Research across Sepsis
Related studies from across the Sepsis family.
Early Feeding in VLBW Infants Safe, Cuts Sepsis Risk
Early feeding may reduce sepsis in very low birth weight infants
Meta-analysis finds early enteral feeding in VLBW infants reduces sepsis and time to full feeds without increasing NEC or mortality.
Early feeding within 72 hours may help very low birth weight infants reach full nutrition faster and reduce the risk of sepsis.
Higher PNI scores are associated with lower short-term mortality in patients with sepsis
Nutritional scores help identify patients at risk from sepsis
This meta-analysis of 34,810 patients evaluated various nutritional assessment tools for sepsis mortality. Higher PNI scores were associated…
New data shows that specific nutritional assessment tools can help doctors identify which sepsis patients are at the highest risk for death.
Butyrylcholinesterase activity predicts in-hospital mortality in critically ill adults with sepsis
Butyrylcholinesterase levels help predict survival in patients with sepsis
This individual participant data meta-analysis of 482 critically ill adults with sepsis found that higher Day-1 butyrylcholinesterase (BChE)…
Doctors may soon use butyrylcholinesterase levels to better predict which critically ill patients with sepsis are at higher risk of dying.
Elevated syndecan-1 levels correlate with severity and poor outcomes in patients with sepsis
Higher syndecan-1 levels linked to severe sepsis and poor outcomes
This meta-analysis of 4985 patients, including 3902 with sepsis, found significantly higher circulating syndecan-1 levels in sepsis patients…
A new analysis shows that higher levels of a specific protein can help doctors identify patients with the most severe forms of sepsis.
Balanced crystalloid solutions reduce mortality and acute kidney injury in adult patients with sepsis
Balanced crystalloid solutions show lower death rates in sepsis patients
This meta-analysis of 7 trials involving 8,173 adults with sepsis found that balanced crystalloids significantly reduced mortality (RR 0.92)…
A large review of over 8,000 patients suggests balanced crystalloid fluids may reduce mortality and kidney damage for those with sepsis.
Mitochondrial dysfunction shapes immune cell function across sepsis phases, review finds
Mitochondrial Function Shapes Immune Response During Sepsis
This mini-review synthesizes evidence on mitochondrial immunometabolism in sepsis, describing how bioenergetic dysfunction and quality-contr…
New research highlights how mitochondrial health impacts immune cell function and organ damage during different stages of sepsis.
Five pathways drive sepsis-induced cardiomyopathy; imaging and biomarker panels improve early diagnosis
New Strategies for Managing Sepsis Induced Heart Damage
This systematic review synthesizes current knowledge on sepsis-induced cardiomyopathy (SIC), identifying five major pathological pathways th…
Newer imaging tools and biomarker panels help doctors identify heart damage from sepsis earlier to move toward more precise, targeted treatm…
Low-dose corticosteroids reduce 90-day mortality in adults with severe community-acquired pneumonia
Low dose steroids may lower death rates in severe lung infections
This meta-analysis of 4,622 patients found that low-dose corticosteroids (≤400 mg hydrocortisone-equivalent daily) significantly reduced sho…
A review of clinical trials suggests that low-dose corticosteroids can reduce 90-day mortality for adults with severe lung infections like p…
Neonatal neutrophil function varies by assay; chemotaxis and NETs often constrained
Understanding How Immune Cells Protect Newborns from Serious Infections
This mini review synthesizes human neonatal studies on neutrophil function. Chemotaxis and extracellular-trap formation are often developmen…
New research looks at how white blood cells in babies fight infections while trying to avoid causing tissue damage.
FSP1 acts as an endogenous inhibitor of endothelial ferroptosis and vascular leakage in sepsis
New research identifies protein pathways that may protect against sepsis
This systematic review explores the role of Ferroptosis Suppressor Protein 1 (FSP1) in sepsis-related pathology. The authors synthesize mech…
Scientists have identified how specific proteins and signaling pathways might prevent organ damage and blood vessel leakage during severe in…
Tachypnoea at 60 breaths per minute increases odds of mortality in infants with sepsis
Rapid breathing in infants linked to higher sepsis mortality
This meta-analysis evaluates the association between tachypnoea and mortality or culture-confirmed sepsis in infants aged 0 to 59 days. Tach…
Fast breathing rates can signal a serious risk of death in newborns with sepsis, helping doctors identify the most at-risk infants more quic…
IgM-enriched immunoglobulin shows directionally favorable but statistically inconclusive results for short-term mortality in sepsis
IgM Therapy for Sepsis Shows Promise but Not Proof
This meta-analysis of 411 adults with sepsis or septic shock found that IgM-enriched immunoglobulin (Pentaglobin) showed a favorable trend f…
A new analysis hints IgM therapy may lower sepsis deaths, but the evidence isn't strong enough to recommend it yet.