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Home › Conditions › Influenza

Influenza

Part of Orthomyxoviridae Infections

Subtypes of Influenza

Influenza A(H3N2) 5 Highly Pathogenic Avian Influenza A(H5N1) Virus Infection 1 Influenza-Associated Encephalitis 1 Influenza-Associated Encephalopathy 1 Invasive pulmonary aspergillosis following influenza 1 Avian Influenza A(H5) Infection 0 Influenza B/Victoria Virus Infection 0

61 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Influenza

437 trials tracked for Influenza: 234 in phase 3 or 4 and 60 with published results. The most-cited published study has 919 citations.

437Trials tracked
234Phase 3 & 4
0Recruiting
60With published results
Phase distribution
Phase 4 100 Phase 3 134 Phase 2 127 Phase 1 30 Other / NA 46
  1. Phase 3 A Study of S-033188 (Baloxavir Marboxil) Compared With Placebo or Oseltamivir in Otherwise Healthy Patients With Influenza Completed · 919 cited
  2. Phase 4 T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 3, 2011 Completed · 333 cited
  3. Phase 4 T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) - Year 1, 2009 Completed · 333 cited
  4. Phase 4 T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 2, 2010 Completed · 333 cited
  5. Phase 3 Protective Efficacy of Flublok® Quadrivalent Versus Licensed Inactivated Influenza Vaccine in Adults ≥50 Years of Age Completed · 284 cited
  6. Phase 4 Control of Epidemic Influenza Through a School-based Influenza Vaccination Program Completed · 276 cited
Show 44 more trials
  1. Phase 3 Study of S-033188 (Baloxavir Marboxil) Compared With Placebo or Oseltamivir in Patients With Influenza at High Risk of Influenza Complications Completed · 259 cited
  2. Phase 3 Efficacy, Safety, and Immunogenicity of a Plant-Derived Quadrivalent Virus-Like Particles (VLPs) Influenza Vaccine in Adults Completed · 192 cited
  3. Phase 3 Immunogenicity, Safety, Reactogenicity, Efficacy, Effectiveness and Lot Consistency of FluBlok Completed · 161 cited
  4. Phase 4 Comparison of Immune Responses to Influenza Vaccine In Adults of Different Ages (SLVP015 2007-2017) Completed · 151 cited
  5. Phase 4 Pilot Study in Young Adults to Examine the Kinetics of Changes in the B-cell Repertoire Following TIV Immunization Completed · 142 cited
  6. Phase 3 Safety and Efficacy of H1N1 Vaccines in Children Aged 6 Months to Less Than 10 Years of Age Completed · 141 cited
  7. Phase 3 Study to Assess Efficacy and Safety of Baloxavir Marboxil In Combination With Standard-of-Care Neuraminidase Inhibitor In Hospitalized Participants With Severe Influenza Completed · 135 cited
  8. Phase 3 Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Healthy Pediatric Participants With Influenza-Like Symptoms Completed · 115 cited
  9. Phase 3 Efficacy Study of an Investigational Influenza Vaccine (Vero Cell Derived) to Prevent Culture Confirmed Influenza Infection (CCII) Completed · 100 cited
  10. Phase 3 Study to Evaluate the Safety and Immunogenicity of a Pandemic Influenza Vaccine in Adults Aged 18 Years and Above Completed · 94 cited
  11. Phase 3 Study to Evaluate Immunogenicity and Safety of an Investigational Influenza Vaccine (H1N1) in Adults Completed · 85 cited
  12. Phase 3 Safety and Immunogenicity of High-Dose Quadrivalent Influenza Vaccine in Participants ≥65 Years in the US Completed · 75 cited
  13. Phase 3 Lot-to-lot Consistency of a Plant-Derived Quadrivalent Virus-Like Particles Influenza Vaccine in Healthy Adults Completed · 72 cited
  14. Phase 3 Clinical Study to Evaluate the Safety, Immunogenicity and Efficacy of Investigational Flu Vaccine Compared to Approved Flu Vaccine in Children. Completed · 67 cited
  15. Phase 4 B-cell Immunity to Influenza (SLVP017) - Years 2 (2010) & 3 (2011) Completed · 56 cited
  16. Phase 4 B-cell Immunity to Influenza (SLVP017)- Year 1, 2009 Completed · 56 cited
