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Gastroenterology
Meta-analysis
Systematic review and meta-analysis assesses SWDS diagnostic accuracy for MASLD liver inflammation grading
Shear-wave dispersion slope helps doctors grade liver inflammation in metabolic disease
This systematic review and diagnostic test accuracy meta-analysis evaluates the Shear-wave dispersion slope (SWDS) for detecting and grading…
A new analysis shows a noninvasive test can accurately detect and grade liver inflammation in patients with metabolic dysfunction-associated…
May 1, 2026
Gastroenterology
RCT
Chiglitazar reduces liver fat in MASLD patients with hypertriglyceridemia and insulin resistance
Two doses of chiglitazar cut liver fat far more than a placebo in 18 weeks
In a phase II randomized, double-blind, placebo-controlled trial, 104 patients with MASLD, hypertriglyceridemia, and insulin resistance rece…
Patients with fatty liver disease and high triglycerides saw liver fat drop significantly with chiglitazar compared to placebo after 18 week…
May 1, 2026
Diabetes & Endocrinology
Cohort
PON1 genetic variants rs2057681 and rs854572 modulate PONase activity and dysmetabolic risk in MASLD
Your Liver's Hidden Genetic Shield
This cohort study of 922 Portuguese individuals from the PREVADIAB2 cohort examined associations between PON1 genetic variants and metabolic…
Your specific DNA pattern for a liver enzyme predicts diabetes and liver scarring risk better than simple blood tests alone.
medRxiv
Apr 16, 2026