Network meta-analysis of ketamine regimens for pediatric ED procedural sedation safety and efficacy
Ketamine combos ease pain in kids with less nausea
This network meta-analysis evaluated ketamine-based regimens versus IV ketamine for pediatric procedural sedation in the emergency departmen…
A new analysis reveals a ketamine-propofol mix calms injured children faster and with fewer side effects than ketamine alone.
Meta-analysis of ketamine versus other analgosedatives in critically ill children receiving invasive mechanical ventilation
Ketamine cuts opioid use in ventilated kids
This systematic review and meta-analysis evaluated continuous ketamine infusion compared with other analgosedatives in critically ill childr…
A new analysis suggests ketamine could help reduce opioid use in children on breathing machines, offering a safer path to pain control in in…
Network meta-analysis of sedation strategies in therapeutic gastrointestinal endoscopy shows ketamine-propofol reduces hypoxia and bradycardia versus propofol-opioid.
Better Sedation Choices Could Reduce Side Effects During Stomach Tests
This network meta-analysis evaluated pharmacological sedation strategies in 7,071 patients undergoing therapeutic gastrointestinal endoscopy…
Mixing ketamine with propofol lowers breathing and blood pressure risks for patients undergoing long stomach procedures compared to standard…
Retrospective cross-sectional study characterizes arachnoiditis patient presentation and treatment responses in 1105 participants.
Back Pain That Won't Go Away
This retrospective cross-sectional study characterized clinical presentation, comorbidities, and treatments in 1105 participants with physic…
A massive online community of chronic pain patients helped researchers finally map the symptoms and treatments for the often missed conditio…
Meta-analysis finds ketamine shows no significant pain benefit for acute bone fractures in adults
Ketamine Does Not Reduce Pain in Broken Bones
A systematic review and meta-analysis of 1,453 adult patients with acute bone fractures found ketamine monotherapy or adjuvant therapy showe…
Ketamine does not reduce pain in broken bones versus standard care, yet patients face higher risks of nervous system and psychiatric side ef…
Outpatient IV sedation for dental care in special needs patients shows 3.3% minor complication rate
Study describes use of IV sedation for dental care in patients with special needs
A retrospective cohort study of 212 special health care needs patients (mean age 11.1 years) undergoing outpatient IV sedation for dental pr…
Over 2,200 dental procedures were safely performed on children with autism and Down syndrome using IV sedation at a Venezuelan clinic, with …
Phase 2 trial of ketamine for tinnitus in 42 adults did not report main results
Can a single ketamine dose quiet the brain's noise in people with tinnitus?
A phase 2 clinical trial investigated ketamine hydrochloride versus placebo in 42 adults with tinnitus. The primary outcome was GABA and Glx…
A single ketamine dose may quiet brain noise in tinnitus by blocking glutamate receptors and boosting calming GABA chemicals, offering hope …
Ketamine shows cognitive effects in animal models but cognitive worsening in human Huntington's disease study
Can ketamine help brain injuries? Animal studies say maybe, but human evidence is thin.
A systematic review and meta-analysis of 22 studies (21 animal, 1 human) found ketamine showed positive cognitive effects in 93.2% of animal…
Animal studies suggest ketamine might help brain injuries, but the only human trial found it worsened thinking in patients with Huntington's…
Ketamine may reduce positional pain more than dexmedetomidine or nerve block in femur fracture patients
Which drug works best for pain when positioning patients with broken hips?
A 75-patient RCT compared IV ketamine (0.3 mg/kg), IV dexmedetomidine (0.5 μg/kg), and femoral nerve block for analgesia during positioning …
Ketamine outperformed nerve blocks and dexmedetomidine for reducing severe pain when positioning patients with broken hips before surgery.
Intranasal ketamine shows similar pain relief to IV opioids for renal colic in ED meta-analysis
Intranasal ketamine and IV opioids show similar pain relief for kidney stones
A meta-analysis of 4 RCTs including 454 patients with renal colic found no significant differences in pain scores at 5, 15, or 30 minutes be…
Nasal ketamine and IV opioids provide equal pain relief for kidney stones, with no difference in side effects or need for extra medication.
Ketamine in Orthopedic Trauma: Potential to Reduce Pain and Opioid Use
Could Ketamine Be the Key to Easing Pain and Healing Minds After Surgery?
This Phase 4 trial investigates ketamine's efficacy in reducing postoperative pain and opioid use in orthopedic trauma patients. Primary out…
A new trial tests if giving ketamine during orthopedic surgery reduces pain, opioid needs, and symptoms of depression and PTSD compared to s…