Network meta-analysis of finerenone and SGLT2 inhibitors in heart failure with preserved or mildly reduced ejection fraction
New analysis shows finerenone and SGLT2 drugs help lower heart failure hospitalization risks for patients with preserved ejection fraction
This network meta-analysis evaluated finerenone, sodium–glucose cotransporter 2 inhibitors, renin–angiotensin system inhibitors, and angiote…
A large review of over 65,000 patients found that finerenone and SGLT2 inhibitors reduce hospital stays and worsening heart failure compared…
Meta-analysis finds conduction system pacing reduces heart failure hospitalizations in HFmrEF
New pacing method cuts hospital stays for heart failure patients with mildly reduced function
This systematic review and meta-analysis of 1867 patients with heart failure with mildly reduced ejection fraction (HFmrEF) found that condu…
A new pacing method reduced hospital visits for heart failure patients with mildly reduced function compared to standard care.
Structured Exercise Training Improves LVEF and LDL-C in HFmrEF Patients After PCI
Heart function improved more with exercise than medicine alone in stable heart disease patients
This single-center randomized trial of 120 stable CAD patients with HFmrEF (LVEF 40-49%) post-PCI found that adding a 52-week structured exe…
A 52-week program of structured exercise plus standard heart medicines helped heart function recover better than medicines alone in patients…
Higher Lactate Dehydrogenase-to-Albumin Ratio Associated With Increased Readmissions and Mortality in Heart Failure
High Blood Marker Tied to Worse Heart Failure Outcomes
This retrospective cohort study included 1,084 hospitalized patients with heart failure with reduced or mildly reduced ejection fraction.
A new blood marker combo can spot heart failure patients most likely to get worse — helping doctors act sooner.
Research across Heart Failure
Related studies from across the Heart Failure family.
Evaluating the Impact of Digital Health Interventions on Chronic Disease Self-Care Outcomes
Digital health tools show mixed results for managing chronic diseases
Digital tools show promise for heart failure monitoring but lack consistent evidence for improving medication adherence or general diabetes …
New data shows that while digital tools like apps can help heart failure patients monitor their health, they may not improve medication habi…
Aprotinin and tranexamic acid show varying efficacy for hemostasis in neonatal cardiac surgery
Trial Shows Aprotinin May Reduce Blood Loss in Infant Heart Surgery
This network meta-analysis of 27 studies involving 4,556 patients evaluated various hemostatic strategies in neonatal and infant cardiac sur…
A large review of 4,556 patients suggests aprotinin may be more effective than other treatments for managing blood loss during infant heart …
High-intensity interval aerobic exercise improves brachial FMD in coronary artery disease and heart failure
High intensity interval training improves blood flow in heart patients
This network meta-analysis of 6,818 adults with coronary artery disease or chronic heart failure found that high-intensity interval aerobic …
Specific types of intense exercise may improve blood vessel function for people living with heart failure or coronary artery disease.
SGLT2 inhibitors provide robust prognostic benefits in heart failure with inconsistent results in post-myocardial infarction settings
SGLT2 inhibitors show promise for heart failure and diabetes
This narrative review examines the cardiovascular and metabolic effects of SGLT2 inhibitors, specifically empagliflozin and dapagliflozin. T…
New evidence shows how SGLT2 inhibitors may protect the heart and manage risks for patients with type 2 diabetes and heart failure.
Research in coronary heart disease shows misalignment between investment and clinical guideline priorities
China's heart disease research focuses on bioequivalence, not innovation
This guideline-based research trend analysis of 3,339 publications identifies a significant gap between current research investments and cli…
A review of 3,339 publications shows China's coronary heart disease research heavily emphasizes bioequivalence studies over innovative drug …
Network meta-analysis reveals resistance training offers largest LVEF gains for adult heart failure patients compared to other exercise types
Resistance training shows greatest heart function boost in network analysis
A network meta-analysis of 3,519 adult heart failure patients found resistance training yielded the greatest improvement in left ventricular…
A network meta-analysis of 3,519 heart failure patients found resistance training improved heart function more than other exercise types, wi…
Conduction system pacing improves LVEF and reduces HF hospitalization vs biventricular pacing in heart failure
Conduction system pacing shows promise for heart failure patients
This systematic review and meta-analysis of 7,019 adult HF patients (LVEF ≤ 50%) found that conduction system pacing (CSP) was associated wi…
A meta-analysis of 7,019 heart failure patients suggests conduction system pacing may improve heart function and reduce hospitalizations com…
Systematic review suggests modest risk reduction with SGLT2 inhibitors or ARNIs added to standard therapy in severe heart failure
Moderate evidence supports adding SGLT2 inhibitors to heart failure treatment
This systematic review and network meta-analysis evaluated adding SGLT2 inhibitors or angiotensin receptor-neprilysin inhibitors to neurohor…
A large analysis suggests adding SGLT2 inhibitors may lower risk of death or hospitalization for heart failure, though caution is advised.
Natriuresis-guided diuretic protocols improve fluid removal and shorten hospital stays for acute decompensated heart failure patients compared to standard care approaches in this meta-analysis review
Trial shows natriuresis-guided diuretics help heart failure patients
This systematic review and meta-analysis of 831 patients found that natriuresis-guided diuretic protocols significantly enhanced fluid remov…
A review of 831 patients finds that guiding diuretics by sodium output can increase urine output and shorten hospital stays for acute heart …
Rate of drug concentration rise alters hemodynamic responses and mortality risk in coronary heart disease patients
New analysis shows how fast drug levels change affects patient safety outcomes
This narrative review and theoretical framework synthesizes evidence on rate-dependent pharmacology. It highlights divergent hemodynamic res…
This review explains that how quickly medicine levels rise in the body matters for safety. Fast changes can cause more harm than slow ones, …
Two-lead CRT-D with atrial sensing shows noninferiority versus three-lead systems in heart failure patients
A simpler heart device works as well as the standard three-wire option for heart failure patients
A randomized trial confirms that a two-lead CRT-D capable of atrial sensing is noninferior to a standard three-lead device. Patients receivi…
A two-wire heart device matched the standard three-wire version in keeping patients alive and avoiding hospital visits over one year.
Renal denervation combined with pulmonary vein isolation increases freedom from atrial fibrillation risk in resistant hypertension patients
Renal denervation may help resistant hypertension patients with heart issues
This systematic review and meta-analysis evaluated renal denervation in patients with resistant hypertension. The pooled analysis included 8…
A meta-analysis suggests renal denervation improves heart and sleep markers in patients with resistant hypertension, though larger trials ar…
Questions about heart failure with mildly reduced ejection fraction
Are SGLT2 inhibitors effective for treating heart failure with mildly reduced ejection fraction?
Yes, SGLT2 inhibitors are effective for treating heart failure with mildly reduced ejection fraction, reducing heart failure hospitalizations and improving outcomes.
Full answer →Does finerenone help patients with heart failure with mildly reduced ejection fraction?
Yes, finerenone reduces cardiovascular death and worsening heart failure events in patients with heart failure with mildly reduced ejection fraction, based on a network meta-analysis and the FINEARTS-HF trial.
Full answer →Can structured exercise training improve my heart function in HFmrEF after a stent?
Yes, a 52-week structured exercise program significantly improves LVEF (by about 5%) and reduces LDL cholesterol in HFmrEF patients after PCI, beyond standard medications alone.
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