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Intraventricular hemorrhage

Part of Intracranial Hemorrhage

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for intraventricular hemorrhage

6 trials tracked for intraventricular hemorrhage: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 62 citations.

6Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 1 Phase 2 3
  1. Phase 3 Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III Completed · 62 cited
  2. Phase 4 Comparative Infection Rates for the Codman BACTISEAL TM External Ventricular Drainage (EVD) System Completed
  3. Phase 4 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine Completed
  4. Phase 2 Clinical Trial on Treatment of Intraventricular Hemorrhage Completed
  5. Phase 2 Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury Completed
  6. Phase 2 Antibiotic "Dysbiosis" in Preterm Infants Completed

Showing the 6 most-cited and recently-updated of 6 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Intraventricular hemorrhage: what the trials found

Clinical evidence regarding the management of intraventricular hemorrhage includes evaluations of caffeine citrate and surgical drainage technologies. Caffeine citrate was associated with a Bayley Scales of Infant Development Cognitive Score of 85.6 to 88.0 at 2 years of age 1.

The use of Bactiseal TM EVD demonstrated specific metrics for catheter management, including an average of approximately 9.5 to 14 days to proven infection and a mean duration of roughly 8.7 to 10.4 days with the indwelling catheter 2.

In studies evaluating Alteplase, there was no statistically significant difference in functional outcomes. Results showed no significant difference in the proportion of participants achieving an mRS score of ↄ or less (p=0.554), ordinal mRS scores (p=0.484), or mRS scores of ↄ or less (p=0.552) 3.

Recent results — preliminary, needs further review

  • Indomethacin was evaluated for its impact on survival without severe IVH (Grades 3 or 4) or PVL, with reported percentages ranging from 10.9% to 22.2% 5.
  • Tissue plasminogen activator (rt-PA) showed an average daily percentage clot size resolution of approximately 20% to 24% over the first 3 days, with a mean 90-day GOS score of 2.3 6.

For the clinician treating this condition

  • Caffeine citrate is associated with specific cognitive scores at 2 years of age in pediatric populations 1.
  • Alteplase did not show statistically significant improvements in Modified Rankin Scale (mRS) outcomes compared to control groups 3.
  • Bactiseal TM EVD provides measurable metrics for infection timing and catheter duration 2.

AI synthesis of 5 cited trials, updated Jun 24, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Intracranial Hemorrhage

Related studies from across the Intracranial Hemorrhage family.

