Becotatug vedotin shows 20.9% objective response in recurrent head and neck squamous cell carcinoma after prior therapy
For patients with advanced head and neck cancer, a new drug showed a 21% response rate in early testing
This multicenter, Phase IIa trial evaluated intravenous becotatug vedotin in 67 patients with recurrent or metastatic squamous cell carcinom…
A new drug shrank tumors in 21% of patients with advanced head and neck cancer who had run out of standard treatment options.
Phase 1b ABBV-368 combinations in recurrent/metastatic HNSCC show 14.3% overall response rate
Early study of ABBV-368 plus other drugs showed limited tumor response in head and neck cancer patients
This phase 1b, multicenter, open-label study enrolled 30 adults with recurrent or metastatic head and neck squamous cell carcinoma across th…
Early trials of ABBV-368 combined with other drugs showed limited tumor shrinkage in head and neck cancer patients despite a generally safe …
Low OT-NLR predicts superior survival in recurrent/metastatic HNSCC treated with cetuximab plus nivolumab
A Simple Blood Ratio May Predict Cancer Drug Success
This Phase II clinical trial evaluated patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) receiving combine…
A low white blood cell ratio found in blood tests predicts better survival and treatment response for advanced head and neck cancer patients…
Phase 3 trial compares pembrolizumab with or without lenvatinib in PD-L1+ recurrent/metastatic HNSCC
Phase 3 trial tests pembrolizumab with or without lenvatinib for advanced head and neck cancer
A phase 3 randomized controlled trial enrolled 511 patients with PD-L1 selected recurrent or metastatic head and neck squamous cell carcinom…
A completed Phase 3 trial tested pembrolizumab with or without lenvatinib for advanced head and neck cancer, but detailed results are not ye…
Research across Head and Neck Cancer
Related studies from across the Head and Neck Cancer family.
Plant extracts like curcumin and resveratrol may inhibit HNSCC growth via specific signaling pathways
Plant extracts may slow growth of head and neck cancer
This systematic review examines the effects of plant extracts, including resveratrol, curcumin, quercetin, and anthocyanins, on head and nec…
Certain plant compounds like curcumin and resveratrol show promise in stopping cancer cell growth and resisting chemotherapy in lab studies.
Egg consumption associated with reduced glioma risk in Eastern populations and increased head and neck cancer risk
Egg consumption shows mixed links to glioma and head and neck cancer
This meta-analysis of observational studies involving 1,274,437 participants found that egg consumption was associated with a reduced risk o…
New data shows a link between egg consumption and lower glioma risk in some groups, but a potential link to higher head and neck cancer risk…
Radiation therapy and nasopharyngeal cancer significantly increase risk of chronic rhinosinusitis in head and neck cancer patients
Head and neck cancer treatments may increase risk of sinus issues
This meta-analysis of 3685 patients identifies a 0.37 pooled incidence of chronic rhinosinusitis in head and neck cancer patients. The analy…
Patients with head and neck cancers face a higher risk of developing chronic sinus inflammation, especially after radiation therapy.
IMRT plus cetuximab does not improve quality of life compared to IMRT plus cisplatin
Trial compares cetuximab and cisplatin for oropharyngeal cancer quality of life
This Phase III randomized controlled trial of 375 patients with p16+ oropharyngeal cancer found no significant difference in quality of life…
A clinical trial found that replacing cisplatin with cetuximab did not improve quality of life or swallowing for patients with oropharyngeal…
Submental Artery Island Flap Shows 16% Pooled Locoregional Recurrence in Oral Cavity Reconstruction
Submental artery island flap is a safe option for oral cancer
This meta-analysis pooled data on the submental artery island flap (SAIF) for oral cavity defects after oral squamous cell carcinoma resecti…
A specific surgical technique called the submental artery island flap shows a low recurrence rate for patients with oral cavity defects.
Empowered Survivor digital tool boosts self-efficacy in oral cancer survivors
Digital Intervention Improves Self-Care for Oral Cancer Survivors
In a randomized trial of 643 oral/oropharyngeal cancer survivors, the Empowered Survivor digital intervention improved self-efficacy at 2 an…
A new digital program helps oral cancer patients feel more confident and perform more self-care activities like swallowing and mobility exer…
Impact of Perineural Invasion on Survival Outcomes in Oral Squamous Cell Carcinoma
Perineural invasion linked to poorer outcomes in oral squamous cell carcinoma
A meta-analysis of 23,580 patients confirms that perineural invasion is a potent independent predictor of poor survival and high recurrence …
A large review of over 23,000 patients shows that cancer cells spreading along nerves are linked to higher recurrence and lower survival rat…
Higher pretreatment HALP score is associated with improved overall survival in head and neck cancer
Higher HALP scores linked to better survival in head cancer
This meta-analysis of 1759 patients found that a higher pretreatment HALP score is associated with improved overall survival (95% CI 0.41-0.…
A new analysis shows that a specific blood score can help doctors predict survival outcomes for patients with head and neck cancer.
Cetuximab-based regimens achieve 47% objective response rate in HNSCC after immune checkpoint inhibitor failure
Cetuximab shows activity for head and neck cancer patients
This meta-analysis evaluates cetuximab-based regimens for patients with recurrent or metastatic head and neck squamous cell carcinoma follow…
New data shows cetuximab-based treatments provide meaningful results for head and neck cancer patients after other treatments fail.
AI-based MRI shows 0.82 AUC for detecting cervical lymph node metastases in oral squamous cell carcinoma
AI tools help detect lymph node spread in oral cancer
This meta-analysis of 548 patients evaluates AI-based MRI for detecting cervical lymph node metastases in oral squamous cell carcinoma. The …
Artificial intelligence may help doctors better identify if oral cancer has spread to lymph nodes before surgery.
Immune cell-based therapy shows no significant benefits for tumor response or survival in HNSCC trials
Immune cell therapy shows limited promise for head and neck cancer
This meta-analysis of 30 trials involving 953 patients evaluated immune cell-based therapy (ICT) for head and neck squamous cell carcinoma. …
New data on immune cell-based therapies for head and neck cancer shows mixed results and a need for more rigorous testing.
C3-derived skeletal muscle index shows strong correlation with L3 index in head and neck cancer
C3 Muscle Index Shows Strong Link to L3 Muscle Levels
This meta-analysis of 2017 patients evaluates the correlation between C3 and L3 skeletal muscle indices in head and neck cancer. The study f…
A new way to measure muscle mass in head and neck cancer patients may offer a simpler, radiation-sparing method for tracking muscle loss.
Questions about Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
What is the objective response rate for becotatug vedotin in recurrent head and neck cancer?
Becotatug vedotin showed a 20.9% objective response rate in recurrent or metastatic head and neck squamous cell carcinoma after prior therapy.
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