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Myocardial Infarction

Part of Myocardial ischemia

66 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Myocardial Infarction

139 trials tracked for Myocardial Infarction: 55 in phase 3 or 4 and 20 with published results. The most-cited published study has 3076 citations.

139Trials tracked
55Phase 3 & 4
0Recruiting
20With published results
Phase distribution
Phase 4 20 Phase 3 35 Phase 2 22 Other / NA 62
  1. Phase 3 Colchicine Cardiovascular Outcomes Trial (COLCOT) Completed · 3,076 cited
  2. Phase 3 Secondary Prevention of Cardiovascular Disease in the Elderly Trial Completed · 325 cited
  3. Phase 3 Impact of EMpagliflozin on Cardiac Function and Biomarkers of Heart Failure in Patients With Acute MYocardial Infarction Completed · 306 cited
  4. Phase 3 Interleukin-1 (IL-1) Blockade in Acute Myocardial Infarction (VCU-ART3) Completed · 301 cited
  5. Phase 3 Dapagliflozin Effects on Cardiometabolic Outcomes in Patients With an Acute Heart Attack. Completed · 292 cited
  6. Phase 3 EMPACT-MI: A Study to Test Whether Empagliflozin Can Lower the Risk of Heart Failure and Death in People Who Had a Heart Attack (Myocardial Infarction) Completed · 286 cited
Show 44 more trials
  1. Phase 4 Impact Of Eplerenone On Cardiovascular Outcomes In Patients Post Myocardial Infarction Completed · 187 cited
  2. Phase 3 Effect of High Dose Fish Oil Supplementation After Recent Heart Attack Using Magnetic Resonance Imaging Completed · 171 cited
  3. Phase 4 INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure Completed · 137 cited
  4. Phase 3 Insulin Resistance Intervention After Stroke Trial Completed · 108 cited
  5. Phase 4 Subclinical Cardiovascular Disease in Psoriatic Disease Completed · 99 cited
  6. Phase 3 Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction Completed · 58 cited
  7. Phase 4 STrategic Reperfusion in Elderly Patients Early After Myocardial Infarction Completed · 55 cited
  8. Phase 3 Glutamate for Metabolic Intervention in Coronary Surgery Completed · 46 cited
  9. Phase 3 Trial to Assess Chelation Therapy 2 Completed · 27 cited
  10. Phase 4 Vorapaxar in Patients With Prior Myocardial Infarction Treated With Prasugrel and Ticagrelor Completed · 22 cited
  11. Phase 4 Vorapaxar as an Add-On Antiplatelet Therapy in Patients With and Without Diabetes Mellitus Completed · 19 cited
  12. Phase 3 Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI Completed · 18 cited
  13. Phase 3 Myocardial Ischemia and Transfusion Completed · 11 cited
  14. Phase 3 STREAM-Strategic Reperfusion (With Tenecteplase and Antithrombotic Treatment) Early After Myocardial Infarction Completed · 7 cited
  15. Phase 4 Alirocumab in Patients With Acute Myocardial Infarction Completed
  16. Phase 4 Antiplatelet Therapy Effect on Extracellular Vesicles in Acute Myocardial Infarction Completed
  17. Phase 4 Vorapaxar on Thrombin Generation and Coagulability Completed
  18. Phase 4 Pre-hospital Administration of Thrombolytic Therapy With Urgent Culprit Artery Revascularization Completed
  19. Phase 4 CES1 Crossover Trial of Clopidogrel and Ticagrelor Completed
  20. Phase 4 Effects of N-acetylcysteine on Low T3 Syndrome Completed
  21. Phase 4 Intravenous Exenatide in Coronary Intensive Care Unit (ICU) Patients Completed
  22. Phase 4 APRICOT-3: Antithrombotics in the Prevention of Reocclusion In COronary Thrombolysis -3 Completed
  23. Phase 4 Comparison Between Thrombolysis and Primary Percutaneous Coronary Intervention (PCI) to Treat ST-Segment Elevation Myocardial Infarction Completed
  24. Phase 4 Hyperglycemia and Cardiovascular Outcomes With Type 2 Diabetes Completed
  25. Phase 4 Efficacy of Everolimus-Eluting Versus Zotarolimus-Eluting Sten for Coronary Lesions in Acute Myocardial Infarction Completed
  26. Phase 4 A 30 Day Study to Evaluate Efficacy and Safety of Pre-hospital vs. In-hospital Initiation of Ticagrelor Therapy in STEMI Patients Planned for Percutaneous Coronary Intervention (PCI) Completed
  27. Phase 4 Pilot Study of Edaravone to Treat Acute Myocardial Infarction Completed
  28. Phase 4 Aspirin Dose and Atherosclerosis in Patients With Heart Disease Completed
  29. Phase 3 Single Bolus Recombinant Nonimmunogenic Staphylokinase Versus Single Bolus Tenecteplase (Metalyse) in STEMI Completed
  30. Phase 3 SPECTACL: SPECTroscopic Assessment of Coronary Lipid Completed
  31. Phase 3 Omega-3 Fatty Acids to Improve Depression and Reduce Cardiovascular Risk Factors Completed
  32. Phase 3 Safety and Effectiveness of Two Blood Transfusion Strategies in Surgical Patients With Cardiovascular Disease Completed
  33. Phase 3 Myocardial Ischemia and Transfusion Pilot Completed
  34. Phase 3 Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial Completed
  35. Phase 3 Zyban as an Effective Smoking Cessation Aid for Patients Following an Acute Coronary Syndrome: The ZESCA Trial Completed
  36. Phase 3 Trial to Assess the Ocular Safety of Vorapaxar (SCH 530348) in Participants With Atherosclerosis (Study P05183) Completed
  37. Phase 3 Multicenter Study to Rule Out Myocardial Infarction by Cardiac Computed Tomography Completed
  38. Phase 3 Occluded Artery Trial (OAT) Completed
  39. Phase 3 IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium. Completed
  40. Phase 3 IMPROVE-IT: Examining Outcomes in Subjects With Acute Coronary Syndrome: Vytorin (Ezetimibe/Simvastatin) vs Simvastatin (P04103) Completed
  41. Phase 3 Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Patients With Atherosclerosis (TRA 2°P - TIMI 50) (P04737) Completed
  42. Phase 3 An Efficacy and Safety Study for Rivaroxaban in Patients With Acute Coronary Syndrome Completed
  43. Phase 3 Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin Completed
  44. Phase 3 Women's Health Study (WHS): A Randomized Trial of Low-dose Aspirin and Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer Completed

