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Home › Conditions › Respiratory Tract Infections

Respiratory Tract Infections

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Respiratory Tract Infections

26 trials tracked for Respiratory Tract Infections: 7 in phase 3 or 4 and 4 with published results. The most-cited published study has 192 citations.

26Trials tracked
7Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 2 Phase 3 5 Phase 2 4 Other / NA 15
  1. Phase 3 Efficacy, Safety, and Immunogenicity of a Plant-Derived Quadrivalent Virus-Like Particles (VLPs) Influenza Vaccine in Adults Completed · 192 cited
  2. Phase 3 Efficacy of a Plant-derived Quadrivalent Virus-like Particle (VLP) Vaccine in the Elderly Completed · 192 cited
  3. Phase 3 Lot-to-lot Consistency of a Plant-Derived Quadrivalent Virus-Like Particles Influenza Vaccine in Healthy Adults Completed · 74 cited
  4. Phase 3 Efficacy of Antibiotics in Children With Acute Sinusitis: Which Subgroups Benefit? Completed · 42 cited
  5. Phase 4 Study to Evaluate the Safety and Clinical Efficacy of Augmentin® Extra Strength-600 in Children With Acute Otitis Media in India Completed
  6. Phase 4 Individualizing Treatment for Asthma in Primary Care Completed
Show 20 more trials
  1. Phase 3 A Phase 3 Study to Determine if RTB101 Prevents Clinically Symptomatic Respiratory Illness in the Elderly Completed
  2. Phase 2 A Study to Describe the Safety and Immunogenicity of a RSV Vaccine in Healthy Adults Completed
  3. Phase 2 Daily Vitamin D for Sickle-cell Respiratory Complications Completed
  4. Phase 2 A Study to Evaluate Safety and Immunogenicity of One or Two Booster Vaccinations With H5N6 Influenza Vaccine in Adults Primed With H5N1 Influenza Vaccine or Unprimed Completed
  5. Phase 2 A Study to Evaluate the Safety, Tolerability and Immunogenicity of an Investigational RSV Vaccine Candidate (Ad26.RSV.preF) in Adults 18 to 50 Years of Age, and RSV-seropositive Toddlers 12 to 24 Months of Age Completed
  6. N/A Novel Mucosal Correlates Of RSV Protection In Older Adults Completed
  7. N/A Patient Portal Flu Vaccine Reminders (5) Completed
  8. N/A Compliance And Safety Study In Children With Upper And Lower Respiratory Tract Infections Completed
  9. N/A Patient Portal Flu Vaccine Reminders_RCT 5 (LADHS) Completed
  10. N/A Measuring the Influence of Kefir on Children's Stools on Antibiotics (MILK) Completed
  11. N/A Study on Cefotaxime and Sulbactam Sodium for Injection (2:1) for Treatment of Respiratory and Urinary Tract Infection Completed
  12. N/A Patient Portal Reminder/Recall for Influenza Vaccination in a Health System- UCLA Portal R/R Influenza RCT 3 Completed
  13. N/A Evaluation of the Treatment With Klacid SR in Patients With Acute Tracheitis, Tracheobronchitis and Bronchitis, Acute Exacerbation of Chronic Bronchitis and Mild Community-acquired Pneumonia in Common Clinical Practice in Ukraine Completed
  14. N/A Improving Antimicrobial-Prescribing in Emergency Departments Completed
  15. N/A Patient Portal - Flu Reminder Recall Completed
  16. N/A Patient Portal Flu Vaccine Reminders (RCT 6) Completed
  17. N/A Rapid Diagnostics for Upper Respiratory Infections in the Emergency Department Completed
  18. N/A Probiotics and Infections in Conscripts in Military Service Completed
  19. N/A Patient Portal Reminder/Recall for Influenza Vaccination in a Health System- RCT 2 Completed
  20. N/A Acute Safety and Acceptability Study of Experimental Device RD19 for Protection From Human Respiratory Disease Pathogens Completed

Showing the 26 most-cited and recently-updated of 26 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Respiratory Tract Infections: what the trials found

Vaccination with a Quadrivalent VLP Influenza Vaccine demonstrated high rates of seroprotection across multiple strains, with reported percentages ranging from 40.6% to 98.7% [5, 6, 7]. This vaccine also showed significant seroconversion rates (ranging from 15.5% to 73.3%) and consistent geometric mean fold rises in HI antibody responses [5, 6, 7].

Amoxicillin-clavulanate was associated with a statistically significant reduction in the distribution of children experiencing treatment failure for rhinosinusitis (p=0.003) 8. However, its impact on the Pediatric Rhinosinusitis Symptom Scale (PRSS) based on colored nasal discharge did not reach statistical significance (p=0.37) 8.

Recent results — preliminary, needs further review

  • Administration of aH5N6c on Day 1 resulted in varying geometric mean fold increases (GMFI) of HI antibodies against the H5N6 strain, with values ranging from 1.45 to 12.13 1.
  • Daily oral vitamin D3 (3,333 IU) was evaluated for its effect on lung function metrics including FEV1/FVC ratio and RV/TLC ratios 10.

For the clinician treating this condition

  • Quadrivalent VLP Influenza vaccines provide robust seroprotection across multiple strains as evidenced by high HI antibody response rates.
  • Amoxicillin-clavulanate is associated with a lower rate of treatment failure in pediatric rhinosinusitis patients compared to other groups.

AI synthesis of 3 cited trials, updated Jun 27, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Asthma, allergy, and low parental education linked to recurrent respiratory infections in preschoolers
Allergy & Immunology Meta-analysis
Asthma, allergy, and low parental education linked to recurrent respiratory infections in preschoolers Risk factors for frequent respiratory infections in preschool children
This meta-analysis of 15,271 preschool children estimates the prevalence of recurrent respiratory tract infections (RRTIs) at 24.14% and ide…
New data identifies how asthma, allergies, and environmental factors like smoking increase the risk of repeat respiratory infections in youn…
Nov 6, 2026
Azithromycin does not raise macrolide-resistant gene prevalence in preterm infants
Pediatrics RCT
Azithromycin does not raise macrolide-resistant gene prevalence in preterm infants Azithromycin in Preterm Infants Raises Resistance Gene
This randomized controlled trial in 1108 preterm-born infants found that azithromycin treatment did not increase the overall prevalence of m…
Antibiotic resistance genes stayed high in preterm infants even with azithromycin, raising concerns about antibiotic use.
Aug 15, 2026
Probiotic regimens may reduce cough duration and illness length in children with respiratory infections
Pulmonology & Critical Care Meta-analysis
Probiotic regimens may reduce cough duration and illness length in children with respiratory infections Probiotics shorten cough and illness in children
This network meta-analysis evaluated various probiotic regimens, including Bifidobacterium and Lactobacillus, for managing symptoms of respi…
Certain probiotics may shorten coughs and illnesses in healthy kids, but not all strains work equally.
Frontiers Aug 7, 2026
Meta-analysis links asthma, passive smoking, and frequent snacks to recurrent respiratory infections in preschoolers
Pediatrics Meta-analysis
Meta-analysis links asthma, passive smoking, and frequent snacks to recurrent respiratory infections in preschoolers Three habits that spark repeated colds in toddlers
A meta-analysis of observational studies involving 170,915 preschool children globally identified asthma (OR=3.26), passive smoking (OR=1.50…
Parents can lower their child's risk of repeated infections by managing asthma, keeping homes smoke-free, and limiting frequent snacking.
Apr 12, 2026