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Oncology
Meta-analysis
Modified pectoral plane block (PECS II) provides longer analgesia duration and lower morphine use
New nerve block technique may reduce morphine use after mastectomy
This meta-analysis of 790 patients undergoing modified radical mastectomy found that the PECS II technique provided significantly longer ana…
A new nerve block method could provide longer pain relief and lower morphine needs for patients undergoing breast cancer surgery.
Jun 8, 2026
Anesthesiology & Pain Medicine
Meta-analysis
Transversus abdominis plane block reduces morphine use and pain after kidney removal surgery in patients
Nerve block cuts morphine use after kidney removal surgery
A systematic review of 639 patients found that transversus abdominis plane blocks significantly lowered morphine needs and pain scores follo…
A simple nerve block before kidney removal surgery reduced morphine use by 16.67 mg and lowered pain scores for 24 hours.
Frontiers
Jun 4, 2026
Anesthesiology & Pain Medicine
Meta-analysis
Superficial parasternal intercostal plane block reduces 24-hour morphine use by 8.53 mg in cardiac surgery patients
S-PIP block lowers pain and opioid needs for adult heart surgery patients in this review
This meta-analysis evaluated the superficial parasternal intercostal plane (S-PIP) block versus standard or placebo analgesia in 1760 adult …
A review of seventeen hundred patients found that adding a S-PIP block to standard care reduced early pain and opioid use after heart surger…
Jun 1, 2026
Anesthesiology & Pain Medicine
Meta-analysis
Wound infusion catheter shortens hospital stay and provides comparable analgesia to epidural after laparotomy
Wound catheter shows shorter hospital stay after abdominal surgery
This systematic review and meta-analysis of 778 patients found that wound infusion catheter (WC) provided comparable postoperative analgesia…
A review of 778 patients found wound catheters led to shorter hospital stays than epidural pain control after abdominal surgery, with simila…
Jun 1, 2026
Anesthesiology & Pain Medicine
Meta-analysis
Perioperative nefopam failed to lower morphine needs or pain scores in spine surgery patients undergoing randomised trials
Perioperative nefopam did not reduce morphine use or pain after spine surgery
A systematic review of five hundred fifty-three spine surgery patients found that adding nefopam did not decrease twenty-four hour morphine …
A review of spine surgery patients found that taking nefopam did not lower morphine use or pain scores in the first few days after the opera…
May 22, 2026
Anesthesiology & Pain Medicine
RCT
Laparoscopic assisted TAP block reduces morphine consumption after elective minimally invasive colon surgery
L-TAP block reduces morphine use after colon surgery
Laparoscopic-assisted TAP block demonstrates superiority over placebo in reducing postoperative morphine use during colon surgery.
A new type of nerve block may help reduce the amount of morphine patients need during the first day after minimally invasive colon surgery.
May 6, 2026
ENT (Otolaryngology)
RCT
Lignocaine-based opioid-free anesthesia increases sevoflurane need in head-and-neck cancer surgery
Opioid-free surgery needs more gas to keep patients asleep safely
This randomized trial in 30 patients undergoing head-and-neck cancer surgery found that lignocaine-based opioid-free anesthesia required hig…
Opioid-free anesthesia using lignocaine needs more breathing gas and causes more blood pressure spikes than morphine during major head surge…
May 1, 2026
Drug Pipeline
Meta-analysis
Systematic review and meta-analysis on oliceridine versus morphine for postoperative nausea and vomiting
Oliceridine at low doses reduces nausea and vomiting after surgery compared with morphine
This systematic review and meta-analysis of 1,767 patients found that oliceridine significantly reduced postoperative nausea and vomiting co…
A meta-analysis shows oliceridine lowers nausea and vomiting after anesthesia compared to morphine, with fewer side effects at specific dose…
Frontiers
Apr 24, 2026
Orthopedics & Sports Medicine
RCT
Intraoperative methadone alters 72-hour postoperative morphine use after hip fracture surgery in older adults
Can a single dose of methadone during hip surgery reduce painkiller needs?
In this randomized trial of 129 patients aged 60 or older undergoing hip fracture surgery, a single intraoperative dose of methadone (0.10 m…
A single methadone dose during hip surgery cuts early morphine use but keeps older patients in the hospital longer than those given a placeb…
Apr 17, 2026
Oncology
Sys. Review
Case report of semi-implantable IDDS for advanced cancer pain in three patients
Can a small pump stop severe cancer pain in just one day?
This case-based study describes three representative patients with advanced cancer pain treated with a semi-implantable intrathecal drug del…
A small pump delivered direct spinal medicine to three advanced cancer patients, dropping their worst pain from near maximum to zero within …
Frontiers
Apr 16, 2026
Anesthesiology & Pain Medicine
RCT
Auditory distraction and VR reduce pain during burn dressing changes in adults receiving morphine
Can music or VR help ease the agony of burn dressing changes?
A single-center RCT in 60 adults undergoing burn dressing changes found both auditory distraction and VR significantly reduced pain severity…
Listening to music or watching nature scenes on a headset reduced pain and improved breathing during burn dressing changes just as well as m…
Apr 3, 2026
Oncology
RCT
Guided Breathing VR Reduces Opioid Use Post-PTBD in Cancer Patients by 64%
Can Virtual Reality and Breathing Techniques Reduce Cancer Pain?
In a randomized trial, guided breathing VR (VRBG) significantly reduced opioid use post-PTBD compared to conventional VR (VROG), with a mean…
Cancer patients using virtual reality with guided breathing took significantly less pain medication after a painful procedure than those usi…
Mar 27, 2026