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Home › Medications › morphine

morphine

17 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of morphine

81 trials tracked of morphine: 50 in phase 3 or 4 and 11 with published results. The most-cited published study has 179 citations.

81Trials tracked
50Phase 3 & 4
0Recruiting
11With published results
Phase distribution
Phase 4 36 Phase 3 14 Phase 2 15 Phase 1 4 Other / NA 12
  1. Phase 3 Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Abdominoplasty Completed · 179 cited
  2. Phase 4 Geriatric Ketamine for Pain Management Study Completed · 79 cited
  3. Phase 4 NAS Treatment - Opiate Versus Non-Opiate Completed · 76 cited
  4. Phase 4 Low-dose Ketamine vs Morphine for Vaso-occlusive Crisis in Sicklers Completed · 70 cited
  5. Phase 3 Morphine Sulfate/Placebo for the Treatment of PulmonAry Fibrosis Cough Completed · 59 cited
  6. Phase 4 Effect of Methylnaltrexone on the PK/PD Profiles of Ticagrelor in Patients Treated With Morphine Completed · 36 cited
Show 44 more trials
  1. Phase 3 Study of MK-0663/Etoricoxib in Postorthopedic Knee Replacement Surgery Pain (MK-0663-098) Completed · 36 cited
  2. Phase 4 Morphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence Syndrome Completed · 35 cited
  3. Phase 4 An Interventional Study for Patient With Cancer Pain to Evaluate the Efficacy and Safety of OxyNorm® Compared to Morphine Sulfate Through the IV Continuous Infusion. Completed · 19 cited
  4. Phase 4 Intrathecal Morphine for Cesarean Delivery Completed · 13 cited
  5. Phase 4 Intrathecal Opioids for Colorectal Resection Completed · 2 cited
  6. Phase 4 Intrathecal Opioids for Pain Control After Cesarean Delivery: Determining the Optimal Dose Completed
  7. Phase 4 Methadone Versus Morphine for Orthopedic Surgery Patients Completed
  8. Phase 4 Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms Completed
  9. Phase 4 Comparison Between Methadone and Morphine for Neonatal Opiate Withdrawal Completed
  10. Phase 4 Sub-dissociative Ketamine for the Management of Acute Pediatric Pain Completed
  11. Phase 4 Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur Fractures Completed
  12. Phase 4 Psoas Compartment Block Versus Periarticular Local Anesthetic for Total Hip Arthroplasty Completed
  13. Phase 4 Reduction of Bladder Injection Pain With Belladonna Opiate Suppository Completed
  14. Phase 4 The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI) Completed
  15. Phase 4 Effect of Dexmedetomidine on Postoperative Glucose and Insulin Levels. Completed
  16. Phase 4 Effect of Mu-opioid Receptor Genetics on 3 Doses of Spinal Morphine for Postoperative Analgesia After Cesarean Section Completed
  17. Phase 4 Low Dose Ketamine (LDK) Versus Morphine for Acute Pain Control in the Emergency Department Completed
  18. Phase 4 Brain Effects of Opiate Agonist and Antagonist Completed
  19. Phase 4 Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures Completed
  20. Phase 4 Intraosseous Morphine in Primary TKA Completed
  21. Phase 4 Effect of Combined Morphine and Duloxetine on Chronic Pain Completed
  22. Phase 4 2 Dose Neuraxial Morphine for Prevention of PDPH Completed
  23. Phase 4 Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement) Completed
  24. Phase 4 Influence of Morphine on Pharmacokinetics and Pharmacodynamics of Ticagrelor in Patients With Acute Myocardial Infarction Completed
  25. Phase 4 Safety and Pharmacokinetic Study of Oral Morphine Sulfate in Pediatric Subjects Completed
  26. Phase 4 Safety and Efficacy of the Addition of Morphine Chloride to a Low Dose of Bupivacaine as Intradural Anaesthetic for the Removal Surgery of the Hemorrhoids Completed
  27. Phase 4 An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Thai Participants With Chronic Non-Malignant Pain Completed
  28. Phase 4 Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty Completed
  29. Phase 4 Analgetic and Anxiolytic Effect of Preoperative Pregabalin Completed
  30. Phase 4 Low Dose Ketamine Versus Morphine for Moderate to Severe Pain in the Emergency Department Completed
  31. Phase 4 RCT Comparing the Analgesic Efficacy of 4 Therapeutic Strategies Based on 4 Different Major Opioids (Fentanyl, Oxycodone, Buprenorphine vs Morphine) in Cancer Patients With Moderate/Severe Pain, at the Moment of Starting 3rd Step of WHO Analgesic Ladder. Completed
  32. Phase 4 Effects of General Anesthesia and Spinal-Morphine Anesthesia on Recovery and Comfort After Benign Abdominal Hysterectomy Completed
  33. Phase 4 Periarticular Multimodal Drug Injections in Total Knee Arthroplasty Completed
  34. Phase 3 Immediate-Release Oxycodone Capsules Study in Cancer Pain Completed
  35. Phase 3 Trial Comparing Morphine to Hydromorphone in Elderly Patients With Severe Pain Completed
  36. Phase 3 Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Bunionectomy Completed
  37. Phase 3 Dexmedetomidine to Treat Bariatric Surgery-associated Pain Completed
  38. Phase 3 Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients Completed
  39. Phase 3 Non-Opiate Treatment After Prenatal Opiate Exposure to Prevent Postnatal Injury to the Young Brain Completed
  40. Phase 3 Open-Label, Safety, and Efficacy Study of Dexmedetomidine in Preterm Subjects Ages ≥28 Weeks to <36 Weeks Gestational Age Completed
  41. Phase 3 Study Evaluating Safety and Efficacy of Dexmedetomidine (DEX) in Intubated and Mechanically Ventilated Pediatric Intensive Care Unit (PICU) Subjects Completed
  42. Phase 3 A Trial to Evaluate CG5503 Efficacy and Safety in Acute Pain After Bunionectomy Completed
  43. Phase 3 Choosing Opioid Management for Pain and Analyzing Acute Chest Syndrome (ACS) Rates Equally Completed
  44. Phase 3 A Study to Evaluate the Efficacy and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain After Abdominal Hysterectomy Completed

