Research across Major Depressive Disorder
Related studies from across the Major Depressive Disorder family.
Prenatal exposure to certain psychotropic medications is associated with increased risk of gestational diabetes
Prenatal exposure to certain psychiatric drugs linked to gestational diabetes
This meta-analysis examined the relationship between prenatal exposure to antipsychotics and antidepressants and the risk of gestational dia…
New data shows that some medications used for mental health during pregnancy may increase the risk of gestational diabetes.
Transcranial magnetic stimulation modulates transcriptomic and connectomic changes in treatment-resistant depression
Magnetic brain stimulation may change how cells respond to depression
This narrative review explores the molecular and structural mechanisms of transcranial magnetic stimulation (TMS) in treatment-resistant dep…
New research explores how magnetic pulses may reshape brain cell activity and connections for people with treatment-resistant depression.
Shared gray matter volume reductions in ventromedial prefrontal cortex and insula across schizophrenia, MDD, and AUD
Shared Brain Structure Changes Link Schizophrenia, Depression, and Alcohol Use
This meta-analysis of imaging data identifies shared gray matter volume deficits in the ventromedial prefrontal cortex, ventral anterior cin…
New research identifies shared gray matter reductions in the brain for people with schizophrenia, depression, and alcohol use disorders.
Nightmare frequency and disorder correlate with PTSD and major depressive disorder via shared genetic architecture
Genetic links connect frequent nightmares to depression and PTSD
This meta-analysis of genome-wide association studies identifies a 7.4% SNP-based heritability for nightmare frequency in European participa…
New research finds that the genes linked to frequent nightmares are also connected to depression and post-traumatic stress disorder.
Photobiomodulation shows consistent anti-inflammatory effects but inconsistent clinical results in various neurodegenerative disorders
Red and near-infrared light may help certain brain disorders
This narrative review explores the role of photobiomodulation in treating Alzheimer's disease, Multiple Sclerosis, Parkinson's disease, and …
Red and near-infrared light therapy shows promise for some brain conditions, though results are mixed for others.
Psychiatric Comorbidities in Patients Diagnosed with Dissociative Identity Disorder
Common Mental Health Conditions Often Coexist with Dissociative Identity Disorder
A meta-analysis identifies high prevalence rates of PTSD, major depressive disorder, and borderline personality disorder in patients with DI…
A large review of 858 adults shows that many people with Dissociative Identity Disorder also experience PTSD and depression.
Resting-state functional MRI reveals distinct regional homogeneity patterns in MDD, BD, and Schizophrenia
Brain Imaging Reveals Shared Patterns in Depression and Schizophrenia
This meta-analysis of resting-state functional MRI studies identifies specific regional homogeneity (ReHo) abnormalities in patients with MD…
New research identifies specific brain activity patterns that overlap and differ between depression, bipolar disorder, and schizophrenia.
PGx-guided antidepressants modestly increase short-term response and remission in MDD
Genetic testing may help patients find the right antidepressant
This meta-analysis examines pharmacogenomic-guided antidepressant treatment versus usual care in adults with major depressive disorder. Gene…
Using genetic tests to guide antidepressant choice may help more people with depression find relief during the first few months of treatment…
Antidepressants combined with psychotherapy do not significantly improve depression severity in major depressive disorder
Adding antidepressants to psychotherapy may not improve depression severity
This meta-analysis evaluated the efficacy of adding antidepressants to psychotherapy for patients with major depressive disorder. The analys…
New data suggests that adding antidepressant medication to talk therapy does not necessarily improve depression scores for people with major…
GERD shows strong genetic overlap with internalizing psychiatric disorders like MDD and PTSD
Acid reflux and mental health share a common genetic link
This meta-analysis explores the genetic architecture of gastroesophageal reflux disease (GERD) and its relationship to psychiatric condition…
New research shows that acid reflux and mental health conditions like depression and PTSD share the same genetic roots.
Lumateperone 42 mg plus ADT improves MADRS scores in MDD with anxious distress
Lumateperone May Help Depression and Anxiety in Specific Patients
This post hoc analysis of a Phase 3 randomized trial evaluated 481 outpatients with MDD and inadequate response to 1-2 ADTs. Lumateperone 42…
A study suggests adding lumateperone to standard treatment may improve depression and anxiety symptoms for patients with anxious distress.
Lower baseline IL-2 and IL-6 levels signal potential antidepressant treatment response in Major Depressive Disorder
Specific markers may help predict response to depression medication
This meta-analysis of baseline peripheral inflammatory biomarkers in adults with Major Depressive Disorder found no significant difference i…
New data suggests that certain inflammatory markers in the blood could help predict which patients will respond to common antidepressants.