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Home › Medications › dexmedetomidine

dexmedetomidine

19 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of dexmedetomidine

103 trials tracked of dexmedetomidine: 56 in phase 3 or 4 and 19 with published results. The most-cited published study has 307 citations.

103Trials tracked
56Phase 3 & 4
0Recruiting
19With published results
Phase distribution
Phase 4 37 Phase 3 19 Phase 2 15 Phase 1 5 Other / NA 27
  1. Phase 4 Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery Completed · 307 cited
  2. Phase 3 Intranasal Dexmedetomidine Premedication in Children Completed · 286 cited
  3. Phase 3 The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure Completed · 280 cited
  4. Phase 4 Dexmedotomidine for Acute Pain Control in Patients With Multiple Rib FracturesRandomized Controlled Trial Completed · 203 cited
  5. Phase 3 Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep Completed · 66 cited
  6. Phase 4 UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study Completed · 63 cited
Show 44 more trials
  1. Phase 4 Dexmedetomidine Versus Morphine and Midazolam in Prevention and Treatment of Delirium After Adult Cardiac Surgery Completed · 50 cited
  2. Phase 4 Can Dexmedetomidine For Procedural Sedation In Knee Arthroplasty Reduce Postoperative Pain? A Randomized Control Study Completed · 40 cited
  3. Phase 4 Influence of Dexmedetomidine and Lidocaine on Opioid Consumption in Laparoscopic Intestine Resection Completed · 28 cited
  4. Phase 4 Cognitive Functions After TIVA With Dexmedetomidine Completed · 26 cited
  5. Phase 3 Effects of Dexmedetomidine on Delirium Duration of Non-intubated ICU Patients (4D Trial) Completed · 22 cited
  6. Phase 4 Evaluation of Dexmedetomidine on Post-operative Narcotic Requirements and Pain Scores in Bariatric Patients Completed · 21 cited
  7. Phase 4 The Synergistic Effect of Dexmedetomidine on Propofol for Sedation for Pediatric Endoscopy Completed · 21 cited
  8. Phase 4 The Effects of Dexmedetomidine on the Heart Beat During Elective Surgery in Children Completed · 13 cited
  9. Phase 3 Study of DA-9501 In Pediatric Subjects In The Intensive Care Unit Completed · 9 cited
  10. Phase 4 Effects of Dexmedetomidine on Activity in the Subthalamic Nucleus Completed · 7 cited
  11. Phase 3 Self-management of Sedative Therapy by Ventilated Patients Completed · 4 cited
  12. Phase 3 Clinical Study to Investigate the Efficacy and the Safety of DA-9501 in Sedation During the Surgery With Epidural Anesthesia or Spinal Anesthesia Without Intubation Completed · 3 cited
  13. Phase 4 Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy Completed · 2 cited
  14. Phase 4 Intranasal Dexmedetomidine vs Intranasal Midazolam as Anxiolysis Prior to Pediatric Laceration Repair Completed
  15. Phase 4 Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion Completed
  16. Phase 4 The Effect of Dexmedetomidine Infusion on Post-operative Cognitive Function and Oxidative Stress in Cardiac Surgery Completed
  17. Phase 4 Effect of Dexmedetomidine on Emergence Agitation in Children With or Without Tube Insertion Under General Anesthesia Completed
  18. Phase 4 Propofol and Dexmedetomidine Versus a Propofol Only Regimen for Sedation During Colonoscopy Completed
  19. Phase 4 Dexmedetomidine and Propofol for Pediatric MRI Sedation Completed
  20. Phase 4 Study of Sedative Medications in Patients With Severe Infection and Respiratory Failure Completed
  21. Phase 4 the Analgesic Duration of Dexmedetomidine Compared to Dexamethasone as Adjuncts to Single Shot Interscalene Block Completed
  22. Phase 4 Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels. Completed
  23. Phase 4 Safety and Efficacy of Dexmedetomidine (DEX) for Sedation of Subjects ≥1 Month to <17 Years Undergoing MRI Scans Completed
  24. Phase 4 Study on the Effects of Intravenous Dexmedetomidine on Pain in Patients Undergoing Elective Spinal Surgery Completed
  25. Phase 4 Narcotic Free TIVA and Incidence of Unacceptable Movements Under Anesthesia During ACDF Surgery Completed
  26. Phase 4 Multimodal Versus Opioid aNalgesia in carDiAc Surgery Completed
  27. Phase 4 Effect of Dexmedetomidine of Gastrointestinal Motility Completed
  28. Phase 4 Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea Completed
  29. Phase 4 Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis Completed
  30. Phase 4 Dexmedetomidine vs Fentanyl for BMT Completed
  31. Phase 4 Effect of Single-dose Dexmedetomidine on Airway Reflex in Adult With Oral Intubation After Thyroidectomy Completed
  32. Phase 4 A Trial Of Oral Chloral Hydrate Versus Intranasal Dexmedetomidine For Sedated Abr Exams Completed
  33. Phase 4 Prevention of N-methyl-D-aspartate (NMDA) Antagonist-induced Psychosis in Kids Completed
  34. Phase 4 Dexmedetomidine vs Propofol TIVA (Total Intravenous Anesthesia) and Interscalene Block Completed
  35. Phase 4 Dexmedetomidine to Prevent Agitation After Free Flap Surgery Completed
  36. Phase 4 Dexmedetomidine for Immediate Perioperative Analgesia in Pediatric Patients Undergoing Tonsillectomy Completed
  37. Phase 4 Efficacy of Single-Shot Dexmedetomidine Versus Placebo in Preventing Pediatric Emergence Delirium in Strabismus Surgery Completed
  38. Phase 4 Open-Label, Safety Study Evaluating the Use of Dexmedetomidine in Pediatric Subjects Undergoing Procedure-Type Sedation Completed
  39. Phase 3 Decrease Emergence Agitation and Provide Pain Relief for Children Undergoing Tonsillectomy & Adenoidectomy Completed
  40. Phase 3 Use of Dexmedetomidine to Reduce Emergence Delirium Incident in Children Completed
  41. Phase 3 Dexmedetomidine to Treat Bariatric Surgery-associated Pain Completed
  42. Phase 3 Placebo Controlled Clinical Trial of the Postoperative Opioid Sparing Effects of Intraoperative Dexmedetomidine Infusion for Thoracic Surgery Completed
  43. Phase 3 Sedation Using Intranasal Dexmedetomidine in Upper Gastrointestinal Endoscopy Completed
  44. Phase 3 Neuroimaging Study of Dexmedetomidine-Induced Analgesia Completed

