Research across Sepsis
Related studies from across the Sepsis family.
Hyperoxygenation target (PaO2: 100-150 mmHg) reduces 28-day mortality in patients with sepsis
Higher oxygen targets may lower death rates for sepsis patients
This randomized controlled trial of 270 patients with sepsis found that a hyperoxygenation target of PaO2: 100-150 mmHg significantly reduce…
A new trial shows that giving higher levels of oxygen to patients with sepsis can significantly reduce deaths within the first 28 days.
Lactobacillus rhamnosus GG does not significantly impact composite outcomes in VLBW infants
Trial shows probiotic LGG does not improve outcomes for infants
This randomized controlled trial of 236 enterally-fed very low birth weight infants found no significant difference in the primary composite…
A trial of 236 very low birth weight infants found that a specific probiotic did not reduce risks like sepsis or intestinal issues.
Novel biomarkers and machine learning algorithms facilitate earlier identification and diagnosis of sepsis
New Diagnostic Tools May Help Identify Sepsis More Quickly
This narrative review explores the evolution of sepsis diagnostic strategies from traditional clinical scoring systems to advanced markers l…
Newer biomarkers and machine learning tools are evolving beyond traditional scoring systems to help doctors identify sepsis earlier in patie…
Bovine milk fortifiers non-inferior to human milk fortifiers for NEC and sepsis in pre-term newborns
Bovine Milk Fortifiers Show Similar Results to Human Milk
This meta-analysis of 3371 publications found that bovine milk-based fortifiers are non-inferior to human milk-based fortifiers for necrotiz…
A large review of research suggests that bovine milk based fortifiers are as safe and effective as human milk for newborns with specific con…
Elevated HMGB1 levels correlate with sepsis diagnosis and increased mortality risk in adult patients
High HMGB1 levels linked to sepsis and higher mortality
This meta-analysis of 3,110 patients found that serum or plasma HMGB1 levels are significantly higher in sepsis patients compared to healthy…
Higher levels of the protein HMGB1 in the blood are linked to more severe cases of sepsis and an increased risk of death for patients.
Neutrophil extracellular traps contribute to vascular dysfunction and endothelial injury in patients with sepsis
Neutrophil traps contribute to blood vessel damage in sepsis
This systematic review examines the role of neutrophil extracellular traps (NETs) in sepsis pathophysiology. The authors conclude that NETs …
New research identifies how specific immune cells called NETs cause severe blood vessel damage during life-threatening sepsis infections.
Vitamin D deficiency increases odds of sepsis and mechanical ventilation in neonates
Vitamin D Deficiency Linked to Higher Sepsis Risk in Neonates
This meta-analysis of 18 studies involving 1981 patients found that Vitamin D deficiency is associated with a higher risk of sepsis and incr…
Low vitamin D levels are linked to higher rates of sepsis and longer hospital stays for babies in neonatal intensive care units.
Cystatin C shows good diagnostic performance with an AUC of 0.88 for early detection of SA-AKI
Cystatin C shows promise for early detection of kidney injury
This meta-analysis of 17 studies evaluates the diagnostic performance of Cystatin C for detecting acute kidney injury in patients with sepsi…
A new look at 17 studies suggests that Cystatin C could help doctors identify kidney damage in sepsis patients much earlier than current met…
Sepsis Mortality Prediction Models Show Moderate Performance
Prediction models show moderate success in forecasting sepsis deaths
A meta-analysis of 84 studies finds that externally validated models for sepsis mortality achieve a pooled AUC of 0.794, but most studies ha…
New data from millions of records helps identify which factors most accurately predict if a patient with sepsis will survive.
Prediction models show moderate discrimination for ARDS occurrence and mortality in sepsis patients
Machine Learning Models Show Mixed Results for Predicting Sepsis Lung Injury
This systematic review and meta-analysis evaluated prediction models for ARDS occurrence and short-term mortality in patients with sepsis-as…
New analysis shows that while machine learning can predict lung injury in sepsis patients, these models do not consistently outperform stand…
Gut microbiota dysbiosis and microbial metabolites impair renal function in sepsis-associated acute kidney injury
Sepsis may damage kidneys by letting gut bacteria toxins leak into the blood
This narrative review examines the role of gut microbiota dysbiosis in sepsis-associated acute kidney injury and acute kidney injury. The au…
A review suggests that sepsis changes gut bacteria, causing harmful toxins to leak and hurt kidneys in humans and animals.
Modulation of neutrophil function and death in critically ill patients with sepsis is discussed in this narrative review
Review discusses neutrophil modulation in sepsis for critically ill patients
This narrative review discusses modulation of neutrophil function and death in critically ill patients with sepsis. The authors synthesize c…
This narrative review explores how changing neutrophil function might affect sepsis outcomes in critically ill patients, though no specific …