Showing the 50 most-cited and recently-updated of 139 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Myocardial Infarction: what the trials found

Pharmacological management of myocardial infarction includes several agents with established profiles. Tenecteplase was associated with significantly higher rates of successful reperfusion compared to the comparator 9. Ticagrelor demonstrated no significant difference in TIMI flow grade or ST-segment resolution compared to its comparator 18, while alirocumab showed a significant reduction in LDL cholesterol but did not significantly impact hsCRP levels 16.

Antiplatelet and other pharmacological interventions show varied results. Prasugrel was associated with lower maximal platelet aggregation 10, whereas Vorapaxar did not show a statistically significant difference in maximal platelet aggregation in patients with DM 11 or in response to specific activating peptides 14. Clopidogrel showed a significant change in maximal platelet aggregation compared to the baseline, while Ticagrelor did not differ significantly from its comparator in this metric 12. Aspirin and/or Atorvastatin were associated with changes in inflammatory transcripts 8, and Aspirin alone was associated with changes in nitric oxide formation 22.

Other interventions include Exenatide, which showed significant improvements in steady-state glucose values and time to steady state 19. N-acetylcysteine was evaluated regarding serum T3 levels 17.

Recent results — preliminary, needs further review

  • • Physical activity was associated with significantly improved self-reported physical function scores (p<0.001), but no significant difference in cardiovascular events or non-cardiovascular mortality (p=0.49, p=0.85) 1. • IVL with Shockwave C2+ 2Hz Coronary IVL Catheter showed a 98.6% rate of freedom from MACE within 30 days and a 97.9% procedural success rate 4. • Ferric carboxymaltose was associated with a decrease in the Wall Motion Score Index 5. • Eplerenone significantly reduced the first event of cardiovascular mortality, re-hospitalization, or extended hospital stay due to heart failure (p<0.0001), though it did not significantly impact overall cardiovascular mortality or diagnosis of heart failure 6.

