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Home › Medications › ketamine

ketamine

16 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of ketamine

139 trials tracked of ketamine: 61 in phase 3 or 4 and 28 with published results. The most-cited published study has 600 citations.

139Trials tracked
61Phase 3 & 4
0Recruiting
28With published results
Phase distribution
Phase 4 46 Phase 3 15 Phase 2 41 Phase 1 10 Other / NA 27
  1. Phase 4 Research Study for Major Depressive Disorder: Investigation of Glutamate Medications Completed · 600 cited
  2. Phase 4 The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine Completed · 559 cited
  3. Phase 4 Ketamine in the Treatment of Suicidal Depression Completed · 428 cited
  4. Phase 4 Ketamine For Suicidal Ideation Completed · 297 cited
  5. Phase 3 ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD) Completed · 262 cited
  6. Phase 3 Ketamine as a Treatment for Post-Traumatic Stress Disorder (PTSD) Completed · 240 cited
Show 44 more trials
  1. Phase 4 Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial Completed · 163 cited
  2. Phase 3 Pain Reduction With Intranasal Medications for Extremity Injuries Completed · 116 cited
  3. Phase 4 Biomarker Assessment of Glutamatergic Target Engagement Completed · 104 cited
  4. Phase 4 Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery Completed · 95 cited
  5. Phase 4 Geriatric Ketamine for Pain Management Study Completed · 79 cited
  6. Phase 4 Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients Completed · 78 cited
  7. Phase 4 UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study Completed · 63 cited
  8. Phase 3 Study on the Use of Low Dose Ketamine After Gastric Bypass and Gastrectomy Completed · 46 cited
  9. Phase 4 Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression Completed · 41 cited
  10. Phase 4 Low Dose Peri-operative IV Ketamine for Chronic Post-surgery Pain Prevention Completed · 32 cited
  11. Phase 4 Ketamine and Propofol for Upper Endoscopy Completed · 29 cited
  12. Phase 4 Randomized Trial of Sedative Choice for Intubation Completed · 27 cited
  13. Phase 4 Ketamine Infusion for Adolescent Depression and Anxiety Completed · 20 cited
  14. Phase 4 The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression. Completed · 18 cited
  15. Phase 3 Subdissociative Dose Ketamine for Treatment of Acute Pain in Subjects With Chronic Pain Completed · 14 cited
  16. Phase 4 Ketamine for Older Adults Pilot Completed · 13 cited
  17. Phase 3 Ketamine for Treatment Resistant Late-Life Depression Completed · 12 cited
  18. Phase 4 Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Ketamine Completed · 11 cited
  19. Phase 4 Ketamine Versus Fentanyl for Surgical Abortions Completed · 9 cited
  20. Phase 4 The Impact of Perioperative Ketamine Infusion on Surgical Recovery Completed · 7 cited
  21. Phase 3 Subcutaneous Ketamine for Postoperative Pain Relief in Rwanda Completed · 7 cited
  22. Phase 3 Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility Trial Completed · 5 cited
  23. Phase 4 NMDA Antagonists in Bipolar Depression Completed
  24. Phase 4 Efficacy Study of Ketamine for Postoperative Pain in Opioid Dependent Patients Completed
  25. Phase 4 Ketamine For Acute Treatment of Pain in Emergency Department Completed
  26. Phase 4 A Comparison of Intra-op Ketamine vs Placebo in Patients Having Spinal Fusion Completed
  27. Phase 4 Sub-dissociative Ketamine for the Management of Acute Pediatric Pain Completed
  28. Phase 4 Ketamine for Depression: An MRI Study Completed
  29. Phase 4 Ketamine Versus Etomidate for Rapid Sequence Intubation Completed
  30. Phase 4 Effect of Ketamine on Analgesia Post-Cardiac Surgery Completed
  31. Phase 4 Ketamine Effect After Laparoscopic Gastric Reduction: A Randomized, Double-Blinded, Placebo Controlled Study Completed
  32. Phase 4 A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD) Completed
  33. Phase 4 Low Dose Ketamine (LDK) Versus Morphine for Acute Pain Control in the Emergency Department Completed
  34. Phase 4 Ketamine vs Hydromorphone Completed
  35. Phase 4 Low Dose Ketamine as an Adjunct to Opiates for Acute Pain in the Emergency Department Completed
  36. Phase 4 Evaluating the Hemodynamic Effects of Ketamine Versus Etomidate During Rapid Sequence Intubation Completed
  37. Phase 4 Sub-dissociative Dose Ketamine Dosing Study Completed
  38. Phase 4 Effect of Postoperative Single Dose of Ketamine on Pain After Mastectomy Completed
  39. Phase 4 Narcotic Free TIVA and Incidence of Unacceptable Movements Under Anesthesia During ACDF Surgery Completed
  40. Phase 4 Ketamine Treatment Effects on Synaptic Plasticity in Depression Completed
  41. Phase 4 Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis Completed
  42. Phase 4 Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain Completed
  43. Phase 4 Low Dose Ketamine Infusion for Analgesia in the Emergency Department to Reduce Side Effects Completed
  44. Phase 4 The Effect of Ketamine on Interleukin-6 Synthesis in Hepatic Resections Requiring Temporary Porto-arterial Occlusion Completed

