Research across Major Depressive Disorder
Related studies from across the Major Depressive Disorder family.
Antidepressant-antipsychotic combination doubles likelihood of improvement in psychotic depression
Combination therapy doubles improvement odds in psychotic depression
This meta-analysis of randomized trials found that combination pharmacotherapy (antidepressant-antipsychotic) is associated with a significa…
For psychotic depression, pairing an antidepressant with an antipsychotic more than doubles the chance of improvement compared to other trea…
Magnetic seizure therapy preserves cognitive function better than electroconvulsive therapy in major depressive disorder
Magnetic seizure therapy may protect memory in depression treatment
This meta-analysis of 429 patients with major depressive disorder compared magnetic seizure therapy (MST) to electroconvulsive therapy (ECT)…
New data suggests magnetic seizure therapy helps preserve memory and speech compared to electroconvulsive therapy for major depressive disor…
TMS targeting the ventral attention network may address heterogeneity in alcohol use disorder with depression
New target for brain stimulation in alcohol and depression
This mini review explores transcranial magnetic stimulation (TMS) targeting the ventral attention network (VAN) for individuals with alcohol…
A new focus on the ventral attention network could help create more precise treatments for people facing both alcohol use disorder and depre…
Elevated peripheral blood Neuron-specific enolase levels correlate with increased risk of MDD and PSD
Blood Protein Levels Linked to Risk of Major Depression
This meta-analysis of 18 studies indicates that abnormally elevated levels of peripheral blood Neuron-specific enolase (NSE) are closely rel…
New research identifies a specific protein in the blood that may serve as an early warning sign for major and poststroke depression.
Active VNS increases likelihood of meaningful improvement in suicidal ideation with OR 1.43
Active vagus nerve stimulation may reduce suicidal thoughts in depression
This randomized controlled trial of 463 participants with treatment-resistant depression and baseline suicidal ideation found that active VN…
A new trial shows that active vagus nerve stimulation can help reduce suicidal thoughts for people with treatment-resistant depression.
Assertive case management reduces suicidal thoughts and behaviors in outpatients with Major Depressive Disorder
Assertive Case Management Reduces Suicidal Thoughts in Depression Patients
This randomized clinical trial of 314 outpatients with MDD and high suicide risk found that 6 months of assertive case management (ACM) sign…
A new clinical trial shows that adding assertive case management to standard care can significantly reduce suicidal thoughts and anxiety for…
Intravenous ketamine reduces suicidal and depressive symptoms in acute Major Depressive Episode
Ketamine infusions reduce suicidal and depressive symptoms in some patients
This meta-analysis of randomized clinical trials indicates that intravenous ketamine, administered as single or repeated infusions, signific…
New data shows that intravenous ketamine can quickly lower both depression and suicidal thoughts for people facing a major depressive episod…
Neuronavigation and connectivity guided targeting in rTMS may improve outcomes for bipolar disorder
Brain mapping may help patients with bipolar disorder find relief
This narrative review examines repetitive transcranial magnetic stimulation (rTMS) for patients with bipolar disorder and major depressive d…
New research suggests that using specific brain maps can help doctors better target treatments for bipolar disorder and depression.
Unguided Internet Based Cognitive Behavioral Therapy Reduces Symptoms of Major Depressive Disorder
Trial Shows Internet Based Therapy Reduces Major Depressive Symptoms
A randomized trial shows that unguided internet-based CBT significantly reduces depressive symptoms and improves remission rates in adults w…
A new trial shows that an unguided internet course can significantly reduce symptoms of major depression and improve quality of life.
Multidimensional biomarker panels suggest a complex pathological basis for post-stroke depression in the DRN-mPFC circuit
New framework identifies biological markers for depression after a stroke
This narrative review synthesizes evidence regarding the biological drivers of post-stroke depression (PSD). It proposes a framework where P…
A new research framework identifies how different biological factors, like inflammation and chemicals in the brain, combine to cause depress…
TMS electrophysiological biomarkers show distinct patterns across ADHD, Tourette syndrome, MDD, ASD, and CP
Brain scans help identify ADHD and other childhood neurological disorders
This meta-analysis of 26 studies synthesized TMS electrophysiological biomarkers in children and adolescents with neurological disorders. Th…
New research shows that magnetic pulses can reveal specific brain patterns in children with ADHD, Tourette syndrome, and autism.
Heterogeneous definitions and clinical inconsistencies currently hinder the accurate identification of treatment-resistant depression
New ways to define treatment resistant depression are emerging
This narrative review examines the phenotypic definition of treatment-resistant depression (TRD) and its associated biological correlates. T…
Doctors struggle to treat some types of depression because the current definition is inconsistent. New research looks at how biology and beh…