Showing the 50 most-cited and recently-updated of 103 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Gastrodin, intranasal insulin, and cognitive training show greatest preventive effectiveness for postoperative cognitive dysfunction after cardiac surgery
Neurology Meta-analysis
Gastrodin, intranasal insulin, and cognitive training show greatest preventive effectiveness for postoperative cognitive dysfunction after cardiac surgery Insulin, Gastrodin, and Training May Protect Brain After Heart Surgery
A systematic review and Bayesian network meta-analysis of 46 RCTs (9,928 patients) ranked 20 strategies for preventing postoperative cogniti…
A review of 46 trials suggests certain drugs and cognitive training may help prevent confusion and memory loss after cardiac surgery.
Frontiers Jul 26, 2026
Remifentanil lowers maternal mean arterial pressure at intubation but may decrease 1-minute Apgar scores
Anesthesiology & Pain Medicine Meta-analysis
Remifentanil lowers maternal mean arterial pressure at intubation but may decrease 1-minute Apgar scores Remifentanil impacts mother and baby health during emergency C-sections
This meta-analysis of randomized controlled trials evaluated remifentanil for parturients and newborns during cesarean sections under genera…
New data shows remifentanil helps stabilize a mother's blood pressure during surgery but may lower a newborn's first minute health score.
Frontiers Jul 24, 2026
Dexmedetomidine is associated with lower delirium incidence in mechanically ventilated adult ICU patients
Neurology Meta-analysis
Dexmedetomidine is associated with lower delirium incidence in mechanically ventilated adult ICU patients Dexmedetomidine may lower delirium risk for patients on ventilators
This systematic review and meta-analysis of 1,603 adult ICU patients found that dexmedetomidine was associated with a lower delirium inciden…
A new review suggests that the medication dexmedetomidine could reduce delirium in ICU patients, though it requires careful heart monitoring…
Frontiers Jul 22, 2026
Benzodiazepines increase delirium and sleep fragmentation risk while dexmedetomidine shows mixed evidence in pediatric ICU
Pediatrics Sys. Review
Benzodiazepines increase delirium and sleep fragmentation risk while dexmedetomidine shows mixed evidence in pediatric ICU Sedation Choices May Impact Brain Health in Critically Ill Children
This narrative review examines sedation practices and neurocognitive outcomes in critically ill infants and children. It suggests benzodiaze…
Choosing different sedative medications for children in intensive care may impact their sleep quality and long-term brain health.
Frontiers Jul 21, 2026
IEN plus NACT shows greatest improvement in CD4+ counts among ranked strategies
Rheumatology Meta-analysis
IEN plus NACT shows greatest improvement in CD4+ counts among ranked strategies New research identifies ways to protect immune cells during cancer surgery
This network meta-analysis of 82 RCTs evaluates multimodal interventions to maintain T lymphocyte subsets in patients with solid tumors unde…
A new analysis shows that combining specific nutrition and therapies can help maintain vital immune cell levels for patients undergoing soli…
Frontiers Jul 19, 2026
Multimodal pharmacological and behavioral strategies may improve perioperative sleep management in cardiac surgery patients
Cardiology Sys. Review
Multimodal pharmacological and behavioral strategies may improve perioperative sleep management in cardiac surgery patients New ways to manage sleep for heart surgery patients
This evidence-oriented narrative review synthesizes the efficacy of melatonin, dexmedetomidine, GABAergic hypnotics, and respiratory support…
