Research across Crohn's Disease
Related studies from across the Crohn's Disease family.
ILC3-to-ILC1 transition is strongly supported in Crohn's Disease but evidence for UC plasticity is limited
Immune Cell Changes May Offer New Paths for Crohn's Disease
This narrative review explores the role of innate lymphoid cell (ILC) plasticity in Crohn's disease and ulcerative colitis. The authors find…
New research explores how specific immune cells change in Crohn's disease, potentially leading to more precise treatments for inflammatory b…
Extracellular vesicle-based therapies show potential for tissue repair and barrier restoration in inflammatory bowel disease
Extracellular Vesicles Show Potential for Inflammatory Bowel Disease
This narrative review explores the therapeutic potential of various extracellular vesicle-based therapies for ulcerative colitis and Crohn's…
New research explores how tiny particles called extracellular vesicles might help repair tissue and manage symptoms in Crohn's disease and u…
Gut-brain axis dysregulation links Crohn's disease activity with heterogeneous mood improvements from emerging therapies
Newer gut brain therapies show promise for Crohn's disease depression
This narrative review explores the gut-brain axis as a mechanism for depression in patients with Crohn's disease. The authors synthesize evi…
Living with Crohn's disease and depression is a heavy burden. New research explores how targeting the gut brain axis could help manage both …
Ustekinumab reduces risk of fatigue and arthritis/arthralgia in moderate-to-severe active Crohn's disease
Ustekinumab Shows Potential Benefits for Fatigue in Crohn's Disease
This meta-analysis of 23 RCTs involving 7,810 patients found that ustekinumab significantly reduced the risk of fatigue (IRR 0.53) and arthr…
A large review of clinical trials suggests ustekinumab may reduce fatigue and joint pain for adults with moderate to severe Crohn's disease.
Crohn disease and ulcerative colitis causally raise ankylosing spondylitis risk
Crohn's disease and ulcerative colitis linked to joint inflammation
This Mendelian randomization meta-analysis found positive causal relationships between Crohn disease and ulcerative colitis and ankylosing s…
People with Crohn's disease or ulcerative colitis face a higher risk of developing ankylosing spondylitis, a form of inflammatory joint dise…
Terminal ileal intubation provides a 0.28% diagnostic yield for clinically significant pathology in asymptomatic patients
Colonoscopy technique shows low yield for finding Crohn's disease
This meta-analysis of 25,659 asymptomatic adults undergoing colonoscopy found that terminal ileal intubation (TII) yields only 0.28% for cli…
A large review of over 25,000 procedures shows that extra checks in the small intestine rarely find significant issues like Crohn's disease.
Acceptance and Commitment Therapy reduces anxiety, depression, and stress in patients with inflammatory bowel disease
Acceptance and Commitment Therapy reduces anxiety for inflammatory bowel disease
This meta-analysis of 459 patients with Crohn's disease or ulcerative colitis found that Acceptance and Commitment Therapy (ACT) significant…
A new review shows that Acceptance and Commitment Therapy can significantly lower anxiety, stress, and depression for people with Crohn's or…
Bidirectional associations exist between obstructive lung diseases and inflammatory bowel disease across 30 observational studies
Lung Disease and Inflammatory Bowel Disease Show Linked Risks
This meta-analysis of 30 observational studies identifies bidirectional associations between obstructive lung diseases (COPD, asthma, bronch…
Research shows a link between inflammatory bowel disease and several lung conditions, including asthma and COPD, suggesting these issues oft…
Acute cellular senescence facilitates tissue repair while chronic accumulation drives intestinal fibrosis in Crohn's disease
Chronic cell aging may drive scarring in Crohn's disease
This systematic review examines the role of cellular senescence in intestinal fibrosis within Crohn's disease. The authors conclude that acu…
New research reveals how the timing of cellular aging determines whether your body heals properly or develops harmful scar tissue.
Mucus-barrier regulatory programs in Crohn's disease and ulcerative colitis involve ER stress and microbial sensing
New findings show how mucus barriers fail in Crohn's and Ulcerative Colitis
This meta-analysis of transcriptomic datasets and an Agr2-/- mouse model identifies consensus mucus-barrier regulatory programs in active IB…
Researchers found that specific genes control the protective mucus layer in the gut. These same pathways are disrupted in people with IBD.
IBD-related neuroimaging shows brain alterations in emotional networks with distinguishable phenotypes for Crohn's and ulcerative colitis
Brain scans show different emotional patterns in Crohn's and ulcerative colitis
This bibliometric analysis and systematic scoping review examines 175 articles on IBD-related neuroimaging literature from Web of Science an…
A review of 175 articles found that brain activity in Crohn's and ulcerative colitis affects emotion centers differently. This suggests dist…
Darvadstrocel shows 48.8% combined remission in Crohn's perianal fistulas, not superior to placebo
Darvadstrocel showed no better results than placebo for Crohn's disease fistulas
This Phase 3 randomized trial in adults with Crohn's disease and complex perianal fistulas found that darvadstrocel did not achieve a statis…
A major trial found darvadstrocel did not improve closure of Crohn's fistulas compared to placebo, showing no significant benefit for patien…