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Home › Conditions › adenocarcinoma of the gastroesophageal junction

Adenocarcinoma of the gastroesophageal junction

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for adenocarcinoma of the gastroesophageal junction

41 trials tracked for adenocarcinoma of the gastroesophageal junction: 6 in phase 3 or 4 and 5 with published results. The most-cited published study has 693 citations.

41Trials tracked
6Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 3 6 Phase 2 31 Phase 1 3 Other / NA 1
  1. Phase 3 Pembrolizumab/Placebo Plus Trastuzumab Plus Chemotherapy in Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Advanced Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-811/KEYNOTE-811) Completed · 693 cited
  2. Phase 3 A Study of Ramucirumab (LY3009806) in Combination With Capecitabine and Cisplatin in Participants With Stomach Cancer Completed · 284 cited
  3. Phase 3 A Study of Pembrolizumab (MK-3475) Versus Paclitaxel for Participants With Advanced Gastric/Gastroesophageal Junction Adenocarcinoma That Progressed After Therapy With Platinum and Fluoropyrimidine (MK-3475-061/KEYNOTE-061) Completed · 167 cited
  4. Phase 3 Radiation Therapy, Paclitaxel, and Carboplatin With or Without Trastuzumab in Treating Patients With Esophageal Cancer Completed · 102 cited
  5. Phase 3 A Study of Paclitaxel With or Without Ramucirumab (LY3009806) in Participants With Gastric or Gastroesophageal Cancer Completed · 94 cited
  6. Phase 3 Tucatinib, Trastuzumab, Ramucirumab, and Paclitaxel Versus Paclitaxel and Ramucirumab in Previously Treated HER2+ Gastroesophageal Cancer Completed
Show 35 more trials
  1. Phase 2 Study of VE800 and Nivolumab in Patients With Selected Types of Advanced or Metastatic Cancer Completed
  2. Phase 2 Sorafenib, Docetaxel, and Cisplatin in Treating Patients With Metastatic or Advanced Gastric or Gastroesophageal Junction Cancer Completed
  3. Phase 2 A Study of Ramucirumab in Participants With Gastric or Gastroesophageal Junction Adenocarcinoma Completed
  4. Phase 2 Panitumumab, Docetaxel, Cisplatin, Radiation Therapy, and Surgery in Treating Patients With Newly Diagnosed, Locally Advanced Esophageal Cancer or Cancer of the Gastroesophageal Junction Completed
  5. Phase 2 Bortezomib With or Without Irinotecan in Treating Patients With Cancer of the Gastroesophageal Junction or Stomach Completed
  6. Phase 2 A Study of Pembrolizumab (MK-3475) in Participants With Recurrent or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma (MK-3475-059/KEYNOTE-059) Completed
  7. Phase 2 Irinotecan Hydrochloride With or Without Alvocidib in Treating Patients With Advanced Stomach or Gastroesophageal Junction Cancer That Cannot Be Removed By Surgery Completed
  8. Phase 2 S1201: Combination Chemo for Patients W/Advanced or Metastatic Esophageal, Gastric, or Gastroesophageal Junction Cancer Completed
  9. Phase 2 Pralatrexate and Oxaliplatin in Treating Patients With Unresectable or Metastatic Esophageal, Stomach, or Gastroesophageal Junction Cancer Completed
  10. Phase 2 Heated Mitomycin and Cisplatin During Surgery in Treating Patients With Stomach or Gastroesophageal Cancer Completed
  11. Phase 2 A Study of Emibetuzumab in Combination With Ramucirumab (LY3009806) in Participants With Advanced Cancer Completed
  12. Phase 2 Combination Chemotherapy With or Without Vismodegib in Treating Patients With Advanced Stomach Cancer or Gastroesophageal Junction Cancer Completed
  13. Phase 2 PET Scan Imaging in Assessing Response in Patients With Esophageal Cancer Receiving Combination Chemotherapy Completed
  14. Phase 2 Akt Inhibitor MK2206 in Treating Patients With Advanced Gastric or Gastroesophageal Junction Cancer Completed
  15. Phase 2 Capecitabine With or Without Sunitinib Malate as First-Line Therapy in Treating Patients With Metastatic Cancer of the Esophagus or Gastroesophageal Junction Completed
  16. Phase 2 Study of Modified Docetaxel, Cisplatin, and Fluorouracil (mDCF) in Unresectable or Metastatic Gastric and Gastroesophageal Junction Adenocarcinoma Completed
  17. Phase 2 Epacadostat and Pembrolizumab in Treating Patients With Metastatic or Unresectable Gastroesophageal Junction or Gastric Cancer Completed
  18. Phase 2 Pembrolizumab and Palliative Radiation Therapy in Treating Patients With Metastatic Esophagus, Stomach, or Gastroesophageal Junction Cancer Completed
  19. Phase 2 A Phase 2 Study of Ramucirumab (LY3009806) in Participants With Gastric or Gastroesophageal Junction (GEJ) Cancer Completed
  20. Phase 2 Everolimus and Combination Chemotherapy in Treating Patients With Metastatic Stomach or Esophageal Cancer Completed
  21. Phase 2 Bevacizumab and Combination Chemotherapy Before Surgery in Treating Patients With Locally Advanced Esophageal or Stomach Cancer Completed
  22. Phase 2 Pembrolizumab, Combination Chemotherapy, and Radiation Therapy Before Surgery in Treating Adult Patients With Locally Advanced Gastroesophageal Junction or Gastric Cardia Cancer That Can Be Removed by Surgery Completed
  23. Phase 2 Study to Evaluate the Efficacy and Safety of Andecaliximab Combined With Nivolumab Versus Nivolumab Alone in Adults With Unresectable or Recurrent Gastric or Gastroesophageal Junction Adenocarcinoma Completed
  24. Phase 2 Docetaxel, Oxaliplatin, Capecitabine, Fluorouracil, and Radiation Therapy in Treating Patients With Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction Completed
  25. Phase 2 TAS 102 in Combination With Ramucirumab in Advanced, Refractory Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma Completed
  26. Phase 2 Perioperative Chemo and Pembrolizumab in Gastric Cancer Completed
  27. Phase 2 Saracatinib in Treating Patients With Locally Advanced or Metastatic Stomach or Gastroesophageal Junction Cancer Completed
  28. Phase 2 Study of Pembrolizumab in Subjects With Advanced Gastric or Gastroesophageal Junction Adenocarcinoma Who Progressed After First-Line Therapy With Platinum and Fluoropyrimidine: Integration of Molecular Subtypes Through Integrative Genomic Analysis Completed
  29. Phase 2 Pilot Trial of CRLX101 in Treatment of Patients With Advanced or Metastatic Stomach, Gastroesophageal, or Esophageal Cancer That Cannot be Removed by Surgery Completed
  30. Phase 2 Phase II Study of Oxaliplatin, Irinotecan, and Capecitabine in Advanced Gastric/Gastroesophageal Junction Carcinoma Completed
  31. Phase 2 A Study of Ramucirumab (LY3009806) in Combination With Paclitaxel in Participants With Gastric Cancer Completed
  32. Phase 1 A Study of Ramucirumab Plus Pembrolizumab in Participants With Gastric or GEJ Adenocarcinoma, NSCLC, Transitional Cell Carcinoma of the Urothelium, or Biliary Tract Cancer Completed
  33. Phase 1 SL-279252 (PD1-Fc-OX40L) in Subjects With Advanced Solid Tumors or Lymphomas Completed
  34. Phase 1 A Trial of ZD6474, Paclitaxel, Carboplatin, 5-Fluorouracil, and Radiation Therapy Followed by Surgery Completed
  35. N/A 64Cu DOTA-Trastuzumab PET/CT in Studying Patients With Gastric Cancer Completed

