Diabetes mellitus acts as a context-dependent modifier of risk and phenotype in neurological disorders
Diabetes May Influence Risk and Progress of Neurological Disorders
This narrative review synthesizes evidence regarding the role of diabetes mellitus (DM) as a disease modifier across various neurological co…
New research suggests that diabetes can change how certain neurological conditions progress, potentially opening doors for new treatment opt…
Systematic review and meta-analysis of retinal biomarkers in frontotemporal dementia and Alzheimer disease
Retinal scans show thinner layers in frontotemporal dementia than Alzheimer disease
This systematic review and meta-analysis synthesized optical coherence tomography data on retinal biomarkers in frontotemporal dementia, Alz…
A new analysis of retinal scans found that people with frontotemporal dementia have thinner eye layers than those with Alzheimer disease or …
Plasma proteomics profiling reveals differential protein expression in Alzheimer's and frontotemporal dementia
Can a simple blood test tell Alzheimer's from frontotemporal dementia?
An observational cohort study of 101 Asian individuals with known pTau217 status used plasma proteomics profiling to identify 1,168 proteins…
A simple blood test could distinguish Alzheimer's from frontotemporal dementia by spotting unique protein patterns linked to brain inflammat…
Mini-review synthesizes dementia risk and cognitive trajectories in individuals with schizophrenia
Do people with schizophrenia face a higher risk of dementia, and what does that mean for their care?
This mini-review examines the relationship between schizophrenia and dementia, covering Alzheimer's disease, vascular dementia, and other fo…
People with schizophrenia face a two- to threefold higher risk of dementia, but it's not a direct path to Alzheimer's—brain development, agi…
Research across Dementia
Related studies from across the Dementia family.
Comprehensive dementia care interventions improve caregiver self-efficacy in those with lower baseline scores
Comprehensive Care Programs May Improve Confidence for Dementia Caregivers
This secondary analysis of a randomized pragmatic clinical trial involved 2037 caregivers of community-dwelling persons living with dementia…
Caregivers of people with dementia can improve their self-efficacy and confidence through comprehensive care programs.
Non-pharmacological interventions for sleep disturbances in mild cognitive impairment and early dementia provide management guidance
Sleep Care Plan for Early Dementia: Best Evidence
This integrative review and guideline identifies 44 evidence items across 11 themes for managing sleep disturbances in patients with mild co…
A new review maps 44 best evidence items for managing sleep problems in mild cognitive impairment and early dementia.
Impact of Domain Specific Physical Activity on Risk of All Cause Dementia
High levels of physical activity linked to lower dementia risk
A massive meta-analysis of over 4 million participants reveals that specific types of physical activity significantly influence dementia ris…
Active lifestyles, especially during leisure time, are linked to a lower risk of developing Alzheimer's and other forms of dementia.
Increased Risk of Dementia Diagnosis Among Individuals Diagnosed With Bipolar Disorder
Bipolar disorder linked to triple dementia risk
A large-scale meta-analysis identifies a significant correlation between bipolar disorder and an elevated risk of dementia diagnosis.
People with bipolar disorder face a higher risk of dementia, a new analysis finds. The link is strong but the evidence has limits.
Dementia prevalence 24.3% in older adults with psychotic disorders, meta-analysis finds
Dementia found in 1 in 4 older adults with psychotic disorders
This meta-analysis of older adults with psychotic disorders reports a pooled dementia prevalence of 24.3% (95% CI: 20.5%-28.5%), with high h…
A new analysis finds dementia in 24.3% of older adults with psychotic disorders, highlighting the need for better care planning.
Animal-assisted interventions improve depression in dementia, but not other outcomes
Animal interactions may help ease depression in people with dementia
This overview of systematic reviews and meta-analyses found moderate evidence that animal-assisted interventions (AAIs) improve depression i…
Interacting with animals can significantly improve feelings of depression for people living with dementia, according to a review of recent r…
Prolonged FVEP-P2 latency is associated with Alzheimer's disease and other forms of dementia
Brain Signal Delays Linked to Alzheimer's and Dementia Types
This meta-analysis of 18 comparisons involving 1,778 participants found significantly prolonged FVEP-P2 latency in patients with Alzheimer's…
A large review found that specific brain signal delays are linked to Alzheimer's disease and other forms of cognitive decline.
Person-centered non-pharmacological interventions significantly reduce verbal agitation in patients with dementia
Personalized care helps reduce agitation in people with dementia
This meta-analysis of randomized controlled trials evaluates the impact of person-centered non-pharmacological interventions on agitation in…
Tailored, person-centered care can significantly lower verbal agitation in people living with dementia compared to standard methods.
SGLT2 inhibitors significantly reduce dementia risk in patients with type 2 diabetes
Diabetes drugs may lower dementia risk, study finds
This network meta-analysis involving 845,433 participants analyzed the impact of SGLT2 inhibitors on dementia outcomes in patients with type…
A large analysis of over 845,000 people with type 2 diabetes found that certain diabetes drugs, especially empagliflozin, were linked to a l…
Gabapentinoid use is associated with modestly higher odds of Alzheimer's disease and related dementias
Reviewing the Link Between Gabapentin Use and Risk of Developing Dementia
This meta-analysis of 325,245 individuals found that gabapentinoid use was associated with modestly higher odds of Alzheimer's disease and r…
A large review looked at how gabapentin and pregabalin affect brain health. Some findings suggest a possible link to dementia.
Diabetic retinopathy is associated with a significantly higher risk of all-cause dementia
Diabetic retinopathy is linked to a higher risk of dementia
This meta-analysis of observational studies involving 2,887,409 patients found that diabetic retinopathy is associated with an increased ris…
A large analysis shows people with diabetic retinopathy may face an increased risk of developing dementia, highlighting the need for closer …
Elevated neutrophil-to-lymphocyte ratio correlates with greater cerebral small vessel disease burden and white matter hyperintensities
High Neutrophil Levels Linked to Brain Small Vessel Damage
This systematic review and meta-analysis of 62,961 patients found that elevated neutrophil-to-lymphocyte ratio (NLR) is associated with the …
A large analysis finds that higher neutrophil-to-lymphocyte ratios are linked to more severe damage in the brain's small blood vessels.