For the clinician treating this condition

  • Tenecteplase is associated with superior reperfusion rates compared to alternatives in acute settings 9.
  • Eplerenone significantly reduces composite outcomes including re-hospitalization and extended stay for heart failure (p<0.0001) 6.
  • Physical activity improves patient-reported physical function scores post-MI 1.

AI synthesis of 15 cited trials, updated Jun 25, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Myocardial ischemia

Related studies from across the Myocardial ischemia family.

Functional Coronary Angiography Improves Clinical Outcomes in Multivessel STEMI Patients
Cardiology RCT
Functional Coronary Angiography Improves Clinical Outcomes in Multivessel STEMI Patients Physiology guided heart procedures show lower risk of major events
Physiology-guided revascularization significantly reduces major adverse cardiac events and improves safety profiles compared to traditional …
A large international trial shows that using functional imaging to guide heart artery procedures may lower the risk of stroke and heart atta…
Ticagrelor monotherapy following primary PCI for STEMI shows reduced non-access site bleeding
Cardiology RCT
Ticagrelor monotherapy following primary PCI for STEMI shows reduced non-access site bleeding Trial shows ticagrelor monotherapy may reduce bleeding after heart attack
This pilot study compared ticagrelor monotherapy against ticagrelor plus aspirin in patients with STEMI after primary PCI. The trial reporte…
A pilot study suggests that using ticagrelor alone after a heart attack may reduce specific types of bleeding compared to a dual-drug approa…
High-dose statin preloading increases TIMI flow grade 3 and reduces all-cause mortality in STEMI
Cardiology Meta-analysis
High-dose statin preloading increases TIMI flow grade 3 and reduces all-cause mortality in STEMI High dose statins may improve outcomes for heart attack patients
This meta-analysis of 1862 patients with STEMI undergoing primary PCI indicates that high-dose statin preloading is associated with improved…
A high dose of statins before a heart procedure may improve blood flow and lower death rates for patients with a heart attack.
Ticagrelor monotherapy after primary PCI shows 3.1% MACCE versus 2.0% in DAPT group
Cardiology RCT
Ticagrelor monotherapy after primary PCI shows 3.1% MACCE versus 2.0% in DAPT group Trial shows ticagrelor alone may reduce bleeding after heart attack
This pilot randomized controlled trial of 200 STEMI patients compared ticagrelor monotherapy to ticagrelor plus aspirin (DAPT) after primary…
A new trial looks at whether using one blood thinner instead of two can reduce bleeding risks for patients after a heart attack.
Pressure optimization protocol improves reperfusion success and reduces postdilation in STEMI patients
Cardiology RCT
Pressure optimization protocol improves reperfusion success and reduces postdilation in STEMI patients New stenting technique improves blood flow after heart attacks
This multicenter randomized trial of 607 patients undergoing primary PCI for STEMI found that a pressure optimization protocol (POP) signifi…
A new pressure optimization method during heart surgery helps restore blood flow faster and reduces the need for extra procedures.
Adjunctive intracoronary thrombolysis reduces major adverse cardiovascular events in patients with STEMI
Cardiology Meta-analysis
Adjunctive intracoronary thrombolysis reduces major adverse cardiovascular events in patients with STEMI Intracoronary Thrombolysis Linked to Lower Risks After Heart Attack
This meta-analysis evaluated the impact of adjunctive intracoronary thrombolysis during primary percutaneous coronary intervention for patie…
Adding intracoronary thrombolysis during heart procedures may lower the risk of major complications and improve blood flow for patients with…
Persistent microvascular obstruction predicts higher MACE and death risks following ST-segment elevation myocardial infarction
Cardiology Meta-analysis
Persistent microvascular obstruction predicts higher MACE and death risks following ST-segment elevation myocardial infarction Persistent heart muscle damage after heart attack increases risk
This meta-analysis of 2180 patients with STEMI identifies persistent microvascular obstruction as a significant prognostic indicator. Persis…
Patients with lasting microvascular obstruction after a heart attack face higher risks of death and major complications compared to those wi…
Intracoronary mesenchymal stem cell administration improves left ventricular ejection fraction following ST-segment elevation myocardial infarction
Cardiology Meta-analysis
Intracoronary mesenchymal stem cell administration improves left ventricular ejection fraction following ST-segment elevation myocardial infarction Stem cells improve heart function after heart attack but not outcomes
This meta-analysis of 8 randomized controlled trials found that intracoronary mesenchymal stem cell (MSC) administration significantly impro…
New data shows stem cell treatment improves heart muscle pumping power after a heart attack, though it does not yet reduce hospital visits o…
Ticagrelor reduces mortality and major adverse cardiovascular events compared to clopidogrel in STEMI patients
Cardiology Meta-analysis
Ticagrelor reduces mortality and major adverse cardiovascular events compared to clopidogrel in STEMI patients Ticagrelor Shows Lower Mortality Risk Than Clopidogrel for Heart Patients
This meta-analysis of 31,729 adult STEMI patients post-PCI found that ticagrelor significantly reduced all-cause mortality (OR = 0.64) and m…
A large analysis of over 31,000 patients suggests ticagrelor may lower mortality and heart attack risks compared to clopidogrel after a hear…
Transvalvular microaxial flow pump plus PCI does not reduce infarct size in anterior STEMI
Cardiology RCT
Transvalvular microaxial flow pump plus PCI does not reduce infarct size in anterior STEMI Trial shows microaxial flow pump does not reduce heart damage
This randomized controlled trial of 527 adults with acute anterior STEMI found that LV unloading with a transvalvular microaxial flow pump f…
A clinical trial found that using a transvalvular microaxial flow pump before heart surgery did not reduce the size of heart tissue damage.
Staged revascularization shows no significant difference versus immediate revascularization for major adverse cardiovascular events in STEMI and MVD patients
Cardiology Meta-analysis
Staged revascularization shows no significant difference versus immediate revascularization for major adverse cardiovascular events in STEMI and MVD patients Timing of heart surgery does not change survival for a specific heart attack group
This meta-analysis reviewed 5077 patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease comparing …
A large review found that waiting for staged heart surgery did not improve survival or reduce heart attacks compared to immediate surgery fo…
Complete revascularization shows high probability of benefit for NSTEMI patients with multivessel disease
Cardiology RCT
Complete revascularization shows high probability of benefit for NSTEMI patients with multivessel disease Complete revascularization shows high probability of benefit for NSTEMI patients with multivessel disease
This Bayesian re-analysis of a randomized trial evaluated complete versus culprit-only revascularization in patients with non-ST-elevation m…
A Bayesian re-analysis suggests complete revascularization offers a high probability of clinically meaningful benefit compared to treating o…

