Meta-analysis finds decreased GDNF levels in bipolar disorder but high heterogeneity limits conclusions
Brain chemical levels differ in bipolar disorder compared to healthy people
This meta-analysis of 825 patients with bipolar disorder (BD) and 885 healthy controls found significantly lower circulating GDNF levels in …
A large review found lower levels of a specific brain chemical in people with bipolar disorder. This difference was clear even when comparin…
Meta-analysis on psychological interventions and early psychosis care for depression and psychosis
Psychological interventions cut major depression risk by 43% after treatment
This meta-analysis synthesizes evidence on psychological interventions for subclinical depression and early intervention for first-episode p…
Early psychological help for subclinical symptoms lowers major depression risk by 43% after treatment and 33% a year later, a meta-analysis …
Blood biomarker variance in UK Biobank influenced by technical, demographic, and behavioral factors
Why Blood Tests Fail to Predict Mental Health
This UK Biobank cohort study examined how technical, demographic, behavioral, and temporal factors influence 29 blood biomarkers. Variance e…
Many doctors rely on blood work to check your physical health.
Polygenic risk scores show stronger associations with comorbid anxiety and depression cases in cohort studies
Do anxiety and depression share the same genetic roots when they appear together?
This observational cohort study in UK Biobank and MoBa participants found polygenic risk scores for anxiety and depression were more strongl…
When anxiety and depression occur together, their shared genetic risk is much stronger than when each disorder appears alone.