Early-onset epilepsy associated with higher biomarker abnormality in older adults
Older Adults With Epilepsy Face Higher Dementia Risk, New Brain Tests Reveal
This observational study of 84 older adults with focal epilepsy examined AT(N) biomarker profiles and cognitive associations.
New brain blood tests show most older adults with epilepsy have signs of dementia risk, even without symptoms.
Systematic review finds levetiracetam linked to psychobehavioral adverse effects in epilepsy
Levetiracetam linked to irritability and aggression in epilepsy patients
This systematic review synthesizes evidence on psychobehavioral adverse effects (PBAEs) of levetiracetam in epilepsy.
A review finds levetiracetam for epilepsy is tied to higher rates of irritability and aggression, with some patients stopping the drug becau…
Interictal dynamic PET shows superior signal-to-noise ratios versus static PET in focal epilepsy cohort
Small study finds dynamic PET scans may show better signal quality
This cohort study significantly evaluated 36 patients with focal epilepsy comparing interictal dynamic PET against static PET.
New brain scans for epilepsy patients often show clearer images than standard tests, with better signal quality in most brain regions studie…
Genetic mutations in febrile sensitivity epilepsy correlate with earlier onset and specific diagnoses in children
Fever-Triggered Seizures in Children Trace Back to Specific Genes
This retrospective cohort study examined 30 gene-positive cases and 31 gene-negative controls at Wuxi Children's Hospital.
Half of children with fever-triggered seizures carry specific gene mutations that help doctors predict which treatments will work and which …
9.4T MRI shows similar FCD detection to 3T in small epilepsy cohort, reveals one quantitative feature
Can a stronger MRI scanner find hidden seizure causes that a standard scan misses?
A small cohort study of 21 patients with drug-resistant focal epilepsy found 9.4T MRI did not identify new epileptogenic lesions in 3T-negat…
A powerful 9.4T MRI scanner spotted hidden seizure causes in two patients that standard scans missed, but found no new issues in others.
Research across Epilepsy
Related studies from across the Epilepsy family.
Prenatal ultrasound findings and NIPS may facilitate identification of 15q duplication syndrome
New prenatal screening may help identify 15q duplication syndrome earlier
This case report and pooled analysis of 35 cases examines prenatal ultrasound findings and identification potential for 15q duplication synd…
New data suggests that non-invasive prenatal screening can help identify 15q duplication syndrome before a baby is born.
KCNIP2 and AP3D1 genetic variants colocalise with generalized epilepsy signals in specific neuronal types
Genetic variants in KCNIP2 and AP3D1 linked to epilepsy
This meta-analysis identifies KCNIP2 and AP3D1 as genetic variants associated with generalized epilepsy through cell-type-resolved colocalis…
New research identifies specific genetic markers in the brain that may help scientists find better ways to treat generalized epilepsy.
Aviophobia linked to temporal and limbic epileptiform activity in narrative review
Fear of Flying May Link to Specific Brain Activity
This narrative review examines a possible relationship between aviophobia and neurological activity, suggesting that certain stressful aviop…
Certain types of intense fear of flying may be linked to specific brain activity that can cause symptoms similar to those seen in epilepsy.
Transcutaneous auricular vagus nerve stimulation shows potential for depression, epilepsy, migraine, and post-stroke rehabilitation
Vagus Nerve Stimulation Shows Potential for Depression and Migraine
This narrative review of 72 articles explores the mechanism and therapeutic potential of transcutaneous auricular vagus nerve stimulation (t…
A new method of nerve stimulation may offer potential benefits for managing conditions like migraine, epilepsy, and depression.
Newer-generation antiseizure medications improve treatment retention and safety in older adults with epilepsy
Newer Antiseizure Medications May Improve Treatment Retention in Seniors
This meta-analysis of 2,507 patients found no significant difference in seizure freedom between newer and older antiseizure medications. How…
Newer antiseizure medications may help older adults stay on their treatment more consistently than older medications for managing epilepsy.
Low-frequency rTMS and cathodal tDCS provide consistent seizure reductions in drug-resistant epilepsy
Non-invasive Neuromodulation Shows Promise for Drug-Resistant Epilepsy
This narrative review explores non-invasive neuromodulation for drug-resistant epilepsy, highlighting low-frequency rTMS and cathodal tDCS a…
Newer non-invasive brain stimulation methods like rTMS and tDCS show consistent results in reducing seizure frequency for patients with drug…
Sleep disturbances and obstructive sleep apnea lower seizure thresholds and impact sleep architecture in epilepsy
Sleep patterns and conditions impact seizure control in epilepsy
This narrative review explores the bidirectional relationship between epilepsy and sleep disorders. It highlights how NREM sleep promotes se…
New insights show how specific sleep stages and conditions like sleep apnea can influence seizure activity and quality of life for people wi…
Psychological and behavioral interventions significantly reduce depression severity in people with epilepsy
Behavioral Therapies May Help Reduce Depression in People with Epilepsy
This meta-analysis evaluates the efficacy of psychological and behavioral interventions for depression in patients with epilepsy. The analys…
Psychological and behavioral therapies, such as cognitive behavioral therapy, show promise in reducing depression symptoms for people living…
LLM-based risk-of-bias assessments show limited agreement with human reviewers in neurology prognosis studies
AI Tools Show Potential for Assessing Medical Research Quality
This systematic review evaluates an LLM-based pipeline using zero-shot prompting for Risk-of-Bias (ROB) assessment using the QUIPS framework…
New research explores how AI models can help experts quickly assess the quality and bias of medical studies on conditions like stroke and ep…
253 autism-associated genes identified via rare coding variation in 62,429 individuals
253 genes linked to autism may also affect other conditions
This meta-analysis of exome sequencing data from over 1.5 million individuals identified 253 autism-associated genes and 497 genes impacting…
A massive genetic study found 253 autism-linked genes, many tied to other brain and body conditions, opening new paths for understanding.
Exercise may stabilize neuroprotective biomarkers and improve immunometabolic profiles in patients with epilepsy
Exercise May Help Protect Brain Health in People with Epilepsy
This narrative review explores the impact of exercise on fluid biomarkers including S100β, GFAP, and NfL in epilepsy. The authors suggest th…
New research suggests that regular exercise may help stabilize brain proteins and protect nerve cells in people living with epilepsy.
Depressive symptoms affect 40% and anxiety 36% of adults with epilepsy
Depression and anxiety common in epilepsy
This meta-analysis of cross-sectional studies found that depressive symptoms occur in 40% and anxiety symptoms in 36% of adults with epileps…
About 40% of adults with epilepsy screen positive for depression and 36% for anxiety, a new meta-analysis finds.
Questions about focal epilepsy
Are there specific diagnoses for children with genetic focal epilepsy?
Yes, children with genetic focal epilepsy often have specific diagnoses based on the exact gene mutation found, such as SCN1A or PCDH19, which also predict early onset and developmental delays.
Full answer →Do genetic mutations cause earlier onset in children with focal epilepsy?
Yes, certain genetic mutations are linked to earlier seizure onset in children with focal epilepsy, with some variants associated with onset in the first months of life.
Full answer →