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Acute exacerbation of chronic obstructive pulmonary disease

Part of Chronic Obstructive Pulmonary Disease

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for acute exacerbation of chronic obstructive pulmonary disease

12 trials tracked for acute exacerbation of chronic obstructive pulmonary disease: 4 in phase 3 or 4 and 3 with published results. The most-cited published study has 125 citations.

12Trials tracked
4Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 2 Phase 3 2 Phase 2 1 Other / NA 7
  1. Phase 4 Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of Long-acting β2-agonist (LABA) and Inhaled Corticosteroid (ICS) Completed · 125 cited
  2. Phase 3 TNF-alpha Antagonists for AECOPD: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial Completed · 102 cited
  3. Phase 3 Effectiveness of Low-Dose Theophylline for the Management of Biomass-Associated COPD Completed · 14 cited
  4. Phase 4 Comparison Between Levofloxacin and Prulifloxacin, in Internal Medicine Patients With Acute Exacerbation of COPD Completed
  5. Phase 2 Anti-ST2 (MSTT1041A) in COPD (COPD-ST2OP) Completed
  6. N/A Increasing Adherence to Pulmonary Rehabilitation After COPD Related Hospitalizations (Pilot Study) Completed
Show 6 more trials
  1. N/A Molecular Breath Print of COPD Patients With Exacerbations Despite Triple Inhalational Therapy Completed
  2. N/A Early Assisted Discharge for COPD Exacerbations With Telemonitoring. Completed
  3. N/A Acupuncture Treatment of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation Completed
  4. N/A COPD Aerosol Study Comparing the Efficacy of Nebulizers Versus Dry Powder Inhalers Completed
  5. N/A Telehealth Pulmonary Rehabilitation for Hispanic and African-American Patients Admitted With Exacerbation of COPD Completed
  6. N/A Increasing Adherence to Pulmonary Rehabilitation After COPD Related Hospitalizations (Study 2) Completed

Showing the 12 most-cited and recently-updated of 12 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Chronic Obstructive Pulmonary Disease

Related studies from across the Chronic Obstructive Pulmonary Disease family.