Showing the 50 most-cited and recently-updated of 81 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Quadratus lumborum block reduces 24-h morphine consumption by 3.19 mg in cesarean section patients
Anesthesiology & Pain Medicine Meta-analysis
Quadratus lumborum block reduces 24-h morphine consumption by 3.19 mg in cesarean section patients Quadratus lumborum block reduces morphine use after C section
This meta-analysis of 23 RCTs involving 1,935 patients found that quadratus lumborum block (QLB) significantly reduced 24-hour morphine cons…
A specific nerve block can lower the amount of morphine needed for pain management during and after a cesarean birth.
Frontiers Jul 24, 2026
Unilateral biportal endoscopic laminotomy with bilateral decompression can result in postoperative epidural hematoma
Orthopedics & Sports Medicine Guideline
Unilateral biportal endoscopic laminotomy with bilateral decompression can result in postoperative epidural hematoma New Case Report Highlights Risks in Spinal Stenosis Surgery
This case report describes a 56-year-old male with L3-4 spinal stenosis who developed a postoperative epidural hematoma following UBE-ULBD s…
A rare complication during a specific spinal stenosis procedure highlights the importance of careful surgical techniques and drainage for pa…
Frontiers Jul 7, 2026
Tegileridine provides superior analgesic efficacy over placebo for postoperative acute pain with a favorable safety profile
Anesthesiology & Pain Medicine Meta-analysis
Tegileridine provides superior analgesic efficacy over placebo for postoperative acute pain with a favorable safety profile Tegileridine shows promise for managing pain after surgery
This meta-analysis of 1,011 patients evaluated tegileridine for postoperative acute pain. Tegileridine significantly reduced rSPID24 and rSP…
A new medication called tegileridine may offer a way to manage severe pain after surgery with fewer side effects like nausea and vomiting.
Frontiers Jul 5, 2026
Peripheral nerve blocks reduce 24-hour morphine use by 16.20 mg in kidney transplant recipients
Anesthesiology & Pain Medicine Meta-analysis
Peripheral nerve blocks reduce 24-hour morphine use by 16.20 mg in kidney transplant recipients Nerve blocks cut opioid use after kidney transplant surgery
This meta-analysis of adult kidney transplant recipients found that peripheral nerve blocks (PNBs) reduced 24-hour morphine consumption by 1…
A new analysis shows nerve blocks reduce opioid use by 16 mg after kidney transplant, with no reported side effects.
Jun 16, 2026
Intercostal nerve cryoablation reduces inpatient opioid consumption by 102 morphine milligram equivalents
Anesthesiology & Pain Medicine Meta-analysis
Intercostal nerve cryoablation reduces inpatient opioid consumption by 102 morphine milligram equivalents Cryoablation reduces opioid use after thoracic and cardiac surgery
This meta-analysis of 18,465 patients undergoing non-pectus repair thoracic or cardiac procedures found that intercostal nerve cryoablation …
A new analysis shows that freezing specific nerves before chest surgery can significantly lower the amount of opioid pain medication patient…
Jun 13, 2026
Modified pectoral plane block (PECS II) provides longer analgesia duration and lower morphine use
Oncology Meta-analysis
Modified pectoral plane block (PECS II) provides longer analgesia duration and lower morphine use New nerve block technique may reduce morphine use after mastectomy
This meta-analysis of 790 patients undergoing modified radical mastectomy found that the PECS II technique provided significantly longer ana…
A new nerve block method could provide longer pain relief and lower morphine needs for patients undergoing breast cancer surgery.
Jun 8, 2026