Showing the 41 most-cited and recently-updated of 41 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Adenocarcinoma of the gastroesophageal junction: what the trials found

Pembrolizumab has demonstrated significant improvements in clinical outcomes for adenocarcinoma of the gastroesophageal junction. In a Phase 3 trial, pembrolizumab showed superior Progression Free Survival (PFS) (10.0 vs. 8.1; p=0.0002), Overall Survival (OS) (20.0 vs. 16.8; p=0.0040), and Objective Response Rate (ORR) (72.6% vs. 60.1%; p=0.00020) 1. However, in another Phase 3 trial involving PD-L1 positive participants, pembrolizumab showed no significant difference in PFS compared to the control (p=0.98358), though a statistically significant improvement in OS was observed (9.1 vs. 8.3; p=0.04205) 3.

Ramucirumab has been evaluated in multiple Phase 3 trials. One study reported an ORR of 41.1% compared to 36.4% and a Disease Control Rate (DCR) of 81.9% versus 76.5% 2. Another trial showed significantly improved Progression Free Survival (PFS) with ramucirumab (4.14 vs. 3.15; p=0.0184) and an ORR of 26.5% vs. 21.9% 5. A third Phase 3 trial evaluating ramucirumab did not show statistically significant differences in PFS or OS compared to the control 22.

Chemotherapy agents such as Carboplatin have been studied, with one study reporting a two-year OS of 63.3% and a two-year PFS rate of 16.7% 13. Another trial using carboplatin showed no significant difference in Disease-free Survival (DFS) or Pathologic Complete Response at surgery compared to control 4.

Recent results — preliminary, needs further review

  • Cisplatin was evaluated in a Phase 2 study 7.
  • VE800 was evaluated in a Phase 2 study 9.
  • TAS 102 was evaluated in a Phase 2 study 11.
  • Bevacizumab was evaluated in a Phase 2 study 12.
  • Oxaliplatin showed no significant difference in complete pathological response among PET/CT non-responders 16.

For the clinician treating this condition

  • Pembrolizumab is associated with statistically significant improvements in PFS, OS, and ORR in certain cohorts 1, though results regarding PFS specifically in PD-L1 positive patients were not statistically significant 3.
  • Ramucirumab has shown evidence of improved PFS and ORR in some trials 5, while other Phase 3 studies did not reach statistical significance for primary endpoints like PFS or OS 22.
  • Chemotherapy options such as Carboplatin have established data regarding two-year survival rates and surgical response, though specific comparisons to standard controls were not significant in all tested cohorts [4, 13].

AI synthesis of 12 cited trials, updated Jun 28, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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