Research across Major Depressive Disorder
Related studies from across the Major Depressive Disorder family.
Heterogeneous definitions and clinical inconsistencies currently hinder the accurate identification of treatment-resistant depression
New ways to define treatment resistant depression are emerging
This narrative review examines the phenotypic definition of treatment-resistant depression (TRD) and its associated biological correlates. T…
Doctors struggle to treat some types of depression because the current definition is inconsistent. New research looks at how biology and beh…
Public health interventions improve mental health in young people in LMICs: systematic review
Public health interventions improve mental health in young people in LMICs
A systematic review of 30 studies found that public health interventions, including digital health, improved mental health outcomes in young…
A review of 30 studies finds that public health interventions, including digital tools, can improve mental health in young people in low-inc…
Bidirectional link between cannabis use disorder and major depressive disorder affects over 3 million individuals
Depression and cannabis use disorder often go hand in hand for millions of people
This meta-analysis examines the bidirectional association between cannabis use disorder and major depressive disorder across psychiatric and…
A massive analysis of over 3 million people shows depression and cannabis use disorder are closely linked, with higher rates of each conditi…
Global analysis reveals high major depressive disorder rates among women during pregnancy and postpartum periods across diverse regions
Depression rates are highest in the first two weeks after birth for women and girls
A massive review of nearly two million women shows depression affects roughly six percent during pregnancy and slightly more after birth. Re…
A massive review of data from 90 countries shows depression is most common right after delivery, not just during pregnancy.
Cognitive Deficits in Major Depressive Disorder Linked to Psychosocial Function
Memory and thinking skills link to daily life in depression
This systematic review and meta-analysis of 6991 participants with major depressive disorder found domain-specific, small-to-moderate associ…
A large review shows memory and thinking skills connect to daily life in depression, but work function did not show a clear link.
No significant association between BDNF genotypes and remission in major depressive disorder patients treated with antidepressants
Genetic markers do not predict antidepressant success in major depression
This meta-analysis review examined 599 Caucasian patients with a major depressive episode treated with SSRIs, SNRIs, or TCAs. The analysis f…
A large review found that specific genetic markers do not predict who will recover from depression when taking common antidepressant medicat…
Emotion decoding deficits in older adults with depression may reflect impaired recognition, not hypersensitivity
Mixed signals on how depression affects emotional processing in older adults
This commentary critiques a meta-analysis on emotion recognition in older adults with major depressive disorder. It argues that negative sta…
A commentary suggests depression might impair how older adults decode emotions, but study selection heavily influences these conclusions.
Review of Cannabis sativa for Major Depressive Disorder offers no clinical efficacy data
Review of cannabis sativa for major depressive disorder shows mixed results and safety concerns
This narrative review examines Cannabis sativa and its bioactive constituents in the context of Major Depressive Disorder. The source provid…
This review looked at how cannabis sativa might help with major depressive disorder. Results are unclear because many details were missing f…
Meta-analysis identifies genetic links between IBS and psychiatric traits in European ancestry populations
New genes link gut pain to depression and anxiety risks
This meta-analysis examines genetic correlations between irritable bowel syndrome, major depressive disorder, and neuroticism in individuals…
A massive genetic study shows irritable bowel syndrome shares DNA roots with depression and anxiety, hinting at why gut pain often comes wit…
Transdiagnostic behavior therapy shows comparable efficacy to disorder-specific therapies in veterans with depression, PTSD, and panic disorder
Veterans with depression or anxiety found similar results using transdiagnostic behavior therapy compared to disorder specific treatments
This randomized controlled trial in 304 veterans compared transdiagnostic behavior therapy to disorder-specific therapies for major depressi…
A study of 304 veterans showed that transdiagnostic behavior therapy worked just as well as standard disorder specific treatments. Patients …
CBT and STPP Reduce Avoidant Traits in Major Depressive Disorder
Depression Therapy Fixes Shyness Too Doctors Didn't Expect This
This randomized trial in 265 adults with major depressive disorder found that neither avoidant personality traits nor avoidant coping modera…
• Depression treatment also reduces shyness and social fears • Helps depressed adults who feel overly shy or rejected • Still needs more rea…
IPD meta-analysis identifies risk factors for persistent PTSD and MDD after trauma
Depression Symptoms After Trauma May Predict Long-Term PTSD Risk
This individual participant data meta-analysis synthesized findings from five prospective studies of 2,571 participants in emergency and cri…
New research shows that early depression symptoms after trauma can predict who will struggle with PTSD months later, offering a chance for e…