HMGB1 acts as a progression-associated inflammatory amplifier in Alzheimer's, Parkinson's, and ALS models
New research explores a protein linked to several brain diseases
This narrative review explores the role of HMGB1 in various neurodegenerative diseases including Alzheimer's, Parkinson's, and ALS. The auth…
A specific protein called HMGB1 may act as a driver of inflammation in conditions like Alzheimer's and Parkinson's disease.
Diabetes mellitus acts as a context-dependent modifier of risk and phenotype in neurological disorders
Diabetes May Influence Risk and Progress of Neurological Disorders
This narrative review synthesizes evidence regarding the role of diabetes mellitus (DM) as a disease modifier across various neurological co…
New research suggests that diabetes can change how certain neurological conditions progress, potentially opening doors for new treatment opt…
Systematic review and meta-analysis of retinal biomarkers in frontotemporal dementia and Alzheimer disease
Retinal scans show thinner layers in frontotemporal dementia than Alzheimer disease
This systematic review and meta-analysis synthesized optical coherence tomography data on retinal biomarkers in frontotemporal dementia, Alz…
A new analysis of retinal scans found that people with frontotemporal dementia have thinner eye layers than those with Alzheimer disease or …
Plasma proteomics profiling reveals differential protein expression in Alzheimer's and frontotemporal dementia
Can a simple blood test tell Alzheimer's from frontotemporal dementia?
An observational cohort study of 101 Asian individuals with known pTau217 status used plasma proteomics profiling to identify 1,168 proteins…
A simple blood test could distinguish Alzheimer's from frontotemporal dementia by spotting unique protein patterns linked to brain inflammat…
Mini-review synthesizes dementia risk and cognitive trajectories in individuals with schizophrenia
Do people with schizophrenia face a higher risk of dementia, and what does that mean for their care?
This mini-review examines the relationship between schizophrenia and dementia, covering Alzheimer's disease, vascular dementia, and other fo…
People with schizophrenia face a two- to threefold higher risk of dementia, but it's not a direct path to Alzheimer's—brain development, agi…
Research across Dementia
Related studies from across the Dementia family.
Higher GrimAge epigenetic age acceleration is significantly associated with higher dementia risk
GrimAge metric shows link to increased risk of dementia
This meta-analysis of 46,365 individuals with neurodegenerative diseases found that only the GrimAge metric showed a significant association…
One specific biological age clock, known as GrimAge, showed a link to higher dementia risk in a large study of over 46,000 people.
Social isolation and loneliness are significant determinants of cognitive decline and dementia risk in older adults
Social isolation and loneliness increase risk of dementia in older adults
This systematic review examines the impact of social isolation and loneliness on cognitive decline and dementia risk in older adults. The au…
Loneliness and social isolation are linked to faster cognitive decline and a higher risk of dementia in older adults.
Chronic pain is associated with poorer executive functioning and processing speed in dementia patients
Chronic pain is linked to poorer thinking in people with dementia
This systematic scoping review explores the relationship between chronic pain and cognitive performance in individuals with dementia. The re…
Living with chronic pain may make it harder for people with dementia to manage tasks and process information quickly.
HMB and vitamin D enriched protein supplements may support muscle and cognitive health in dementia
Nutrition Drink May Help Muscles In Dementia Patients
This narrative review examines the role of high protein oral nutritional supplements enriched with HMB and vitamin D for older adults at ris…
A high protein drink with HMB and vitamin D may support muscle health in older adults with dementia, but brain benefits remain unproven.
Mesenchymal stromal cells and MSC-derived extracellular vesicles may reprogram neuroimmune responses in neurodegenerative diseases
Stem cells and vesicles show potential for neurodegenerative diseases
This critical review examines the mechanisms and translational barriers of mesenchymal stromal cells (MSCs) and MSC-derived extracellular ve…
New research explores how stem cell products might protect the brain and repair blood-brain barriers in diseases like Parkinson's and Alzhei…
HRSN assessment tools lack sufficient psychometric testing and reliability data for geriatric populations
New Review Highlights Gaps in Alzheimer's and Dementia Care Tools
This systematic review of 7 studies evaluated the methodological rigor and psychometric properties of HRSN assessment tools in older adults.…
Current tools used to measure social needs for seniors with dementia lack enough testing to ensure they are accurate for older adults.
Scoping review protocol to map living arrangement and carer variables in dementia help-seeking research
Mapping How Living Arrangements Affect Help Seeking for Dementia
This is a scoping review protocol, not a completed study, that will map how living arrangement and supporter or carer related variables are …
New research plans to map how living situations and family support impact how people with memory problems seek a diagnosis for dementia.
Impact of Receptor Stimulating Antihypertensive Medications on Alzheimer Disease Risk in Elderly Patients
Certain blood pressure medications may link to lower dementia risk
Retrospective analysis suggests receptor-stimulating antihypertensives may correlate with lower ADRD incidence compared to receptor-inhibiti…
A large study of over 1.5 million seniors suggests specific blood pressure medications may be linked to lower rates of dementia and cognitiv…
Comprehensive dementia care interventions improve caregiver self-efficacy in those with lower baseline scores
Comprehensive Care Programs May Improve Confidence for Dementia Caregivers
This secondary analysis of a randomized pragmatic clinical trial involved 2037 caregivers of community-dwelling persons living with dementia…
Caregivers of people with dementia can improve their self-efficacy and confidence through comprehensive care programs.
Non-pharmacological interventions for sleep disturbances in mild cognitive impairment and early dementia provide management guidance
Sleep Care Plan for Early Dementia: Best Evidence
This integrative review and guideline identifies 44 evidence items across 11 themes for managing sleep disturbances in patients with mild co…
A new review maps 44 best evidence items for managing sleep problems in mild cognitive impairment and early dementia.
Impact of Domain Specific Physical Activity on Risk of All Cause Dementia
High levels of physical activity linked to lower dementia risk
A massive meta-analysis of over 4 million participants reveals that specific types of physical activity significantly influence dementia ris…
Active lifestyles, especially during leisure time, are linked to a lower risk of developing Alzheimer's and other forms of dementia.
Increased Risk of Dementia Diagnosis Among Individuals Diagnosed With Bipolar Disorder
Bipolar disorder linked to triple dementia risk
A large-scale meta-analysis identifies a significant correlation between bipolar disorder and an elevated risk of dementia diagnosis.
People with bipolar disorder face a higher risk of dementia, a new analysis finds. The link is strong but the evidence has limits.
Questions about Frontotemporal dementia
How does the progression of frontotemporal dementia compare to Alzheimer's disease?
Frontotemporal dementia tends to progress faster than Alzheimer's disease, with shorter survival and quicker cognitive and functional decline, though symptoms and patterns differ.
Full answer →Are there specific retinal changes seen in frontotemporal dementia patients?
Yes. Studies show FTD is linked to thinning of specific retinal layers, especially the nerve fiber layer and ganglion cell layer, though these changes are not yet unique enough to diagnose FTD on their own.
Full answer →Is there a difference in protein expression in frontotemporal dementia patients?
Research shows that patients with frontotemporal dementia (FTD) exhibit distinct patterns of protein expression, particularly in the blood and in response to inflammation.
Full answer →Are there specific retinal biomarkers used to identify frontotemporal dementia?
Research suggests retinal thinning on OCT scans may be a non-invasive marker in frontotemporal dementia, but no retinal biomarker is yet specific enough to diagnose FTD on its own.
Full answer →