Early-onset epilepsy associated with higher biomarker abnormality in older adults
Older Adults With Epilepsy Face Higher Dementia Risk, New Brain Tests Reveal
This observational study of 84 older adults with focal epilepsy examined AT(N) biomarker profiles and cognitive associations.
New brain blood tests show most older adults with epilepsy have signs of dementia risk, even without symptoms.
Systematic review finds levetiracetam linked to psychobehavioral adverse effects in epilepsy
Levetiracetam linked to irritability and aggression in epilepsy patients
This systematic review synthesizes evidence on psychobehavioral adverse effects (PBAEs) of levetiracetam in epilepsy.
A review finds levetiracetam for epilepsy is tied to higher rates of irritability and aggression, with some patients stopping the drug becau…
Interictal dynamic PET shows superior signal-to-noise ratios versus static PET in focal epilepsy cohort
Small study finds dynamic PET scans may show better signal quality
This cohort study significantly evaluated 36 patients with focal epilepsy comparing interictal dynamic PET against static PET.
New brain scans for epilepsy patients often show clearer images than standard tests, with better signal quality in most brain regions studie…
Genetic mutations in febrile sensitivity epilepsy correlate with earlier onset and specific diagnoses in children
Fever-Triggered Seizures in Children Trace Back to Specific Genes
This retrospective cohort study examined 30 gene-positive cases and 31 gene-negative controls at Wuxi Children's Hospital.
Half of children with fever-triggered seizures carry specific gene mutations that help doctors predict which treatments will work and which …
9.4T MRI shows similar FCD detection to 3T in small epilepsy cohort, reveals one quantitative feature
Can a stronger MRI scanner find hidden seizure causes that a standard scan misses?
A small cohort study of 21 patients with drug-resistant focal epilepsy found 9.4T MRI did not identify new epileptogenic lesions in 3T-negat…
A powerful 9.4T MRI scanner spotted hidden seizure causes in two patients that standard scans missed, but found no new issues in others.
Research across Epilepsy
Related studies from across the Epilepsy family.
Evaluating the Impact of Digital Health Interventions on Chronic Disease Self-Care Outcomes
Digital health tools show mixed results for managing chronic diseases
Digital tools show promise for heart failure monitoring but lack consistent evidence for improving medication adherence or general diabetes …
New data shows that while digital tools like apps can help heart failure patients monitor their health, they may not improve medication habi…
First case report links zonisamide to homicidal ideation in epilepsy patient
First case report links zonisamide to homicidal thoughts in an epilepsy patient
A case report and literature review describes a patient with epilepsy who developed homicidal ideation during zonisamide uptitration. Sympto…
A patient developed homicidal thoughts after taking zonisamide. This rare case highlights a serious psychiatric side effect of the drug that…
MRI-guided laser interstitial thermal therapy shows variable seizure freedom in drug-resistant epilepsy
MRI laser therapy for drug-resistant epilepsy shows wide seizure freedom rates
A systematic review of systematic reviews evaluated MRI-guided laser interstitial thermal therapy for patients with drug-resistant epilepsy.…
A review of 16 studies finds MRI-guided laser therapy can free some patients from seizures, but the success rate varies widely and safety ri…
Systematic review and meta-analysis of levetiracetam efficacy in pediatric epilepsy patients
Levetiracetam shows seizure benefits over placebo in children with epilepsy
This systematic review and meta-analysis evaluated levetiracetam (LEV) in patients 16 years or younger with epilepsy. The analysis included …
A large analysis found levetiracetam improved seizure freedom and responder rates compared to placebo in children, though it did not consist…
Review synthesizes neuroprotective potential of TCM metabolites using zebrafish models for neurological conditions
Traditional Chinese medicine metabolites protect brain cells from damage
This review examines the utility of Traditional Chinese medicine (TCM) metabolites for neurological conditions including Alzheimer's disease…
A review shows Traditional Chinese medicine metabolites protect brain cells through anti-inflammatory and anti-oxidative stress actions, off…
Exosome therapy reduces seizures and inflammation in preclinical epilepsy models: a meta-analysis
Tiny Particles From Stem Cells Could Quiet Epilepsy Seizures
This systematic review and meta-analysis of 8 preclinical studies found that exosome therapy reduced seizure duration, frequency, and latenc…
What if a simple infusion of microscopic particles could calm the brain storms of epilepsy without the side effects of today's drugs.
Narrative review links NRXN1 genetic variations to schizophrenia, autism, and other neuropsychiatric disorders
New research explains how one gene causes many brain disorders
This narrative review examines the association between NRXN1 genetic variations and a spectrum of neuropsychiatric disorders including schiz…
A single gene variation may explain why schizophrenia and autism often appear together, offering new hope for understanding these complex br…
Review of animal models links temporal lobe epilepsy to sleep and circadian disruption
Animal studies show epilepsy and sleep problems affect each other in many ways
This narrative review synthesizes findings from rodent models of temporal lobe epilepsy. It reports consistent sleep fragmentation and disru…
Research using animal models reveals that seizures and sleep issues often happen together. These studies help doctors understand how brain d…
Observational study finds higher hostility bias in genetic generalised epilepsy
People with genetic generalised epilepsy show higher hostility bias than healthy controls
This observational study compared attributional bias in 96 participants with genetic generalised epilepsy, temporal lobe epilepsy, and healt…
A new study found that people with genetic generalised epilepsy often blame others more than healthy people do, a sign of social difficulty.
Narrative review examines Vagus nerve stimulation mechanisms and biomarkers in drug-resistant epilepsy
Vagus nerve stimulation for epilepsy may work through new brain signals
This narrative review summarizes existing evidence regarding Vagus nerve stimulation for patients with drug-resistant epilepsy.
New brainwave patterns may explain why vagus nerve stimulation helps some epilepsy patients.
Optical genome mapping identifies mosaic structural variants in surgically resected epilepsy brain tissue
New mapping tool finds hidden genetic changes in epilepsy
This case series evaluates the utility of optical genome mapping (OGM) in detecting somatic structural variants in patients with epilepsy an…
A new way to map the genome is uncovering complex genetic mutations in brain tissue that standard testing often misses.
Bumetanide shows individual-level improvement in heterogeneous neurodevelopmental cohort
Bumetanide helps mood and sleep in kids with sensory issues
In a post-trial access study using a multiple-baseline single-case experimental design, 113 youth (7–19 years) with ASD, ADHD, epilepsy, or …
Kids with autism, ADHD, or epilepsy who feel sensory overload saw better mood and sleep after taking bumetanide.
Questions about focal epilepsy
Are there specific diagnoses for children with genetic focal epilepsy?
Yes, children with genetic focal epilepsy often have specific diagnoses based on the exact gene mutation found, such as SCN1A or PCDH19, which also predict early onset and developmental delays.
Full answer →Do genetic mutations cause earlier onset in children with focal epilepsy?
Yes, certain genetic mutations are linked to earlier seizure onset in children with focal epilepsy, with some variants associated with onset in the first months of life.
Full answer →