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Home › Conditions › Apnea

Apnea

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Apnea

8 trials tracked for Apnea: 2 in phase 3 or 4 and 1 with published results. The most-cited published study has 5 citations.

8Trials tracked
2Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 2 1 Other / NA 5
  1. Phase 4 Apnea in Hospitalized Preterm Infants Following the Administration of Routine Childhood Vaccines Completed · 5 cited
  2. Phase 4 Nu-Mask Intraoral Airway Device Versus Conventional Bag Valve Mask Ventilation Crossover Trial Completed
  3. Phase 2 Effectiveness of Continuous Negative External Pressure in Preventing Upper Airway Impairment During Routine Colonoscopy Completed
  4. N/A Ventilation Using a Bag Valve Mask With Integrated Internal Handle Completed
  5. N/A Novel Treatment of Comorbid Insomnia and Sleep Apnea in Older Veterans Completed
  6. N/A Use of Capnography in EGD and Colonoscopy With Moderate Sedation. Completed
Show 2 more trials
  1. N/A A Safety Study For Prevenar 13 Among Chinese Children Completed
  2. N/A Ventilation Using a Bag Valve Mask With Supplemental External Handle Completed

Showing the 8 most-cited and recently-updated of 8 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Apnea: what the trials found

Administration of PCV13 was associated with a statistically significant reduction in the occurrence of apnea (p=0.0104) 1. However, this intervention did not result in a statistically significant change in the number of apneic episodes (p=0.11) or the duration of those episodes (p=0.36) 1.

The use of an intraoral airway device (NuMask) significantly increased the received minute volume compared to standard measures (p=<0.001) 2. Additionally, trials evaluating modified Ambu Spur II bag valve masks showed no significant difference in received tidal volume (p=0.280) 6, and these devices were utilized in clinical settings for airway management 8.

Recent results — preliminary, needs further review

  • Airway Management System (AMS) was associated with a lower rate of respiratory incidents (RI), defined as oxygen saturation < 90% or apneas/hypopneas > 15 seconds, compared to no cNEP (p=<0.022) 3.
  • Interventions targeting insomnia and PAP adherence significantly improved sleep quality (p=<0.001) and reduced both sleep onset latency (p=0.013) and wake after sleep onset (p=0.019) 5.

For the clinician treating this condition

  • PCV13 is effective in reducing the occurrence of apnea, though it does not significantly alter the frequency or duration of individual apneic events.
  • NuMask intraoral airway devices are associated with a significant increase in received minute volume.
  • Modified Ambu Spur II bag valve masks do not appear to significantly impact tidal volume compared to standard protocols.

AI synthesis of 6 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Backup ventilation timing after apnoea in extremely preterm infants on nCPAP
Pediatrics RCT
Backup ventilation timing after apnoea in extremely preterm infants on nCPAP Is a faster backup breath better for tiny, fragile lungs?
This randomized cross-over trial in 22 extremely preterm infants <28 weeks on nCPAP compared backup ventilation start after 4 vs 16 seconds …
Waiting 16 seconds instead of 4 before a baby's breathing machine steps in keeps oxygen levels just as safe for tiny lungs.
Apr 19, 2026