Specific reversal agents offer high-affinity neutralization but face cost and access barriers in thromboembolism management
New Options and Challenges for Reversing Blood Clot Treatments
This systematic review evaluates procoagulant strategies including specific reversal agents like idarucizumab and non-specific options for t…
Doctors are evaluating specific and non-specific agents to safely reverse the effects of anticoagulant medications in patients with blood cl…
DOACs reduce thromboembolic events in pediatric patients compared to standard anticoagulation
A Pill Form of Blood Thinner May Be Safer for Kids Than Standard Shots
A meta-analysis of 2,002 pediatric patients found direct oral anticoagulants (DOACs) significantly reduced thromboembolic event recurrence (…
New oral blood thinners cut dangerous blood clot recurrences in half for children without increasing bleeding risks compared to standard sho…
Research across Embolism and Thrombosis
Related studies from across the Embolism and Thrombosis family.
Apixaban reduces VTE risk across multiple chemotherapy regimens in ambulatory cancer patients
Apixaban reduces blood clot risk for patients starting chemotherapy
This post hoc analysis of a randomized, double-blind, placebo-controlled trial of 563 ambulatory cancer patients found that apixaban (2.5 mg…
A new analysis shows that the blood thinner apixaban significantly lowers the risk of dangerous blood clots in cancer patients starting chem…
Non-recommended dosing regimens may be associated with major bleeding in patients treated with DOACs
Non-Recommended Dosing May Link to Bleeding in VTE Patients
This meta-analysis evaluates the impact of dosing regimens and adherence on major bleeding in patients with venous thromboembolism treated w…
Using non-recommended doses of blood thinners for venous thromboembolism may be linked to an increased risk of major bleeding.
Venous thromboembolism is estimated to be infrequent in children with lower limb fractures
Blood Clots After Kids' Leg Fractures Are Rare, Review Finds
This meta-analysis of retrospective studies examines the incidence of venous thromboembolism in children with lower limb fractures. The anal…
A new review estimates that blood clots affect about 0.53% of children with lower limb fractures, but key questions remain unanswered.
DOACs prescribed in 89.6% of cases following treatment discontinuation in cancer-associated thrombosis
Doctors face inconsistent choices when treating cancer and blood clots
This descriptive analysis of 1458 patients with cancer and venous thromboembolism examined investigator decisions after blinded treatment di…
New data shows that doctors often make inconsistent decisions about blood thinner dosages for cancer patients, highlighting a gap in standar…
AI-guided ultrasound achieves 92.86% sensitivity for DVT triage, avoids 35.32% of standard scans
AI guidance helps doctors find blood clots in leg veins
In a multicenter nonrandomized study of 594 patients, an AI guidance system for proximal lower extremity compression ultrasounds achieved di…
A new AI system helps doctors quickly identify deep vein thrombosis and may reduce the need for standard ultrasound exams.
DOACs reduce thrombosis recurrence and major bleeding compared to warfarin in morbidly obese VTE patients
DOACs Show Lower Risk of Blood Clots in Patients with Obesity
This meta-analysis of 44,672 patients found that DOACs are associated with lower risks of thrombosis recurrence (OR 0.74) and major bleeding…
New data suggests that direct acting oral anticoagulants may be more effective than warfarin for managing blood clots in patients with morbi…
Evaluating Enoxaparin Dosing Strategies for Venous Thromboembolism Prophylaxis in Bariatric Surgery Patients
Higher enoxaparin doses do not change outcomes for bariatric surgery
A meta-analysis of 1,276 patients indicates that while 60 mg enoxaparin achieves higher anti-factor Xa levels, clinical outcomes remain simi…
A review of 1,276 patients shows that higher doses of the blood thinner enoxaparin do not improve safety or results for those undergoing wei…
Direct oral anticoagulants reduce thrombotic events and major bleeding in cirrhosis with atrial fibrillation or venous thromboembolism
Direct oral anticoagulants show promise for patients with liver cirrhosis
A meta-analysis of predominantly observational studies compared direct oral anticoagulants with traditional anticoagulants in patients with …
New analysis suggests direct oral anticoagulants may reduce blood clots and major bleeding risks for patients with liver cirrhosis and heart…
LMWH remains useful when oral anticoagulants are difficult to use safely in venous thromboembolism patients
Low-molecular-weight heparin remains useful when oral anticoagulants are difficult to use safely
This narrative review examines low-molecular-weight heparin dosing, anti-factor Xa monitoring, treatment interruption, and switching strateg…
A review suggests low-molecular-weight heparin stays useful when oral anticoagulants are difficult to use safely for patients with venous th…
Pre-infection vaccination linked to lower cardiovascular and cerebrovascular event risks in SARS-CoV-2 infected individuals
Vaccination Before Infection Cuts Heart and Stroke Risks in COVID Patients
This systematic review and meta-analysis examined the association between pre-infection COVID-19 vaccination and cardiovascular outcomes in …
Pre-infection COVID-19 vaccination significantly lowers risks of heart attacks, strokes, and other cardiovascular events in infected individ…
Postoperative VTE prediction models show substantial heterogeneity and high bias risk in lung cancer surgery patients undergoing systematic review analysis
Existing lung cancer VTE prediction models show mixed results in surgery patients
A systematic review of twenty prediction models for venous thromboembolism in lung cancer surgery patients revealed substantial heterogeneit…
A review of twenty studies found that current tools for predicting blood clots in lung cancer surgery patients vary widely in accuracy and c…
Network meta-analysis compares DOACs and VKAs for intracranial hemorrhage risk
Dabigatran may be safest for brain bleeding risk
This network meta-analysis of 127,267 patients with venous thromboembolism or atrial fibrillation found that all DOACs had lower risk of int…
All blood thinners beat warfarin for brain bleed risk, but dabigatran may be the safest choice.