  17. Phase 3 Safety and Immunogenicity of Flublok Quadrivalent vs IIV4 in Adults 18-49 Years of Age Completed · 56 cited
  18. Phase 4 Effect of Age and Prior Immunity to Response to Seasonal Influenza Vaccines in Children Completed · 51 cited
  19. Phase 4 Comparison of Three Licensed Influenza Vaccines Completed · 51 cited
  20. Phase 3 Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of an MF59-Adjuvanted Quadrivalent Influenza Vaccine Compared to Non-influenza Vaccine Comparator in Adults ≥ 65 Years of Age Completed · 48 cited
  21. Phase 4 Randomized Trial of High Dose Influenza Vaccine in Long Term Care Setting Completed · 45 cited
  22. Phase 4 Immunogenicity Trial of Egg- Versus Non-Egg-Based Influenza Vaccines Among HCP Completed · 45 cited
  23. Phase 4 Rapid Empiric Treatment With Oseltamivir Study (RETOS) Completed · 44 cited
  24. Phase 3 An Efficacy Study of GlaxoSmithKline (GSK) Biologicals' Candidate Influenza Vaccine GSK2321138A in Children Completed · 43 cited
  25. Phase 3 Safety, Immunogenicity, and Relative Efficacy of H1N1 Vaccines in Adults Aged 18 Years and Older Completed · 39 cited
  26. Phase 3 A Study of mRNA-1083 (SARS-CoV-2 and Influenza) Vaccine in Healthy Adult Participants, ≥50 Years of Age Completed · 37 cited
  27. Phase 3 Study to Evaluate the Immunogenicity and Safety of an Investigational Influenza Vaccine (H1N1) in Children Completed · 34 cited
  28. Phase 3 Safety and Immunogenicity Study of GSK Biologicals' Pandemic Influenza Candidate Vaccine (H1N1) (GSK2340272A) Completed · 34 cited
  29. Phase 3 Evaluation of the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Quadrivalent Influenza Vaccine Influsplit™ Tetra (Fluarix™ Tetra) (GSK2321138A) When Co-administered With Pneumovax™ 23 in Adults 50 Years of Age and Older Completed · 32 cited
  30. Phase 3 Immunogenicity and Safety Study of an Inactivated Influenza Vaccine (Split Virus, Vero Cell Derived) in Adults Aged 50 Years and Older Completed · 30 cited
  31. Phase 4 Safety and Immunogenicity of Fluzone® Quadrivalent Vaccine Administered to Healthy Children Completed · 29 cited
  32. Phase 3 Study to Assess the Efficacy of Baloxavir Marboxil Versus Placebo to Reduce Onward Transmission of Influenza A or B in Households Completed · 28 cited
  33. Phase 3 Assess Consistency of Immunogenicity of GlaxoSmithKline Biologicals' Pandemic Influenza Vaccine (GSK1562902A) in Adults Completed · 23 cited
  34. Phase 3 Immunogenicity of GSK Biologicals' Pandemic Influenza Vaccine (GSK1562902A) at Different Boosting Vaccination Schedules Completed · 23 cited
  35. Phase 4 Self-Administered Nasal Influenza Feasibility Study Completed · 22 cited
  36. Phase 4 The Immunogenicity of Simultaneous Administration of Quadrivalent Influenza Vaccine and 23-valent Pneumococcal Vaccine Completed · 20 cited
  37. Phase 3 Study to Evaluate the Immunogenicity & Safety of an Investigational Influenza Vaccine (H1N1) in Adults Completed · 18 cited
  38. Phase 3 Immunogenicity and Safety Study of an Investigational Influenza (H1N1 Influenza Virus) Vaccine in Adults Completed · 18 cited
  39. Phase 4 Safety of LAIV4 in Children With Asthma Completed · 17 cited
  40. Phase 3 Immunogenicity and Safety of a Quadrivalent Influenza Vaccine Given by Intramuscular Route in Subjects Aged 18 to 60 Years Completed · 15 cited
  41. Phase 3 Safety and Immunogenicity Study of QIVc in Healthy Pediatric Subjects Completed · 15 cited
  42. Phase 3 Safety, Reactogenicity and Immunogenicity of Flublok Quadrivalent (Recombinant Influenza Vaccine,Seasonal Formulation) Completed · 14 cited
  43. Phase 4 Study of GSK Biologicals' Influenza Vaccine Arepanrix™ in Japanese Adults 65 Years of Age or Older Completed · 12 cited
  44. Phase 3 Study to Evaluate Immunological Equivalence Between Two Investigational Influenza Vaccines in Adults (H1N1) Completed · 11 cited

