Research across Major Depressive Disorder
Related studies from across the Major Depressive Disorder family.
Lifestyle Therapy Matches CBT for Moderate-to-Severe Depression in Australian Trial
Lifestyle Therapy Shows Similar Results to CBT for Depression
A telehealth lifestyle program was non-inferior to CBT for depressive symptoms at 8 weeks, with MADRS drops of 8.55 versus 6.82 points.
A new trial shows that a lifestyle program involving diet and exercise is as effective as cognitive behavioral therapy for moderate to sever…
Lumateperone adjunct therapy improves sexual functioning in patients with major depressive disorder
New medication helps sexual function in patients with depression
This study evaluated the impact of adding lumateperone to standard antidepressant therapy for adults with major depressive disorder who had …
A new treatment for depression may help patients regain sexual function that is often lost during standard antidepressant treatments.
Silexan shows clinically important adjusted mean value differences of over 0.2 points in MADRS
Lavender Oil Preparation Shows Potential for Treating Depression
This randomized, double-blind, placebo-controlled trial of 498 patients with mild or moderate major depressive disorder found silexan superi…
A clinical trial suggests that a lavender oil preparation called Silexan may help manage symptoms of mild to moderate depression.
DORAs show strongest evidence for insomnia while sedating antidepressants vary in antidepressant activity and side effects
Sedating Antidepressants and DORAs Show Different Benefits for Depression and Insomnia
This narrative review examines sedating antidepressants and dual orexin receptor antagonists (DORAs) for patients with major depressive diso…
New research highlights how different sedating antidepressants and DORAs offer varying levels of support for patients with depression and in…
Home-based and remotely supervised tDCS produces small, statistically significant improvement in Major Depressive Disorder
Home based brain stimulation shows modest relief for depression
This meta-analysis of 12 studies (6 randomized sham-controlled trials) found that home-based and remotely supervised tDCS provides a small, …
A new review shows that home-based brain stimulation can provide a small but measurable improvement for people living with depression.
Evaluating Pharmacogenomic Guided Treatment Efficacy for Patients with Major Depressive Disorder
Trial shows pharmacogenomics guidance does not improve well-being in depression
A randomized trial evaluates if adding pharmacogenomic guidance to standard guidelines improves well-being in patients with major depressive…
A clinical trial found that adding genetic testing to standard treatment for major depression did not improve patient well-being over one ye…
Inflammatory biomarkers show inconsistent and small associations with antidepressant and ECT treatment response in MDD
Inflammatory Biomarkers Show Inconsistent Links to Antidepressant Success
This umbrella review synthesized evidence regarding inflammatory biomarkers and treatment response in patients with Major Depressive Disorde…
New research looks at how inflammation markers might relate to how well patients with major depression respond to medication.
Electroconvulsive therapy improves symptoms in all age groups of patients with major depressive disorder
ECT helps depression across all ages, older patients may benefit most
This meta-analysis of 15 studies involving 1617 patients found that electroconvulsive therapy (ECT) significantly reduces HAMD, MADRS, and H…
A new analysis of 1,617 patients finds ECT eases depression in all age groups, with older adults showing the biggest gains.
Desipramine shows large effect in adolescent MDD while other antidepressants show no significant difference
Analysis shows only one antidepressant outperformed placebo for teen depression
This systematic review and network meta-analysis evaluated five antidepressants for adolescent MDD. While desipramine showed a large effect …
New data reveals that while most common antidepressants showed no significant difference from a placebo for teens with depression.
tDCS combined with cognitive-behavioral interventions shows no significant benefit over sham for depressive symptoms
tDCS Plus Talk Therapy Shows No Extra Depression Benefit
This meta-analysis of 321 patients with depressive disorders found no statistically significant difference in depressive symptoms, response …
Adding brain stimulation to talk therapy didn't beat sham for depression in a new analysis of 321 patients.
Therapist-guided I-BA reduces depression severity more than TAU in adolescents with MDD
Therapist Guided Internet Programs Help Teens With Depression
This randomized controlled trial of 219 adolescents with mild to moderate major depressive disorder found that therapist-guided internet-bas…
A new trial shows that therapist-guided online behavioral activation can reduce depression severity in teens while being more cost-effective…
Specific resting-state functional connectivity alterations correlate with anhedonia severity in Major Depressive Disorder
Brain Connectivity Patterns Linked to Anhedonia Severity
This meta-analysis of neuroimaging data identifies specific resting-state functional connectivity (rsFC) patterns associated with anhedonia …
A meta-analysis finds specific brain connectivity patterns tied to anhedonia severity in depression, offering new clues for targeted treatme…