Specific reversal agents offer high-affinity neutralization but face cost and access barriers in thromboembolism management
New Options and Challenges for Reversing Blood Clot Treatments
This systematic review evaluates procoagulant strategies including specific reversal agents like idarucizumab and non-specific options for t…
Doctors are evaluating specific and non-specific agents to safely reverse the effects of anticoagulant medications in patients with blood cl…
DOACs reduce thromboembolic events in pediatric patients compared to standard anticoagulation
A Pill Form of Blood Thinner May Be Safer for Kids Than Standard Shots
A meta-analysis of 2,002 pediatric patients found direct oral anticoagulants (DOACs) significantly reduced thromboembolic event recurrence (…
New oral blood thinners cut dangerous blood clot recurrences in half for children without increasing bleeding risks compared to standard sho…
Research across Embolism and Thrombosis
Related studies from across the Embolism and Thrombosis family.
LMWH remains useful when oral anticoagulants are difficult to use safely in venous thromboembolism patients
Low-molecular-weight heparin remains useful when oral anticoagulants are difficult to use safely
This narrative review examines low-molecular-weight heparin dosing, anti-factor Xa monitoring, treatment interruption, and switching strateg…
A review suggests low-molecular-weight heparin stays useful when oral anticoagulants are difficult to use safely for patients with venous th…
Pre-infection vaccination linked to lower cardiovascular and cerebrovascular event risks in SARS-CoV-2 infected individuals
Vaccination Before Infection Cuts Heart and Stroke Risks in COVID Patients
This systematic review and meta-analysis examined the association between pre-infection COVID-19 vaccination and cardiovascular outcomes in …
Pre-infection COVID-19 vaccination significantly lowers risks of heart attacks, strokes, and other cardiovascular events in infected individ…
Postoperative VTE prediction models show substantial heterogeneity and high bias risk in lung cancer surgery patients undergoing systematic review analysis
Existing lung cancer VTE prediction models show mixed results in surgery patients
A systematic review of twenty prediction models for venous thromboembolism in lung cancer surgery patients revealed substantial heterogeneit…
A review of twenty studies found that current tools for predicting blood clots in lung cancer surgery patients vary widely in accuracy and c…
Network meta-analysis compares DOACs and VKAs for intracranial hemorrhage risk
Dabigatran may be safest for brain bleeding risk
This network meta-analysis of 127,267 patients with venous thromboembolism or atrial fibrillation found that all DOACs had lower risk of int…
All blood thinners beat warfarin for brain bleed risk, but dabigatran may be the safest choice.
Systematic review and meta-analysis links D-dimer and ultrasound findings to recurrent venous thromboembolism risk
Doctors find high D-dimer levels and ultrasound results predict higher risk of blood clot return
This systematic review and meta-analysis of 48 articles evaluates the association between residual vein thrombosis and positive post-treatme…
A review of many studies shows that leftover blood clots and high D-dimer levels after treatment raise the chance of venous thromboembolism …
Subprophylactic anti-Xa levels linked to higher venous thromboembolism risk in critically ill adults receiving low-molecular-weight heparin
Low blood clot prevention drug levels linked to higher risk in sick adults
A systematic review and meta-analysis of 7,124 critically ill adults reveals that 47% failed to achieve target anti-Xa levels. Subprophylact…
A large review found that nearly half of critically ill adults did not reach safe drug levels. Those with lower levels faced a much higher c…
Meta-analysis identifies prognostic factors for recurrent VTE and bleeding in 96 753 adult cancer patients
Certain cancer types and health factors raise risk of blood clots or bleeding in adults with cancer and VTE
This meta-analysis evaluated prognostic factors for recurrent venous thromboembolism (VTE) or anticoagulant-related bleeding in 96 753 adult…
A large review found that specific cancers and health factors significantly increase the risk of recurrent blood clots or bleeding in adults…
Systematic review and meta-analysis finds high VTE incidence in stroke patients and moderate model performance
Doctors Rethink How to Spot Blood Clots in Stroke Patients
This systematic review and meta-analysis of seven prediction models found a pooled VTE incidence of 20.8% in stroke patients.
It starts with a small ache in the leg. A little swelling.
Inflammatory and cardiac markers linked to VTE and bleeding risks in cancer patients on apixaban
New Blood Tests May Predict Clot and Bleed Risks in Cancer
A post hoc analysis of an RCT in 574 ambulatory cancer patients with a Khorana score ≥2 found that elevated baseline growth differentiation …
Scientists found specific blood markers that signal higher risks of clots and bleeding in cancer patients.
Meta-analysis finds increased VTE risk in pediatric IBD, especially ulcerative colitis
Kids with Bowel Disease Face a Hidden Blood Clot Risk Adults Miss
A systematic review and meta-analysis of over 100,000 children and teenagers with IBD found a significantly increased risk of venous thrombo…
Children with Crohn's or ulcerative colitis face nearly seven times the blood clot risk of healthy kids, yet prevention guidelines for teens…
Early LMWH prophylaxis in surgical patients with severe hypertensive intracerebral hemorrhage
The Blood Thinner Timing Puzzle After a Brain Bleed
This retrospective cohort study evaluated early low-molecular-weight heparin calcium prophylaxis for venous thromboembolism in 123 surgical …
After brain bleed surgery, doctors face a tough choice — start blood thinners early to prevent leg clots, or wait and risk a dangerous clot …
Asthma associated with increased odds of venous thromboembolism, pulmonary embolism, and deep vein thrombosis in observational studies
Asthma Linked to Higher Risk of Blood Clots in Observational Data
This meta-analysis of observational studies involving patients with asthma found a statistically significant association between asthma and …
People with asthma face a 1.61 times higher risk of blood clots, with the danger of pulmonary embolism rising 2.41 times and deep vein throm…