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Home › Conditions › Rhinitis

Rhinitis

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Rhinitis

22 trials tracked for Rhinitis: 10 in phase 3 or 4 and 1 with published results. The most-cited published study has 92 citations.

22Trials tracked
10Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 8 Phase 2 5 Phase 1 1 Other / NA 6
  1. Phase 3 The Safety and Efficacy of Intralymphatic Immunotherapy in Pollen Allergic Adolescents and Young Adults With Asthma Completed · 92 cited
  2. Phase 4 Study of Asthma and Nasal Steroids Completed
  3. Phase 4 A Study of Onset of Action of Loratadine and Fexofenadine in Participants With Seasonal Allergic Rhinitis (P08712) Completed
  4. Phase 3 The Effect of Pseudoephedrine on Rhinitis and Sleep Completed
  5. Phase 3 A Study Investigating the Immunologic Effects and Safety of 60-day Treatment of the ALK HDM Tablets in Adult Subjects With HDM-Induced Allergic Rhinitis and/or Atopic Asthma Completed
  6. Phase 3 Safety Study of Levocetirizine Oral Solution for Japanese Pediatrics Completed
Show 16 more trials
  1. Phase 3 Study FFR116365, an Open-label Study of GW685698X in Paediatric Subjects With Perennial Allergic Rhinitis Completed
  2. Phase 3 Efficacy and Safety of Grass Sublingual Tablet in Adults (P05238 AM3)(COMPLETED) Completed
  3. Phase 3 Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays Completed
  4. Phase 3 Efficacy and Safety of Grass Sublingual Tablet in Children and Adolescents (P05239 AM3)(COMPLETED) Completed
  5. Phase 2 Intranasal SB-705498 in Allergic Rhinitis (AR) Patients Completed
  6. Phase 2 SB705498 Proof of Concept Chamber Challenge in Subjects With Non Allergic Rhinitis Completed
  7. Phase 2 Effects of Phenylephrine on Nasal Congestion in Participants With Seasonal Allergic Rhinitis (P08156 AM2)(Completed) Completed
  8. Phase 2 Safety Study of Ragweed Allergy Immunotherapy Tablet in Subjects 50 Years of Age and Older (Study P06081) Completed
  9. Phase 2 A Study to Compare the Efficacy of Levocetirizine to Placebo in Reducing Symptoms of Seasonal Allergic Rhinitis (SAR) in Sensitive Subjects Exposed to Ragweed Pollen Completed
  10. Phase 1 Bioequivalence Study Between Levocetirizine Oral Disintegrating Tablet (ODT) and Levocetirizine Immediate Release Tablet (IRT) Completed
  11. N/A ClariFix Cryoablation Clinical Study Completed
  12. N/A Treatment With Rhinospray Plus in Patients With Acute Rhinitis in the Everyday Curative Routine in Hungary Completed
  13. N/A Safety of Aerius Syrup in Pediatric Patients Aged 1-5 Years Old With Allergic Rhinitis or Chronic Idiopathic Urticaria (Study P04446AM1)(COMPLETED) Completed
  14. N/A Response of Desloratadine Syrup in the Relief of Symptoms Associated With Perennial Allergic Rhinitis in Pediatric Patients (Study P04299) Completed
  15. N/A Screening Scottish Swimmers for Asthma and Rhinitis Completed
  16. N/A Evaluation of Desloratadine When Used in Patients With Either Allergic Rhinitis or Chronic Idiopathic Urticaria Completed

Showing the 22 most-cited and recently-updated of 22 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Rhinitis: what the trials found

Several pharmacological interventions have been evaluated for the management of rhinitis symptoms. Fluticasone furoate demonstrated a significant reduction in the 3 Total Nasal Symptom Score (3TNSS) over a 12-week treatment period, with mean percentage reductions ranging from approximately 31% to 53% across various measurement intervals 6. Mometasone Furoate monohydrate was also evaluated in Phase 4 clinical trials for this condition 1.

Antihistamines and other agents show evidence of efficacy or safety in rhinitis management. Desloratadine was evaluated in multiple studies [21, 22], while Loratadine showed specific mean scores for Major Symptom Complex (MSC) and individual symptoms such as runny nose and itchy nose during post-treatment evaluations 2. Levocetirizine was studied regarding its impact on allergic rhinitis and associated pruritus 7.

Specific interventions like ALK Alutard were evaluated in the context of birch or 5-grasses, showing a reduction in symptoms following nasal allergen challenge 3. Other agents such as Mitizax 4, Pseudoephedrine 5, and Triamcinolone acetonide nasal spray 10 have been studied for rhinitis management.

Placebo-controlled studies established that placebo groups showed significant differences in Total Combined Symptom (TCS) scores and Rhinoconjunctivitis Daily Symptom Scores (DSS) compared to active treatment or baseline during grass pollen seasons [8, 9].

The investigational agent SB-705498 was evaluated for its effects on total nasal symptom scores and ocular symptoms following cold dry air challenges [11, 13].

Recent results — preliminary, needs further review

  • ClariFix device showed a statistically significant reduction in rhinitis symptom severity (rTNSS) and visual analog scale (VAS) scores 17.
  • Phenylephrine HCl was evaluated for its effect on daily reflective nasal congestion scores, though results did not show a statistically significant change from baseline 15.
  • Levocetirizine IRT 5 mg was assessed in early-phase trials 16.
  • A study evaluating multiple single symptom scores (blocked nose, sneezing, and running nose) reported mean changes of -2 to -3 at the final visit 18.

For the clinician treating this condition

  • Fluticasone furoate provides consistent reduction in 3TNSS over a 12-week period, with significant percentage improvements noted as early as week 2 6.
  • Desloratadine and Loratadine are established options for managing rhinitis symptoms including runny nose and itchy nose [2, 21, 22].
  • Placebo groups in grass pollen season studies demonstrated significantly higher symptom scores (TCS and DSS) compared to treatment arms, confirming the efficacy of active interventions during peak seasons [8, 9].

AI synthesis of 12 cited trials, updated Jun 27, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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