Narrative review discusses tezepelumab for severe asthma in type 2-low patients on GINA Step 4–5 therapy
New Asthma Drug Works for Hard-to-Treat Patients Who Had Few Options
This narrative review examines tezepelumab for severe asthma, specifically focusing on type 2-low patients currently prescribed GINA Step 4–…
This new treatment offers hope for severe asthma patients who don’t respond to standard therapies, including a group previously left out of …
Serum specific IgE testing reveals dust mite sensitization in 37.0% of patients with allergic diseases in Ningbo, China
Dust mites top allergen list in large Chinese patient cohort
This cohort study of 19,787 patients with suspected allergic diseases undergoing serum specific IgE testing in Ningbo, China, identified dus…
In a study of nearly 20,000 patients, dust mites were the most common allergen causing sensitization, followed by milk and mixed grasses.
Narrative review proposes framework for TWAS signature-matching in drug prioritization
New method finds better drug targets using your DNA data
This narrative review and framework proposal examines the TWAS signature-matching approach with varying parameters, including TWAS method, e…
A new gene-based method can point doctors to better drugs, but the right settings are critical for accuracy.
AI-Based Adjudication of MACE Events Shows High Agreement with Human CEC in MI Trial
AI Can Spot Heart Attacks and Strokes in Medical Records—But Should We Trust It?
This randomized trial compared an AI-based adjudication system (Auto-MACE) to physician CEC adjudication for MACE events in 5,661 patients w…
This new AI tool could speed up medical research by automatically checking medical records for heart problems, saving doctors hundreds of ho…
Meta-analysis of 15 observational studies links e-cigarette use to higher COPD odds
E-Cigs Linked to Higher COPD Risk Even Without Smoking
This meta-analysis of 15 observational studies assessed the association between e-cigarette use and the prevalence of chronic obstructive pu…
Using e-cigarettes today is connected to a much higher chance of developing COPD, even if you have never smoked a regular cigarette before.
Systematic review links gut-lung axis in COPD and inflammatory bowel disease
Shared genes link COPD and inflammatory bowel disease
This systematic review synthesizes evidence on shared mechanisms between COPD and inflammatory bowel disease.
A new review reveals that COPD and IBD share genetic roots, explaining why lung and gut inflammation often occur together.
mNGS on BALF samples shows higher pathogen detection in pulmonary infections vs. conventional testing
mNGS detects more lung infection pathogens than standard tests
This observational cohort study compared metagenomic next-generation sequencing (mNGS) on bronchoalveolar lavage fluid (BALF) to conventiona…
In 136 patients, mNGS found lung pathogens more often than conventional tests and better spotted mixed infections, especially in immunocompr…
Clinical-immuno-inflammatory signature for Aspergillus–Mucorales co-infection in ICU patients
ICU patients with co-infection show higher but not significant mortality
This single-center observational cohort study of 93 critically ill ICU patients found that a clinical-immuno-inflammatory signature for earl…
Critically ill patients with both Aspergillus and Mucorales infections had higher ICU mortality, but the difference was not statistically si…
FeNO measurement shows limited diagnostic performance for asthma in school-age children
FeNO breath test shows limited accuracy for diagnosing asthma in school-age children
This observational cohort study of 1,979 school-age children found that fractional exhaled nitric oxide (FeNO) had poor discrimination for a…
A breath test for asthma showed poor accuracy in children, especially those without allergies, raising questions about its use as a standalo…
De-implementation of low-value bronchiolitis practices showed sustained adherence two years post-trial in a cluster RCT follow-up
Doctors Stick to Better Bronchiolitis Care—2 Years Later
This cluster randomised controlled trial (cRCT) follow-up study assessed the sustainability of de-implementing low-value bronchiolitis pract…
It’s 2 a.m. in a busy children’s hospital.
Single-center retrospective study associates ferritin and eosinophil levels with acute asthma exacerbation in children
High Iron Levels Signal Worse Asthma Attacks in Kids
This single-center retrospective study examined 120 children with asthma to identify markers associated with acute exacerbation.
Checking iron levels alongside standard asthma markers could help doctors predict dangerous flare-ups sooner.
Benralizumab reduces asthma exacerbations in severe eosinophilic asthma patients over 24 weeks
New Asthma Shot May Cut Severe Attacks to Zero
This prospective, single-arm, multicenter, phase IV study evaluated benralizumab in 138 benralizumab-naïve adults (18–75 years) with severe …
A new injection appears safe and effective at reducing severe asthma attacks in adults.