial surgery patients?
For oral and maxillofacial surgery patients, key risk factors for postoperative delirium include age over 65, male sex, alcohol use, smoking, and insomnia.
Full answer →Can preoperative psychological factors increase my risk of Postoperative Delirium in older adults?
Yes, preoperative psychological factors like depression and anxiety can increase your risk of postoperative delirium in older adults.
Full answer →Does remimazolam anesthesia lower the risk of Postoperative Delirium compared to other drugs?
Current evidence shows remimazolam does not significantly lower postoperative delirium risk compared to propofol or other sedatives, and may increase risk versus dexmedetomidine.
Full answer →