Research across Crohn's Disease
Related studies from across the Crohn's Disease family.
Acute cellular senescence facilitates tissue repair while chronic accumulation drives intestinal fibrosis in Crohn's disease
Chronic cell aging may drive scarring in Crohn's disease
This systematic review examines the role of cellular senescence in intestinal fibrosis within Crohn's disease. The authors conclude that acu…
New research reveals how the timing of cellular aging determines whether your body heals properly or develops harmful scar tissue.
Mucus-barrier regulatory programs in Crohn's disease and ulcerative colitis involve ER stress and microbial sensing
New findings show how mucus barriers fail in Crohn's and Ulcerative Colitis
This meta-analysis of transcriptomic datasets and an Agr2-/- mouse model identifies consensus mucus-barrier regulatory programs in active IB…
Researchers found that specific genes control the protective mucus layer in the gut. These same pathways are disrupted in people with IBD.
IBD-related neuroimaging shows brain alterations in emotional networks with distinguishable phenotypes for Crohn's and ulcerative colitis
Brain scans show different emotional patterns in Crohn's and ulcerative colitis
This bibliometric analysis and systematic scoping review examines 175 articles on IBD-related neuroimaging literature from Web of Science an…
A review of 175 articles found that brain activity in Crohn's and ulcerative colitis affects emotion centers differently. This suggests dist…
Darvadstrocel shows 48.8% combined remission in Crohn's perianal fistulas, not superior to placebo
Darvadstrocel showed no better results than placebo for Crohn's disease fistulas
This Phase 3 randomized trial in adults with Crohn's disease and complex perianal fistulas found that darvadstrocel did not achieve a statis…
A major trial found darvadstrocel did not improve closure of Crohn's fistulas compared to placebo, showing no significant benefit for patien…
Mediterranean diet shows no significant advantage over control diets for inducing remission in inflammatory bowel disease patients
Mediterranean diet helps some patients with inflammatory bowel disease reach remission better than control diets
This systematic review and meta-analysis evaluated the Mediterranean diet versus control diets in patients with inflammatory bowel disease. …
A review of studies found that a Mediterranean diet helped about 62% of patients reach remission. This approach worked well for both Crohn's…
Guideline secondary analysis shows non-significant trend for higher enteral nutrition use in pediatric Crohn's disease registry groups
Registry tool shows mixed results for pediatric Crohn's nutrition
This guideline secondary analysis of a cluster-randomized trial examines enteral nutrition patterns in 110 children with Crohn's disease. Th…
A new registry tool did not significantly boost enteral nutrition use in children with Crohn's, but it may lower steroid use in the first 90…
Meta-analysis of GWAS data identifies genetic risk factors for inflammatory bowel disease in 125,992 individuals
Genetic map reveals new targets for inflammatory bowel disease
This meta-analysis review synthesizes genome-wide association study data from 125,992 individuals with IBD and more than 1.2 million control…
A massive genetic study found 619 new signals linked to Crohn's and ulcerative colitis, offering fresh clues for future treatments.
FDA Approves Hadlima (adalimumab) for Multiple Inflammatory Indications
FDA approves Hadlima, a new biosimilar for several inflammatory diseases.
The FDA approved Hadlima (adalimumab) for several inflammatory conditions including rheumatoid arthritis, juvenile idiopathic arthritis, pso…
The FDA approved Hadlima (adalimumab) for treating conditions like rheumatoid arthritis, psoriasis, and Crohn's disease. It is a biosimilar,…
Meta-analysis associates childhood antibiotic use with increased inflammatory bowel disease risk
Early antibiotics may raise your risk of developing inflammatory bowel disease later in life
This meta-analysis of 8 studies involving 2783 cases examines the association between antibiotic use in children aged 1 to 17 years and the …
New research shows that taking antibiotics during childhood could increase the chance of developing inflammatory bowel disease later in life
Narrative review discusses NF-kB inhibition for inflammatory bowel diseases and related conditions
Blocking NF-κB May Ease Gut Inflammation in IBD
This narrative review explores the role of NF-kB pathway inhibition in treating inflammatory conditions.
A review finds that blocking a key inflammatory pathway could help treat Crohn's, colitis, and celiac disease.
Meta-analysis shows reduced oral microbial Shannon diversity in Crohn's disease versus controls
Oral bacteria shifts could reveal Crohn's disease risk
This meta-analysis reviews data from multiple cohorts involving 1,136 IBD patients and 759 controls.
A new study links distinct mouth bacteria changes to higher gut inflammation levels in Crohn's disease patients.
Enteral nutrition therapy associated with clinical remission in 60% of Chinese inflammatory bowel disease patients over 6 weeks
Enteral nutrition helps many IBD patients reach remission faster
This retrospective cohort study evaluated enteral nutrition therapy in 750 Chinese patients with Crohn's disease or ulcerative colitis.
Special liquid food formulas helped 60% of patients reach remission faster while improving nutrition and reducing inflammation in their bodi…