Transversus abdominis plane block reduces morphine use and pain after kidney removal surgery in patients
Anesthesiology & Pain Medicine Meta-analysis
Transversus abdominis plane block reduces morphine use and pain after kidney removal surgery in patients Nerve block cuts morphine use after kidney removal surgery
A systematic review of 639 patients found that transversus abdominis plane blocks significantly lowered morphine needs and pain scores follo…
A simple nerve block before kidney removal surgery reduced morphine use by 16.67 mg and lowered pain scores for 24 hours.
Frontiers Jun 4, 2026
Superficial parasternal intercostal plane block reduces 24-hour morphine use by 8.53 mg in cardiac surgery patients
Anesthesiology & Pain Medicine Meta-analysis
Superficial parasternal intercostal plane block reduces 24-hour morphine use by 8.53 mg in cardiac surgery patients S-PIP block lowers pain and opioid needs for adult heart surgery patients in this review
This meta-analysis evaluated the superficial parasternal intercostal plane (S-PIP) block versus standard or placebo analgesia in 1760 adult …
A review of seventeen hundred patients found that adding a S-PIP block to standard care reduced early pain and opioid use after heart surger…
Jun 1, 2026
Wound infusion catheter shortens hospital stay and provides comparable analgesia to epidural after laparotomy
Anesthesiology & Pain Medicine Meta-analysis
Wound infusion catheter shortens hospital stay and provides comparable analgesia to epidural after laparotomy Wound catheter shows shorter hospital stay after abdominal surgery
This systematic review and meta-analysis of 778 patients found that wound infusion catheter (WC) provided comparable postoperative analgesia…
A review of 778 patients found wound catheters led to shorter hospital stays than epidural pain control after abdominal surgery, with simila…
Jun 1, 2026
Perioperative nefopam failed to lower morphine needs or pain scores in spine surgery patients undergoing randomised trials
Anesthesiology & Pain Medicine Meta-analysis
Perioperative nefopam failed to lower morphine needs or pain scores in spine surgery patients undergoing randomised trials Perioperative nefopam did not reduce morphine use or pain after spine surgery
A systematic review of five hundred fifty-three spine surgery patients found that adding nefopam did not decrease twenty-four hour morphine …
A review of spine surgery patients found that taking nefopam did not lower morphine use or pain scores in the first few days after the opera…
May 22, 2026
Laparoscopic assisted TAP block reduces morphine consumption after elective minimally invasive colon surgery
Anesthesiology & Pain Medicine RCT
Laparoscopic assisted TAP block reduces morphine consumption after elective minimally invasive colon surgery L-TAP block reduces morphine use after colon surgery
Laparoscopic-assisted TAP block demonstrates superiority over placebo in reducing postoperative morphine use during colon surgery.
A new type of nerve block may help reduce the amount of morphine patients need during the first day after minimally invasive colon surgery.
May 6, 2026
Lignocaine-based opioid-free anesthesia increases sevoflurane need in head-and-neck cancer surgery
ENT (Otolaryngology) RCT
Lignocaine-based opioid-free anesthesia increases sevoflurane need in head-and-neck cancer surgery Opioid-free surgery needs more gas to keep patients asleep safely
This randomized trial in 30 patients undergoing head-and-neck cancer surgery found that lignocaine-based opioid-free anesthesia required hig…
Opioid-free anesthesia using lignocaine needs more breathing gas and causes more blood pressure spikes than morphine during major head surge…
May 1, 2026

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