Intranasal Dexmedetomidine Plus Midazolam Improves Sedation Success Versus Chloral Hydrate in Children
Dexmedetomidine Plus Midazolam Works Better for Kids
This randomized controlled trial enrolled 180 children aged 1–6 years undergoing outpatient procedural sedation. The dexmedetomidine plus mi…
A common sedation combo for children fails more often and causes more side effects than a better alternative most clinics already use.
Systematic review suggests dexmedetomidine may improve tolerance and reduce agitation in pediatric and adult non-invasive respiratory support.
Calm Kids Need Breathing Help
This systematic review and meta-analysis evaluates dexmedetomidine use in pediatric and adult patients receiving non-invasive respiratory su…
Imagine a child struggling to breathe. They are scared, agitated, and fighting the mask that saves their life.
Meta-analysis shows dexmedetomidine lowers mean arterial pressure compared to midazolam-fentanyl in surgical patients.
A Calmer Sedative May Make Surgery Safer for Patients
This systematic review and meta-analysis evaluated 259 surgical patients receiving either dexmedetomidine or midazolam-fentanyl during intra…
A newer sedative keeps patients calmer with steadier vitals and fewer breathing problems than the older standard combination during surgery.
Maternal voice intervention effects on sleep in children with congenital heart disease undergoing open-heart surgery remain unreported in this protocol.
Imagine your child is in the hospital after major heart surgery. Machines beep. Lights stay on. It’s a stressful place to rest, let alone sleep deeply. But what if the most powerful tool for healing wasn't a new machine, but a sound they've known since before they were born?
This randomized controlled trial protocol investigates the effect of a maternal voice-based auditory intervention on sleep efficiency in chi…
For a child in intensive care, better sleep isn't just about rest—it could be a key part of physical recovery.
Benzodiazepines, Dexmedetomidine, and Physical Restraints Associated with Next-Day Delirium in Critically Ill Children
Study finds link between certain medications, restraints, and delirium in critically ill children
A secondary analysis of a pilot RCT dataset in 1,006 critically ill children across seven PICUs found previous-day benzodiazepine and dexmed…
Higher doses of sedatives like midazolam and any use of physical restraints are linked to increased confusion in critically ill children the…
Ketamine may reduce positional pain more than dexmedetomidine or nerve block in femur fracture patients
Which drug works best for pain when positioning patients with broken hips?
A 75-patient RCT compared IV ketamine (0.3 mg/kg), IV dexmedetomidine (0.5 μg/kg), and femoral nerve block for analgesia during positioning …
Ketamine outperformed nerve blocks and dexmedetomidine for reducing severe pain when positioning patients with broken hips before surgery.