Intracranial immunotherapy delivery does not improve survival for pediatric high-grade glioma compared to systemic administration
Intracranial Delivery Shows Higher Neurotoxicity Risk in Pediatric Brain Tumors
This meta-analysis of 22 studies evaluated intracranial versus systemic immunotherapy delivery in pediatric patients with high-grade and dif…
New analysis shows that while delivery methods do not change survival for pediatric brain tumors, some routes carry a higher risk of severe …
Review of glioma organoid models for mechanistic discovery and therapy development
Finally Lab-Grown Brain Models Could Speed Up Glioma Treatments
This narrative review summarizes glioma organoid model systems for studying tumor-neural interactions. It concludes these models provide a f…
• Tiny lab-grown brains mimic real tumor behavior better than old methods • Kids and adults fighting deadly brain cancers like glioblastoma …
Review of STING agonists for high-grade and diffuse midline glioma discusses systemic toxicity and delivery constraints
New Brain Drug Target Could Wake Up the Immune System
This narrative review examines the potential of STING agonists, cyclic dinucleotides, and related compounds for treating high-grade glioma a…
A new brain drug target aims to wake up the immune system's defenses against dangerous, hard-to-treat tumors that hide from the body's natur…
Research across Cancer
Related studies from across the Cancer family.
CAR T-cell therapies targeting specific antigens show potential for treating pediatric CNS tumors
New CAR T-cell therapies show promise for pediatric brain tumors
This narrative review synthesizes 18 studies, including preclinical and early-phase clinical trials, regarding CAR T-cell therapy for pediat…
CAR T-cell therapy is showing potential to shrink tumors and extend life in children with aggressive brain cancers like DIPG.
Targeted cytokine delivery platforms in canine oncology provide data for human immuno-oncology dose selection
Cytokine Therapies Show Potential for Treating Canine Cancers
This mini review synthesizes evidence on targeted cytokine delivery platforms, such as IL-12 and IFN-beta, in dogs with various spontaneous …
New research explores how targeted cytokine delivery systems can treat various cancers in dogs and provide data for future human cancer trea…
Peer support may impact fear of disease progression and psychological symptoms in patients with glioma
Peer support may ease fear in glioma patients
This is a protocol for a systematic review and meta-analysis regarding the impact of peer support on fear of disease progression, fatigue, d…
A new meta-analysis protocol will examine whether peer support reduces fear of disease progression in glioma patients.
Symptomatic radiation necrosis occurs in 5.7% of intracranial brachytherapy patients
Brachytherapy for brain tumors: 5.7% risk of radiation necrosis
This meta-analysis of 3666 patients undergoing intracranial brachytherapy for glioma, brain metastases, or meningioma found a pooled inciden…
About 1 in 18 patients who get internal radiation for brain tumors develop symptomatic radiation necrosis, a new analysis finds.
MRI Radiomics Predicts TERTp Mutation in Glioma with Moderate Accuracy
MRI Radiomics Help Predict TERTp Mutation in Glioma Patients
Meta-analysis of 14 studies shows MRI radiomics predicts TERTp mutation in glioma with AUC 0.79; combined models improve accuracy to 0.82.
New analysis shows MRI-based radiomics can help predict specific genetic mutations in glioma, potentially aiding early diagnosis and treatme…
NODI parameters ODI and V-ISO differentiate gliomas from brain metastases in contrast-enhancing regions
Brain scan technique helps tell gliomas from metastases
This meta-analysis evaluates the use of Neurite orientation dispersion and density imaging (NODDI) to distinguish gliomas from brain metasta…
A new imaging method may help doctors distinguish between gliomas and brain metastases without invasive biopsy.
Deep learning models for glioma segmentation achieve high whole tumor accuracy with DSC 0.860
New AI tools show high accuracy for mapping brain tumors before surgery
This systematic review and meta-analysis of 36 deep learning models for preoperative glioma segmentation found high whole tumor segmentation…
AI models mapped brain tumors with high accuracy, but performance varied. Training on specific datasets helped, yet no single factor fully e…
Systematic review of preclinical CBD effects in canine cancers
Lab tests suggest CBD may help treat cancer in dogs
This is a systematic review of preclinical studies on cannabidiol for canine cancers. It synthesizes evidence of antiproliferative and proap…
Lab tests suggest CBD may help treat cancer in dogs by slowing growth and triggering cell death, though human use remains unproven.
Systematic review explores metabolic-immune axis in glioma progression and resistance
Metabolic-immune link in glioma opens new treatment avenues
This systematic review synthesizes evidence on the metabolic-immune interplay in glioma. It finds that metabolic reprogramming and immune mi…
A systematic review reveals how metabolic reprogramming and immune evasion work together in glioma, pointing to new targets for therapy.
Systematic Review Links Neural Circuit Disturbances to Glioma Symptoms and Survival
Brain tumor growth linked to disrupted neural circuits
This systematic review synthesizes evidence that circuit-level disturbances in the neural microenvironment correspond with glioma-related ep…
A new review shows that glioma disrupts brain circuits, linking seizures, mood changes, and survival. Could rewiring the brain help treat tu…
Experimental agents show response rates up to 70% in relapsed or refractory diffuse large B-cell lymphoma
New cancer therapies double response rates for tough lymphoma
This systematic review and meta-analysis of phase 1-2 trials evaluated experimental agents alone or combined with CD20-antibodies in adults …
Patients with aggressive lymphoma once had few options after standard treatments failed, but new therapies are changing that outlook in ways…
High tumour mutation burden improves overall survival in solid tumours treated with immune checkpoint inhibitors
High Mutation Counts May Predict Better Cancer Survival Outcomes
This systematic review and meta-analysis evaluated 5278 patients with solid tumours treated with immune checkpoint inhibitors or chemotherap…
High mutation counts in tumors may help predict who will survive longer when taking powerful immune-boosting cancer drugs