Questions about Myocardial Infarction

Will a special breathing machine help if I have sleep problems after my heart attack?

Yes, a special breathing machine (ASVmv) can reduce nighttime oxygen drops in heart attack patients with sleep-disordered breathing, but it's not a standard treatment for all sleep problems after a heart attack.

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Can I choose between moderate or high-intensity exercise to recover from my heart attack?

Both moderate and high-intensity exercise similarly improve heart function after a heart attack, but you should start with moderate intensity and get your doctor's approval before increasing intensity.

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Does my kidney number creatinine level affect my risk after a heart attack procedure?

Yes, higher creatinine levels are linked to a greater risk of adverse events after a heart attack procedure, especially if you also have anemia.

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How do artificial intelligence tools compare to doctors for predicting heart attack biomarkers?

AI tools can match or slightly outperform doctors in predicting heart attack biomarkers, but most studies lack real-world validation.

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Do beta-blockers reduce my risk of death if my heart function is normal after MI?

For patients with normal heart function after MI, beta-blockers do not appear to reduce the risk of death or recurrent heart attack based on recent large trials.

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Does having a specific type of myocardial injury increase my risk of future heart events?

Yes, the type of myocardial injury matters: type 1 MI carries the highest risk of future heart events, but type 2 MI and acute/chronic myocardial injury also increase risk compared to no injury.

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See all 6 questions about Myocardial Infarction →