Evaluating the Impact of Digital Health Interventions on Chronic Disease Self-Care Outcomes
Physical Medicine & Rehab Meta-analysis
Evaluating the Impact of Digital Health Interventions on Chronic Disease Self-Care Outcomes Digital health tools show mixed results for managing chronic diseases
Digital tools show promise for heart failure monitoring but lack consistent evidence for improving medication adherence or general diabetes …
New data shows that while digital tools like apps can help heart failure patients monitor their health, they may not improve medication habi…
Structured exercise improves 6-minute walk distance by 38.62 m in idiopathic pulmonary fibrosis
Rheumatology Meta-analysis
Structured exercise improves 6-minute walk distance by 38.62 m in idiopathic pulmonary fibrosis Structured exercise improves endurance for people with lung scarring
This systematic review and meta-analysis of 503 patients found that structured exercise, particularly mind-body integrated training, signifi…
Specific types of structured exercise can improve walking distance and breathing for people living with idiopathic pulmonary fibrosis.
IoT-assisted pulmonary rehabilitation protocol for moderate-to-severe stable COPD patients in single institution
Rheumatology RCT
IoT-assisted pulmonary rehabilitation protocol for moderate-to-severe stable COPD patients in single institution New plan tests smart technology for managing chronic lung disease
This prospective, non-randomized controlled intervention study protocol outlines an IoT-assisted pulmonary rehabilitation program for 588 pa…
A new trial plans to see if smart devices and apps can help people with chronic lung disease manage their symptoms at home.
Higher preoperative NLR and SII show increased risk for postoperative pneumonia and pulmonary complications in lung and esophageal surgery
Rheumatology Meta-analysis
Higher preoperative NLR and SII show increased risk for postoperative pneumonia and pulmonary complications in lung and esophageal surgery Blood inflammation markers linked to higher lung surgery infection risk
This systematic review and meta-analysis of 3,936 patients found that higher preoperative neutrophil-to-lymphocyte ratio and systemic immune…
A review of nearly 4,000 patients found that higher preoperative blood inflammation markers were linked to a greater chance of pneumonia and…
1 in 7 COPD patients decline or discontinue long-term PAP therapy, meta-analysis finds
Pulmonology & Critical Care Meta-analysis
1 in 7 COPD patients decline or discontinue long-term PAP therapy, meta-analysis finds 1 in 7 COPD patients decline or stop breathing therapy
This systematic review and meta-analysis of patients with COPD newly prescribed long-term noninvasive positive airway pressure (PAP) therapy…
A new analysis finds 14% of COPD patients decline or stop long-term breathing therapy, often within six weeks.
COPD patients show heightened sympathetic nerve activity compared to healthy adults
Pulmonology & Critical Care Meta-analysis
COPD patients show heightened sympathetic nerve activity compared to healthy adults COPD patients have much higher nerve activity than healthy adults
A meta-analysis finds COPD patients have significantly higher sympathetic nerve activity than controls, with no change from common therapies…
People with COPD show significantly higher sympathetic nerve activity compared to healthy adults, which may explain their heart and exercise…
Diabetes mellitus linked to higher SSI risk after hernia repair, other factors not significant
Orthopedics & Sports Medicine Meta-analysis
Diabetes mellitus linked to higher SSI risk after hernia repair, other factors not significant Large study shows diabetes may raise infection risk during hernia repair surgery for patients
This systematic review and meta-analysis of 97,428 patients undergoing abdominal wall hernia repair found that diabetes mellitus was associa…
A huge review of nearly 100,000 patients found that having diabetes might slightly increase the chance of infection after hernia surgery. Ot…
Pirfenidone reduces lung cancer incidence by 73% in IPF patients with a pooled risk ratio of 0.39
Pulmonology & Critical Care Meta-analysis
Pirfenidone reduces lung cancer incidence by 73% in IPF patients with a pooled risk ratio of 0.39 Antifibrotic drugs may lower lung cancer risk in patients with idiopathic pulmonary fibrosis
This systematic review and meta-analysis evaluated antifibrotic therapies in 15582 patients with idiopathic pulmonary fibrosis. The pooled a…
A large review suggests antifibrotic drugs like pirfenidone might lower lung cancer risk in people with idiopathic pulmonary fibrosis, but m…
FAM13A variants influence tissue destruction in COPD and fibrotic remodeling in pulmonary fibrosis
Genetics & Precision Medicine Sys. Review
FAM13A variants influence tissue destruction in COPD and fibrotic remodeling in pulmonary fibrosis New research links FAM13A gene to lung disease tissue changes
This narrative review examines the role of FAM13A in chronic obstructive pulmonary disease and pulmonary fibrosis. The authors associate FAM…
A review suggests the FAM13A gene plays different roles in lung diseases like COPD and pulmonary fibrosis, offering clues for future treatme…
Combination voriconazole and micafungin improved a boy with CGD and invasive Aspergillus lentulus infection
Rheumatology Guideline
Combination voriconazole and micafungin improved a boy with CGD and invasive Aspergillus lentulus infection Combination antifungals helped a boy with rare lung infection before transplant
This guideline discusses a case report of a boy with chronic granulomatous disease and invasive pulmonary Aspergillus lentulus infection. Th…
A boy with chronic granulomatous disease improved on two antifungal drugs before a pending stem cell transplant.
Tubeless thoracic surgery may reduce pain and hospital stay in pulmonary nodule resection, though long-term safety remains unconfirmed
Orthopedics & Sports Medicine Meta-analysis
Tubeless thoracic surgery may reduce pain and hospital stay in pulmonary nodule resection, though long-term safety remains unconfirmed Tubeless lung surgery may reduce pain and hospital stays for some patients
This narrative synthesis reviews 59 articles on tubeless thoracic surgery for patients with pulmonary nodules. The authors note reductions i…
A review of 59 articles suggests tubeless lung surgery might lower pain and hospital stays, though long-term safety needs more proof.
Ultrasound-facilitated catheter-directed alteplase reduces early recurrence in intermediate-risk pulmonary embolism
Emergency Medicine RCT
Ultrasound-facilitated catheter-directed alteplase reduces early recurrence in intermediate-risk pulmonary embolism New trial shows ultrasound-guided clot-busting drugs help some patients with serious lung clots recover faster and safely
This randomized controlled trial evaluated ultrasound-facilitated, catheter-directed fibrinolysis with alteplase plus anticoagulation versus…
A large study found that using ultrasound to guide clot-busting medicine helped patients with serious lung clots avoid bad outcomes. The tre…