Potent bisphosphonate therapy reduces incident vertebral fractures by 71% after denosumab discontinuation
Potent bisphosphonates may lower fracture risk after denosumab treatment stops
This meta-analysis of 683 adults with osteoporosis or low bone mass found that potent bisphosphonate therapy significantly reduced incident …
Patients with osteoporosis may have a lower risk of spine fractures when switching to potent bisphosphonates after stopping denosumab.
Deep learning shows 0.92 specificity and 0.83 sensitivity for opportunistic vertebral fracture detection on CT
Deep Learning Shows Promise in Detecting Vertebral Fractures
This meta-analysis evaluates the diagnostic accuracy of deep learning for identifying vertebral fractures on routine thoraco-abdominal CT sc…
New analysis shows that deep learning tools can accurately identify vertebral fractures during routine abdominal CT scans for patients.
Systematic review links slower Timed Up-and-Go test to higher fracture risk in older adults
Slower movement test results linked to higher chance of breaking bones in older adults
This systematic review and meta-analysis examines the association between Timed Up-and-Go (TUG) test performance and fracture risk in older …
A large review found that older people who take longer to stand up and walk have a higher risk of hip and other bone breaks. This simple tes…
VBQ and Hounsfield Units Predict Subsequent Fractures After Vertebral Augmentation
Vertebral Bone Quality Scores Predict Fracture Risk After Vertebral Augmentation
This meta-analysis of 7364 patients found that higher VBQ scores and lower HU values are significantly associated with subsequent fractures …
A large analysis of 7,364 patients shows Vertebral Bone Quality scores better predict future fractures after vertebral augmentation than sta…
Bisphosphonates reduce vertebral fracture risk in multiple myeloma, spinal cord compression effect unclear
Can bone drugs protect the spine in multiple myeloma? A new review weighs in
A meta-analysis of 11 randomized trials in adults with multiple myeloma found bisphosphonates reduced vertebral fracture risk compared to no…
Bone drugs called bisphosphonates lower the risk of spine fractures in multiple myeloma patients, though evidence on preventing spinal cord …
Questions about Vertebral Fracture
Do Hounsfield Units help predict a new vertebral fracture after surgery?
Yes. Lower Hounsfield Unit (HU) values on CT scans are linked to a higher chance of a new vertebral fracture after vertebral surgery, and HU can help predict that risk [4][6][7].
Full answer →Can deep learning software detect a vertebral fracture on a routine CT scan?
Yes. Pooled data from seven studies show deep learning detects moderate to severe vertebral fractures on routine CT with about 83% sensitivity and 92% specificity [2], and one 2026 study found DL matched residents in accuracy [6].
Full answer →Can VBQ scores predict if a patient will have another vertebral fracture?
Yes. Higher VBQ scores are linked to a higher chance of a new vertebral fracture after treatment, and VBQ predicts this reasonably well, though not perfectly [4][6][7][8].
Full answer →