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Intraventricular hemorrhage

Part of Intracranial Hemorrhage

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for intraventricular hemorrhage

6 trials tracked for intraventricular hemorrhage: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 61 citations.

6Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 1 Phase 2 3
  1. Phase 3 Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III Completed · 61 cited
  2. Phase 4 Comparative Infection Rates for the Codman BACTISEAL TM External Ventricular Drainage (EVD) System Completed
  3. Phase 4 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine Completed
  4. Phase 2 Clinical Trial on Treatment of Intraventricular Hemorrhage Completed
  5. Phase 2 Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury Completed
  6. Phase 2 Antibiotic "Dysbiosis" in Preterm Infants Completed

Showing the 6 most-cited and recently-updated of 6 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Intraventricular hemorrhage: what the trials found

Clinical evidence regarding the management of intraventricular hemorrhage includes evaluations of caffeine citrate and surgical drainage technologies. Caffeine citrate was associated with a Bayley Scales of Infant Development Cognitive Score of 85.6 to 88.0 at 2 years of age 1.

The use of Bactiseal TM EVD demonstrated specific metrics for catheter management, including an average of approximately 9.5 to 14 days to proven infection and a mean duration of roughly 8.7 to 10.4 days with the indwelling catheter 2.

In studies evaluating Alteplase, there was no statistically significant difference in functional outcomes. Results showed no significant difference in the proportion of participants achieving an mRS score of ↄ or less (p=0.554), ordinal mRS scores (p=0.484), or mRS scores of ↄ or less (p=0.552) 3.

Recent results — preliminary, needs further review

  • Indomethacin was evaluated for its impact on survival without severe IVH (Grades 3 or 4) or PVL, with reported percentages ranging from 10.9% to 22.2% 5.
  • Tissue plasminogen activator (rt-PA) showed an average daily percentage clot size resolution of approximately 20% to 24% over the first 3 days, with a mean 90-day GOS score of 2.3 6.

For the clinician treating this condition

  • Caffeine citrate is associated with specific cognitive scores at 2 years of age in pediatric populations 1.
  • Alteplase did not show statistically significant improvements in Modified Rankin Scale (mRS) outcomes compared to control groups 3.
  • Bactiseal TM EVD provides measurable metrics for infection timing and catheter duration 2.

AI synthesis of 5 cited trials, updated Jun 24, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Intracranial Hemorrhage

Related studies from across the Intracranial Hemorrhage family.

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Individualized shunt pressure titration may slow autologous skull graft resorption in patients with hydrocephalus
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Triple Pill Therapy Lowers Recurrent Stroke Incidence in Patients With Prior Intracerebral Hemorrhage
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Higher m-cSVD scores linked to increased stroke risk in hemorrhage-prone patients
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Narrative review proposes integrative monitoring framework for intracerebral hemorrhage
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Current ways to track brain bleeding often miss the complex chemical changes happening inside. A review suggests better tools could help doc…
Meta-analysis links high acute glycemic variability to increased short-term mortality in subarachnoid hemorrhage patients
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Meta-analysis links high acute glycemic variability to increased short-term mortality in subarachnoid hemorrhage patients Blood Sugar Swings Linked to Higher Death Risk After Brain Bleed
This meta-analysis pooled data from 10,119 adult patients with subarachnoid hemorrhage to evaluate the association between high acute glycem…
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Haemorrhage pattern predicts complications in angiogram-negative subarachnoid haemorrhage patients
Radiology & Imaging Meta-analysis
Haemorrhage pattern predicts complications in angiogram-negative subarachnoid haemorrhage patients Blood pattern predicts risk for hidden brain vessel issues in patients
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New data shows that how blood spreads in the brain helps doctors decide if a second scan is needed to find hidden vessel problems
Meta-analysis links perihematomal edema growth to poor outcomes in intracerebral hemorrhage patients
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Early swelling in the brain after a bleed may predict higher risk of death or disability within three months.
Pre-admission statin use linked to better 30-day outcomes after aneurysmal SAH
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This observational study of 1,431 patients with aneurysmal subarachnoid hemorrhage found that pre-admission statin use was associated with a…
Using statins before a brain bleed may improve early recovery chances, but benefits did not last to 90 days in this real-world study.
Five-variable admission model predicts 90-day outcomes in 245 aneurysmal subarachnoid hemorrhage patients
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A simple 5-factor model at hospital admission accurately predicts 90-day recovery after bleeding stroke.