Research across Multiple Sclerosis
Related studies from across the Multiple Sclerosis family.
Glutamatergic agents show preclinical promise in Multiple Sclerosis but fail in clinical trials
Laboratory tests show promise for multiple sclerosis but face hurdles
This narrative review examines the efficacy of glutamatergic agents in experimental autoimmune encephalomyelitis models versus human clinica…
Certain drugs showed success in lab models for multiple sclerosis, but these same medicines failed to work during actual human clinical tria…
Prevalence of neurogenic bladder in patients with multiple sclerosis and associated urinary symptoms
Nearly half of people with MS have bladder problems
This meta-analysis investigated the prevalence of neurogenic bladder and specific urinary symptoms among individuals with multiple sclerosis…
A new analysis finds that almost half of people with multiple sclerosis experience bladder issues, with storage symptoms being the most comm…
Autonomic gastrointestinal dysfunction occurs in 31.4% of people with multiple sclerosis
Many people with multiple sclerosis experience significant digestive issues
This meta-analysis of 1,272,170 individuals identifies high prevalence rates for various gastrointestinal symptoms and disorders in patients…
Over 30% of people with multiple sclerosis experience autonomic gut dysfunction, making digestive health a major part of managing the condit…
Serum neurofilament light chain shows modest diagnostic performance for multiple sclerosis disease activity
Serum neurofilament light chain shows limited accuracy for MS activity
This meta-analysis of 11,213 adults with MS evaluated serum neurofilament light chain (sNfL) as a biomarker for disease activity. The analys…
A large review of data suggests a specific protein in the blood cannot yet be used on its own to track MS disease activity.
Fingolimod reduces annualized relapse rate by 1.17 per patient-year in pediatric MS
Fingolimod Reduces Relapse Rates for Children with Multiple Sclerosis
This meta-analysis of 585 pediatric multiple sclerosis patients found that fingolimod significantly reduced annualized relapse rate by 1.17 …
A review of data shows that fingolimod can significantly lower the number of annual relapses in children living with multiple sclerosis.
Long-term particulate matter exposure increases risk of Parkinson's disease by 10% to 18%
Long term air pollution exposure linked to Parkinson's disease risk
This meta-analysis evaluates the association between long-term outdoor air pollution and neurodegenerative diseases. It found a significant …
Long-term exposure to outdoor air pollution like particulate matter is linked to an increased risk of developing Parkinson's disease.
Dynamic gratings serve as tools for diagnosis and treatment evaluation in neuro-ophthalmic conditions
Dynamic gratings help doctors understand and treat eye conditions
This narrative review explores the use of dynamic gratings, such as phase-alternating oscillation and rapid serial visual presentation, to e…
Moving patterns on a screen, called dynamic gratings, offer new ways to study and treat vision issues like glaucoma and diabetic retinopathy…
Mesenchymal stem cell transplantation shows no significant improvement in EDSS scores for progressive multiple sclerosis
Stem cell therapy safe but no benefit for multiple sclerosis
This meta-analysis of 143 patients with progressive multiple sclerosis found that mesenchymal stem cell transplantation did not significantl…
A new analysis finds stem cell transplants are safe for progressive MS but don't improve disability scores.
Heterogeneous management of Radiologically isolated syndrome highlights significant gaps in standardized treatment algorithms
Survey Reveals Gaps in Managing Radiologically Isolated Syndrome
This cross-sector survey of 127 neurologists evaluates real-world management practices for Radiologically isolated syndrome (RIS). The study…
New survey data shows that doctors currently lack standardized tools and consistent methods for managing patients with Radiologically Isolat…
tDCS improves lower limb motor function and walking distance in patients with multiple sclerosis
Trial Shows Brain Stimulation Improves Lower Limb Function in MS
This meta-analysis of 299 individuals with multiple sclerosis found that transcranial direct current stimulation (tDCS) significantly improv…
Brain stimulation may improve lower limb movement and walking distance for people with multiple sclerosis, but results vary by treatment int…
Rituximab is noninferior to ocrelizumab in suppressing T2-weighted MRI lesions from month 6 to 24
Trial shows rituximab works as well as ocrelizumab for MS
This Phase 3 randomized controlled trial of 218 adults with newly diagnosed relapsing multiple sclerosis found rituximab noninferior to ocre…
A new study finds that two different treatments for multiple sclerosis show similar success in stopping brain lesions and managing disease a…
Extended-interval natalizumab dosing shows no significant difference in disability progression for relapsing-remitting multiple sclerosis
Extended dosing of natalizumab shows similar outcomes for multiple sclerosis
This meta-analysis of patients with relapsing-remitting multiple sclerosis found that extended-interval dosing (EID) of natalizumab did not …
New data suggests that spacing out natalizumab doses may work as well as standard schedules for patients with relapsing-remitting multiple s…