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Intraventricular hemorrhage

Part of Intracranial Hemorrhage

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for intraventricular hemorrhage

6 trials tracked for intraventricular hemorrhage: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 62 citations.

6Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 1 Phase 2 3
  1. Phase 3 Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III Completed · 62 cited
  2. Phase 4 Comparative Infection Rates for the Codman BACTISEAL TM External Ventricular Drainage (EVD) System Completed
  3. Phase 4 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine Completed
  4. Phase 2 Clinical Trial on Treatment of Intraventricular Hemorrhage Completed
  5. Phase 2 Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury Completed
  6. Phase 2 Antibiotic "Dysbiosis" in Preterm Infants Completed

Showing the 6 most-cited and recently-updated of 6 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Intraventricular hemorrhage: what the trials found

Clinical evidence regarding the management of intraventricular hemorrhage includes evaluations of caffeine citrate and surgical drainage technologies. Caffeine citrate was associated with a Bayley Scales of Infant Development Cognitive Score of 85.6 to 88.0 at 2 years of age 1.

The use of Bactiseal TM EVD demonstrated specific metrics for catheter management, including an average of approximately 9.5 to 14 days to proven infection and a mean duration of roughly 8.7 to 10.4 days with the indwelling catheter 2.

In studies evaluating Alteplase, there was no statistically significant difference in functional outcomes. Results showed no significant difference in the proportion of participants achieving an mRS score of ↄ or less (p=0.554), ordinal mRS scores (p=0.484), or mRS scores of ↄ or less (p=0.552) 3.

Recent results — preliminary, needs further review

  • Indomethacin was evaluated for its impact on survival without severe IVH (Grades 3 or 4) or PVL, with reported percentages ranging from 10.9% to 22.2% 5.
  • Tissue plasminogen activator (rt-PA) showed an average daily percentage clot size resolution of approximately 20% to 24% over the first 3 days, with a mean 90-day GOS score of 2.3 6.

For the clinician treating this condition

  • Caffeine citrate is associated with specific cognitive scores at 2 years of age in pediatric populations 1.
  • Alteplase did not show statistically significant improvements in Modified Rankin Scale (mRS) outcomes compared to control groups 3.
  • Bactiseal TM EVD provides measurable metrics for infection timing and catheter duration 2.

AI synthesis of 5 cited trials, updated Jun 24, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Intracranial Hemorrhage

Related studies from across the Intracranial Hemorrhage family.

