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Home › Conditions › Refractive errors

Refractive errors

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Refractive errors

47 trials tracked for Refractive errors.

47Trials tracked
0Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 2 3 Other / NA 44
  1. Phase 2 Evaluation of the Safety and Effectiveness of Aceclidine/Brimonidine (LNZ101) and Aceclidine (LNZ100) in the Treatment of Presbyopia Completed
  2. Phase 2 Dilated Versus Non-Dilated Wavefront Corrections for Patients With Down Syndrome Completed
  3. Phase 2 Evaluation of the Safety and Effectiveness of Aceclidine (LNZ101) and Aceclidine + Brimonidine (LNZ100) in the Treatment of Presbyopia Completed
  4. N/A Clinical Comparison of Two Daily Disposable Soft Contact Lenses Completed
  5. N/A Clinical Evaluation of a Silicone Hydrogel Daily Wear Monthly Replacement Contact Lens Completed
  6. N/A Clinical Assessment of a Daily Wear Monthly Replacement Silicone Hydrogel Toric Contact Lens Completed
Show 41 more trials
  1. N/A Clinical Performance of Two Daily Disposable Toric Soft Contact Lenses Completed
  2. N/A Measurement of Refractive SE Following Implantation of LS313 MF30 IOL Completed
  3. N/A Clinical Performance of Two Daily Disposable Soft Contact Lenses Completed
  4. N/A Early Feasibility Study to Evaluate the AccuraSee in Correcting Residual Refractive Errors After Cataract Surgery Completed
  5. N/A Clinical Evaluation of a Daily Wear Frequent Replacement Silicone Hydrogel Lens Completed
  6. N/A Providing Financial Incentives to Improve Adherence to Referral Eye Care Visits Completed
  7. N/A Bifocal & Atropine in Myopia (BAM) Study Completed
  8. N/A Clinical Performance of a Silicone Hydrogel Contact Lens Following Six Nights of Extended Wear Completed
  9. N/A Clinical Characterization of an Investigational Frequent Replacement Daily Wear Silicone Hydrogel Sphere Contact Lens Completed
  10. N/A Clinical Evaluation of Two Monthly Contact Lenses Completed
  11. N/A Clinical Performance Assessment of Two Silicone Hydrogel Daily Disposable Contact Lenses Completed
  12. N/A VisuMax Femtosecond Laser Small Incision Lenticule Extraction for the Correction of High Myopia Completed
  13. N/A DD T2 Daily Disposable Registration Trial Completed
  14. N/A Assessing the Clinical Performance of Two Frequent Replacement Silicone Hydrogel Multifocal Toric Contact Lenses Completed
  15. N/A Safety and Effectiveness of the Qualis Contact Lens Completed
  16. N/A Bifocal Lenses In Nearsighted Kids Completed
  17. N/A Assessing Fitting Guides in Alcon Multifocal Contact Lenses Completed
  18. N/A Clinical Comparison of Two Daily Disposable Contact Lenses Completed
  19. N/A Clinical Assessment of a HYDRAGLYDE® Regimen Completed
  20. N/A Clinical Assessment of a Daily Disposable Soft Silicone Hydrogel Contact Lens Completed
  21. N/A Study of a Hand-held Device Plus Mobile App Versus Standard Eye Care Devices in Measuring Refractive Error of the Eye Completed
  22. N/A Pilot Clinical Performance of a Silicone Hydrogel Lens for Up to Six Nights of Extended Wear Completed
  23. N/A Clinical Performance Assessment of a Daily Wear Monthly Replacement Soft Silicone Hydrogel Contact Lens Completed
  24. N/A Clinical Comparison of Two Daily Wear Frequent Replacement Silicone Hydrogel Soft Contact Lenses Completed
  25. N/A Clinical Performance of a Monthly Replacement Silicone Hydrogel Lens Completed
  26. N/A Clinical Evaluation of a Daily Wear Silicone Hydrogel Lens Completed
  27. N/A Clinical Performance of Two Reusable Silicone Hydrogel Contact Lenses Completed
  28. N/A Clinical Characterization of an Investigational Soft Silicone Hydrogel Contact Lens Completed
  29. N/A Clinical Performance of Two Commercial, Daily Disposable Contact Lenses Completed
  30. N/A Three Daily Wear Monthly Replacement Silicone Hydrogel Contact Lenses With Two Multi-purpose Disinfecting Solution Combinations Completed
  31. N/A Clinical Assessment of Two Reusable Silicone Hydrogel Contact Lenses Completed
  32. N/A Performance Assessment of a Modified Daily Disposable Contact Lens Completed
  33. N/A Safety and Suitability of ICL for Correction of Refractive Errors Without the Use of Dispersive OVDs Completed
  34. N/A Clinical Comparison of 2 Daily Disposable Contact Lenses - Pilot Study 1 Completed
  35. N/A Clinical Assessment of Two Daily Wear Reusable Soft Silicone Hydrogel Contact Lenses Completed
  36. N/A Clinical and Refractive Outcomes After Contoura® Refractive Surgery Planned Using Phorcides Surgery Planning Software Completed
  37. N/A Clinical Validation of DACP Digital Design Completed
  38. N/A Clinical Comparison of 2 Daily Disposable Contact Lenses - Pilot Study 2 Completed
  39. N/A Clinical Biocompatibility Evaluation of Contact Lens Coatings Completed
  40. N/A Clinical Evaluation of a Daily Wear Monthly Replacement Silicone Hydrogel Lens Completed
  41. N/A Clinical Performance of a Silicone Hydrogel Contact Lens Following One Night of Extended Wear Completed

Showing the 47 most-cited and recently-updated of 47 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Refractive errors: what the trials found

The combination of Aceclidine and Brimonidine ophthalmic solution significantly improved near vision while maintaining distance vision; specifically, the percentage of participants achieving a ≥ 3-line improvement in near vision with no loss of ≥ 5 letters in distance vision was 71.4% and 74.0% respectively [2, 3].

Several types of contact lenses have been evaluated for refractive management, including Delefilcon A [6, 19], Verofilcon A [16, 21], and Lehfilcon A [14, 17, 22].

Recent results — preliminary, needs further review

  • Dilated Refraction showed no statistically significant differences in distance visual acuity (p=0.92), near visual acuity (p=0.62), or participant ratings of distance vision quality (p=0.56) 1.

For the clinician treating this condition

  • Aceclidine and Brimonidine combination therapy is effective for improving near vision without compromising distance vision.
  • Multiple contact lens types, including Delefilcon A, Verofilcon A, and Lehfilcon A, are established interventions in the management of refractive errors.

AI synthesis of 1 cited trial, updated Jul 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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