Research across Sepsis
Related studies from across the Sepsis family.
Heparin Shows No Mortality Benefit in Sepsis Meta-Analysis of 426 Patients
Heparin treatment shows mixed results for patients with sepsis
This meta-analysis examined heparin use in critically ill patients with sepsis, pooling data from 426 patients. No significant mortality red…
New data on heparin for sepsis shows it does not significantly reduce death rates, and its role in blood clotting remains unclear.
MitoQ acts as an upstream mitochondrial redox modulator to attenuate oxidative injury in SALI
MitoQ may protect lung cells from damage during severe infection
This narrative review explores the role of MitoQ in treating sepsis and acute lung injury. The authors suggest MitoQ may mitigate mitochondr…
A new review suggests the compound MitoQ could protect lung tissue and energy production during severe infections like sepsis.
Hemodiafiltration in Neonates: Narrative Review Maps Applications but Reports No Clinical Outcomes
Hemodiafiltration in Babies: What We Still Do Not Know
This narrative review examines hemodiafiltration (HDF) in neonates and infants, focusing on clinical applications, potential benefits, safet…
A new review looks at hemodiafiltration for newborns and infants, but reports no actual results or safety data.
Higher H3.1 nucleosome levels associate with 48% increased 28-day mortality in septic shock
H3.1 Nucleosome Levels Linked to Sepsis Mortality and Kidney Risk
This secondary analysis of a multicenter randomized controlled trial involved 971 patients with sepsis and septic shock. Higher plasma H3.1 …
Higher levels of H3.1 nucleosomes in patients with sepsis and septic shock are linked to a higher risk of death and need for kidney replacem…
Phoenix Sepsis Criteria outperforms IPSCC criteria for pediatric in-hospital mortality risk stratification
New criteria improve risk prediction for children with sepsis
This meta-analysis of 15 studies and 16 cohorts involving 2,601,038 encounters evaluates the Phoenix Sepsis Criteria (PSC) compared to IPSCC…
A new scoring system helps doctors better predict which children with severe infections are at the highest risk of dying in the hospital.
Feasibility study for meropenem versus piperacillin/tazobactam in sepsis shows 30.5% 30-day mortality
Trial Tests Meropenem for Treatment of Sepsis in Critical Care
This feasibility study of 200 critically ill adults with sepsis in 10 Danish ICUs evaluated the trial's operational viability. The study rep…
A new feasibility study explores the use of meropenem to treat critically ill adults suffering from sepsis in intensive care units.
Sepsis-associated delirium affects 43% of ICU patients, mechanical ventilation strongest risk factor
Risk Factors Linked to Delirium in Patients with Sepsis
This meta-analysis of 89,789 ICU patients estimates the pooled incidence of sepsis-associated delirium (SAD) at 43% (95% CI 39%-47%). Higher…
A large review of ICU patients identifies key risk factors, such as advanced age and mechanical ventilation, for developing delirium during …
Elevated BMI is associated with lower short-term and long-term mortality in adult sepsis patients
Higher BMI Linked to Lower Mortality in Patients with Sepsis
This meta-analysis of 130755 patients indicates that an elevated BMI (≥30 kg/m) is associated with significantly lower short-term and long-t…
A large review of data suggests that patients with a higher BMI may have lower mortality rates when treated for sepsis.
Mongolian Medicine Compounds Show Immunomodulatory Potential in Sepsis, But Direct Evidence Remains Scarce
Traditional Mongolian Medicine shows potential for treating sepsis models
This narrative review examines Traditional Mongolian Medicine compounds (Daruqi particles, HHQG, Hohgardi-9, Nagab-9, Monflu, Batri-7, Qiqir…
Traditional Mongolian medicines like quercetin and berberine show potential to manage inflammation in sepsis models, though more human trial…
Proposed evidence-mapping framework addresses diagnostic discordance and pharmacological limitations in sepsis-induced cardiomyopathy
New framework helps doctors manage heart damage from sepsis
This guideline provides a proposed evidence-mapping framework for interpreting bedside diagnostic indices in patients with septic shock and …
New research highlights why current heart tests often fail to show the full extent of damage caused by sepsis.
Point-of-care ultrasound supports source identification and physiologic reassessment in patients with sepsis and septic shock
Ultrasound helps doctors identify infection sources in sepsis patients
This narrative review examines the role of point-of-care ultrasound (POCUS) for source-oriented assessment and physiologic reassessment in e…
Point-of-care ultrasound can help emergency doctors find infection sources and monitor fluid levels in patients with life-threatening sepsis…
Limited clinical translation of sepsis biomarkers highlights significant gap between discovery and deployment
Few Sepsis Biomarkers Are Currently Ready for Clinical Use
This mini review examines the clinical utility of various sepsis biomarkers, including procalcitonin, lactate, and host-response tests. The …
While many biomarkers have been identified for sepsis, only a small number are currently approved for use in hospitals to guide patient care…