Tranexamic acid does not improve mortality or neurological outcomes in acute brain injury
Neurology Meta-analysis
Tranexamic acid does not improve mortality or neurological outcomes in acute brain injury Tranexamic acid does not improve survival in acute brain injuries
This meta-analysis of over 12,000 patients found that tranexamic acid did not significantly impact short-term or long-term mortality or func…
A large review of over 12,000 patients shows that tranexamic acid does not improve survival or recovery after a serious brain injury.
Higher aneurysm treatment rates are associated with improved outcomes and lower mortality in poor-grade aSAH
Neurology Meta-analysis
Higher aneurysm treatment rates are associated with improved outcomes and lower mortality in poor-grade aSAH Higher Treatment Rates Linked to Better Outcomes in Brain Hemorrhages
This meta-analysis of 7,726 patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH) found that higher treatment rates correlate w…
Research shows that higher treatment rates for severe brain bleeds are linked to better survival and functional recovery for patients.
Intracerebral hemorrhage survivors face annual rates of 2.1% recurrent ICH and 2.0% ischemic stroke
Neurology Meta-analysis
Intracerebral hemorrhage survivors face annual rates of 2.1% recurrent ICH and 2.0% ischemic stroke Atrial Fibrillation Linked to Stroke Risk After Brain Bleed
This systematic review and meta-analysis of 198,289 adults with intracerebral hemorrhage (ICH) identifies an annual recurrence rate of 2.1% …
A large review of over 198,000 patients shows a significant link between atrial fibrillation and stroke risk following an intracerebral hemo…
AI-driven and traditional imaging markers provide a structured framework for predicting hematoma expansion in acute ICH
Neurology Sys. Review
AI-driven and traditional imaging markers provide a structured framework for predicting hematoma expansion in acute ICH AI tools may better predict bleeding in the brain
This systematic review evaluates the evolution of imaging-based prediction methods for hematoma expansion in patients with acute intracerebr…
A new review shows AI methods may predict brain bleed expansion better than traditional scans, but hurdles remain.
Remote DWI lesions after intracerebral hemorrhage signal ischemic injury but mechanisms remain unclear
Neurology Sys. Review
Remote DWI lesions after intracerebral hemorrhage signal ischemic injury but mechanisms remain unclear Remote Imaging Lesions May Predict Outcomes for Brain Bleeds
This systematic review examines remote diffusion-weighted imaging (R-DWI) lesions in patients with spontaneous intracerebral hemorrhage. The…
New imaging techniques can identify remote brain tissue damage in patients with a brain bleed, which may help doctors predict patient outcom…
Individualized shunt pressure titration may slow autologous skull graft resorption in patients with hydrocephalus
Orthopedics & Sports Medicine Sys. Review
Individualized shunt pressure titration may slow autologous skull graft resorption in patients with hydrocephalus Adjusting Shunt Pressure May Slow Skull Graft Resorption
This case report and literature review describes a patient with intracerebral hemorrhage, cerebral arteriovenous malformation, and communica…
A case study shows that tailoring shunt pressure can help manage skull graft resorption in patients with specific types of brain injuries.
MIPS and ES rank highest for functional outcomes in patients with spontaneous intracerebral hemorrhage
Neurology Meta-analysis
MIPS and ES rank highest for functional outcomes in patients with spontaneous intracerebral hemorrhage Minimally Invasive Surgery Shows Better Outcomes for Brain Bleeds
This network meta-analysis of 18 randomized controlled trials evaluated surgical interventions for spontaneous intracerebral hemorrhage. MIP…
New research suggests minimally invasive and endoscopic surgeries may offer better functional recovery for patients with brain bleeds compar…
Triple Pill Therapy Lowers Recurrent Stroke Incidence in Patients With Prior Intracerebral Hemorrhage
Neurology RCT
Triple Pill Therapy Lowers Recurrent Stroke Incidence in Patients With Prior Intracerebral Hemorrhage Single pill with three blood pressure drugs cuts stroke risk after brain bleed
This multinational randomized controlled trial enrolled 1670 patients with a history of intracerebral hemorrhage and baseline systolic blood…
A single pill combining three low-dose blood pressure drugs reduced recurrent stroke risk by 39% in people who had a brain bleed.
Women critically ill adults on EEG have higher intracranial hemorrhage and seizure discharge rates than men
Emergency Medicine RCT
Women critically ill adults on EEG have higher intracranial hemorrhage and seizure discharge rates than men Trial finds women with impaired consciousness have different outcomes
This post hoc analysis of a multicenter randomized trial included 364 critically ill adults requiring electroencephalography. Women showed h…
A trial of critically ill adults found women with impaired consciousness had higher rates of brain bleeding and seizures but similar surviva…
Intracranial hemorrhage rates were higher in tenecteplase than standard care at 14.4% versus 9.2% in minor ischemic stroke
Neurology RCT
Intracranial hemorrhage rates were higher in tenecteplase than standard care at 14.4% versus 9.2% in minor ischemic stroke Even small bleeds after minor stroke raise death risk in this trial analysis
This secondary analysis of a multicenter randomized controlled trial evaluated 865 patients with minor ischemic stroke within 12 hours of sy…
A look at trial data shows that small bleeds after minor stroke are linked to higher death rates, even if they do not worsen long-term funct…
Higher m-cSVD scores linked to increased stroke risk in hemorrhage-prone patients
Neurology RCT
Higher m-cSVD scores linked to increased stroke risk in hemorrhage-prone patients High small-vessel disease scores raise stroke risk in hemorrhage-prone patients
This post hoc analysis of a prospective, multicenter randomized controlled trial in 1,454 hemorrhage-prone patients found that higher modifi…
Patients with high small-vessel disease scores face higher risks of ischemic stroke and heart events, even if they have a history of bleedin…
Narrative review proposes integrative monitoring framework for intracerebral hemorrhage
Neurology Sys. Review
Narrative review proposes integrative monitoring framework for intracerebral hemorrhage New monitoring tools may help tailor iron treatments for brain bleeding
This narrative review critiques current monitoring strategies for intracerebral hemorrhage and proposes a multidimensional integrative frame…
Current ways to track brain bleeding often miss the complex chemical changes happening inside. A review suggests better tools could help doc…

Questions about intraventricular hemorrhage

What is the infection rate for ventriculosubgaleal shunts after an intraventricular hemorrhage?

The infection rate for ventriculosubgaleal shunts after intraventricular hemorrhage is about 9% based on a meta-analysis, with older studies reporting 14%.

Full answer →
Is a ventriculosubgaleal shunt safe for babies with posthemorrhagic hydrocephalus and intraventricular hemorrhage?

Yes, a ventriculosubgaleal shunt appears safe for babies with posthemorrhagic hydrocephalus, with low infection and revision rates based on systematic reviews.

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Does removing blood products reduce shunting risk after an intraventricular hemorrhage?

Yes, removing blood products reduces the risk of needing a permanent shunt after intraventricular hemorrhage in preterm infants, based on meta-analyses showing a 33% lower risk.

Full answer →