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Drug Pipeline
Meta-analysis
Systematic review and meta-analysis on oliceridine versus morphine for postoperative nausea and vomiting.
Oliceridine at low doses reduces nausea and vomiting after surgery compared with morphine
This systematic review and meta-analysis of 1,767 patients found that oliceridine significantly reduced postoperative nausea and vomiting co…
A meta-analysis shows oliceridine lowers nausea and vomiting after anesthesia compared to morphine, with fewer side effects at specific dose…
Frontiers
Apr 24, 2026
Orthopedics & Sports Medicine
RCT
Intraoperative methadone alters 72-hour postoperative morphine use after hip fracture surgery in older adults
Can a single dose of methadone during hip surgery reduce painkiller needs?
In this randomized trial of 129 patients aged 60 or older undergoing hip fracture surgery, a single intraoperative dose of methadone (0.10 m…
A single methadone dose during hip surgery cuts early morphine use but keeps older patients in the hospital longer than those given a placeb…
Apr 17, 2026
Oncology
Sys. Review
Case report of semi-implantable IDDS for advanced cancer pain in three patients
Can a small pump stop severe cancer pain in just one day?
This case-based study describes three representative patients with advanced cancer pain treated with a semi-implantable intrathecal drug del…
A small pump delivered direct spinal medicine to three advanced cancer patients, dropping their worst pain from near maximum to zero within …
Frontiers
Apr 16, 2026
Anesthesiology & Pain Medicine
RCT
Auditory distraction and VR reduce pain during burn dressing changes in adults receiving morphine
Can music or VR help ease the agony of burn dressing changes?
A single-center RCT in 60 adults undergoing burn dressing changes found both auditory distraction and VR significantly reduced pain severity…
Listening to music or watching nature scenes on a headset reduced pain and improved breathing during burn dressing changes just as well as m…
Apr 3, 2026
Oncology
RCT
Guided Breathing VR Reduces Opioid Use Post-PTBD in Cancer Patients by 64%
Can Virtual Reality and Breathing Techniques Reduce Cancer Pain?
In a randomized trial, guided breathing VR (VRBG) significantly reduced opioid use post-PTBD compared to conventional VR (VROG), with a mean…
Cancer patients using virtual reality with guided breathing took significantly less pain medication after a painful procedure than those usi…
Mar 27, 2026