Research across Crohn's Disease
Related studies from across the Crohn's Disease family.
Crohn's disease patients exhibit reduced fungal alpha diversity compared to healthy controls
Lower fungal diversity found in people with Crohn's disease
This meta-analysis of gut fungal communities in patients with Crohn's disease and ulcerative colitis found a reduced fungal alpha diversity …
People with Crohn's disease have less variety in their gut fungal communities compared to healthy individuals, highlighting a key difference…
Machine learning models predict anti-TNF-alpha treatment response in Crohn's disease with C-indices up to 0.883
Machine Learning Helps Predict Success of Crohn's Disease Treatment
This meta-analysis evaluates machine learning models for predicting anti-TNF-alpha therapy response in patients with Crohn's disease. The st…
New machine learning models may help doctors predict how well patients with Crohn's disease will respond to anti-TNF-alpha therapy.
Traditional Chinese medicine may alleviate Crohn's disease symptoms through multi-target and multi-pathway mechanisms
Traditional Chinese Medicine May Help Manage Crohn's Disease Symptoms
This systematic review examines the role of Traditional Chinese medicine (TCM) in managing Crohn's disease. The authors suggest TCM may alle…
Traditional Chinese medicine may work alongside Western treatments to improve symptoms and reduce relapse risks for people living with Crohn…
Subcutaneous infliximab maintains clinical remission and doubles serum concentrations in pediatric inflammatory bowel disease
Subcutaneous infliximab maintains remission for children with inflammatory bowel disease
This meta-analysis of 162 patients with Crohn's disease and ulcerative colitis found that subcutaneous infliximab maintained clinical remiss…
Switching to a subcutaneous injection of infliximab can help children with Crohn's disease or ulcerative colitis maintain remission and stay…
Mycobacterium avium subsp. paratuberculosis may contribute to Crohn's disease through complex pathogenic mechanisms
Bacteria May Play a Role in Crohn's Disease and More
This narrative review explores the role of Mycobacterium avium subsp. paratuberculosis (MAP) in Crohn's disease and other conditions like mu…
Research suggests a specific bacterium may contribute to Crohn's disease and show links to other conditions like multiple sclerosis and type…
ILC3-to-ILC1 transition is strongly supported in Crohn's Disease but evidence for UC plasticity is limited
Immune Cell Changes May Offer New Paths for Crohn's Disease
This narrative review explores the role of innate lymphoid cell (ILC) plasticity in Crohn's disease and ulcerative colitis. The authors find…
New research explores how specific immune cells change in Crohn's disease, potentially leading to more precise treatments for inflammatory b…
Extracellular vesicle-based therapies show potential for tissue repair and barrier restoration in inflammatory bowel disease
Extracellular Vesicles Show Potential for Inflammatory Bowel Disease
This narrative review explores the therapeutic potential of various extracellular vesicle-based therapies for ulcerative colitis and Crohn's…
New research explores how tiny particles called extracellular vesicles might help repair tissue and manage symptoms in Crohn's disease and u…
Gut-brain axis dysregulation links Crohn's disease activity with heterogeneous mood improvements from emerging therapies
Newer gut brain therapies show promise for Crohn's disease depression
This narrative review explores the gut-brain axis as a mechanism for depression in patients with Crohn's disease. The authors synthesize evi…
Living with Crohn's disease and depression is a heavy burden. New research explores how targeting the gut brain axis could help manage both …
Ustekinumab reduces risk of fatigue and arthritis/arthralgia in moderate-to-severe active Crohn's disease
Ustekinumab Shows Potential Benefits for Fatigue in Crohn's Disease
This meta-analysis of 23 RCTs involving 7,810 patients found that ustekinumab significantly reduced the risk of fatigue (IRR 0.53) and arthr…
A large review of clinical trials suggests ustekinumab may reduce fatigue and joint pain for adults with moderate to severe Crohn's disease.
Crohn disease and ulcerative colitis causally raise ankylosing spondylitis risk
Crohn's disease and ulcerative colitis linked to joint inflammation
This Mendelian randomization meta-analysis found positive causal relationships between Crohn disease and ulcerative colitis and ankylosing s…
People with Crohn's disease or ulcerative colitis face a higher risk of developing ankylosing spondylitis, a form of inflammatory joint dise…
Terminal ileal intubation provides a 0.28% diagnostic yield for clinically significant pathology in asymptomatic patients
Colonoscopy technique shows low yield for finding Crohn's disease
This meta-analysis of 25,659 asymptomatic adults undergoing colonoscopy found that terminal ileal intubation (TII) yields only 0.28% for cli…
A large review of over 25,000 procedures shows that extra checks in the small intestine rarely find significant issues like Crohn's disease.
Acceptance and Commitment Therapy reduces anxiety, depression, and stress in patients with inflammatory bowel disease
Acceptance and Commitment Therapy reduces anxiety for inflammatory bowel disease
This meta-analysis of 459 patients with Crohn's disease or ulcerative colitis found that Acceptance and Commitment Therapy (ACT) significant…
A new review shows that Acceptance and Commitment Therapy can significantly lower anxiety, stress, and depression for people with Crohn's or…