Deep Learning Models Show Promise for Detecting Cerebral Microbleeds on MRI
Radiology & Imaging Meta-analysis
Deep Learning Models Show Promise for Detecting Cerebral Microbleeds on MRI Deep Learning Shows Promise for Spotting Brain Microbleeds
A meta-analysis of five patient-level studies finds deep learning models can detect cerebral microbleeds on MRI with strong diagnostic accur…
A new meta-analysis suggests deep learning can help detect tiny brain bleeds on MRI, but the evidence is still early.
Blood GFAP levels provide high specificity for identifying intracerebral hemorrhage in acute stroke patients
Neurology Meta-analysis
Blood GFAP levels provide high specificity for identifying intracerebral hemorrhage in acute stroke patients Blood tests may help doctors identify types of stroke faster
This meta-analysis evaluates the diagnostic accuracy of blood GFAP levels to differentiate intracerebral hemorrhage (ICH) from ischemic stro…
A specific protein in the blood, called GFAP, shows high accuracy in helping doctors tell the difference between types of strokes during eme…
Impact of Very Early Exercise Rehabilitation on Functional Outcomes in Intracerebral Hemorrhage
Physical Medicine & Rehab Meta-analysis
Impact of Very Early Exercise Rehabilitation on Functional Outcomes in Intracerebral Hemorrhage Very early exercise improves recovery for brain bleed patients
Meta-analysis suggests very early exercise rehabilitation improves NIHSS and Fugl-Meyer scores in stable intracerebral hemorrhage patients.
Starting exercise rehabilitation very early after a brain bleed may lead to better physical function and movement for patients.
Efficacy of Pressure-Controlled Active CSF Irrigation in Managing Aneurysmal Subarachnoid Hemorrhage
Neurology Meta-analysis
Efficacy of Pressure-Controlled Active CSF Irrigation in Managing Aneurysmal Subarachnoid Hemorrhage Pressure controlled irrigation may reduce brain damage after brain bleeds
Meta-analysis suggests pressure-controlled active CSF irrigation significantly reduces the odds of delayed cerebral infarction and symptomat…
A review of over 2,000 cases suggests that pressure-controlled irrigation can lower the risk of brain tissue death after a ruptured aneurysm…
Hydrocephalus and high Fisher grade blood distribution are strongly associated with post-procedural seizures in SAH
Neurology Meta-analysis
Hydrocephalus and high Fisher grade blood distribution are strongly associated with post-procedural seizures in SAH Specific brain conditions linked to seizures after aneurysm surgery
This meta-analysis of patients undergoing endovascular aneurysm exclusion for subarachnoid hemorrhage identifies hydrocephalus (OR 3.91) and…
New data identifies specific markers, like hydrocephalus, that strongly link to a higher risk of seizures after aneurysm surgery.
Lumbar puncture identifies subarachnoid blood while CT angiography facilitates rapid vascular assessment in SAH
Emergency Medicine Guideline
Lumbar puncture identifies subarachnoid blood while CT angiography facilitates rapid vascular assessment in SAH Lumbar Puncture and CT Angiography Help Diagnose Brain Bleeding
This clinical guideline addresses the management of patients with suspected subarachnoid hemorrhage (SAH) and non-diagnostic head CT scans. …
Doctors use different imaging tools to find brain bleeds when initial scans are unclear, balancing the need for speed against accuracy.
Higher FIB-4 scores are associated with increased odds of poor stroke outcomes and mortality
Neurology Meta-analysis
Higher FIB-4 scores are associated with increased odds of poor stroke outcomes and mortality Higher Fibrosis Scores Linked to Worse Stroke Outcomes
This meta-analysis of 20 cohort studies and 2 cross-sectional studies examines the association between the Fibrosis-4 index (FIB-4) and vari…
A liver health score called FIB-4 shows a link to higher risks of stroke, poor recovery, and death in patients with brain injuries.
Tranexamic acid does not improve mortality or neurological outcomes in acute brain injury
Neurology Meta-analysis
Tranexamic acid does not improve mortality or neurological outcomes in acute brain injury Tranexamic acid does not improve survival in acute brain injuries
This meta-analysis of over 12,000 patients found that tranexamic acid did not significantly impact short-term or long-term mortality or func…
A large review of over 12,000 patients shows that tranexamic acid does not improve survival or recovery after a serious brain injury.
Higher aneurysm treatment rates are associated with improved outcomes and lower mortality in poor-grade aSAH
Neurology Meta-analysis
Higher aneurysm treatment rates are associated with improved outcomes and lower mortality in poor-grade aSAH Higher Treatment Rates Linked to Better Outcomes in Brain Hemorrhages
This meta-analysis of 7,726 patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH) found that higher treatment rates correlate w…
Research shows that higher treatment rates for severe brain bleeds are linked to better survival and functional recovery for patients.
Intracerebral hemorrhage survivors face annual rates of 2.1% recurrent ICH and 2.0% ischemic stroke
Neurology Meta-analysis
Intracerebral hemorrhage survivors face annual rates of 2.1% recurrent ICH and 2.0% ischemic stroke Atrial Fibrillation Linked to Stroke Risk After Brain Bleed
This systematic review and meta-analysis of 198,289 adults with intracerebral hemorrhage (ICH) identifies an annual recurrence rate of 2.1% …
A large review of over 198,000 patients shows a significant link between atrial fibrillation and stroke risk following an intracerebral hemo…
AI-driven and traditional imaging markers provide a structured framework for predicting hematoma expansion in acute ICH
Neurology Sys. Review
AI-driven and traditional imaging markers provide a structured framework for predicting hematoma expansion in acute ICH AI tools may better predict bleeding in the brain
This systematic review evaluates the evolution of imaging-based prediction methods for hematoma expansion in patients with acute intracerebr…
A new review shows AI methods may predict brain bleed expansion better than traditional scans, but hurdles remain.
Remote DWI lesions after intracerebral hemorrhage signal ischemic injury but mechanisms remain unclear
Neurology Sys. Review
Remote DWI lesions after intracerebral hemorrhage signal ischemic injury but mechanisms remain unclear Remote Imaging Lesions May Predict Outcomes for Brain Bleeds
This systematic review examines remote diffusion-weighted imaging (R-DWI) lesions in patients with spontaneous intracerebral hemorrhage. The…
New imaging techniques can identify remote brain tissue damage in patients with a brain bleed, which may help doctors predict patient outcom…

Questions about intraventricular hemorrhage

What is the infection rate for ventriculosubgaleal shunts after an intraventricular hemorrhage?

The infection rate for ventriculosubgaleal shunts after intraventricular hemorrhage is about 9% based on a meta-analysis, with older studies reporting 14%.

Full answer →
Is a ventriculosubgaleal shunt safe for babies with posthemorrhagic hydrocephalus and intraventricular hemorrhage?

Yes, a ventriculosubgaleal shunt appears safe for babies with posthemorrhagic hydrocephalus, with low infection and revision rates based on systematic reviews.

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Does removing blood products reduce shunting risk after an intraventricular hemorrhage?

Yes, removing blood products reduces the risk of needing a permanent shunt after intraventricular hemorrhage in preterm infants, based on meta-analyses showing a 33% lower risk.

Full answer →