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Influenza A(H3N2)

Part of Influenza

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Influenza A(H3N2)

17 trials tracked for Influenza A(H3N2): 4 in phase 3 or 4 and 2 with published results. The most-cited published study has 134 citations.

17Trials tracked
4Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 2 Phase 3 2 Phase 2 6 Phase 1 2 Other / NA 5
  1. Phase 3 Evaluating the Safety and Efficacy of Anti-Influenza Intravenous Hyperimmune Immunoglobulin (IVIG) in Adults Hospitalized With Influenza Completed · 134 cited
  2. Phase 3 Comparing the Efficacy and Safety of High-Titer Versus Low-Titer Anti-Influenza Immune Plasma for the Treatment of Severe Influenza A Completed · 111 cited
  3. Phase 4 Characterizing Late-season Influenza Vaccine Responses to Compare the 2023 and 2024 Vaccine Formulations Completed
  4. Phase 4 Randomized Study of Immune Response to Licensed Influenza Vaccines in Children and Adolescents Completed
  5. Phase 2 Safety and Efficacy of Investigational Anti-Influenza Immune Plasma in Treating Influenza Completed
  6. Phase 2 Study of Efficacy and Safety of IV VIS410 Plus Oseltamivir Versus Oseltamivir in Hospitalized Adults With Influenza A Completed
Show 11 more trials
  1. Phase 2 A Study to Evaluate the Efficacy and Safety of CT-P27 in an Influenza Challenge Model Completed
  2. Phase 2 A Study of MHAA4549A as Monotherapy for Acute Uncomplicated Seasonal Influenza A in Otherwise Healthy Adults Completed
  3. Phase 2 Study Examining PrEP-001 in Healthy Subjects Completed
  4. Phase 2 Exploring Safety & Clinical Benefit of Anti-Influenza Immunoglobulin Intravenous in Hospitalized Adults With Influenza A Completed
  5. Phase 1 Safety and Immunogenicity of the Bris10 M2SR and Sing2016 M2SR H3N2 Monovalent Influenza Vaccines Completed
  6. Phase 1 CC-42344 Safety Study in Healthy Participants Completed
  7. N/A Dose, Safety, and Pathogenicity of a New Influenza A H3N2 Challenge Strain Completed
  8. N/A SARS-CoV-2 and Influenza A/B in Point-of-Care and Non-Laboratory Settings Completed
  9. N/A Collection and Testing of Respiratory Samples Completed
  10. N/A Assessment of Wearable Sensors During Experimental Human Influenza Infection (Sigma Plus) Completed
  11. N/A MGC Health COVID-19 & Flu A+B Home Multi Test Usability Study Completed

Showing the 17 most-cited and recently-updated of 17 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Influenza A(H3N2): what the trials found

The Influenza Fluzone vaccine is established for use in the management of Influenza A(H3N2) 1. Additionally, LAIV has been evaluated as an intervention for this condition 4.

Clinical trials evaluating passive immunity treatments, including Intravenous hyperimmune immunoglobulin (IVIG) 5 and high-titer anti-influenza plasma 6, did not show statistically significant differences in clinical status categories at Day 1, Day 2, or Day 7 compared to control groups.

Recent results — preliminary, needs further review

  • CC-42344 is currently being evaluated in a Phase 1 trial 2.
  • A study of the Influenza A H3N2 virus dose arm 1 reported various peak symptom scores, including Peak Total Symptoms Diary Card Scores ranging from 2.75 to 5.40 3.

For the clinician treating this condition

  • Influenza Fluzone and LAIV are established interventions for Influenza A(H3N2) [1, 4].
  • Passive immunity treatments such as IVIG and high-titer anti-influenza plasma did not demonstrate statistically significant improvements in clinical status over the first week of treatment [5, 6].

AI synthesis of 6 cited trials, updated Jun 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

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