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Home › Conditions › Severe Mental Illness

Severe Mental Illness

6 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Severe Mental Illness

20 trials tracked for Severe Mental Illness.

20Trials tracked
0Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 2 2 Other / NA 18
  1. Phase 2 Proactive Outreach for Smoking Treatment Completed
  2. Phase 2 Treating Smokers With Mental Illness Completed
  3. N/A Recovery Bridge: Peer Intervention to Bridge Transition Post Discharge Completed
  4. N/A MISSION-Vet HUD-VASH Implementation Study Completed
  5. N/A Assessing the Effect of Distance Learning Vocational Rehabilitation on Employment Outcomes of Veterans With Psychiatric Illness and Histories of Legal Convictions Completed
  6. N/A Using MOVE! With Seriously Mentally Ill Veterans Completed
Show 14 more trials
  1. N/A Evaluating Vocational Materials for Incarcerated Veterans With Mental Illness or Substance Abuse Completed
  2. N/A Evaluation of Peer Specialists on VA PACTs Completed
  3. N/A Electronic Decision Support Systems for Smokers With Severe Mental Illness Completed
  4. N/A Sibling-Support for Adolescent Girls (SSAGE) Completed
  5. N/A The Use of Skills Training to Augment Compensated Work Therapy (CWT)/VI for Veterans With SMI Completed
  6. N/A Trial of Integrated Smoking Cessation, Exercise and Weight Management in Serious Mental Illness: TRIUMPH Completed
  7. N/A Wellness Self-Management Completed
  8. N/A Enhancing Mental Health Care by Scientifically Matching Patients to Providers' Strengths Completed
  9. N/A Brief COVID-19 Intervention for People With Serious Mental Illness and Co-Morbid Medical Conditions Completed
  10. N/A Illness Management and Recovery Treatment Integrity Scale Validation and Leadership Intervention Development Completed
  11. N/A Maintaining Independence and Sobriety Through Systems Integration, Outreach, and Networking Completed
  12. N/A Goal Elicitation, Treatment Prioritization, & Electronically-Practiced Discussion for Psychiatry Completed
  13. N/A Best Practices to Prevent COVID-19 Illness in Staff and People With Serious Mental Illness and Developmental Disabilities in Congregate Living Settings Completed
  14. N/A Decision Support for Smoking Cessation in Young Adults With Severe Mental Illness Completed

Showing the 20 most-cited and recently-updated of 20 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Preoperative comorbidities linked to reduced weight loss after metabolic and bariatric surgery in adults
Nutrition & Obesity Medicine Meta-analysis
Preoperative comorbidities linked to reduced weight loss after metabolic and bariatric surgery in adults Pre-existing health conditions may slightly reduce weight loss after surgery
A meta-analysis of twenty-three studies reveals that mental illness, diabetes, and sleep apnea are associated with slightly lower weight los…
Adults with mental illness or diabetes before surgery saw slightly less weight loss. Other conditions like high blood pressure did not affec…
Jun 6, 2026
Meta-analysis shows AI virtual patient simulations improve psychiatric interview training in health professions education
Rheumatology Meta-analysis
Meta-analysis shows AI virtual patient simulations improve psychiatric interview training in health professions education AI Virtual Patients Boost Psychiatric Interview Skills
This meta-analysis synthesizes evidence from approximately 450 participants across 10 studies in health professions education. The authors r…
New AI tools help train doctors to talk better to patients with mental health issues by simulating real conversations.
Frontiers May 14, 2026
Narrative review examines multimorbidity impact on sepsis morbidity and mortality outcomes
Cardiology Sys. Review
Narrative review examines multimorbidity impact on sepsis morbidity and mortality outcomes Sepsis Risk Skyrockets When You Have Multiple Chronic Conditions
This narrative review synthesizes evidence regarding sepsis in patients with multimorbidity including type 2 diabetes and heart failure.
Common chronic diseases like diabetes and heart failure create hidden traps that make sepsis much harder to fight and treat.
Frontiers Apr 29, 2026
Literature review synthesizes Schisandra chinensis effects on gut microbiota and metabolic pathways across multiple conditions
Gastroenterology Sys. Review
Literature review synthesizes Schisandra chinensis effects on gut microbiota and metabolic pathways across multiple conditions This Ancient Berry May Quiet Inflammation From Your Gut to Your Brain
This literature review examines the potential of Schisandra chinensis regarding gut health and metabolic regulation.
An ancient berry used for centuries may rebalance gut bacteria to calm inflammation linked to digestive issues, liver disease, diabetes, and…
Frontiers Apr 19, 2026
Sociodemographic and clinical factors predict psychiatric ED utilization within six months of inpatient discharge
Primary Care & Family Medicine RCT
Sociodemographic and clinical factors predict psychiatric ED utilization within six months of inpatient discharge Patient Factors Linked to Psychiatric Emergency Department Visits After Hospital Discharge
This secondary analysis of a pragmatic stepped-wedge cluster-randomized trial examined predictors of psychiatric emergency department (ED) v…
Patients aged 26 to 40 are less likely to visit the emergency room after psychiatric hospital discharge, a study of over 1,000 people in Can…
Apr 6, 2026
Antithrombotic agents may reduce symptoms in severe mental illness, but evidence is very low certainty
Psychiatry Meta-analysis
Antithrombotic agents may reduce symptoms in severe mental illness, but evidence is very low certainty Blood-thinning drugs show possible benefit for severe mental illness symptoms
A systematic review and meta-analysis of 742 patients with severe mental illness found antithrombotic agents may reduce depressive symptoms …
Blood-thinning drugs might slightly ease severe mental illness symptoms, but experts warn the evidence is very uncertain and more research i…
Apr 2, 2026

Questions about Severe Mental Illness

Are there specific medications to reduce symptoms in Severe Mental Illness?

Yes, antipsychotics are standard for schizophrenia; metformin can prevent weight gain from antipsychotics; antithrombotic agents show very low-certainty evidence for reducing depressive symptoms.

Full answer →
Can people with Severe Mental Illness experience less weight loss after metabolic surgery?

Yes, people with severe mental illness may experience slightly less weight loss after metabolic surgery, based on a meta-analysis showing a small but significant difference.

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Does having a Severe Mental Illness affect weight loss after bariatric surgery?

Yes, severe mental illness is linked to slightly less weight loss after bariatric surgery, likely due to medication effects and metabolic factors.

Full answer →