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Home › Conditions › Femur Fracture

Femur Fracture

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Femur Fracture

6 trials tracked for Femur Fracture: 2 in phase 3 or 4 and 1 with published results. The most-cited published study has 6 citations.

6Trials tracked
2Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Other / NA 4
  1. Phase 4 Postoperative Pain Management in Patients Undergoing Intramedullary Nail Fixation After Tibia and Femoral Fractures Completed · 6 cited
  2. Phase 4 Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur Fractures Completed
  3. N/A Skeletal Versus Cutaneous Traction For Treatment of Femur Fractures Completed
  4. N/A Distal Targeter vs Free-hand Completed
  5. N/A Dalteparin in Preventing DVT in Participants With Cancer Completed
  6. N/A Intramedullary Nailing of the Femur:Trochanteric vs Piriformis Starting Portals Completed

Showing the 6 most-cited and recently-updated of 6 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Femur Fracture: what the trials found

Clinical evaluation of pain management for femur fractures shows that a combination of intravenous ketorolac and oral acetaminophen resulted in significant improvements in patient-reported outcomes at the 24-hour mark (p=0.041).

While the 24-hour VAS scores showed statistically significant improvement, the 12-hour and 36-hour post-intervention pain scores did not reach statistical significance (p=0.215 and p=0.12 respectively).

Recent results — preliminary, needs further review

  • The use of a distal targeting jig is currently under investigation but has not been corroborated.
  • The efficacy of Dalteparin for this condition is not yet corroborated.
  • Femoral traction was evaluated regarding the time to pass a guidewire after attaining a starting point, but results are not yet corroborated.
  • Antegrade intramedullary nailing was studied but findings are not yet corroborated.

For the clinician treating this condition

  • A combination of intravenous ketorolac and oral acetaminophen is associated with statistically significant reductions in VAS pain scores at 24 hours post-injury.
  • Pain scores at the 12-hour and 36-hour marks following this specific pharmacological intervention did not show statistically significant differences.

AI synthesis of 0 cited trials, updated Jun 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Systematic review and meta-analysis compares ESIN versus plating for pediatric femoral shaft fractures
Pediatrics Meta-analysis
Systematic review and meta-analysis compares ESIN versus plating for pediatric femoral shaft fractures Elastic Nails Beat Plates for Kids’ Broken Thigh Bones
This systematic review and meta-analysis evaluates elastic stable intramedullary nailing (ESIN) versus plating for patients ≤18 years with d…
Kids with broken thigh bones recover faster and with fewer setbacks when treated with elastic nails instead of metal plates, a major review …
Frontiers Apr 28, 2026
Ketamine may reduce positional pain more than dexmedetomidine or nerve block in femur fracture patients
Orthopedics & Sports Medicine RCT
Ketamine may reduce positional pain more than dexmedetomidine or nerve block in femur fracture patients Which drug works best for pain when positioning patients with broken hips?
A 75-patient RCT compared IV ketamine (0.3 mg/kg), IV dexmedetomidine (0.5 μg/kg), and femoral nerve block for analgesia during positioning …
Ketamine outperformed nerve blocks and dexmedetomidine for reducing severe pain when positioning patients with broken hips before surgery.
Apr 2, 2026