Systemic Inflammatory Response Syndrome

All Systemic Inflammatory Response Syndrome Articles

• Sepsis is an inflammation-driven immune reprogramming disorder characterized by time-resolved trajectories and biologically defined subtypes
• Adrenergic receptor signaling modulates pulmonary innate immunity and barrier integrity in acute lung injury
• Lactobacillus rhamnosus GG does not significantly impact composite outcomes in VLBW infants
• Hyperoxygenation target (PaO2: 100-150 mmHg) reduces 28-day mortality in patients with sepsis
• Base excess shows 85.8% sensitivity and 82.9% specificity for neonatal sepsis diagnosis in meta-analysis
• Novel biomarkers and machine learning algorithms facilitate earlier identification and diagnosis of sepsis
• Bovine milk fortifiers non-inferior to human milk fortifiers for NEC and sepsis in pre-term newborns
• Elevated HMGB1 levels correlate with sepsis diagnosis and increased mortality risk in adult patients
• Neutrophil extracellular traps contribute to vascular dysfunction and endothelial injury in patients with sepsis
• Vitamin D deficiency increases odds of sepsis and mechanical ventilation in neonates
• Cystatin C shows good diagnostic performance with an AUC of 0.88 for early detection of SA-AKI
• Sepsis Mortality Prediction Models Show Moderate Performance
• Prediction models show moderate discrimination for ARDS occurrence and mortality in sepsis patients
• Meropenem and norepinephrine managed a case of chorioamnionitis and septicemia involving Hafnia alvei
• Gut microbiota dysbiosis and microbial metabolites impair renal function in sepsis-associated acute kidney injury
• Modulation of neutrophil function and death in critically ill patients with sepsis is discussed in this narrative review
• Antibiotic stewardship bundle aims to cut antibiotic use in Chinese NICUs
• Source control and antibiotic stewardship remain cornerstones of sepsis management
• Arterial hypotension is a late sign of decompensated shock linked to increased mortality and adverse neurologic outcomes in critically ill children
• Azithromycin reduces maternal infection in laboring women in low- and middle-income countries
• Interleukin-7 therapy improves lymphocyte counts in sepsis and COVID-19 patients
• Immediate antituberculosis therapy did not reduce mortality in HIV-related sepsis overall
• Model-informed precision dosing improves vancomycin target attainment in critically ill children compared to standard therapeutic drug monitoring
• Antioxidant nanomedicine in sepsis: a narrative review with no reported outcomes or safety data
• Systematic review and meta-analysis of sepsis screening tools in low- and middle-income countries
• Narrative review on PAD4-mediated citrullination and PAD4-directed therapies for multiple inflammatory conditions
• Review discusses metabolic reprogramming of macrophages for sepsis-associated acute lung injury with noted limitations
• Secondary analysis of 342 sepsis patients reveals limited diagnostic utility for serum biomarkers in invasive candidiasis diagnosis
• Systematic Review and Meta-Analysis Finds IL-27 Superior to CRP for Neonatal Sepsis Diagnosis
• Network meta-analysis of immunomodulatory therapies for sepsis mortality
• Scoping review on androgen pathways and therapy in adult sepsis and septic shock
• Conservative oxygen targets show no mortality difference in mechanically ventilated critically ill adults
• Narrative review evaluates Oxford Nanopore sequencing for pediatric infectious disease diagnostics
• Systematic review and meta-analysis of CALLY index in sepsis patients
• Narrative review on sepsis in end-stage liver disease and acute-on-chronic liver failure
• Delphi guideline establishes sepsis care quality indicators for Chinese emergency and ICU settings
• Sepsis survivors face high readmission, mortality, and long-term impairments
• Procalcitonin-guided care in sepsis shows no difference in early antibiotic initiation but lower 28-day mortality
• Polymyxin B haemoadsorption associated with lower mortality in endotoxic septic shock patients
• Meta-analysis shows association between adequate antimicrobial therapy and reduced hospital length of stay
• Narrative review on multi-omic technologies for pediatric sepsis biomarker discovery
• Narrative review of Shenfu Injection for sepsis-induced gastrointestinal injury and septic shock
• Selective decontamination of the digestive tract reduces hospital mortality in mechanically ventilated ICU adults
• Large language models show varying accuracy for data extraction in sepsis guidelines
• Sarcopenia in older patients with sepsis is associated with specific plasma metabolomic changes
• Systematic review identifies dual role of NLRP3 inflammasome in sepsis induced immune dysregulation
• Active sepsis prevention program reduces maternal infection-related complications in Malawi and Uganda
• Narrative review examines multimorbidity impact on sepsis morbidity and mortality outcomes
• Narrative review of Dachengqi Decoction for sepsis-induced organ injury
• Non-invasive ultrasound defines snuffbox artery RI and PI reference ranges in healthy volunteers versus ICU patients with septic shock or hypertension
• Early enteral nutrition linked to favorable biomarker trajectories and lower mortality risk in adult ICU sepsis patients
• Serum N-myc and STAT interactor (NMI) levels predict 30-day mortality and septic shock in adult sepsis patients
• Narrative review explores immunopathological framework for complicated intra-abdominal infection and intra-abdominal sepsis
