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Home › Conditions › Gastroparesis

Gastroparesis

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Gastroparesis

23 trials tracked for Gastroparesis: 4 in phase 3 or 4 and 2 with published results. The most-cited published study has 242 citations.

23Trials tracked
4Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 2 Phase 3 2 Phase 2 12 Phase 1 1 Other / NA 6
  1. Phase 4 Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy Completed · 242 cited
  2. Phase 4 Pharmacokinetics of Immediate-Release vs. Delayed-Release Omeprazole in Gastroparesis Completed · 4 cited
  3. Phase 3 Sancuso® for Gastroparesis: An Open Label Study. Completed
  4. Phase 3 Temporary Gastric Electrical Stimulation for Drug Refractory Gastroparesis Completed
  5. Phase 2 Dose Response of 28 Days of Dosing of GSK962040 in Type I and II Diabetic Male and Female Subjects With Gastroparesis Completed
  6. Phase 2 A Study to Assess the Effect of Repeat Doses of GSK962040 on the Pharmacokinetics of L-DOPA in Subjects With Parkinson's Disease Exhibiting Delayed Gastric Emptying Completed
Show 17 more trials
  1. Phase 2 Efficacy and Safety of Cannabidiol for Gastroparesis and Functional Dyspepsia Completed
  2. Phase 2 A Study of CNSA-001 in Women With Diabetic Gastroparesis Completed
  3. Phase 2 A Pilot Study of Hemin Therapy for Gastroparesis (Diabetes Mellitus) Completed
  4. Phase 2 Safety and Efficacy of Relamorelin Administered to Participants With Vomiting Symptoms and Moderate to Severe Diabetic Gastroparesis Completed
  5. Phase 2 Buspirone for Early Satiety and Symptoms of Gastroparesis Completed
  6. Phase 2 Safety, PK and Efficacy of PCS12852 on Gastric Emptying Rate in Patients With Moderate to Severe Gastroparesis Completed
  7. Phase 2 Aprepitant for the Relief of Nausea in Patients With Chronic Nausea and Vomiting of Presumed Gastric Origin Trial Completed
  8. Phase 2 Study to Assess the Efficacy of VLY-686 in Relieving Symptoms of Gastroparesis Completed
  9. Phase 2 Efficacy and Safety of Metoclopramide Nasal Spray Solution in Diabetic Patients With Gastroparesis Completed
  10. Phase 2 A Study to Evaluate the Effect of Camicinal on Gastroparesis Symptoms in Type 1 and 2 Diabetic Subjects With Gastroparesis Completed
  11. Phase 1 Pioglitazone for Idiopathic Gastroparesis Completed
  12. N/A Non-invasive Vagal Nerve Stimulation (nVNS) for Symptomatic Exacerbation of Nausea in Patients With Gastroparesis and Related Disorders Completed
  13. N/A Effect of Vibrant Capsule on Gastric Emptying and Antropyloroduodenal Motility in Healthy Volunteers Completed
  14. N/A Placebo Controlled Trial of Botulinum Toxin for Gastroparesis Completed
  15. N/A GEBT Telehealth Administration Usability Study Completed
  16. N/A Magnetically Controlled Capsule Endoscopy Feasibility Study in Gastric Motility Completed
  17. N/A Impact of KUVAN® on Gastric Relaxation in Women With Diabetic Gastroparesis. Completed

Showing the 23 most-cited and recently-updated of 23 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Gastroparesis: what the trials found

Several interventions have been established for the management of gastroparesis. GLP-1 medication has been evaluated in a Phase 4 trial 2, and the use of immediate-release omeprazole is also documented in Phase 4 evidence 3.

Pharmacological options include Sancuso®, which demonstrated statistically significant improvements in both total composite symptom scores (p<0.01) and gastrointestinal nausea and vomiting symptom index scores (p<0.01) 4. Additionally, the Gastric Electrical Stimulator (Enterra, Medtronics, Inc.) has been utilized in Phase 3 clinical trials 5.

Recent results — preliminary, needs further review

  • Magnetically Controlled Capsule Endoscopy is currently being investigated in a new trial 1.

For the clinician treating this condition

  • Established options for gastroparesis include GLP-1 medications, immediate-release omeprazole, and the Gastric Electrical Stimulator (Enterra) [2, 3, 5].
  • Sancuso® has shown statistically significant improvements in both overall symptom scores and specific nausea/vomiting indices 4.

AI synthesis of 5 cited trials, updated Jun 24, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Same-day discharge after G-POEM for gastroparesis shows no difference in readmission rates
Primary Care & Family Medicine Meta-analysis
Same-day discharge after G-POEM for gastroparesis shows no difference in readmission rates Same-day discharge after G-POEM shows shorter procedure time without more readmissions
This systematic review and meta-analysis compared same-day discharge (SDD) versus overnight admission after G-POEM for gastroparesis.
A new analysis finds patients can go home the same day after G-POEM surgery with fewer complications and no higher risk of returning to the …
May 1, 2026
G-POEM shows 63.5% clinical success at 6 months for refractory gastroparesis after esophagectomy
ENT (Otolaryngology)
G-POEM shows 63.5% clinical success at 6 months for refractory gastroparesis after esophagectomy Can a new procedure help when the stomach won't empty after cancer surgery?
A multicenter retrospective cohort study of 108 patients with refractory gastroparesis following esophagectomy found that gastric peroral en…
A new scope procedure helped half of patients with severe stomach emptying problems after cancer surgery feel significantly better within si…
Apr 3, 2026