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Home › Medications › hydrocortisone

hydrocortisone

6 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of hydrocortisone

42 trials tracked of hydrocortisone: 15 in phase 3 or 4 and 10 with published results. The most-cited published study has 285 citations.

42Trials tracked
15Phase 3 & 4
0Recruiting
10With published results
Phase distribution
Phase 4 5 Phase 3 10 Phase 2 19 Phase 1 4 Other / NA 4
  1. Phase 3 Vitamin C, Thiamine, and Steroids in Sepsis Completed · 285 cited
  2. Phase 3 Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed · 256 cited
  3. Phase 3 Hydrocortisone for BPD Completed · 112 cited
  4. Phase 3 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations Completed · 87 cited
  5. Phase 3 A Study of the Efficacy, Safety and Tolerability of Chronocort in Treating CAH Completed · 86 cited
  6. Phase 4 Veteran Stress and Learning Study Completed · 22 cited
Show 36 more trials
  1. Phase 4 Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent Shock - Pilot Study Completed · 13 cited
  2. Phase 3 Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal Hyperplasia Completed · 11 cited
  3. Phase 4 Effect of Low Dose Corticosteroids on Perioperative Markers of Thrombosis and Fibrinolysis in Total Knee Arthroplasty Completed
  4. Phase 4 Steroids in Bilateral Total Knee Replacement Completed
  5. Phase 4 Hydrocortisone Replacement in Patients With Secondary Adrenal Insufficiency (SUPREME CORT) Completed
  6. Phase 3 A Study Comparing LEO 80190 Ointment With Hydrocortisone Ointment, Both Applied Once Daily in the Treatment of Psoriasis Vulgaris on the Face and Intertriginous Areas Completed
  7. Phase 3 Hydrocortisone for Term Hypotension Completed
  8. Phase 3 Efficacy and Safety of Calcipotriol Plus Hydrocortisone Ointment in Psoriasis Vulgaris on the Face and Skin Folds Completed
  9. Phase 3 Phenytoin as a Neuroprotective Agent Against Corticosteroid-induced Functional Imaging Changes Completed
  10. Phase 2 Randomized Trial of Hydrocortisone in Very Preterm High-Risk Infants Completed
  11. Phase 2 ALL Adult Consortium Trial: Adult ALL Trial Completed
  12. Phase 2 Phase 2 Study of Autologous Followed by Nonmyeloablative Allogeneic Transplantation Using TLI & ATG Completed
  13. Phase 2 Phase 2 Trial of Prophylactic Rituximab Therapy for Prevention of CGVHD Completed
  14. Phase 2 NHL16: Study For Newly Diagnosed Patients With Acute Lymphoblastic Lymphoma Completed
  15. Phase 2 Vilazodone for Corticosteroid-Induced Memory Impairment Completed
  16. Phase 2 Use of Low Dose Ketoconazole in Prostate Cancer That Does Not Respond to Hormone Therapy and Prior Chemotherapy Completed
  17. Phase 2 Corticosteroid Therapy in Refractory Shock Following Cardiac Arrest Completed
  18. Phase 2 HCT+F vs. HCT Alone in Critically Ill Medical Septic Shock Patients Completed
  19. Phase 2 A Study in Adults With Untreated Acute Lymphoblastic Leukemia Completed
  20. Phase 2 Rituximab, Rasburicase, and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Advanced B-Cell Leukemia or Lymphoma Completed
  21. Phase 2 Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis. Completed
  22. Phase 2 Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement Completed
  23. Phase 2 Hybrid Immunotherapy for Hemophagocytic LymphoHistiocytosis Completed
  24. Phase 2 Dexamethasone Treatment of Congenital Adrenal Hyperplasia Completed
  25. Phase 2 Combination Chemotherapy and Rituximab in Treating Patients With Newly Diagnosed Burkitt's Lymphoma or Leukemia Completed
  26. Phase 2 Corticosteroids in Postoperative Critically Ill Neonates With Low Cardiac Output Syndrome With Congenital Heart Disease Completed
  27. Phase 2 Allogeneic Transplantation From Related Haploidentical Donors Completed
  28. Phase 2 Ketoconazole and Dexamethasone in Prostate Cancer Completed
  29. Phase 1 Comparison of Pharmacokinetics of Infacort® Versus Immediate-release Hydrocortisone Completed
  30. Phase 1 Palbociclib in Combination With Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL) Completed
  31. Phase 1 CRF - Nociceptin Receptor Interactions Completed
  32. Phase 1 A Trial of Temsirolimus With Etoposide and Cyclophosphamide in Children With Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma Completed
  33. N/A Effect of Postop Steroids on Cardiovascular/Respiratory Function in Neonates Undergoing Cardiopulmonary Bypass Completed
  34. N/A Initiation of Hydrocortisone for the Treatment of Septic Shock Completed
  35. N/A Peri-Operative Steroid Management in Patients Completed
  36. N/A Effect of Steroids on Thrombosis (Blood Clot Formation) and Inflammation in Patients Undergoing Hip Surgery Completed