• Elevated pre-sepsis vitamin B12 levels associated with increased 90-day mortality in adults with sepsis
• Narrative review discusses natural bioactive compounds in sepsis with noted pharmacokinetic and safety limitations
• Gut Microbiota Dysbiosis Linked to Sepsis in Infants and Young Children With Severe Pneumonia
• Dataset describes continuous monitoring in premature VLBW infants across four US NICUs
• Retrospective cohort study links pulse pressure levels to 28-day mortality in septic shock patients
• Sterile-site yeast isolates linked to fungemia, sepsis, and mortality in a retrospective cohort study
• Prospective observational study of inflammatory mediators in adult ED patients with suspected infection
• Meta-analysis of 34 Studies Shows Buffered Solutions Do Not Lower Mortality Compared to 0.9% Saline
• Meta-analysis finds preadmission metformin use associated with reduced mortality in diabetic sepsis patients
• Pooled analysis review of rezafungin versus caspofungin for candidemia and invasive candidiasis
• Systematic review proposes S100A8/A9–NETosis feedback loop as core sepsis mechanism
• Selective Decontamination of the Digestive Tract showed no mortality benefit over standard care in mechanically ventilated patients
• Review of preclinical EVs for sepsis-associated acute lung injury
• Hematocrit–albumin gap linked to sepsis risk in ICU adults in retrospective analysis
• Seraph Microbind filter used in a 7-year-old with refractory septic shock and invasive Streptococcus pyogenes infection
• MAIT cell frequency decreased in sepsis-related liver injury, with altered phenotype and function in murine models
• Narrative review on sepsis and the microbiome, highlighting unresolved causality and variability
• Insulin administration associated with lower 28-day mortality in non-diabetic sepsis patients
• CAR T-cell therapy linked to endocrine adverse events in FAERS analysis
• 7-Day Antibiotic Regimen Non-Inferior to 14-Day for Uncomplicated Neonatal Sepsis in RCT
• Corticosteroids reduce short-term and long-term mortality in adult sepsis patients according to a systematic review
• Biomarkers and clinical factors show statistical associations with sepsis-induced coagulopathy in 37,459 patients
• Thiamin supplementation associated with reduced mortality in septic shock patients
• Protein nutritional support in critically ill adults shows heterogeneous mortality benefits and potential harm from very high early doses
• Retrospective cohort study examines MRSA prevalence and resistance patterns in nosocomial bloodstream infections among 96 patients in central China
• AMR strategies in LMIC newborns reduce antibiotic use and mortality in meta-analysis
• A 1-hour sepsis bundle is associated with reduced short-term mortality compared to non-bundle care in a meta-analysis of 4435 patients
• Immune dysregulation score predicts mortality and identifies hydrocortisone responders in community-acquired pneumonia
• Maternal preeclampsia modestly increases neonatal sepsis risk in infants up to 28 days of age
• RDW trajectories during sepsis hospitalization predict 30- and 90-day mortality in retrospective study
• CytoSorb hemoadsorption shows no benefit and potential harm in small septic shock trial
• AI applications in acute care showed potential but face significant implementation challenges
• Red blood cell parameters predict sepsis in children with ALL and chemotherapy-induced neutropenia
• Macrophage glycolysis interactions modulate inflammation and polarization in sepsis
• NTIS subtypes and thyroid antibodies associated with higher in-hospital mortality in sepsis cohort
• Meta-analysis identifies clinical signs associated with sepsis and mortality in young infants
• Neostigmine infusion in septic shock linked to lower TNF-alpha and 28-day mortality in single-center RCT
• Socioeconomic factors associated with increased mortality in adults with sepsis or septic shock
• Corticosteroids in cirrhotic shock show no mortality benefit but increase bleeding and organ failure risk
• Observational study examines septicemia death rates in US adults aged 65 and older
• Report describes sepsis program activities in US acute care hospitals
• Procalcitonin shows moderate accuracy for bloodstream infection detection in retrospective cohort
• Case-control study identifies K. pneumoniae proteins associated with lack of neonatal sepsis
• Meta-analysis finds diaphragmatic atrophy and weakness in critically ill patients on ventilation or with sepsis
• Extracellular histones drive thrombo-inflammation in sepsis, stroke, and ARDS, review finds
• Systematic review explores pathogenesis and emerging treatments for sepsis-induced cardiomyopathy
• Network meta-analysis finds PMX and HA 330 blood purification may reduce mortality in severe septic shock
• Higher baseline chondroitin sulfate predicts greater mortality benefit from restrictive fluid strategy in sepsis
• VR and in-person sepsis simulation show similar skill outcomes in medical student pilot study
• Serum procalcitonin shows moderate accuracy for sepsis diagnosis in critically ill ICU patients
• Balanced salt solution in pediatric septic shock linked to lower AKI and RRT rates versus normal saline
• Procalcitonin-guided antibiotic protocols reduce therapy duration in critically ill sepsis patients
• PAC use in cardiogenic shock associated with lower mortality but higher sepsis risk in meta-analysis
• Chlorhexidine May Reduce Neonatal Mortality and Infection in LMICs