Showing the 50 most-cited and recently-updated of 437 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
ACIP Recommends Routine Annual Influenza Vaccination for All Persons Aged 6 Months and Older
Allergy & Immunology
ACIP Recommends Routine Annual Influenza Vaccination for All Persons Aged 6 Months and Older Health officials recommend annual flu shots for nearly everyone age 6 months and older
The Advisory Committee on Immunization Practices (ACIP) has issued recommendations for the prevention and control of seasonal influenza.
Health officials recommend annual flu shots for nearly everyone age 6 months and older to prevent flu illness and serious complications.
CDC Apr 4, 2026
Surveillance report describes influenza-associated encephalopathy or encephalitis in US children
Pediatrics
Surveillance report describes influenza-associated encephalopathy or encephalitis in US children What happens when the flu affects a child's brain? A new report describes cases
A US surveillance report describes cases of influenza-associated encephalopathy or encephalitis in children.
A new report describes cases where the flu virus affected children's brains, causing inflammation of the nervous system during recent flu se…
CDC Apr 4, 2026
Influenza and pertussis cause substantial disease burden in pregnant women and unvaccinated infants
OB/GYN & Women's Health
Influenza and pertussis cause substantial disease burden in pregnant women and unvaccinated infants Influenza and pertussis pose significant health risks to pregnant women and young infants
A review of evidence from the United States describes the disease burden of influenza and pertussis among pregnant women and infants too you…
Flu and whooping cough cause serious sickness in pregnant women and infants too young for vaccines, making protection a top public health pr…
CDC Apr 4, 2026
Influenza and Tdap vaccination coverage among pregnant women in the United States
OB/GYN & Women's Health
Influenza and Tdap vaccination coverage among pregnant women in the United States Report examines flu and whooping cough vaccination rates in pregnant women
An observational report describes influenza and Tdap vaccination coverage among pregnant women in the United States.
A new report examines flu and whooping cough vaccination rates for pregnant women during the 2019-20 season, highlighting the need for more …
CDC Apr 4, 2026
Report examines influenza, Tdap, and COVID-19 vaccination coverage and hesitancy in pregnant women
OB/GYN & Women's Health
Report examines influenza, Tdap, and COVID-19 vaccination coverage and hesitancy in pregnant women How many pregnant women are getting their recommended vaccines?
An observational report from the United States describes influenza, Tdap, and COVID-19 vaccination coverage and hesitancy among pregnant wom…
A new report examines how many pregnant people are getting flu, Tdap, and COVID-19 vaccines and explores reasons behind any hesitation.
CDC Apr 4, 2026
Interim data show 2019-20 flu vaccine reduced doctor visit risk by 45% overall, 55% in children
Pediatrics
Interim data show 2019-20 flu vaccine reduced doctor visit risk by 45% overall, 55% in children How well did this year's flu shot work? Early data shows protection, especially for kids
Preliminary observational estimates from the U.S.
Early data shows this year's flu shot cuts the risk of seeing a doctor for the flu by 45% overall and 55% for children.
CDC Apr 4, 2026
Surveillance report tracks influenza-associated hospitalizations in US children and adults
Pediatrics
Surveillance report tracks influenza-associated hospitalizations in US children and adults U.S. surveillance network tracks influenza hospitalizations in children and adults
A surveillance summary from the US Influenza Hospitalization Surveillance Network (FluSurv-NET) reports on laboratory-confirmed influenza-as…
The U.S. FluSurv-NET tracks hospitalizations for confirmed flu cases in children and adults across seasons from 2010-11 through 2022-23.
CDC Apr 4, 2026
Surveillance report describes influenza-associated pediatric deaths in 2024-25 season
Pediatrics
Surveillance report describes influenza-associated pediatric deaths in 2024-25 season What does this flu season mean for children's safety?
A U.S. surveillance report describes influenza-associated pediatric deaths during the 2024-25 influenza season.
A new report confirms that children have died from influenza during the 2024-25 season, proving the flu remains a serious threat to young li…
CDC Apr 4, 2026
Coinfection with SARS-CoV-2 and influenza studied in hospitalized or deceased pediatric patients
Pediatrics
Coinfection with SARS-CoV-2 and influenza studied in hospitalized or deceased pediatric patients U.S. report examines COVID-19 and flu coinfection in hospitalized children
An observational report examined SARS-CoV-2 and influenza coinfection in children and adolescents aged 18 years who were hospitalized or die…
A U.S. report tracks hospitalized children with both COVID-19 and the flu during the 2021-22 season, though specific results and safety conc…
CDC Apr 4, 2026
ACIP Issues Recommendations for Seasonal Influenza Vaccine Use in 2022-23
Allergy & Immunology
ACIP Issues Recommendations for Seasonal Influenza Vaccine Use in 2022-23 What flu shot should you get this year? Here are the official recommendations
The Advisory Committee on Immunization Practices (ACIP) has published its annual recommendations for seasonal influenza vaccine use in the U…
The 2022-23 flu season has official vaccine recommendations from experts to help you get the best protection against circulating strains.
CDC Apr 4, 2026
CDC Issues Recommendations for Seasonal Influenza Prevention and Control with Vaccines
Allergy & Immunology
CDC Issues Recommendations for Seasonal Influenza Prevention and Control with Vaccines Health officials release updated recommendations for seasonal flu vaccines
The CDC has published recommendations and reports for the prevention and control of seasonal influenza with vaccines in the United States.
CDC releases updated flu vaccine guidance for the upcoming season, advising doctors and the public on who should get vaccinated and when.
CDC Apr 3, 2026
Reference-free computational method identifies spike-specific BCR sequences with over 90% purity in mRNA vaccinees
Allergy & Immunology Cohort
Reference-free computational method identifies spike-specific BCR sequences with over 90% purity in mRNA vaccinees New computational method identifies vaccine-specific immune cells with high precision
An observational methodological study in healthy SARS-CoV-2 mRNA vaccine recipients evaluated a reference-free computational framework (LM-Q…
Researchers developed a computational method to identify immune cells that respond specifically to vaccines.
medRxiv Apr 3, 2026

