Research across Multiple Sclerosis
Related studies from across the Multiple Sclerosis family.
Ponesimod maintains low disease activity and safety in RRMS over 13 years
Trial Shows Ponesimod Maintains Safety for Relapsing-Remitting Multiple Sclerosis
This Phase 2b randomized controlled trial of 393 participants with relapsing-remitting multiple sclerosis found that ponesimod (10, 20, or 4…
A clinical trial shows that patients with relapsing-remitting multiple sclerosis can stay on ponesimod for up to 13 years with consistent re…
Central vein sign on MRI shows potential diagnostic value in pediatric-onset multiple sclerosis
MRI Central Vein Sign May Help Identify Pediatric Multiple Sclerosis
This meta-analysis of 5 studies evaluated the diagnostic accuracy of the central vein sign (CVS) in pediatric-onset multiple sclerosis. The …
A specific MRI finding called the central vein sign may help doctors identify multiple sclerosis in children and infants.
Specialist monitoring is required for managing alemtuzumab-induced thyroid dysfunction during pregnancy
Managing thyroid issues in pregnant women after alemtuzumab treatment
This case series and literature review examines the management of alemtuzumab-induced Graves' disease and TRAb-positive hypothyroidism in pr…
Pregnant women who develop thyroid issues after alemtuzumab treatment require close monitoring to manage their health and the health of thei…
CAR-T cell therapy shows preliminary clinical activity in refractory neuroimmune diseases
CAR-T Cell Therapy Shows Early Activity in Neuroimmune Diseases
This narrative review synthesizes current evidence on CAR-T cell therapies targeting CD19, BCMA, or dual CD19/BCMA for neuroimmune diseases.…
New CAR-T cell therapies are showing early clinical activity for patients with rare and difficult to treat neuroimmune conditions.
Mycobacterium avium subsp. paratuberculosis may contribute to Crohn's disease through complex pathogenic mechanisms
Bacteria May Play a Role in Crohn's Disease and More
This narrative review explores the role of Mycobacterium avium subsp. paratuberculosis (MAP) in Crohn's disease and other conditions like mu…
Research suggests a specific bacterium may contribute to Crohn's disease and show links to other conditions like multiple sclerosis and type…
Traditional Chinese medicine may modulate neuroimmunomodulatory pathways and immune balance in multiple sclerosis
Traditional Chinese medicine may influence immune responses in multiple sclerosis
This narrative review examines the mechanisms of traditional Chinese medicine (TCM) preparations in the context of multiple sclerosis. The a…
New research explores how traditional Chinese medicine formulas might balance immune cells and reduce inflammation in people with multiple s…
Digitally Enhanced Composite Endpoints Improve Efficiency in Multiple Sclerosis Clinical Trials
New Digital Tools May Speed Up Clinical Trials for MS
Integrating remote smartphone-based gait assessments with clinical progression events significantly reduces required sample sizes and trial …
A new digital method for tracking movement could allow researchers to reach results faster and with fewer patients in multiple sclerosis tri…
IL-34/CSF1R signaling modulates CNS immune cell development and impacts neurodegenerative disease progression
IL-34 Signaling Pathway Shows Complex Role in Brain Disorders
This systematic review examines the role of the IL-34/CSF1R signaling axis in CNS-resident immune cells and its impact on neurological disor…
A specific signaling pathway may play a dual role in brain health, potentially protecting nerves or contributing to diseases like Alzheimer'…
Structured clinical data models show moderate discrimination for predicting relapsing multiple sclerosis outcomes
New Models Show Potential for Predicting Multiple Sclerosis Relapses
This systematic review evaluates models for predicting relapse-related outcomes in patients with relapsing multiple sclerosis. Models based …
New models using clinical data show promise in predicting multiple sclerosis relapses, though more consistent testing is needed for daily us…
Slowly expanding lesions occur in 78% of patients with Multiple Sclerosis
New data shows common types of lesions in Multiple Sclerosis
This meta-analysis of 4,786 patients with Multiple Sclerosis identifies the prevalence and volume of slowly expanding lesions (SELs) and par…
A large study of over 4,000 people with Multiple Sclerosis identifies common patterns in brain lesions to help understand the disease.
Smoking is not significantly associated with disability progression in patients with multiple sclerosis
Smoking and disability progression in multiple sclerosis patients
This meta-analysis investigated the association between smoking and disability progression in patients with multiple sclerosis. The analysis…
New data looks at how smoking affects disability for people with multiple sclerosis, finding no clear link to specific disability scores.
Probiotic supplementation may improve fatigue and pain symptoms in patients with multiple sclerosis
Probiotics may help manage fatigue and pain in multiple sclerosis
This meta-analysis of 282 adults with multiple sclerosis evaluated the impact of various probiotic strains on motor outcomes, mental health,…
New research suggests that probiotic supplements could help manage daily symptoms like fatigue and pain for people living with multiple scle…