Managing sleep after heart surgery is complex. New research looks at how different medications and oxygen tools can help patients rest bette…
Frontiers Jul 10, 2026
Tiletamine-zolazepam provides rapid anesthetic induction for canine and feline patients with dose-dependent hemodynamic effects
Psychiatry Sys. Review
Tiletamine-zolazepam provides rapid anesthetic induction for canine and feline patients with dose-dependent hemodynamic effects Tiletamine-zolazepam Provides Rapid Anesthesia for Dogs and Cats
This narrative review synthesizes the pharmacology, dosage regimens, and clinical applications of tiletamine-zolazepam in canine and feline …
Tiletamine-zolazepam offers fast-acting anesthesia for pets, but its safety depends on the specific health needs of each dog or cat.
Frontiers Jun 17, 2026
Dexmedetomidine plus sufentanil cuts postoperative delirium risk to 4.9% vs 15.28% with sufentanil alone
Anesthesiology & Pain Medicine RCT
Dexmedetomidine plus sufentanil cuts postoperative delirium risk to 4.9% vs 15.28% with sufentanil alone Combining two drugs cuts confusion after lung surgery for older adults
This randomized controlled trial in 287 elderly patients undergoing thoracoscopic lung surgery found that IV patient-controlled dexmedetomid…
Older patients getting a specific mix of IV medicines had far less confusion after lung surgery compared to those getting only one drug.
Jun 1, 2026
FDA Approves Precedex (dexmedetomidine) for Pediatric Procedural Sedation
Neurology FDA Approval
FDA Approves Precedex (dexmedetomidine) for Pediatric Procedural Sedation FDA approves Precedex for sedation in children during procedures.
The FDA approved Precedex (dexmedetomidine) for sedation of non-intubated pediatric patients aged 1 month to less than 18 years during non-i…
The FDA approved Precedex (dexmedetomidine) to sedate children aged 1 month to 17 years during non-invasive procedures. It provides sedation…
FDA May 6, 2026
FDA Approves Dexmedetomidine Hydrochloride for ICU and Procedural Sedation in Adults
Neurology FDA Approval
FDA Approves Dexmedetomidine Hydrochloride for ICU and Procedural Sedation in Adults FDA approves new sedative for hospital and procedure sedation.
FDA approved dexmedetomidine hydrochloride for sedation of initially intubated and mechanically ventilated adult patients in the ICU, and fo…
The FDA approved dexmedetomidine hydrochloride for sedation in intensive care and during procedures. It helps keep patients calm without slo…
FDA May 6, 2026
Meta-analysis associates deep sedation with increased delirium and mortality in ICU patients
Rheumatology Meta-analysis
Meta-analysis associates deep sedation with increased delirium and mortality in ICU patients Deep Sedation in ICU Linked to Higher Delirium and Death Risk
This meta-analysis of 3,466 patients examines the relationship between deep sedation and clinical outcomes in the ICU. The findings suggest …
A new analysis of over 3,400 ICU patients finds that deep sedation is linked to higher rates of delirium, death, and longer hospital stays, …
Frontiers May 4, 2026
Intravenous dexmedetomidine improves sleep quality scores in women after elective cesarean section
Orthopedics & Sports Medicine RCT
Intravenous dexmedetomidine improves sleep quality scores in women after elective cesarean section A single dose of dexmedetomidine improved sleep for women after elective cesarean section
This randomized controlled trial enrolled 68 women undergoing elective cesarean section.
Women who received a specific medicine infusion slept better in the first few days after having an elective cesarean section.
Frontiers May 1, 2026

All dexmedetomidine Articles