Showing the 50 most-cited and recently-updated of 139 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Ketamine may improve abstinence in substance use disorder, but evidence is limited
Psychiatry Meta-analysis
Ketamine may improve abstinence in substance use disorder, but evidence is limited Ketamine May Help People With Substance Use Disorder Stay Abstinent
This meta-analysis of 798 participants suggests ketamine may improve abstinence rates in substance use disorder. However, the abstract lacks…
A new analysis suggests ketamine could improve abstinence rates for people with substance use disorder.
Frontiers Jul 18, 2026
Intravenous ketamine reduces suicidal and depressive symptoms in acute Major Depressive Episode
Psychiatry Meta-analysis
Intravenous ketamine reduces suicidal and depressive symptoms in acute Major Depressive Episode Ketamine infusions reduce suicidal and depressive symptoms in some patients
This meta-analysis of randomized clinical trials indicates that intravenous ketamine, administered as single or repeated infusions, signific…
New data shows that intravenous ketamine can quickly lower both depression and suicidal thoughts for people facing a major depressive episod…
Jul 2, 2026
Oral ketamine significantly reduces depression scores with a 2.38 relative risk for remission
Psychiatry Meta-analysis
Oral ketamine significantly reduces depression scores with a 2.38 relative risk for remission Oral ketamine shows promise for treating several types of depression
This meta-analysis of RCTs involving 414 patients found that oral ketamine significantly reduced depression scores compared to placebo (SMD …
Oral ketamine may help reduce symptoms and improve remission rates for people with unipolar, bipolar, and treatment-resistant depression.
Jul 1, 2026
Tiletamine-zolazepam provides rapid anesthetic induction for canine and feline patients with dose-dependent hemodynamic effects
Psychiatry Sys. Review
Tiletamine-zolazepam provides rapid anesthetic induction for canine and feline patients with dose-dependent hemodynamic effects Tiletamine-zolazepam Provides Rapid Anesthesia for Dogs and Cats
This narrative review synthesizes the pharmacology, dosage regimens, and clinical applications of tiletamine-zolazepam in canine and feline …
Tiletamine-zolazepam offers fast-acting anesthesia for pets, but its safety depends on the specific health needs of each dog or cat.
Frontiers Jun 17, 2026
Systematic review finds ketamine offers no pain advantage over opioids in prehospital trauma care settings
Anesthesiology & Pain Medicine Meta-analysis
Systematic review finds ketamine offers no pain advantage over opioids in prehospital trauma care settings Ketamine works as well as opioids for trauma pain
Analysis of eighteen studies shows ketamine provides similar pain relief to opioids for trauma patients. While heart rate rose slightly, adv…
For traumatic injuries, ketamine relieves pain just as well as opioids, with a modest heart rate increase.
Jun 1, 2026
Network meta-analysis of ketamine regimens for pediatric ED procedural sedation safety and efficacy
Pediatrics Meta-analysis
Network meta-analysis of ketamine regimens for pediatric ED procedural sedation safety and efficacy Ketamine combos ease pain in kids with less nausea
This network meta-analysis evaluated ketamine-based regimens versus IV ketamine for pediatric procedural sedation in the emergency departmen…
A new analysis reveals a ketamine-propofol mix calms injured children faster and with fewer side effects than ketamine alone.
Apr 29, 2026
Meta-analysis of ketamine versus other analgosedatives in critically ill children receiving invasive mechanical ventilation
