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Home › Conditions › Glioblastoma multiforme

Glioblastoma multiforme

Part of Glioma

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Glioblastoma multiforme

60 trials tracked for Glioblastoma multiforme: 1 in phase 3 or 4.

60Trials tracked
1Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 3 1 Phase 2 52 Phase 1 4 Other / NA 3
  1. Phase 3 Study of Imatinib Mesylate in Combination With Hydroxyurea Versus Hydroxyurea Alone as an Oral Therapy in Patients With Temozolomide Resistant Progressive Glioblastoma Completed
  2. Phase 2 Enzastaurin Before and Concomitant With Radiation, Followed by Enzastaurin in Participants With Newly Diagnosed Glioblastoma Completed
  3. Phase 2 Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab Completed
  4. Phase 2 A Study of Bevacizumab and Extended Treatment of Temozolomide in Patients With Recurrent Glioblastoma Multiforme Completed
  5. Phase 2 Temozolomide Chronotherapy for High Grade Glioma Completed
  6. Phase 2 Hypofractionated Intensity-Modulated Radiation Therapy With Temozolomide and Bevacizumab for Glioblastoma Multiforme Completed
Show 44 more trials
  1. Phase 2 FET-PET for Evaluation of Response of Recurrent GBM to Avastin Completed
  2. Phase 2 Convection-Enhanced Delivery (CED) of MDNA55 in Adults With Recurrent or Progressive Glioblastoma Completed
  3. Phase 2 A Study of Avastin (Bevacizumab) and Irinotecan Versus Temozolomide Radiochemistry in Patients With Glioblastoma Completed
  4. Phase 2 Bevacizumab and Temozolomide Following Radiation and Chemotherapy for Newly Diagnosed Glioblastoma Multiforme Completed
  5. Phase 2 Phase 1-2 of Temozolomide and Hypofractionated Radiotherapy in Tx of Supratentorial Glioblastoma Multiform Completed
  6. Phase 2 Phase 1/2 Study of Enzastaurin in Newly Diagnosed Glioblastoma Multiforme (GBM) and Gliosarcoma (GS) Patients Completed
  7. Phase 2 A Study of ICT-107 Immunotherapy in Glioblastoma Multiforme (GBM) Completed
  8. Phase 2 Radiation Therapy and Temozolomide Followed by Temozolomide Plus Sorafenib for Glioblastoma Multiforme Completed
  9. Phase 2 Safety and Efficacy Study of SL-701, a Glioma-Associated Antigen Vaccine To Treat Recurrent Glioblastoma Multiforme Completed
  10. Phase 2 PPX and Concurrent Radiation for Newly Diagnosed Glioblastoma Without MGMT Methylation Completed
  11. Phase 2 Cilengitide (EMD 121974) for Recurrent Glioblastoma Multiforme (Brain Tumor) Completed
  12. Phase 2 Thalidomide and Temozolomide or Camptothecin-11 (CPT-11) in Patients With Gliomas Completed
  13. Phase 2 Bevacizumab in Combination With Metronomic Temozolomide for Recurrent Malignant Glioma Completed
  14. Phase 2 A Study of Avastin (Bevacizumab) And Fotemustine in Patients With Recurrent Glioblastoma Completed
  15. Phase 2 Efficacy, Safety and CNS Exposure of G-202 (Mipsagargin) in Patients With Recurrent or Progressive Glioblastoma Completed
  16. Phase 2 Study to Assess Safety, Pharmacokinetics, and Efficacy of Oral CC-223 for Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma or Multiple Myeloma Completed
  17. Phase 2 Repeated Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Newly Diagnosed GBM Completed
  18. Phase 2 Oral Tarceva Study for Recurrent/Residual Glioblastoma Multiforme and Anaplastic Astrocytoma Completed
  19. Phase 2 Combination of BKM120 and Bevacizumab in Refractory Solid Tumors and Relapsed/Refractory Glioblastoma Multiforme Completed
  20. Phase 2 Study of Sacituzumab Govitecan-hziy (IMMU-132) in Adults With Epithelial Cancer Completed
  21. Phase 2 Avastin/Temozolomide/Irinotecan for Unresectable/Multifocal Glioblastoma Multiforme Completed
  22. Phase 2 Zactima With Temodar During Radiation Treatment for Newly Diagnosed Stage IV Brain Tumors Completed
  23. Phase 2 Study of IDO Inhibitor and Temozolomide for Adult Patients With Primary Malignant Brain Tumors Completed
  24. Phase 2 A Phase 2 Evaluation of TRC105 In Combination With Bevacizumab in Patients With Glioblastoma Completed
  25. Phase 2 A Randomized Phase II Trial of Vandetanib (ZD6474) in Combination With Carboplatin Versus Carboplatin Alone Followed by Vandetanib Alone in Adults With Recurrent High-Grade Gliomas Completed
  26. Phase 2 Amgen 386 for Recurrent Glioblastoma Completed
  27. Phase 2 DC Migration Study for Newly-Diagnosed GBM Completed
  28. Phase 2 Study of XL184 (Cabozantinib) in Adults With Glioblastoma Multiforme Completed
  29. Phase 2 A Study of MEDI-575 in Subjects With Recurrent Glioblastoma Multiforme Completed
  30. Phase 2 BrUOG 263: Prostate Specific Membrane Antigen (PSMA) Glioblastoma Multiforme (GBM) Completed
  31. Phase 2 Phase I/II Evaluation of Temozolomide and ZARNESTRA (R115777) for Recurrent and Progressive Glioblastoma Multiforme Completed
  32. Phase 2 RT, Temozolomide, and Bevacizumab Followed by Bevacizumab/Everolimus in First-line Treatment of GBM Completed
  33. Phase 2 Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma Completed
  34. Phase 2 6-TG, Capecitabine and Celecoxib Plus TMZ or CCNU for Anaplastic Glioma Patients Completed
  35. Phase 2 Safety and Efficacy Study of Tarceva, Temodar, and Radiation Therapy in Patients With Newly Diagnosed Brain Tumors Completed
  36. Phase 2 Vaccine Therapy for the Treatment of Newly Diagnosed Glioblastoma Multiforme Completed
  37. Phase 2 Temozolomide Alone or in Combination With Thalidomide and/or Isotretinoin and/or Celecoxib in Treating Patients Who Have Undergone Radiation Therapy for Glioblastoma Multiforme Completed
  38. Phase 2 Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma Completed
  39. Phase 2 Phase II Feasibility Study of Dendritic Cell Vaccination for Newly Diagnosed Glioblastoma Multiforme Completed
  40. Phase 2 Phase I/II Study To Test The Safety and Efficacy of TVI-Brain-1 As A Treatment For Recurrent Grade IV Glioma Completed
  41. Phase 2 Border Zone Stereotactic Radiosurgery With Bevacizumab in Patients With Glioblastoma Multiforme Completed
  42. Phase 2 Phase 2a Study of CAN-2409 With Standard Radiation Therapy for Malignant Glioma Completed
  43. Phase 2 Study To Test the Safety and Efficacy of TVI-Brain-1 As A Treatment for Recurrent Grade IV Glioma Completed
  44. Phase 2 Disulfiram/Copper With Concurrent Radiation Therapy and Temozolomide in Patients With Newly Diagnosed Glioblastoma Completed

