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Home › Conditions › Mental Disorders

Mental Disorders

Subtypes of Mental Disorders

Psychiatric Disorders 7

16 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Mental Disorders

27 trials tracked for Mental Disorders: 8 in phase 3 or 4 and 3 with published results. The most-cited published study has 20 citations.

27Trials tracked
8Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 1 Phase 3 7 Phase 2 1 Phase 1 1 Other / NA 17
  1. Phase 3 A Study of Flexible-dose Brexpiprazole as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder, the Delphinus Trial Completed · 20 cited
  2. Phase 3 Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial) Completed · 13 cited
  3. Phase 3 Study of the Safety and Efficacy of Fixed-dose Brexpiprazole (OPC-34712) as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder With and Without Anxious Distress Completed · 7 cited
  4. Phase 4 Helping Those With Mental Illness Quit Smoking Completed
  5. Phase 3 Study of the Safety and Efficacy of Fixed Dose OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder (the Pyxis Trial) Completed
  6. Phase 3 Study of the Safety and Efficacy of Two Fixed Doses of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder (the Polaris Trial) Completed
Show 21 more trials
  1. Phase 3 Efficacy and Safety Study of Org 50081 (Esmirtazapine) in Elderly Participants (P05709) Completed
  2. Phase 3 A 6-Month Efficacy and Safety Study of Org 50081 in Adult Patients With Chronic Primary Insomnia (21106/P05701/MK-8265-002) Completed
  3. Phase 2 A Clinical Trial of Intravenous (IV) Ganaxolone in Women With Postpartum Depression Completed
  4. Phase 1 A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of RO6953958 in Healthy Participants Completed
  5. N/A Padres Efectivos (Parent Activation): Skills Latina Mothers Use to Get Healthcare for Their Children Completed
  6. N/A A Transdiagnostic Sleep and Circadian Treatment to Improve Community SMI Outcomes Completed
  7. N/A A Randomized Controlled Trial of Mental Health Peer-Led Education Completed
  8. N/A Testing Effectiveness of a Peer-Led Intervention to Enhance Community Integration Completed
  9. N/A Mechanisms of Action and Outcome Completed
  10. N/A Randomized Controlled Trial of Wellness Recovery Action Planning Completed
  11. N/A Addiction Housing Case Management for Homeless Veterans Completed
  12. N/A Efficacy of the Recovery Workbook as a Psychoeducational Tool for Facilitating Recovery Completed
  13. N/A Harmony at Home: A Pilot Telehealth Program for Rural ADRD Caregivers Completed
  14. N/A Conduct Disorder in Prison: Search for Prospective and Retrospective Recurring and Contextual Elements Completed
  15. N/A Biomarkers of Cardiometabolic Risk in Children Treated With Antipsychotics: A Preliminary Study of Direct Measures Completed
  16. N/A Effectiveness of DECIDE in Patient-Provider Communication, Therapeutic Alliance & Care Continuation Completed
  17. N/A RCT Social Cognition Training and Therapeutic Alliance Focused Therapy for Persons With Severe Mental Illness Completed
  18. N/A Integrated Care & Patient Navigators for Latinos With Serious Mental Illness Completed
  19. N/A Cognitive Behavior Therapy for Work Success in Veterans With Mental Illness: A Pre-post Efficacy Study Completed
  20. N/A The Effectiveness of a Decision-Support Tool for Adult Consumers With Mental Health Needs and Their Care Managers Completed
  21. N/A Pilot Pragmatic Clinical Trial to Embed Tele-Savvy Into Health Care Systems Completed

Showing the 27 most-cited and recently-updated of 27 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Cross-trait analyses reveal complex genetic overlaps between cortical morphology and psychiatric disorders
Genetics & Precision Medicine
Cross-trait analyses reveal complex genetic overlaps between cortical morphology and psychiatric disorders Your Brain's Blueprint May Not Predict Mental Illness After All
This cross-trait analysis examined genetic loci shared between cortical surface area or thickness and various psychiatric conditions.
Brain shape genes and mental illness genes often push in opposite directions, complicating hopes for using scans and DNA to predict conditio…
medRxiv Apr 16, 2026
Narrative synthesis reviews bidirectional links between diabetes and mental disorders
Psychiatry Sys. Review
Narrative synthesis reviews bidirectional links between diabetes and mental disorders Diabetes and Mental Health: Breaking the Cycle Together
This narrative synthesis examined epidemiological evidence, bidirectional mechanisms, and integrated management models for diabetes and ment…
High blood sugar changes brain chemistry while stress raises blood sugar, creating a tough cycle that makes managing diabetes and mental hea…
Frontiers Apr 11, 2026
Meta-analysis finds pharmacogenomics-guided prescribing may be cost-effective for psychiatric disorders
Genetics & Precision Medicine Meta-analysis
Meta-analysis finds pharmacogenomics-guided prescribing may be cost-effective for psychiatric disorders Can genetic testing for psychiatric medication save money? The evidence is promising but not yet clear
A systematic review and meta-analysis of 17 economic studies in adults with psychiatric disorders found 88% of studies favored pharmacogenom…
Genetic testing for psychiatric drugs hints at savings, but mixed study results mean it's not yet clear if the approach truly cuts costs.
Apr 5, 2026
Systematic review suggests omega-3 deficiency may be modifiable risk factor for mental disorders
Neurology Sys. Review
Systematic review suggests omega-3 deficiency may be modifiable risk factor for mental disorders Review finds omega-3 fatty acid levels may be linked to brain health disorders
A systematic review of evidence across mental, neurodevelopmental, and neurodegenerative disorders suggests omega-3 deficiency and altered f…
Low omega-3 levels may act as a changeable risk factor for brain disorders like schizophrenia, ADHD, and Alzheimer's, offering a potential t…
Frontiers Apr 4, 2026

Questions about Mental Disorders

Can omega-3 levels be changed to help mental disorders?

Research suggests that low omega-3 levels are linked to mental disorders, and changing these levels through diet or supplements may help treat conditions like depression and schizophrenia.

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Is violence exposure in childhood linked to mental health problems?

Yes, exposure to violence in childhood is strongly linked to mental health problems, including anxiety, depression, and behavioral issues, and can change brain development.

Full answer →
Can omega-3 deficiency be a risk factor for mental disorders?

Yes, research indicates that a lack of omega-3 fatty acids in the diet may increase the risk of developing mental disorders like depression, anxiety, and schizophrenia.

Full answer →