Pediatrics Meta-analysis
Meta-analysis of ketamine versus other analgosedatives in critically ill children receiving invasive mechanical ventilation Ketamine cuts opioid use in ventilated kids
This systematic review and meta-analysis evaluated continuous ketamine infusion compared with other analgosedatives in critically ill childr…
A new analysis suggests ketamine could help reduce opioid use in children on breathing machines, offering a safer path to pain control in in…
Apr 27, 2026
Network meta-analysis of sedation strategies in therapeutic gastrointestinal endoscopy shows ketamine-propofol reduces hypoxia and bradycardia versus propofol-opioid
Drug Pipeline Meta-analysis
Network meta-analysis of sedation strategies in therapeutic gastrointestinal endoscopy shows ketamine-propofol reduces hypoxia and bradycardia versus propofol-opioid Better Sedation Choices Could Reduce Side Effects During Stomach Tests
This network meta-analysis evaluated pharmacological sedation strategies in 7,071 patients undergoing therapeutic gastrointestinal endoscopy…
Mixing ketamine with propofol lowers breathing and blood pressure risks for patients undergoing long stomach procedures compared to standard…
Frontiers Apr 21, 2026
Retrospective cross-sectional study characterizes arachnoiditis patient presentation and treatment responses in 1105 participants
Neurology
Retrospective cross-sectional study characterizes arachnoiditis patient presentation and treatment responses in 1105 participants Back Pain That Won't Go Away
This retrospective cross-sectional study characterized clinical presentation, comorbidities, and treatments in 1105 participants with physic…
A massive online community of chronic pain patients helped researchers finally map the symptoms and treatments for the often missed conditio…
medRxiv Apr 15, 2026
Meta-analysis finds ketamine shows no significant pain benefit for acute bone fractures in adults
Orthopedics & Sports Medicine Meta-analysis
Meta-analysis finds ketamine shows no significant pain benefit for acute bone fractures in adults Ketamine Does Not Reduce Pain in Broken Bones
A systematic review and meta-analysis of 1,453 adult patients with acute bone fractures found ketamine monotherapy or adjuvant therapy showe…
Ketamine does not reduce pain in broken bones versus standard care, yet patients face higher risks of nervous system and psychiatric side ef…
Apr 11, 2026
Outpatient IV sedation for dental care in special needs patients shows 3.3% minor complication rate
Dermatology Cohort
Outpatient IV sedation for dental care in special needs patients shows 3.3% minor complication rate Study describes use of IV sedation for dental care in patients with special needs
A retrospective cohort study of 212 special health care needs patients (mean age 11.1 years) undergoing outpatient IV sedation for dental pr…
Over 2,200 dental procedures were safely performed on children with autism and Down syndrome using IV sedation at a Venezuelan clinic, with …
Frontiers Apr 8, 2026
Phase 2 trial of ketamine for tinnitus in 42 adults did not report main results
ENT (Otolaryngology) Phase II
Phase 2 trial of ketamine for tinnitus in 42 adults did not report main results Can a single ketamine dose quiet the brain's noise in people with tinnitus?
A phase 2 clinical trial investigated ketamine hydrochloride versus placebo in 42 adults with tinnitus.
A single ketamine dose may quiet brain noise in tinnitus by blocking glutamate receptors and boosting calming GABA chemicals, offering hope …
CT.gov Apr 3, 2026

All ketamine Articles