Showing the 42 most-cited and recently-updated of 42 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Low-dose corticosteroids reduce 90-day mortality in adults with severe community-acquired pneumonia
Pulmonology & Critical Care Meta-analysis
Low-dose corticosteroids reduce 90-day mortality in adults with severe community-acquired pneumonia Low dose steroids may lower death rates in severe lung infections
This meta-analysis of 4,622 patients found that low-dose corticosteroids (≤400 mg hydrocortisone-equivalent daily) significantly reduced sho…
A review of clinical trials suggests that low-dose corticosteroids can reduce 90-day mortality for adults with severe lung infections like p…
Aug 18, 2026
Vasopressin, steroids, and epinephrine triple therapy improves ROSC in in-hospital cardiac arrest
Cardiology Meta-analysis
Vasopressin, steroids, and epinephrine triple therapy improves ROSC in in-hospital cardiac arrest Triple Therapy Shows Promise in Improving Cardiac Arrest Outcomes
This meta-analysis of 3 randomized trials and a network meta-analysis of 21,768 patients evaluates vasopressin, steroids, and epinephrine (V…
A triple therapy of vasopressin, steroids, and epinephrine showed a link to better circulation after cardiac arrest.
Frontiers Aug 5, 2026
Corticosteroids reduce short-term and long-term mortality in adult sepsis patients according to a systematic review
Emergency Medicine Meta-analysis
Corticosteroids reduce short-term and long-term mortality in adult sepsis patients according to a systematic review What Doctors Give Sepsis Patients Is Finally Getting Clearer
This systematic review and network meta-analysis evaluated corticosteroids, specifically hydrocortisone and hydrocortisone plus fludrocortis…
Corticosteroids cut short-term and long-term sepsis death risk for ICU adults in large review, though doctors still need clearer guidance on…
Apr 14, 2026
Hair cortisol concentration correlates with glucocorticoid adequacy and symptoms in adults with adrenal insufficiency
Diabetes & Endocrinology Cohort
Hair cortisol concentration correlates with glucocorticoid adequacy and symptoms in adults with adrenal insufficiency Your Hair Holds a Hidden Record of a Dangerous Hormone Imbalance
This cross-sectional study evaluated hair cortisol concentration (HCC) in 64 adults with hydrocortisone-treated adrenal insufficiency compar…
A strand of hair can reveal months of hormone history, helping fine-tune treatment for adrenal insufficiency to avoid dangerous over- or und…
Frontiers Apr 14, 2026
Immune dysregulation score predicts mortality and identifies hydrocortisone responders in community-acquired pneumonia
Emergency Medicine RCT
Immune dysregulation score predicts mortality and identifies hydrocortisone responders in community-acquired pneumonia Three Blood Markers May Pick Who Benefits From Sepsis Steroids
A multicohort analysis and reanalysis of an RCT developed and validated an immune dysregulation score using three plasma biomarkers in 398 d…
A simple three-blood-test model may finally pick which sepsis patients benefit most from steroid treatment, using biology instead of guesswo…
Apr 13, 2026
Phase 2 trial protocol tests oral hydrocortisone for PTSD prevention after trauma
Psychiatry Phase II
Phase 2 trial protocol tests oral hydrocortisone for PTSD prevention after trauma Study tests single hydrocortisone pill after trauma to prevent PTSD symptoms
A phase 2 randomized controlled trial protocol describes a study of 201 trauma survivors in emergency departments.
A single hydrocortisone pill taken within six hours of trauma might help the brain process memories differently to prevent PTSD symptoms in …
CT.gov Apr 3, 2026