Showing the 50 most-cited and recently-updated of 60 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Glioblastoma multiforme: what the trials found

In a phase 3 trial, imatinib mesylate showed limited efficacy in glioblastoma multiforme, with progression-free survival rates of 5.3%, 6.6%, 2.1%, and 2.1% during the study duration 1.

A phase 2 trial of temozolomide reported grade 3 or 4 lymphopenia (2 patients), thrombocytopenia (0), neutropenia (1), leukopenia (0), and anemia (0 in one group; 1 in another) 2. Quality of life changes were also assessed, with physical well-being scores ranging from 4.00 to 8.32 and social/family well-being scores from 22.45 to 24.29 2.

Recent results — preliminary, needs further review

  • A phase 2 trial of pp65-shLAMP DC with GM-CSF reported no significant improvement in overall survival (16.9 vs 16.2 vs 20.6 months, p=0.196) or progression-free survival (6.1 vs 6.4 vs 7.1 months, p=0.354), but a significant difference in ELISPOT assay (126.3 vs 48.4 vs -162.7, p=0.038) 4.
  • A phase 2 trial of valproic acid showed improved 1-year event-free survival (12 vs 24 events, p<0.05) but grade 3 thrombocytopenia (1%) and neutropenia (3%) were noted 18.
  • A phase 2 trial of unpulsed DCs reported median overall survival of 16, 20, and 19 months (p=0.072) and a significant difference in dendritic cell migration to lymph nodes (6.0% vs 9%, p=0.0195) 16.
  • A phase 2 trial of SL-701 with poly-ICLC reported overall survival at 12 months (20 vs 14 patients) and progression-free survival at 6 and 12 months (1.9 vs 5.6 months) 10.
  • A phase 2 trial of topotecan reported progression-free survival at 6 months for bevacizumab-naive patients (0.44) and at 3 months for prior bevacizumab patients (0.18, 0.11, 0) 21.

For the clinician treating this condition

  • Imatinib mesylate demonstrated limited efficacy in glioblastoma, with low progression-free survival rates 1.
  • Temozolomide was associated with manageable hematologic toxicities and variable quality of life outcomes 2.
  • Several phase 2 trials have explored novel agents, but none have yet shown definitive survival benefits in established settings.

AI synthesis of 7 cited trials, updated Jun 27, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Meta-analysis of bevacizumab therapy in recurrent glioblastoma multiforme shows associations with improved outcomes
Oncology Meta-analysis
Meta-analysis of bevacizumab therapy in recurrent glioblastoma multiforme shows associations with improved outcomes Bevacizumab therapy linked to better survival and fewer bleeding risks in recurrent brain cancer
This meta-analysis evaluates bevacizumab (BEV) therapy, temozolomide (TMZ), and lomustine in patients with recurrent glioblastoma multiforme…
A large review of patients with recurrent brain cancer found bevacizumab therapy linked to better survival and fewer bleeding risks compared…
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PINK1 expression quantified by IHC in adults with newly diagnosed IDH-wild type glioblastoma multiforme
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PINK1 expression quantified by IHC in adults with newly diagnosed IDH-wild type glioblastoma multiforme A Simple Brain Tumor Test Could Predict Your Treatment Path
This prospective observational cohort study evaluated PINK1 expression in adults (18+ years) with newly diagnosed IDH-wild type glioblastoma…
A specific protein in glioblastoma tissue could forecast survival odds, helping patients plan care even though the test is not available yet…
medRxiv Apr 10, 2026

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