Research across Orthomyxoviridae Infections

Related studies from across the Orthomyxoviridae Infections family.

mRNA-1010 shows superior efficacy against influenza in older adults
Drug Pipeline RCT
mRNA-1010 shows superior efficacy against influenza in older adults New flu shot cuts illness by 27 percent in adults over 50
A phase 3 trial found mRNA-1010 vaccine had 26.6% relative efficacy versus standard comparator in adults 50+.
A new mRNA flu vaccine reduced confirmed flu illness by 27 percent compared with the standard shot in adults 50 and older.
May 7, 2026
Coadministration of RSV mRNA vaccine and high-dose flu vaccine noninferior for flu but not for RSV in older adults
Drug Pipeline RCT
Coadministration of RSV mRNA vaccine and high-dose flu vaccine noninferior for flu but not for RSV in older adults New data shows RSV and flu shots work well together
This phase 3 randomized controlled trial in 1900 adults aged 65 and older compared coadministration of mRNA-1345 and quadrivalent influenza …
Older adults can now get their RSV and flu vaccines during one visit without safety risks or extra trips to the clinic for care.
Apr 29, 2026
ACIP Issues Recommendations for Seasonal Influenza Prevention and Control with Vaccines
Allergy & Immunology
ACIP Issues Recommendations for Seasonal Influenza Prevention and Control with Vaccines What's the latest advice on flu shots this season?
The Advisory Committee on Immunization Practices (ACIP) has published recommendations for the prevention and control of seasonal influenza u…
U.S. health officials released updated flu shot advice for the 2023-24 season, emphasizing vaccination as the core way to prevent and contro…
CDC Apr 4, 2026

Questions about Influenza

Does taking the flu shot with RSV vaccine work well for seniors?

Yes, coadministering the high-dose flu shot and RSV vaccine is safe and works well for seniors, though the RSV immune response may be slightly lower.

Full answer →
What new ways are scientists using to make flu vaccines protect more?

Scientists are improving flu vaccines by combining them with other vaccines, using intranasal delivery, and engineering virus-like particles to trigger broader immune responses.

Full answer →